WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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Psychometrics of Flodén Attitudes Toward Organ Donor Advocacy Instrument in Turkish: a Scale Adaptation Study Among Intensive Care Unit Nurses
(Lippincott Williams & Wilkins, 2024) Floden, Anne Charlotte; Utku, Tughan; Kiraner, Ebru; Yayik, Aycan Kelez; Seren, Arzu Kader Harmanci
[No Abstract Available]
Citation - WoS: 11
Citation - Scopus: 11
Synthesis and Biological Evaluation of Novel Aryloxyacetic Acid Hydrazide Derivatives as Anticancer Agents
(Taylor & Francis inc, 2021) Senkardes, Sevil; Erdogan, Omer; Cevik, Ozge; Kucukguzel, S. Guniz
In our continuing search for new anticancer agents, herein we report the synthesis of 2-(4-chloro-3-methylphenoxy)-N'-[(aryl)methylidene]acetohydrazides 3a-j and the evaluation of their anticancer activities on cell viability, morphological changes and caspase-3 activity in cancer cell lines including gastric cancer (MKN45), cervical cancer (HeLa) and breast cancer (MDA-MB-231) cells. 2-(4-chloro-3-methylphenoxy)-N'-[(4-phenylthiophen-2-yl)methylidene] acetohydrazide 3g presented the strongest growth inhibition against MKN45 gastric cancer cell lines with the IC50 value of 1.471 +/- 0.23 mu M. Moreover, compounds 3b and 3g showed high potency against the HeLa and MDA-MB-231 cell lines having IC50 in the range of 2.38-9.72 mu M. These compounds are more selective for the tested human cancer cells than for the mouse fibroblast cell line (NIH/3T3). As a result of the studies conducted in order to understand the molecular mechanism, compounds 3b and 3g enhanced expression of the caspase-3 pro-apoptotic proteins levels besides caspase-3 gene.
Citation - WoS: 1
Citation - Scopus: 1
Synthesis, Molecular Docking Studies and Adme Prediction of Some New Albendazole Derivatives as Α-Glucosidase Inhibitors
(Slovensko Kemijsko Drustvo, 2022) Senkardes, Sevil; Kulabas, Necla; Kucukguzel, S. Guniz
A series of novel 2-(substituted arylidene)-N-(5-(propylthio)-2,3-dihydro-1H-benzo[d]imidazol-2-yl)hydrazine-1-carboxamide derivatives 3a-i were synthesized via condensation of N-(5-(propylthio)-1H-benzo[d]imidazol-2-yl) hydrazinecarboxamide (2), with the corresponding ketone or aldehydes. The chemical structures of the compounds prepared were confirmed by analytical and spectral data. The compounds were screened for their a-glucosidase inhibitory activity and all of them showed better inhibition than acarbose, except 3h. In particular, compound 3a proved to be the most active compound among all synthetic derivatives having IC50 value 12.88 +/- 0.98 mu M. Also, molecular docking studies were carried out for the compounds to figure out the binding interactions. Compound 3a has exhibited the highest binding energy (Delta G = -9.4 kcal/mol) and the most hydrogen bond interactions with active sites. Eventually, in silico studies were in good agreement with in vitro studies.
