PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8

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Efficacy of Different Exercises in Women With Fibromyalgia Syndrome: a Randomised Controlled Trial
(Clinical and Experimental Rheumatology S.A.S., 2025) Şevgin, Ö.; Buğday, B.; Baykara, R.A.; Günendi, G.; Akkurt, B.; Atasoy, H.; Karamancıoğlu, B.
The objective of this study was to evaluate the impact of aerobic exercise, resistance exercise combined with aerobic exercise, and yoga exercises combined with aerobic exercise on pain and disease activity in patients with fibromyalgia syndrome (FM). Methods The study population comprised 60 individuals with FM who met the inclusion criteria. The participants were randomly assigned to one of three groups. The first group underwent aerobic exercise (n=20), the second group combined aerobic exercise with yoga (n=20), and the third group engaged in aerobic and resistance exercise (n=20). All exercise interventions were conducted for a total of 12 weeks. Disease activity was evaluated using the Fibromyalgia Impact Questionnaire (FIQ), while pain status was assessed with the Melzack-Melzack Pain Questionnaire (MMPQ). All assessments were conducted before and following the completion of the exercise programme. The clinical trial number of this study is NCT06006494. Results The measurements of the aerobic exercise and yoga group were significantly lower than those of the aerobic and resistance exercise group. A statistically significant difference was observed between the groups in terms of post-treatment MMPQ scores. The measurements of the aerobic exercise and yoga group were significantly lower than those of the aerobic exercise only and aerobic and resistance exercise groups. No statistically significant difference was observed between the post-treatment MMPQ scores of the aerobic and aerobic resistance exercise groups. Conclusion The combination of aerobic exercise and yoga is more efficacious in the treatment of FM than aerobic exercise alone or a combination of resistance exercises and aerobic exercise. © Copyright CliniCal and ExpErimEntal rhEumatology 2025.
Gold Nanoparticle/Silk Fibroin-Based Nanofiber Enhances Skin Regeneration
(Oxford Univ Press, 2025) Ozcan, Ozan; Tufan, Elif; Muhan, Aleyna; Ak, Esin; Sener, Goksel; Tunali-Akbay, Tugba
Objectives The aim of this study was to determine the wound-healing potential of gold nanoparticles and silk fibroin-based nanofiber produced by green chemistry.Methods The electrospinning method was used to prepare the nanofiber. Twenty rats were exposed to a 7-day treatment period and another 20 rats were exposed to a 21-day treatment period. Rat groups were control, silver, silk fibroin, and silk + gold nanoparticle groups for each period. The effect of the gold nanoparticle/silk fibroin-based nanofiber was examined in skin samples by using biochemical and histological analysis. In biochemical analysis, skin oxidant and antioxidant parameters were determined.Key findings Parameters indicating skin damage returned to their previous levels 7 and 21 days after the wound formation using gold nanoparticle/silk fibroin-based nanofiber. Gold nanoparticle/silk fibroin-based nanofiber initiated hair follicle formation at the wound site and accelerated the re-epithelialization process.Conclusions It was found that the nanofiber prepared by adding gold nanoparticles to silk fibroin had better wound-healing properties than silk fibroin nanofibers without gold nanoparticles.
Investigating the Relationship Between Caregiver Burden and Quality of Life in Burn Care
(Elsevier Sci Ltd, 2025) Seyyah, Mine; Reyhanioglu, Duygu Aktar; Kardas, Ayse Sena Yumbul
Aim: This study aimed to examine the relationship between caregiver burden and quality of life among primary caregivers of burn survivors receiving inpatient treatment in an acute care setting. Methods: This cross-sectional descriptive and correlational study included 53 primary caregivers of hospitalized burn patients, recruited from the Burn Care Unit of a tertiary hospital in Turkey between August 2022 and January 2023. Participants were aged 18 or older, identified as the primary caregiver, and able to communicate in Turkish. Individuals with psychiatric disorders were excluded. Data were collected through face-to-face structured interviews using the Zarit Burden Interview (ZBI) and the Short Form Health Survey (SF-36), in which higher scores indicate better quality of life. Descriptive statistics, Pearson correlation, and linear regression were used to analyze the data. Results: The caregivers had a mean age of 38.75 +/- 10.76 years; 71.7 % were female, and 50.9 % had completed only primary education. The average caregiving duration was 10.6 days. The mean ZBI score was 22.54 +/- 15.11, indicating moderate burden. Demographic variables did not significantly affect caregiver burden (p > .05). A moderate negative correlation was found between caregiver burden and their emotional (r = -0.367, p = .007), psychological (r = -0.313, p = .023), and physical functioning (r = -0.355, p = .009) subdomains of the SF-36. Conclusion: A inverse relationship was observed between caregiver burden and caregiver quality of life, especially in emotional, psychological, and physical functioning domains. Although demographic factors were not influential, lower quality of life was associated with greater caregiver burden.
