WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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Citation Count: 0
Perfusion-Mri for Differentiating Cerebral Metastatic Lesions and Gliomas: an Evidence-Based Review
(Elsevier Sci Ltd, 2025) Azab, Mohammed A.; El-Gohary, Nour; Atallah, Oday; Shama, Mohsen; Ibrahim, Ismail A.
Background: Lesions affecting the brain are variable and have multiple pathologies. Brain metastasis is a common entity of lesions that can be misleading in diagnosis. Brain metastasis affects the patient's life and survival in about 40% of cases; all patients with metastatic brain lesions are indicated for surgery, so proper diagnosis is crucial for each patient. Non-invasive diagnosis is a promising way to confirm the diagnosis of cerebral metastatic lesions for patients who are not indicated for surgery for medical reasons. To our knowledge, this is the first evidence-based review article regarding utilizing perfusion-MRI for approaching cerebral metastatic lesions. Methods: A comprehensive database search on PubMed/Medline, Scopus and Google Scholar was done by the relevant keywords. Eligibility of articles was done by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cochrane risk of bias assessment tool was used to determine the risk of bias among the included studies. Results: From 2989 articles, only 31 studies were eligible for the qualitative synthesis. A comprehensive summary of the included study was made according to population, intervention, comparator and outcomes (PICO) method. Conclusions: Diagnosing cerebral metastases, categorizing subtypes, and monitoring their response to treatment is a challenging endeavor for neurosurgeons, neuroradiologists, and oncologists. Technological advances in MRI software as perfusion-based MRIs are designated to facilitate diagnosis and follow-up for patients with cerebral metastases.
Citation Count: 0
Effectiveness of Postoperative Cephalosporins in Reducing Urinary Tract Infections and Other Parameters Following Transurethral Resection of the Prostate: a Systematic Review and Meta-Analysis
(Mosby-elsevier, 2025) Hafez, Wael; Al-Obeidat, Feras; Rashid, Asrar; Venkatachalapathi, Arun Kumar; Massaod, Amr; Albaha, Ziad; Cherrez-Ojeda, Ivan
[No Abstract Available]
Citation Count: 0
The Psychometric Properties of Body-Related Self-Conscious Emotion Measures for Turkish Adolescents: Esem and Cfa Approaches
(Springer, 2025) Urfa, Osman; Asci, F. Hulya
The aim of this study was to investigate the psychometric properties of the "Body and Appearance Self-Conscious Emotions Scale (BASES)" and "Body and Fitness-Related Self-Conscious Emotions Scale (BSE-FIT)" for Turkish adolescents. Each scale consists of 16 items and four subscales (shame, guilt, authentic pride, and hubristic pride) and items are responded on 5-point Likert scale. The psychometric properties of BASES and BSE-FIT were tested on 332 girls and 264 boys, a total of 596 participants (Mage=13.88, SDage=1.92). Confirmatory factor analysis (CFA) and exploratory structural equation modelling (ESEM) with multi-group analysis (MGA) were used to test the 4-factor and 2-factor structures and measurement invariance. Cronbach's alpha internal consistency coefficient and composite reliability (CR) were calculated for reliability. According to the model fit indices and factor loadings, the most appropriate model was the 4-factor CFA model for BASES and BSE-FIT. Cronbach's alpha and CR coefficients were 0.79 and above in the 4-factor CFA structures of both scales. In addition, MGA demonstrated factor structures, factor loadings, intercepts, and measurement error variance of BASES and BSE-FIT were equivalent according to sex, school level, sport status, region, and body mass index. In conclusion, BASES and BSE-FIT are valid and reliable in Turkish adolescents, and both scales provided measurement invariance in adolescents with different demographic characteristics.