Tracking Step Counts in Adolescents with Juvenile Idiopathic Arthritis and Familial Mediterranean Fever: A 3-Month m-Health Monitoring Study Using Smartwatches
(Elsevier, 2025) Albayrak, A.; Arman, N.; Yekdaneh, A.; Donmez, I.; Acikgoz, Y.; Filiz, G.; Ayaz, N. Aktay
Citation - WoS: 2
Citation - Scopus: 2
Preparation and Application of Caffeic Acid Imprinted Polymer
(Tubitak Scientific & Technological Research Council Turkey, 2023) Ersoy, Seyda K. A. R. A. M. A. N.; Tutem, Esma; Baskan, Kevser SoeZGEN; Apak, Resat
In the present study, molecularly imprinted polymers were synthesized using caffeic acid (CA) as a template molecule and then used for the extraction of CA and chlorogenic acid (CLA) from complex matrices. Syntheses were carried out in tetrahydrofuran as porogenic solvent using 4-vinyl pyridine, methacrylic acid, acrylamide, and 1-vinyl imidazole as monomers, ethylene glycol dimethacrylate as crosslinker and 2,2'-azobisisobutyronitrile as initiator. In polymerization processes, different ratios of the template:monomer:crosslinker (T:M:CrL) were used to obtain the most suitable polymer. Caffeic acid:4-vinylpiridine:ethylene glycol dimethacrylate's 1:4:16 mole ratio of MIP was determined as the most convenient polymer for CA recognition. In addition, nonimprinted polymers (NIPs) without templates were prepared. Dynamic and static adsorption tests were applied to determine the absorption features of the NIPs and CA-MIPs. Separation and purification studies of CA and CLA were performed with molecular imprinted solid phase extraction (MISPE) application. All steps of MISPE (loading, washing, elution) were optimized by HPLC analysis.
Examination of the Mental Health Status of University Students Directly or Indirectly Affected by the Earthquake
(SAGE Publications Inc., 2025) Ayık, Y.; Kaya, H.; Sarısahin, S.; Ozturk, B.; Kayıhan, H.
Objective: This study examines the mental health status of university students directly affected by the earthquake in the disaster zone and those indirectly affected by being outside the earthquake zone during the Kahramanmaraş earthquake that struck Turkey on February 6, 2023. Methods: A total of 109 students from 37 universities in 24 cities participated. Data were collected using an online survey that included a Demographic Information Form, the Impact of Event Scale-Revised (IES-R), the Earthquake Anxiety Scale, the DSM-5 PTSD checklist, and the Depression-Anxiety-Stress Scale-21. Mental health outcomes of directly and indirectly affected students were compared. Results: Students directly affected showed significantly higher levels of post-traumatic stress disorder (PTSD), depression, anxiety, and earthquake-related anxiety. Among indirectly affected students, females reported higher IES-R, PTSD, and earthquake anxiety scores than males. Regression analysis identified factors such as earthquake exposure, loss of relatives, involvement in search and rescue, and relocation as linked to adverse mental health outcomes. Conclusion: Although students directly affected by the earthquake are at greater risk for PTSD, depression, and anxiety, both groups face significant mental health problems. As these effects may be ongoing rather than temporary, the role of occupational therapy in promoting occupational engagement and mental health in disaster management is noteworthy. © The Author(s) 2025
Citation - WoS: 5
Citation - Scopus: 4
Exploring Effects of the Hep (homeostasis-Enrichment Approach as a Comprehensive Therapy Intervention for an Infant With Cerebral Palsy: a Case Report
(Georg Thieme verlag Kg, 2022) Balikci, Aymen
Cerebral palsy (CP) is a common non-progressive neurodevelopmental disorder which causes developmental disabilities in children. Varied interventions for CP exist to address medical and physical needs but with limited effectiveness evidence. Environmental enrichment (EE) is an animal model intervention for many neurodevelopmental disorders, including CP, with considerable positive effects. This case report defines the Homeostasis-Enrichment-Plasticity (HEP) approach, which is based upon principles of EE and ecological theories of development and describes its use to promote the developmental and functional skills of an infant with CP. Parent interviews and assessment data were completed before and after intervention. For the interested parameters data was gathered by developmental history, systematic observation of behaviors in the clinical setting and at home, Beck Anxiety Inventory (BAI), Infant-Toddler Symptom Checklist, the Sensory Profle Infant/Toddler, Peabody Developmental Motor Scales-2, Gross Motor Function Measurement-88 (GMFM-88), the Gross Motor Function Classification System (GMFCS), and Pediatric Evaluation of Disability Inventory (PEDI). The HEP approach intervention was implemented one time per week for 12 months. Following the HEP approach intervention, self-regulation and sensory processing scores improved. GMFM-88 total score improved from 45/264 to 123/264. The Peabody found all gross motor (54-110), fine motor (65-117), and total motor quotient (119-227) scores improved after intervention. Post-intervention observations showed obvious gross motor progress with movement from GMFCS Level IV to Level I. Performance on the Functional Skills Scales and Caregiver Assistance Scales of PEDI also demonstrated notable improvements. BAI scores revealed low anxiety scores for both the mother (13/63 points) and father (14/63) before intervention. These scores did not change after intervention. A definition and detailed description of the HEP approach intervention is presented here for the first time. The case report demonstrated preliminary evidence for the effectiveness of the HEP approach on self-regulation, sensory processing, motor development, functional skills, and caregiver assistance with an infant with CP. Additional studies are needed to validate the findings.