Effects of Motor Imagery Adding To Physiotherapy and Rehabilitation Program in Children With Duchenne Muscular Dystrophy: Does It Make a Difference
(Elsevier Sci Ltd, 2025) Umut, Gulsena Utku; Ozdincler, Arzu Razak; Ulug, Fitnat; Guler, Serhat; Saltik, Sema
Introduction/background: The study aims to investigate the effects of the MI (Motor Imagery) program applied in addition to the PTR (Physiotherapy and Rehabilitation) program on gait and balance in children with DMD (Duchenne Muscular Dystrophy). Methods: The 38 boys with DMD were included in the study and randomized into two groups: the PTR group (mean age: 7.96 +/- 1.94 years) and the MI + PTR group (mean age: 9.03 +/- 1.71 years). In the PTR group, the PTR program was administered 2 days/week for 8 weeks, and in the MI + PTR group, the MI program was administered 5 days/week in addition to the PTR program. Groups were assessed by the Brooke Lower Extremity Functional Classification Scale, Modified Pediatric Mini Mental Scale, Movement Imagery Questionnaire (MIQc), Kinovea (R) Software Program, Timed Up & Go Test (TUG), Timed Function Tests (TFT), Two-Minute Walk Test (2MWT), and Motor Function Measure (MFM-32). Results: As a result of the study, in PTR Group, TFT-Stairs descending (p = 0.049) was improved. In MI + PTR Group, Kinovea (R) Software Program-Walking Speed (p = 0.003), 2MWT (p = 0.037), TFT-Stair descend and 10-m walk (respectively; p = 0.001; p = 0.039), and MFM-32-D1 (p = 0.036) were improved. According to the comparison between groups, the groups were not superior to each other (p > 0.05). Discussion/conclusion: Although the MI program applied in addition to the PTR program contributes to improvements in walking speed, walking distance, and functional performance in children with DMD, it does not demonstrate superiority over the PTR program alone.
Sensory Processing Skills and School Functions in School-Aged Children With Attention Deficit Hyperactivity Disorder: a Gender-Based Analysis
(Routledge Journals, Taylor & Francis Ltd, 2025) Ceyhan, Irem; Akyurek, Gokcen
Sensory processing skills are important for school functioning, learning and school participation. Children with attention deficit hyperactivity disorder (ADHD) may need additional support in the school context. This study aims to assess sensory processing skills and school functions in children with ADHD, focusing on gender differences. We included 118 children of whom 57 had ADHD and 61 were typically developing peers. Sensory processing skills were assessed with the Sensory Integration and Praxis Test subtests (Postrotary Nystagmus, Standing Walk and Balance, Bilateral Motor Coordination), and school functioning was evaluated using the School Function Assessment. Results showed that children with ADHD had worse sensory processing skills and school function, regardless of gender (p < 0.05). In girls with ADHD, Bilateral Motor Coordination emerged as a significant predictor across some sub-parameters of school functioning (Participation: p = 0.022; task supports: p = 0.020; physical tasks: p = 0.012). In boys, balance was particularly significant predictor of physical (p = 0.008) and cognitive functioning (p = 0.008). Boys with ADHD had more difficulty than girls in cognitive/behavioral task adaptations, setup and cleaning, and eating/drinking. Recognizing gender differences among these children is essential for health professionals to deliver more effective and individualized support interventions.