Citation Count: 0
Does Prolotherapy Have an Effect on the Care of Pressure Injuries? a Pilot Study
(Elsevier Sci Ltd, 2025) Eroglu, Nermin; Kokkiz, Rukiye; Eroglu, Hatice Eda; Kocoglu, Hasan
Background: This study contributes to wound healing with prolotherapy in people with pressure injuries. The study was planned and conducted as a randomized controlled trial to determine the effect of prolotherapy on the care of pressure injuries. Methods: The study was carried out with patients with pressure injuries in the intensive care unit of a city hospital between April and June 2023. A power analysis was performed, and the sample size was calculated as 20 patients, including 10 in the intervention and 10 in the control group. The patients in the experimental group were given wound care with gelofusine as prolotherapy in the morning and evening for three days, and the injury site was covered with a sterile sponge and fixation tape. The patients in the control group were treated with saline in the morning and evening for three days. In both groups, the wound width, depth, and length were measured and evaluated prior to each intervention for three days. Results: In the study, a significant difference was found between the mean ages of the participants in the experimental and control groups (p < 0.05). The decrease in width measurements in the experimental group was found to be statistically significant compared to the previous measurements, while the increase in width measurements in the control group was significant compared to the previous measurements (p < 0.05). Depth measurements decreased statistically significantly in the experimental group, while they increased significantly in the control group compared to previous measurement values (p < 0.05). Conclusion: In conclusion, it was determined that the administration of gelofusine for pressure injuries as prolotherapy in the experimental group may be more effective in wound healing than saline treatment applied in the control group. Further studies are warranted.
Citation Count: 0
Populist Securitization of Migration: the Anti-Immigrant Zafer Party Example in Türkiye
(Routledge Journals, Taylor & Francis Ltd, 2025) Ozoflu, Melek Aylin; Uyar, Merve Hazer Yigit; Altintop, Apak Kerem; Uyar, Can
Although T & uuml;rkiye is the largest refugee-hosting country in the world, the Zafer Party's (ZP) (English: Victory Party) discourse on migration as the pioneer representative of the European-style anti-immigrant right party example has been under-studied. To address this gap, this research examines the discursive practices of the ZP through the lens of populist securitization. It focuses on revealing how the ZP employs a people-centred appeal to securitization, explaining how the people are located within its populist discourse as a threatened object of reference and actor. In this way, it empirically contributes to the burgeoning literature bridging between populism and securitization theory. To this end, it conducts an extensive qualitative frame analysis of the party's manifesto, programme, press releases, public speeches uttered by party leader & Uuml;mit & Ouml;zda & gbreve;. The time frame of the research is designated as starting from the establishment of the ZP, i.e. 26 August 2021, to the Presidential and Parliamentary Elections in T & uuml;rkiye, i.e. 14 May 2023. The paper finds out that ZP combines populist and nationalist appeals by creating vertical (down/up) and horizontal (in/out) antagonisms, exhibiting parallels with similar tendencies in its European counterparts.
Citation Count: 0
Presidents' President: Erdoğan-Centred Crony Capitalism and Football Governance in Turkey
(Routledge Journals, Taylor & Francis Ltd, 2025) Irak, Daghan; Erturan-Ogut, Esra
This study seeks to investigate evidence of cronyism within the intricate network of individuals and entities involved in Turkey's football industry, spanning financial, political, and football-related actors. Employing Social Network Analysis (SNA) as its primary methodology, our research aims to visually depict this network's cronyism and provide comprehensive contextual information to enable sociological interpretations of the relationships among these actors. Our findings shed light on the complex entanglement of football management with various networks in Turkey, highlighting that these crony connections obscure the boundary between government and business, resulting in covert political manipulation of the football sector. This interference erodes football management's autonomy through consistent autocratic regulations favouring crony business networks and indirectly violates international governance principles. Our research underscores that comprehending a football environment intertwined with business and politics requires acknowledging the extensive presence of crony capitalism and the necessity for transparency and autonomy within the football industry.
Citation Count: 0
The Challenges Experienced by International Nursing Students in Nursing Education: a Qualitative Study
(Ataturk Univ, 2024) Elmali Simsek, Hulya; Karali, Ece; Arslan, Gunay
Objective: The study aimed to determine the challenges experienced by international nursing undergraduate students during their education period. Methods: A phenomenological research design was used. The study was conducted with 20 international nursing students enrolled in a foundation university in T & uuml;rkiye. Colaizzi's phenomenological data analysis method was employed in the study. Results: Based on the study's results, three main themes, 'Learning in a different environment', 'Challenges', 'Solution-Non Solution' and 'System difference, Language problems in clinical practice, Broad nursing curriculum, Facilitators, Language barrier, Feeling homesick, Racism and discrimination, Housing difficulties, Lack of funding, Instant solution, Failing to find a solution sub-themes themes were created. Conclusion: It has been observed that students experience different environments, uncertainties, and various challenges, and that these situations directly affect their education and success. To that end, both the institutions they receive education and the academicians must support the students in various ways.