Citation - WoS: 3
Citation - Scopus: 4
Analysis for Two-Dimensional Inverse Quasilinear Parabolic Problem by Fourier Method
(Taylor & Francis Ltd, 2021) Kanca, Fatma; Baglan, Irem
In this work, two-dimensional inverse quasi-linear parabolic problem with periodic boundary and integral overdetermination conditions is investigated. The formal solution is obtained by the Fourier approximation. Under some natural regularity and consistency conditions on the input data,the existence, uniqueness and continuously dependence upon the data of the solution are proved by iteration method. The inverse problem is first examined by linearization and then used implicit finite difference scheme for the numerical solution. Also predictor corrector method is considered in the numerical approach. Some results on the numerical solution with two examples are presented with figures and tables. The sensitivity of the scheme with respect to noisy overdetermination data is illustrated.
Assessment of Artificial Lighting Conditions in Sunlight-Deprived Classrooms
(Gazi Univ, Fac Engineering Architecture, 2025) Duyan, Fazila; Kaplan, Elif
Numerous studies on classroom lighting emphasize a close and significant relationship between students' concentration, comprehension of course content, and the efficiency of activities such as drawing, writing, and practices, with the lighting conditions. In this context, it is particularly important to properly design both the physical and psychological effects of artificial lighting, especially in sunlight-deprived classrooms. This study examines the artificial lighting conditions of a classroom located in the basement of a university building, which has no visual connection to the outdoors. The classroom is utilized by students from the departments of Architecture, Interior Architecture, and Industrial Design. The study investigates the effects of current artificial lighting on students, focusing on aspects such as visual perception satisfaction, light colour, illuminance level, glare, and the temporal light modulation effect. To assess students' perception of the existing lighting conditions, an online questionnaire was administered, and a total of 104 students (65 female, 39 male) who had previous experience with the classroom participated in the study. Technical measurements of the existing luminaires were conducted, and the classroom was digitally modelled using the DIALux Evo lighting software. The collected data were analysed using the SPSS statistical analysis program. The findings of the study indicate that students perceived the artificial lighting conditions as inadequate in terms of visual comfort. Moreover, based on technical measurements, simulations, and user evaluations, it was determined that the existing luminaires caused glare and temporal light modulation effects, negatively affecting the classroom environment.
Citation - WoS: 5
Citation - Scopus: 5
Drivers and Barriers on Implementing Xr Technologies in the Construction Industry in Turkey
(Taylor & Francis Ltd, 2024) Seyman-Guray, Tayibe; Kismet, Burcu
This study presents drivers and barriers on construction industry extended reality (XR) implementations in Turkey. It aims to investigate the current state and future directions of XR opportunities for architecture offices and construction companies in a developing country. A quantitative approach was employed which involves conducting a survey, performing statistical analyses, and verification of the hypotheses. The data were analyzed by SPSS and Excel using the frequency, mean score, standard deviation (SD), and one sample t-test. Thirty-three different companies participated in the survey with a return rate of 56.89%. The results were considered statistically significant since all the p-values were below 0.05. The findings revealed that even though 60% of the companies are not using XR, 60% companies have near future plans on implementing them. According to the results, XR was considered as beneficial and highly motivating for the near future, yet it needs to be widespread for companies to keep themselves abreast of information and communication technology trends. Finally, by considering the findings obtained from the results this study reaches a classification of drivers as 'increased efficiency: time-cost-quality' and 'increased communication and coordination' while barriers as 'technical limitations', 'high costs', and 'unqualified professional'.