The Effects of Diaphragmatic Breathing Exercises on Individuals With Premature Ejaculation: a Randomized Controlled Trial
(Oxford Univ Press, 2025) Erkut, Umit; Coskunsu, Dilber Karagozoglu; Erkut, Kubra; Ozden, Ali Veysel
Background There are no standardized, evidence-based rehabilitation protocols for premature ejaculation (PE) which hinders effective management, the development of validated patient-reported outcomes, regulatory oversight, and the potential benefits of targeted interventions. Aim To investigate the effect of diaphragmatic breathing exercises (DBE) on PE. Methods Sixty-two participants with PE were randomly assigned to Group I (n = 31) or Group II (n = 31). Both groups received behavioral therapy (BT) and pelvic floor muscle training (PFMT) twice daily, three days a week, for eight weeks. Additionally, Group I recieved DBE twice daily, every day, for eight weeks. Intravaginal ejaculation latency time (IELT) was calculated with a stopwatch, at the end of the 8th week (post-treatment), and at 1-year follow-up. Pelvic floor muscle (PFM) strength and endurance were evaluated with ultrasound, and changes in the in the autonomic nerves system (ANS) parameters (including the root mean square of successive differences [RMSSD], proportion of NN50 [PNN50], low-frequency [LF] power, and high-frequency [HF] power) were evaluated with an Elite HRV device at pre-treatment and post-treatment by a blinded assessor. Outcomes Primary outcome measurements were IELT, PFM strength and endurance, and changes in ANS paramaters. Results The study was completed by 29 participants (mean age = 31.4 +/- 6.5 years) in Group I and 30 (mean age = 31.3 +/- 7.6 years) in Group II. At post-treatment, all outcome measures showed significant improvements in both groups (P <.001 for all). Compared to Gropu II, Group I showed significantly greater improvements in IELT(P=0.12), RMSDD (P<.001), PNN50 (P=.003), LF Power (P<.001), HF Power (P=.003), strength(P<.001), and endurance (P<.001). The median IELT increase from baseline to post-treatment was 283 seconds (range: 84-870; 900%) in Group I and 204 seconds (range: 44- 581; 690%) in Group II. While IELT declined significantly from post-treatment to 1-year follow-up in Group II, no statistically significant change was found in Group I. Clinical Implications The effect of DBE on the ANS may help regulate the ejaculatory reflex. Strengths and Limitations This is the first study to apply breathing exercises with BT and PFMT in men with PE. Limitations include the lack of exercise adherence records beyond 8 weeks and the estimation-based IELT measurement at baseline. Conclusion Adding DBE, to BT and PFMT, yields better results in IELT (at 8 weeks and 1 year) and inreases PFM strength and endurance of PFM (at 8 weeks) in men with PE.
The Effect of Mirror Therapy on Spasticity in Adult Patients With Stroke: a Systematic Review and Meta-Analysis
(Taylor & Francis Ltd, 2025) Tosun, Anil Tekeoglu; Isiklar, Cagdas; Yeldan, Ipek
Objective This study aims to investigate the effects of Mirror Therapy (MT) on spasticity and related parameters in stroke patients Methods A systematic review was performed in databases PubMed, Web of Science, Science Direct, Cochrane, and Scopus databases for published RCTs (Randomized Controlled Trials) from the date of each database's inception to May 2021. Modified Ashworth Scale (MAS) in adult patients with stroke compared to conventional therapy, sham, and additional therapy control were included. Physiotherapy Evidence Database Scale was used to assess the methodological quality of each study. Results The overall effect of MT on MAS was statistically significant and beneficial when studies were analyzed in terms of both upper and lower extremities (p < 0.001). MT demonstrated a large and beneficial overall effect on the Brunnstrom Assessment compared to conventional therapy (p < 0.001). The overall impact of MT on Fugl-Meyer Assessment (FMA) was large and statistically significant (p < 0.001). However, a meta-analysis of three studies using the 10-meter walk test showed that the overall effect of MT was not statistically significant (p = 0.258). Conclusion This systematic review and meta-analysis demonstrates reductions in upper and lower extremity spasticity and improved motor recovery with MT, both isolated and combined with other treatments, in adults with stroke. PROSPERO registration number CRD42021255154.