Citation Count: 1
The Association of Demographic, Psychological, Social and Activity Factors With Foot Health in People With Plantar Heel Pain
(Wiley, 2024) Gulle, Halime; Morrissey, Dylan; Tayfur, Abdulhamit; Coskunsu, Dilber Karagozoglu; Miller, Stuart; Birn-Jeffery, Aleksandra V.; Prior, Trevor
Background: Plantar Heel Pain (PHP) can be a debilitating musculoskeletal condition from which only 50% recover within a year due to poor understanding of the mechanisms explaining severity and predicting outcomes specific to PHP. Objective: To explore associations between biopsychosocial variables and the severity of people with PHP. Secondly, to determine what combination of self-reported factors distinguishes people with PHP from other foot pain (OFP). Methods: We collected data from 235 participants, including 135 (%57) PHP (age 44 +/- 12 years, 66% female) and 99 OFP (%43) (age 38 +/- 11 years, 57% female) using 5 demographic, 13 biomedical, 8 psychological, 3 social and 8 activity-related factors. These were tested in linear and logistic regression models. Results: Quality of life (QoL) (beta = 0.35; p < 0.001), education (beta = -0.22; p = 0.003), gender (beta = -0.20; p = 0.007), morning pain duration (beta = -0.18; p = 0.01) and disease duration (beta = -0.15; p = 0.040) were significantly associated with severity of PHP. The second model, without QoL, showed that having sensitisation (beta = -0.18; p = 0.002) and a higher level of morning pain (beta = -0.20; p = 0.01) are associated with severity. The logistic regression results revealed that people with PHP tend to have a systemic disease (OR = 3.34; 1.53-7.76), express more kinesiophobia (OR = 1.02; 1.01-1.14), are less likely to have previous injuries (OR = 0.40; 0.19-0.81), worse morning pain (OR = 1.02; 1.01-1.03) and standing pain (OR = 2.60; 1.39-4.87) compared to people with OFP. Conclusions: People with PHP have higher associated levels of a range of psychological, social and activity related factors than people with OFP. The findings highlight the importance of considering psychosocial assessments alongside physical examination.
Citation Count: 0
Seroprevalence of Torch Viral Agents in Pregnant Women in Turkey: Systematic Review and Meta-Analysis
(Mdpi, 2025) Kilbas, Elmas Pinar Kahraman; Ciftci, Ihsan Hakki; Kilbas, Imdat; Toptan, Hande
Rubella Virus, Cytomegalovirus (CMV), Herpes Simplex Virus-2 (HSV-2), Hepatitis B (HBV) and Hepatitis C virus (HCV) can cause serious fetal disease. The seropositivity rates of these agents vary among countries and geographic regions. This study aimed to analyze the prevalence rates and diagnostic methods used in studies investigating the seroprevalence of viral pathogens in the TORCH group among pregnant women in Turkey between 2005 and 2024. A systematic search was conducted using electronic databases between January 2005 and January 2024. A total of 60 studies meeting the inclusion criteria were included. Data quality control was assessed using the Joanna Briggs Institute guideline prevalence studies checklist. Heterogeneity was measured using the I-squared (I-2) statistic in the Comprehensive Meta Analysis (CMA) program. The average seropositivity rates for Rubella, CMV, HSV-2, HBV and HCV in Turkey were determined as 91.18%, 94.81%, 35.52%, 1.66% and 0.25%, respectively. When the diagnostic methods were examined, it was determined that ELISA and ECLIA methods were used most frequently. The seropositivity of the agents did not show statistically significant differences according to the year periods, geographical regions and age of the patients (p > 0.05). The highest prevalence rates of Rubella and HSV-2 in pregnant women were reported in the Mediterranean region, the highest prevalence rates of CMV and HCV in the Southeastern Anatolia region and the highest seroprevalence of Anti HBs in the Marmara region. The results of this study support the necessity of increasing public awareness in the control of fetal infection caused by TORCH viral agents, prenatal screening, vaccination for Rubella and HBV and compliance with hygiene conditions for agents such as CMV, HSV-2 and HCV. The results of this study highlight the need to increase public awareness on prenatal screening for the control of fetal infection caused by all TORCH viral agents, vaccination for Rubella and HBV and compliance with hygiene conditions for agents such as CMV, HSV-2 and HCV.