Panax Ginseng Extract Ameliorates Methotrexate-Induced Multi-Organ Damage Via the Regulation of Oxidative Stress
(Marmara Univ, 2023) Macit, Caglar; Ede-Pazarbasi, Seren; Yilmaz-karaoglu, Suemeyye; Tunali-Akbay, Tugba; Karakaya-Cimen, Fatma Bedia; Ercan, Feriha; Sener, Goksel
Oxidative damage plays an important role in organ toxicities caused by methotrexate (MTX). This study aimed to determine the antioxidant effects of Panax ginseng (PxG) extract against MTX-induced liver, lung, ileum and kidney damage. Twenty-four Sprague Dawley male rats (weight 250-300 g) were used in the study. The animals were randomly separated into three groups: a) Control, b) MTX-treated (MTX) and c) MTX+PxG-treated (MTX+PxG) groups. MTX was administered intraperitoneally at 20 mg/kg, as a single dose to MTX and MTX+PxG groups. PxG was administered orally at 100 mg/kg to the MTX+PxG group for five days. Saline was given to the control and MTX groups for 5 days. At the end of the experiment, liver, lung, ileum, and kidney samples were obtained. Malondialdehyde (MDA) and glutathione (GSH) levels, superoxide dismutase (SOD), glutathione-S-transferase (GST) and tissue factor (TF) activities were determined in all tissues. In addition, histological examinations were done through light microscopy. GraphPad Prism 5v. was used for statistics, and p<0.05 were considered significant. Administration of MTX caused severe injury in tissues. Findings showed that MDA level, SOD, and GST activities were significantly normalized in the MTX+PxG group compared to the control group. A significant reduction in GSH level observed in the MTX group was reversed with PxG administration In addition, TF activity and total protein levels were found to be impaired in the MTX group, but TF activity was significantly improved in liver and lung tissues and total protein level was significantly reversed in lung and ileum in MTX+PxG group. The results of histological examinations showed that MTX-induced damage was ameliorated with the PxG administration. In conclusion, this study shows that Panax ginseng, thanks to its antioxidant properties, reversed MTX-induced tissue damage and therefore may be beneficial against side effects in patients undergoing chemotherapy.
Citation - WoS: 1
Problems and Insights on Space: the Effects of Phenomenology Theory on the Concept of Space
(Yildiz Technical Univ, Fac Architecture, 2020) Ulubay, Serhat; Onal, Feride
This study was an examination of a change in the means and manner of comprehension of the concept of space and the questions it stimulated as a result of the emergence and development of phenomenology theory in the last century. Phenomenology theory is based on the argument that our understanding of phenomena is related to our consciousness and promotes a different and deeper form of comprehension by asking questions about the essence of existence. The movement grew in the early 20th century, and challenged the dominant view of rational reality and Cartesian assumptions. Phenomenology encourages questioning what has been defined as concrete and immutable, arguing that phenomena can be grasped through internal experience rather than simply visible physical appearance and predefined ideas. According to this new concept, all of our acquisitions we call "experience" help us make sense of phenomena. Science makes its inquiries based on adopted and accepted experiences about the world. However, the phenomenological approach suggests that all adopted data, including the fundamentals of science, should also be questioned. The essential objective of the phenomenological philosophy is the extension of the field of questioning to explore the essence of facts and primary phenomena. This radical questioning deeply affected and altered the intellectual agenda of the time. Philosophers discussed and examined the intrinic meaning of many phenomena. The concept of space lends itself to this new kind of assessment. Phenomenology theory, which aims to contribute to the base of scientific knowledge and to increase the critical foundations of philosophy, opened the prevailing semantics of space perceived as an object defined with rational boundaries and mathematical assumptions to discussion. Phenomenological opinion, contrary to the Cartesian