Assessment of Cross-Cultural Adaptations and Patient-Reported Outcome Measures Relevant To Shoulder Disorders in Turkish: a Systematic Review Using the Cosmin Methodology
(Public Library Science, 2025) Isiklar, Cagdas; Sirma, Gamze Cagla; Turgut, Elif
Background There are many shoulder assessment outcome measures in the literature that have been studied for validity and reliability. However, there is no study examining the Turkish-adapted patient outcome measures (PROMs) on the shoulder according to the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist. In addition, there is a small number of studies that carry out this examination on the shoulder internationally. Determining the most appropriate questionnaires for clinical use will also be an important guide in patient evaluation by filling the gap in both literature and clinical aspects.Objective Our aim in this study is to identify the valid and reliable Turkish scales used to evaluate shoulder pain and disability, to reveal how compatible these scales are with the aspects of study quality and psychometric quality according to COSMIN criteria list.Methods A systematic search was performed in the following electronic databases: MED-LINE, Web of Science (WOS), EMBASE, SCOPUS, and ULAKBIM were searched from inception to September 2024.Results A total of 2890 articles were found in the databases. Four articles were included additionally without a search. Then, after eliminating the duplicates, 2231 articles were included based on the title and abstract search. 63 articles were included in full-text review. After the full-text review, according to our criteria, 29 articles were included in the systematic review. According to the assessment by the COSMIN checklist, 28 articles received the final classification of "inadequate". Only 1 article (UCLA-Tr) received the final classification of "adequate".Conclusion There is a wide range of Turkish PROMs available for the shoulder, with only one fully meeting COSMIN methodology criteria. However, this does not imply that other PROMs lack clinical utility. Future studies should focus on refining PROMs by incorporating MCID and PASS scores and prioritizing their responsiveness to enhance their clinical relevance. Additionally, variations in PROM performance across different patient populations highlight the need for context-specific evaluations to ensure their applicability in diverse clinical settings.Trial registration PROSPERO registration number: CRD42022298425.
The Relationship Between Health Literacy and Healthy Lifestyle Behaviors of Women With Preeclampsia
(Assoc Medica Brasileira, 2025) Kolcu, Merve; Akturk, Nur Bahar Kuru; Ozturk, Gizem; Akkus, Mine
OBJECTIVE: The aim of this studywas to explore the relationship between the levels of health literacy and healthy lifestyle behaviors in women with preeclampsia. This research was planned as a descriptive relational study. METHODS: The data were collected from 251 pregnant women with preeclampsia who were admitted to a training and research hospital between February and July 2024. The Patient Information Form, Health Literacy Scale, and Healthy Lifestyle Behaviours in Pregnancy Scale were used for data collection. RESULTS: The mean Health Literacy Scale total score of the women was 76.25 +/- 14.48, and the mean Healthy Lifestyle Behaviours in Pregnancy Scale total score was 110.17 +/- 17.57. A moderate positive correlation was found between the mean total scores of the scales (r=0.365, p<0.05). CONCLUSION: As health literacy levels increased amongwomen diagnosed with preeclampsia, the level of healthy lifestyle behaviors also increased. It would be beneficial to integrate the topic of health literacy into prenatal care and pregnancy preparation classes.
Collagen Peptides and Saccharomyces Boulardii Cncm I-745 Attenuate Acetic Acid-Induced Colitis in Rats by Modulating Inflammation and Barrier Permeability
(Wiley, 2025) Altinok, Oyku; Bas, Murat; Dolanbay, Elif Gelenli; Kolgazi, Meltem; Mert, Tugay; Uslu, Unal
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent episodes of inflammation and tissue damage, with limited treatment options. This study aimed to investigate the effects of collagen peptides and Saccharomyces boulardii on acetic acid (AA)-induced colitis. Thirty-six male Sprague-Dawley rats were randomly divided into the following four groups: normal control (NC), colitis control (CC), collagen peptide (CP; 0.6 g/kg/day), and S. boulardii (SB; 250 mg/day). Colitis was induced by an intrarectal administration of AA in all groups except NC, and treatments were administered daily for 7 days. The therapeutic effects were evaluated by assessing the disease activity index (DAI), colon mass index, macroscopic and microscopic tissue damage, histopathological changes, zonula occludens (ZO)-1 protein expression, and myeloperoxidase (MPO) activity. The results showed that CP and SB treatments substantially alleviated DAI scores (p < 0.05) and reduced the colon mass index. Colon macroscopic and microscopic damages improved compared to the CC group (p < 0.01). Histologically, both treatments reduced inflammatory cell infiltration, crypt damage, and ulceration, with CP showing a slightly more pronounced effect. Immunohistochemical analysis revealed significant restoration of ZO-1 protein expression in the treated groups, indicating improvement in intestinal barrier integrity (p < 0.01). Furthermore, MPO activity was reduced in both CP and SB groups, significantly in the SB group (p < 0.01). These findings are consistent with previous studies that highlight the anti-inflammatory and barrier-enhancing effects of collagen peptides and probiotics in UC models.