Citation Count: 0
Nursing Students' Thoughts and Knowledge Levels About Global Warming
(Marmara Univ, inst Health Sciences, 2024) Gur, Kamer; Kolac, Nurcan; Calik, Kevser Burcu; Nirgiz, Cansu; Dogan, Ridvan
Objective: The aim of this study is to determine nursing students' thoughts and knowledge levels about global warming. Methods: This descriptive study was conducted with 236 nursing students studying at the faculty of health sciences of a state university between May and July 2022. Data were collected using a Sociodemographic Form, the Global Warming Questionnaire. Independent Samples t-test, One-Way ANOVA were used to evaluate the data. Results: Ninety-seven percent of the students stated that global warming was a public health issue. Students' mean score on the global warming knowledge scale was 90.02 +/- 8.76. There was a significant difference between the mean scale score participating in activities on the subject, having received information/education on environment, climate change aside from undergraduate education, wanting to become a member of an environmental non-governmental organization, and school year (p <.05). Conclusion: Participants' knowledge level about global warming was above the average value of the scale. However, they still needed information, greater sensitivityto participate in environmental non-governmental organizations, global warming activities. For all these reasons, it is recommended that nursing students increase their knowledge and sensitivity during their undergraduate education, learn ways to combat the adverse effects of climate change, put them into practice.
Citation Count: 0
in Silico Evaluation of H1-Antihistamine as Potential Inhibitors of Sars-Cov Rna-Dependent Rna Polymerase: Repurposing Study of Covid-19 Therapy
(Galenos Publ House, 2024) Hamdan, Mazin; Kulabas, Necla; Kucukguzel, Ilkay
Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), from the family Coronaviridae, is the seventh known coronavirus to infect humans and cause acute respiratory syndrome. Although vaccination efforts have been conducted against this virus, which emerged in Wuhan, China, in December 2019 and has spread rapidly around the world, the lack of an Food and Drug Administration-approved antiviral agent has made drug repurposing an important approach for emergency response during the COVID-19 pandemic. The aim of this study was to investigate the potential of H1-antihistamines as antiviral agents against SARS-CoV-2 RNA-dependent RNA polymerase enzyme. Materials and Methods: Using molecular docking techniques, we explored the interactions between H1-antihistamines and RNA-dependent RNA polymerase (RdRp), a key enzyme involved in viral replication. The three-dimensional structure of 37 H1-antihistamine molecules was drawn and their energies were minimized using Spartan 0.4. Subsequently, we conducted a docking study with Autodock Vina to assess the binding affinity of these molecules to the target site. The docking scores and conformations were then visualized using Discovery Studio. Results: The results examined showed that the docking scores of the H1-antihistamines were between 5.0 and 8.3 kcal/mol. These findings suggested that among all the analyzed drugs, bilastine, fexofenadine, montelukast, zafirlukast, mizolastine, and rupatadine might bind with the best binding energy (<-7.0 kcal/mol) and inhibit RdRp, potentially halting the replication of the virus. Conclusion: This study highlights the potential of H1-antihistamines in combating COVID-19 and underscores the value of computational approaches in rapid drug discovery and repurposing efforts. Finally, experimental studies are required to measure the potency of H1-antihistamines before their clinical use against COVID-19 as RdRp inhibitors.