way of thinking, argues that space cannot be deliniated by the patterns of a single reality and that an infinite number of descriptors that we discover through our acts and experiences can be applied. This vision of space is discovered through all of our direct life experiences and queries of all realms, including the social and cultural arenas, psychology and the human body, ideas of the self and the question of existence, as well as hard science. Different methodologies applied by philosophers of the phenomenology school of thought diversified the basis of questioning and definition, and thereby enriched the concept of space. This study examines the methods of reading and questioning the definition of space used by phenomenological theorists and the contributions this interpretation brought to the conceptualization of space. The critical approach of the Cartesian way of thinking was compared and contrasted with the phenomenological view. All of the acquisitions and dynamics of life are in a state of constant change. The structure of societies, the way they comprehend the world, cultural and individual mental acts are not fixed like a photograph pausing a moment. A Cartesian view considers space to be a static and frozen object. A primary contribution of phenomenology to the intellectual environment of the last century was to encourage exploration of the fact that the mode of questioning has no boundaries, that the accepted realities cannot constitute the only starting point of our questioning. In addition, it reminded us that all our social and individual experiences are a means to grasp and comprehend the concept of space. We exist in this world through our thoughts, perceptions, memory, and body; therefore, we can comprehend phenomena, including space, via all of our life experience. This study examined how the idea of space has been shaped over time, focusing on the principles of phenomenological questioning and sixteen theorists considered pioneers of this way of thinking. The questioning put forward by phenomenology changes kinetically, and it is possible that such theories of the evaluation of space can be a tool for the diversification of today's thought on the subject and the discovery of news ideas of space.
The Effects of Chard Extract Against Streptozotocin-Induced Erectile Dysfunction in Rats
(Istanbul Univ, Fac Pharmacy, 2024) Aydin, Mustafa; Sacan, Ozlem; Kabasakal, Levent; Cetinel, Sule; Kadihasanoglu, Mustafa; Kendirci, Muammer; Sener, Goksel
Background and Aims: To analyze the potential therapeutic effects of chard against streptozotocin (STZ) -induced erectile dysfunction (ED) and oxidative damage in the corpus cavernousum in rats. Materials and Methods: In this study, Sprague-Dawley rats (250-300g) were allocated into groups as follows: control, diabetic, diabetic + chard, and diabetic + insulin. In order to induce diabetes, rats were given 65 mg/kg intraperitoneal streptozotocin. Chard extract was given orally at a dose 2 g/kg for 45 days beginning on 15 th days. Sixty days after STZ injection, intracavernosal pressure (ICP) was measured and rats were decapitated. Blood samples were obtained for glucose, asymmetric dimethylarginine (ADMA)levels, and lactate dehydrogenase (LDH) activity while cavernous tissues were taken to analyze luminol and lucigenin chemiluminescence (CL), malondialdehyde and glutathione and along with histological analysis. Results: The results revealed that diabetes caused significant decreases in cavernosal tissue glutathione levels, while luminol and lucigenin CL, and malondialdehyde levels were significantly elevated. Plasma glucose, ADMA levels, and LDH activity were also found to be increased in diabetic group. On the other hand, both chard extract and insulin treatment reversed these biochemical parameters significantly. Furthermore, it was found that the ICP value examined for evaluating erectile functions were lower in the diabetic group, but increased in both treatment groups which were similar to the control values. Conclusion: According to our results, chard extract, similar to insulin, reduced diabetes -induced oxidative damage in cavernosal tissue and protected erectile functions. This effects may be attributed its hypoglycemic and antioxidant properties.
