Gold Nanoparticle/Silk Fibroin-Based Nanofiber Enhances Skin Regeneration

dc.authorwosid Tunali Akbay, Tugba/Aas-4127-2020
dc.contributor.author Ozcan, Ozan
dc.contributor.author Tufan, Elif
dc.contributor.author Muhan, Aleyna
dc.contributor.author Ak, Esin
dc.contributor.author Sener, Goksel
dc.contributor.author Tunali-Akbay, Tugba
dc.date.accessioned 2025-07-10T20:04:11Z
dc.date.available 2025-07-10T20:04:11Z
dc.date.issued 2025
dc.department Fenerbahçe University en_US
dc.department-temp [Ozcan, Ozan; Tufan, Elif] Marmara Univ, Inst Hlth Sci, Dept Biochem, TR-34865 Istanbul, Turkiye; [Muhan, Aleyna] Marmara Univ, Inst Hlth Sci, Dept Histol & Embryol, TR-34865 Istanbul, Turkiye; [Ak, Esin] Marmara Univ, Fac Dent, Dept Basic Med Sci Histol & Embryol, TR-34854 Istanbul, Turkiye; [Sener, Goksel] Fenerbahce Univ, Fac Pharm, Dept Pharmacol, TR-34584 Istanbul, Turkiye; [Tunali-Akbay, Tugba] Marmara Univ, Fac Dent, Dept Basic Med Sci Biochem, TR-34854 Istanbul, Turkiye en_US
dc.description.abstract Objectives The aim of this study was to determine the wound-healing potential of gold nanoparticles and silk fibroin-based nanofiber produced by green chemistry.Methods The electrospinning method was used to prepare the nanofiber. Twenty rats were exposed to a 7-day treatment period and another 20 rats were exposed to a 21-day treatment period. Rat groups were control, silver, silk fibroin, and silk + gold nanoparticle groups for each period. The effect of the gold nanoparticle/silk fibroin-based nanofiber was examined in skin samples by using biochemical and histological analysis. In biochemical analysis, skin oxidant and antioxidant parameters were determined.Key findings Parameters indicating skin damage returned to their previous levels 7 and 21 days after the wound formation using gold nanoparticle/silk fibroin-based nanofiber. Gold nanoparticle/silk fibroin-based nanofiber initiated hair follicle formation at the wound site and accelerated the re-epithelialization process.Conclusions It was found that the nanofiber prepared by adding gold nanoparticles to silk fibroin had better wound-healing properties than silk fibroin nanofibers without gold nanoparticles. en_US
dc.description.sponsorship Marmara University Scientific Research Project Department [TDK-2022-10384] en_US
dc.description.sponsorship This study was supported by the Marmara University Scientific Research Project Department (Project ID: TDK-2022-10384). en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1093/jpp/rgaf025
dc.identifier.issn 0022-3573
dc.identifier.issn 2042-7158
dc.identifier.pmid 40522974
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.1093/jpp/rgaf025
dc.identifier.uri https://hdl.handle.net/20.500.14627/1120
dc.identifier.wos WOS:001508799700001
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Oxford Univ Press en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Gold Nanoparticles en_US
dc.subject Silk Fibroin en_US
dc.subject Nanofiber en_US
dc.subject Wound Dressing en_US
dc.subject Antioxidant Effect en_US
dc.title Gold Nanoparticle/Silk Fibroin-Based Nanofiber Enhances Skin Regeneration en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication

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