Citation Count: 0
Ucscs in Treatment of T1dm and T2dm; a Meta-Analysis
(Elsevier Ireland Ltd, 2024) Nada, Ahmed Hossney; Ibrahim, Ismail A.; Shalabi, Laila; Oteri, Vittorio; Asar, Nada Khalid; Aqeilan, Saja Rami; Hafez, Wael
[No Abstract Available]
Citation Count: 0
A Review on Investigating the Effect of Consent Systems on Organ Donation Rates
(Lippincott Williams & Wilkins, 2024) Seren, Arzu Harmanci
[No Abstract Available]
Citation Count: 0
Isolation of Rosmarinic Acid From Rosemary Extract Utilizing a Molecularly Imprinted Polymer
(Springer, 2025) Ersoy, Seyda Karaman
Molecularly imprinted polymers are polymeric materials engineered with specific templates capable of recognizing molecules selectively. Rosmarinic acid, an ester formed from caffeic acid and 3,4-dihydroxyphenyllactic acid and commonly occurring in plants, exhibits a broad spectrum of bioactive properties, including antioxidant, antiviral, analgesic, antibacterial, antimutagenic, antiallergic, anti-inflammatory, and neuroprotective effects. It is prominently present in rosemary (Rosmarinus officinalis) extracts, where it acts as the primary phenolic compound responsible for antioxidant activity. Advancements in the refining techniques for recovering and purifying rosmarinic acid from rosemary extracts have driven progress in molecularly imprinted solid-phase extraction methods. Remarkably, the molecularly imprinted solid-phase extraction approach utilizing the 1:4:16 caffeic acid-imprinted polymer exhibited outstanding selectivity for rosmarinic acid in authentic rosemary samples, achieving a purity level of 84% +/- 2.96%. This research marks a significant advancement in the literature, being the first to demonstrate the effective purification of rosmarinic acid using caffeic acid-imprinted polymers. These findings underscore the efficacy of the MIPs in accurately capturing rosmarinic acid, illuminating their potential applications in pharmaceutical and analytical settings where precise molecule recognition and extraction methodologies are crucial. This innovative approach not only enhances the extraction process but also opens new avenues for the application of MIPs in various fields, including food chemistry and natural product research.
Citation Count: 0
Effectiveness of Non-Invasive Vagal Nerve Stimulation in Parkinson's Disease: a Comprehensive Systematic Review And Meta-analysis
(Elsevier Sci Ltd, 2025) Abouelmagd, Moaz Elsayed; Yousef, Obai; Ibrahim, Ismail A.; Elshahat, Ahmed
Background: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by movement impairments. Vagus nerve stimulation (VNS) is a non-invasive brain stimulation technique that has shown promise in treating various neurological conditions, including PD. This systematic review aimed to evaluate the existing evidence on the efficacy of nVNS in managing PD symptoms. Methods: A comprehensive literature search was conducted to identify relevant studies published up to July 2024. The included studies investigated the effect of nVNS on various PD motor symptoms. The quality of studies was assessed using the Cochrane Risk of Bias 2 (ROB-2) and NIH tool for RCTs, single-arm studies, and case series studies respectively. Statistical analysis was conducted using Review Manager version 5.4.1 with outcomes expressed as Mean differences (MD) with 95% confidence intervals (CI). Results: The systematic review included eight randomized controlled trials (RCTs), one single-arm study, and one case series, encompassing a total of 217 patients with PD. The review revealed that nVNS in increasing Freezing of Gait (FOG) in PD (p = 0.04). However, no significant differences were found in UPDRS-III (p = 0.19 and p = 0.89 for on and off-medication conditions, respectively), UPDRS-II (p = 0.9), UPDRS-I (p = 0.46), Time Up and Go (p = 0.61), stand time (p = 0.87), walking speed (p = 0.22), or step length measured in meters (p = 0.8). Interestingly, a significant improvement was observed in step length measured in centimetres (p = 0.0005). No study reported serious adverse effects associated with nVNS treatment. Conclusion: Our finding suggests a potential benefit of nVNS in reducing FOG in PD, but did not demonstrate a significant improvement in other motor symptoms. Larger, longer follow-up studies are needed to confirm the effect nVNS on PD management. PROSPERO number: CRD42024574822.