Citation - WoS: 2
Citation - Scopus: 2
Lower Urinary Tract Symptoms and Toileting Behaviors in Turkish Adult Women
(Routledge Journals, Taylor & Francis Ltd, 2023) Celenay, Seyda Toprak; Dusgun, Elif Sena; Karaaslan, Yasemin; Urus, Gulcin; Karadag, Mehmet; Ozdemir, Enver
This study aimed to investigate lower urinary tract symptoms (LUTS) in Turkish adult women and to compare toileting behaviors in women with and without LUTS. This cross-sectional study was conducted in 815 women. The International Consultation on Incontinence Modular Questionnaire - Female LUTS and a toileting behaviors form, created by the authors, were used in evaluations. Nearly 50 % of the women had at least one LUTS, 45.8 % had storage symptoms, 7.4 % had voiding symptoms, and 20.2 % had incontinence symptoms. The rates of premature urination, straining during urination, delayed urination, and sitting on the toilet while urinating were higher in women with LUTS than in women without LUTS (p < .05). The rate of squatting on the toilet while urinating was lower in women with LUTS than those without LUTS (p < .05). Various LUTS were common in adult women. Some toileting behaviors such as premature urination, straining during urination, delayed urination, and sitting on the toilet while urinating were higher in women with LUTS compared to women without LUTS. Since the rate of unhealthy toilet behaviors is higher in women with LUTS, it is important to know unhealthy toilet behaviors in the management of LUTS and to organize training programs to prevent these behaviors and LUTS.
Citation - WoS: 1
Citation - Scopus: 1
Validity, Reliability and Responsiveness of the Cognitive Exercise Therapy Approach-Biopsychosocial Questionnaire (bety-Bq) in Knee Osteoarthritis
(Springer Heidelberg, 2025) Bulut, Zeynep Irem; Unal, Edibe; Oksuz, Sevim; Dogru, Atalay; Akyol, Ahmet; Yakut, Yavuz
PurposeThis study was planned to test whether the Cognitive Exercise Therapy Approach- Biopsychosocial Questionnaire (BETY-BQ) is an appropriate questionnaire in assessing the biopsychosocial status in KOA.MethodsFrequently used assessment tools, OA-specific scale The Western Ontario and McMaster Universities OA Index, the Hospital Anxiety and Depression Scale, and the Short Form-36 were utilized for the validity and responsiveness of BETY-BQ in individuals with KOA. The test-retest method, internal consistency analysis, and item analysis were used to test reliability. For the test-retest method, BETY-BQ was administered again to the same 30 individuals 1 week later. To assess the responsiveness of the BETY-BQ, individuals who underwent medical treatment were subjected to a second round of questionnaire administration after a 3-month interval.ResultsModerate to weak correlations between BETY-BQ and the other questionnaires ensued the divergent validity. According to the confirmatory factor analysis, all goodness-of-fit indices of BETY-BQ were acceptable (CMIN/df = 2.212; RMSEA = 0.080; SRMR = 0.08). Both Cronbach's alpha (0.900) and ICC value (0.941) showed that the BETY-BQ has excellent reliability in the KOA population. The Bland-Altman Plot showed high agreement as all differences between the first and second BETY-BQ were found between the 95% lower and upper limits. BETY-BQ demonstrated moderate responsiveness as the effect size and standardized mean response were 0.656 and 0.566, respectively.ConclusionA valid, reliable, responsive, multi-dimensional, and self-reported questionnaire for measuring biopsychosocial status in KOA was introduced to the use of healthcare professionals.