Citation Count: 0
Assessment of the Psychometric Properties of the Online Education Student Satisfaction Scale: a Methodological Study
(Springer Publishing Co, 2024) Seren, Arzu Kader Harmanci; Alan, Handan; Turkmen, Emine; Gungor, Serkan; Baykal, Ulku
Background and Purpose: Assessing student satisfaction is essential in evaluating the quality of education. The number of valid and reliable tools that measure students' satisfaction with online education is limited. This methodological study aimed to assess the psychometric properties of the online education student satisfaction scale. Methods: Eleven academicians from the nursing field provided expert opinions on content validity. Separate 25 students evaluated the language clarity of the draft scale. The study sample included 525 third- and fourth-year nursing students. Finally, a group of 30 nursing students different from the sample participated in the test-retest. The study created an item pool based on the recent literature. The researchers calculated the items' content validity rates and the scale's content validity index by taking the experts' opinions. In addition, item-total score correlation analysis, exploratory factor analysis, discrimination analysis, stability test, and internal consistency analysis were performed. Results: An item with a low-correlation value was excluded from the scale. The correlation coefficients of the remaining items were between .536 and .811. In the second round of exploratory factor analysis, a five-factor structure emerged that explained 72.1% of the total variance. In addition, item discrimination, stability, and internal consistency test results ensured that the scale was valid and reliable. Conclusions: The online education student satisfaction scale with five subdimensions containing 28 items is a valid and reliable tool. Researchers, educators, and managers may use it to evaluate students' satisfaction with online education.
Citation Count: 1
Chatgpt as a Solution To Emotional Loneliness: a New Tool for Interpersonal Communication
(Marmara Univ, Fac Communication, 2024) Sarioglu, Elif Basak; Guregen, Esra Pelin
Loneliness stands as one of the most pervasive and universal health issues in contemporary society. This study, conducted within the scope of emotional loneliness, delves into the nuances of loneliness, understanding its origin and how it manifests in individuals. In the research where students from the Faculty of Communication of a foundation university in Istanbul were chosen as the sample, the data collected through in-depth interviews, a qualitative data collection tool, were analyzed using content analysis method. This phenomenological research design aimed to assess participants' attitudes toward utilizing a chatbot (ChatGPT) as a tool to combat emotional loneliness. Despite their generally positive disposition and strong tendency to anthropomorphize, participants were found to approach the use of ChatGPT with caution. The majority harbored negative judgments about ChatGPT and technological tools meeting emotional and social needs. However, a significant portion believes that the widespread adoption of ChatGPT and similar tools for socialization is imminent in the near future. Concerns predominantly revolve around mistrust in artificial intelligence technologies' ability to meet emotional needs and the potential harms they could inflict on socio-cultural life, with ethical issues forming another major theme. Notably, when expressing their apprehensions, participants frequently referenced artificial intelligence representations in popular culture, such as films, series, and games.
Citation Count: 1
The Effects of Rational Emotive Behavior Therapy and Motivational Interviewing on Emotions, Automatic Thoughts, and Perceived Performance of Elite Female Volleyball Players
(Elsevier, 2023) Urfa, O.; Asci, F. H.
Objectives: The aim of this study was to examine the effect of Rational Emotive Behavior Therapy intervention alone (REBT-A) or with motivational interviewing (REBT + MI) on the emotions, automatic thoughts, and perceived performance of elite female volleyball players. Design: and method: Single-case, staggered multiple-baseline AB and ABC designs were adapted in the study. Five female volleyball players participated in the study, of which three players participated in the REBT-A and two players participated in the REBT + MI. The athletes were competing in the national volleyball league (Mage = 28, SD = 5.52). All participants were elite athletes with at least ten years of sports experience. Three scores (T1, T2, T3) were calculated for the athletes' perceived performance, emotion, and automatic thoughts. T1 was the baseline score calculated before the sessions. T2 was calculated after the first two sessions (the first three sessions for REBT + MI) and T3 was calculated after the last three sessions. In the data analysis, percentage changes, effect size, and visual analyzes were used in the T1, T2, and T3 scores. Results: REBT-A and REBT + MI interventions increased perceived performance, positive emotions, and positive automatic thoughts, and decreased negative emotions and negative automatic thoughts. REBT + MI was more advantageous than REBT-A in increasing positive emotion, positive automatic thought, and perceived performance. Conclusions: As a result, REBT alone or with motivational interviewing has a positive effect on perceived performance, emotions, and automatic thoughts, but REBT + MI has greater potential to increase positive constructs.