Evaluation of Octenidine Dihydrochloride-Induced Cytotoxicity, Apoptosis, and Inflammatory Responses in Human Ocular Epithelial and Retinal Cells
(MDPI, 2025) Ciftci, Ihsan Hakki; Deveci Ozkan, Asuman; Erman, Gulay; Kilbas, Imdat; Aydemir, Ozlem
Background/Objectives: Octenidine dihydrochloride (OCT-D) is a broad-spectrum antiseptic with high chemical stability, low toxicity, and no reported microbial resistance, making it a strong candidate for use on mucosal surfaces. Despite increasing interest in its potential ophthalmic applications, limited data exist regarding its cellular effects on ocular tissues. This study aimed to investigate the cytotoxic, apoptotic, inflammatory, and transcriptional responses induced by OCT-D in human conjunctival (IOBA-NHC) and retinal pigment epithelial (ARPE-19) cells. Methods: Cells were exposed to varying concentrations of OCT-D, and viability was assessed using the WST-1 assay to determine IC50 and IC50/2 values. These concentrations were subsequently used in molecular assays. Pro-inflammatory cytokines (IL-6, IL-1 beta, TNF-alpha, IFN-gamma) were quantified by ELISA. Apoptotic activation was evaluated through caspase-3/7 activity assays. Gene expression analysis of apoptotic (Bax, Bcl-2), DNA damage-related (ATM, Rad51), and inflammatory markers was performed using RT-qPCR. Results: OCT-D induced a marked, dose-dependent reduction in cell viability in both cell lines, with ARPE-19 showing greater sensitivity. Caspase-3/7 activity increased significantly at IC50 and IC50/2, confirming intrinsic apoptotic activation. OCT-D markedly suppressed the release of key inflammatory cytokines and downregulated transcription of inflammatory genes. RT-qPCR revealed upregulation of pro-apoptotic and DNA damage-associated genes, demonstrating coordinated activation of apoptotic and genomic stress pathways. Conclusion: OCT-D triggers integrated cytotoxic, apoptotic, and immunomodulatory responses in conjunctival and retinal epithelial cells. While these findings provide important mechanistic insights into OCT-D's cellular effects, further studies using primary cells, advanced 3D ocular models, and disease-relevant systems are required to support its potential translational use in ophthalmology.
Citation - WoS: 2
Citation - Scopus: 5
Evaluating the Potential Role of Ai Chatbots in Designing Personalized Exercise Programs for Weight Management
(Taylor & Francis inc, 2025) Sarac, Hakan; Ulusoy, Ismet Tarik; Alpay, Janset; Odemis, Hasan; Sogut, Mustafa
This study aimed to evaluate the effectiveness and potential use of artificial intelligence (AI) chatbots in developing personalized exercise programs for weight management. Exercise programs were developed by ChatGPT-4, ChatGPT-4o, Gemini-1.5 Pro models, and a group of human expert trainers for a hypothetical obese individual case. All exercise programs were assessed based on the American College of Sports Medicine (ACSM) and National Academy of Sports Medicine (NASM) guidelines. The chatbot-generated programs were consistent with ACSM and NASM standards, indicating their potential use in low-resource settings. Nevertheless, considerable differences were found between human trainers and chatbots in key parameters, including initial load and target heart rate zone recommendations. While AI chatbots have the potential to enhance accessibility, human expertise remains essential to ensure program safety and effectiveness. The results of this study provide insights into the potential role of AI chatbots in personalized exercise programs for weight management.
Citation - WoS: 3
Citation - Scopus: 2
A Systematic Review and Meta-Analysis for the Efficacy of Transcranial Direct Current Stimulation (tdcs) in Ocd Treatment: A Non-Pharmacological Approach To Clinical Interventions
(Pergamon-elsevier Science Ltd, 2024) Ibrahim, Ismail A.; Nada, Ahmed Hosney; Asar, Nada Khalid; Ibrahim, Rand; Farouk, Rawan Ahmed; Al-Qiami, Almonzer; Noorbakhsh, Seyed Ali
Obsessive-compulsive disorder (OCD) is a prevalent mental condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions), significantly disrupting daily functioning and social interactions. Transcranial direct current stimulation (tDCS) presents a promising non-invasive treatment modality aimed at alleviating symptoms. However, the evidence regarding its effectiveness remains inconclusive. This study seeks to address this gap by conducting a systematic review and meta-analysis of clinical trials, offering improved guidance for clinical intervention. A comprehensive search strategy was implemented across multiple databases, including PubMed, Cochrane CENTRAL, Embase, Scopus, and Web of Science. This search focused strictly on randomized controlled trials (RCTs) involving 147 patients. These trials evaluated the efficacy of tDCS in OCD patients. Subsequent data extraction, risk of bias assessment, and statistical analysis using Review Manager software revealed the potential efficacy of tDCS in reducing OCD symptoms. The meta-analysis not only fails to demonstrate significant superiority of active tDCS over sham tDCS but also suggests that sham tDCS may be more effective than active tDCS in reducing OCD symptoms. This finding diminishes the promise of tDCS as an effective treatment for OCD. Larger trials are warranted to further elucidate these findings.
Citation - WoS: 7
Citation - Scopus: 8
Acute Changes in Electrophysiological Brain Dynamics in Elite Karate Players
(Springer international Publishing Ag, 2020) Duru, Adil Deniz; Balcioglu, Taylan Hayri; Ozcan Cakir, Canan Elif; Goksel Duru, Dilek
Regular physical exercise has enhanced effects on the human anatomy and functionality. Recently, an effect of a single set of exercise is shown to have positive effects on mood and on cognitive functioning. The aim of this study is to investigate the effect of a single bout of moderate exercise on the brain electrophysiological dynamics in resting-state condition and under the mental workload situation from elite-level athletes. For this purpose, electroencephalogram (EEG) is measured before and after the exercise sessions from 17 elite karate players who are members of the national karate team of Turkey. Blood lactate measurements are implemented to monitor the volunteers before EEG measurements. EEG data are analyzed using three metrics: conventional band power of each electrode, coherence metrics between electrodes for each band and source coherence values corresponding to each frequency band. Each metric is statistically analyzed between pre- and post-values, and results revealed that in all frequency bands, right parietal electrode had increased connection values which are thought to be related to ongoing sympathetic nervous system response observed during the recovery period. Another finding is the enhanced connectivity of frontal sources under the resting state as well as during the increased mental workload periods.
Citation - WoS: 4
Citation - Scopus: 6
Comparison of in Vitro Antifungal Activity Methods Using Extract of Chitinase-Producing aeromonas Sp. Bhc02
(Springer, 2023) Cadirci, Bilge Hilal; Yilmaz, Gulesme
Biological control to prevent fungal plant diseases offers an alternative approach to facilitate sustainable agriculture. Since the chitin in fungal cell walls is a target for biocontrol agents, chitinases are one of the important antifungal molecules. In this study, the aim was to investigate a new chitinase isolated from a fluvial soil bacterium and to show the antifungal activity of the characterized chitinase by comparing the three common methods. The bacterium with the highest chitinase activity was identified as Aeromonas sp. by 16 S rRNA sequence analysis. Following the determination of the optimum enzyme production time, the enzyme was partially purified, and the physicochemical parameters of the enzyme were investigated. In the antifungal studies, direct Aeromonas sp. BHC02 cells or partially purified chitinase were used. As a result, in the first method in which the Aeromonas sp. BHC02 cells were spread on the surface of petri dishes, no zone formation was observed around the test fungi spotted on the surface. However, zone formation was observed in the methods in which the antifungal activity was investigated using the partially purified chitinase enzyme. For example, in the second method, the enzyme was spread on the surface of PDA, and zone formation was observed only around Penicillum species among the test fungi spotted on the surface. In the third method, in which the necessary time was given for the formation of mycelium of the test fungi, it was observed that the growth of Fusarium solani, Alternaria alternata and Botrytis cinerea was inhibited by the partially purified chitinase. This study concludes that the results of the antifungal activities depend on the method used and all fungal chitins cannot be degraded with one strain's chitinase. Depending on the variety of chitin, some fungi can be more resistant.

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