Citation Count: 2
Isokinetic Knee Muscular Strength Is Associated With Hematologic Variables in Female Modern Dancers
(Spanish Assoc Sports Performance Analysis-aearedo, 2018) Tekin, Demet; Tekin, Demet; Terapi ve Rehabilitasyon Bölümü
It is important to expose the risk factor in injury in the context of the health and the careers of dancers. Female are at greater risk of developing anemia than men, yet scarce data exist on anemia associated outcomes in female dancers. The aim of the present study was to investigate the relationships between bilateral isokinetic knee extensor and flexor muscles strength, and biochemical hematologic parameters in female modern dancers. Concentric isokinetic peak torque [(PT)-N.m], peak torque % body weight [(PT% BW)-N.m.kg(-1)], average peak torque [(AVGPT)-N.m] and total work [(TW)-J)] of the knee extensor and flexor muscles were measured at a velocity of 60 degrees, 180 degrees and 300 degrees s(-1). To determine hematological parameters [red blood cell count (RBC), hematocrit (Hct), and Hb] were determined. The dancers of LHG and HHG had significant differences (p <= 0.05) for hematological parameters. HHG dancers' strength production in extensors muscles of PT, TW and AVGPT in non-dominant left leg (p <= 0.05) were significantly higher than LHG dancers. There were significant (p <= 0.05) negative correlations between TW (300 degrees s(-1)) of left leg extensor muscles and RBC, Hct and Hb variables. Isokinetic knee muscular strength is associated with hematologic variables in female modern dancers. The current study provides evidence that the low-level hematologic parameters has decreased performance on torque production of extensors knee muscles in non-dominant leg during isokinetic muscle strength endurance in female modern dancers.
Citation Count: 3
Novel Azole-Urea Hybrids as Vegfr-2 Inhibitors: Synthesis, In Vitro Antiproliferative Evaluation And In Silico Studies
(Elsevier, 2023) Küçükgüzel, İlkay; Kulabas, Necla; Erdogan, Omer; Cevik, Ozge; Dere, Damla; Yelekci, Kemal; Kucukguzel, Ilkay; Eczacılık Meslek Bilimleri Bölümü
The vascular endothelial growth factor receptor-2 (VEGFR-2) is a receptor tyrosine kinase known to be abnormally expressed in various malignant tumors, including breast cancer, and is considered one of the most important contributors to tumor angiogenesis. Sorafenib is one of many VEGFR-2 inhibitors that have received approval for clinical use from the US FDA in recent years. Accordingly, in this study, the synthesis of two new pyrazoles, six 1,3,4-oxadiazoles, four 1,3,4-thiadiazoles, and ten 1,2,4-triazole-3-thione derivatives having structural characteristics similar to sorafenib was carried out. A preliminary screening of synthesized compounds and known inhibitors sorafenib and staurosporine at 10 mu M concentration on in vitro activity of VEGFR-2 was performed, and compounds 10c, 8a, and 11 g were identified as the most potent derivatives with% VEGFR-2 residual activities lower than 30%, and dose-dependent inhibition studies was carried out to determine the IC50 values of these inhibitors. Compound 10c was found to be the most potent inhibitor of VEGFR-2 activity with an IC50 value of 0.664 mu M. The anti-proliferative activity of synthesized derivatives was assessed against a breast carcinoma (MCF-7) cell line, a triple negative human breast adenocarcinoma (MDA-MB-231) cell line, and noncancerous fibroblast cells (L929). Compound 8a displayed superior activity when compared to sorafenib against MCF-7 (7.69 fold) and MDA-MB-231 (1.52 fold) cell lines while displaying 3.75-fold less toxicity against the normal L929 cell line. Annexin V binding assay revealed that compound 8a significantly increased early and late apoptosis in MCF-7 cells and late apoptosis and necrosis in MDA-MB-231 cells. Computational studies such as molecular docking and ADMET evaluation were performed to elucidate the binding interactions and druglikeness of the synthesized compounds. The results indicate that compound 8a could be a promising candidate for the development of a novel anti-angiogenic and anti-proliferative agent.

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