Prevalence of Colistin-Resistant Klebsiella Pneumoniae Isolates in Turkey Over a 20-Year Period: a Systematic Review and Meta-Analysis
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Kahraman Kilbas, E.P.; Kilbas, I.; Ciftci, I.H.
Klebsiella pneumoniae is one of the leading causes of healthcare-associated infections and poses challenges in its treatment owing to its high antibiotic resistance. The development of resistance to colistin, which is used as a last resort, has become a major public health problem worldwide. This study was planned according to the PRISMA guidelines and included studies reporting the prevalence of colistin-resistant K. pneumoniae in Turkey between 2004 and 2024 through a systematic literature review. A total of 28 original research articles were included in the meta-analysis. Data were analyzed using the SPSS and CMA software. The pooled colistin resistance of a total of 8916 K. pneumoniae strains from 28 studies included in this meta-analysis was found to be 1.63% (95% CI: 1.51–3.12). Colistin resistance increased significantly over time. A higher resistance rate was detected in the strains tested using the EUCAST guidelines and broth microdilution method. The year of the study and validation methods contributed to the heterogeneity observed in the studies. This meta-analysis reveals that colistin-resistant K. pneumoniae strains have increased over time in Turkey. Current data show that colistin resistance is not only a laboratory finding but has become a crisis, requiring urgent action in terms of hospital infection management and patient safety. Regional and global measures should be taken to ensure the appropriate use of antibiotics to control the development of resistance. © 2025 by the authors.
Perceived Stress and Performance of Daily Activities Among Emergency Healthcare Workers During the Covid-19 Pandemic
(Sage Publications inc, 2025) Yucel, Hulya; Bektas, Selen Aydoner
Background During the COVID-19 pandemic, healthcare workers were exposed to intense stress in the emergency departments and sudden changes in their daily lives. Objective The study aimed to investigate the impact of the pandemic on performance and participation in the activities of daily living, personal lives, and overall well-being of the healthcare workers in an emergency department. Methods Seventy-eight people working in an emergency department of a university hospital (100% of those eligible) participated in the study during June-July 2022. A self-report survey, cross-sectional design was used to collect data. Participants completed the Perceived Stress Scale-10 (PSS) and the Canadian Occupational Performance Measure (COPM). Independent sample t-tests, Pearson correlation, and multiple regression analysis were used for statistical analysis. Results There was a significant negative correlation between PSS and COPM Performance (r = -0.524) as well as between PSS and COPM Satisfaction (r = -0.508), indicating that higher levels of stress were associated with lower performance and satisfaction. In addition, work-related factors, including working experience, daily working hours, and time available for rest at work, were significantly associated with PSS, COPM Performance, and Satisfaction (p < 0.05). The strongest multivariate associations (p = 0.001) were found between lacking time to rest at work and PSS (direct) and COPM Performance and Satisfaction (inverse). Conclusion The stress experienced by emergency healthcare workers during COVID-19 negatively impacted their performance, daily activities, personal lives, and well-being. A potential implication is that policy-makers addressing work-related factors and implementing regulations could improve the well-being of these workers in their professional practices.
Nutritional Experiences of Turkish University Students With Type 1 Diabetes: a Qualitative Study
(Bmc, 2025) Ozkaya, Sebnem Ozgen; Ozkaya, Volkan; Gedikli, Erman; Garipagaoglu, Muazzez
BackgroundThis study was performed in order to describe the nutritional experiences of university students with Type 1 diabetes who try to carry on their educational and social lives together in diabetes self-management.MethodsIn this descriptive and qualitative study, face-to-face and semi-structured in-depth interviews were performed with 15 university students with Type 1 diabetes, aged 18-30, resided in Istanbul, who were diagnosed with Type 1 diabetes at least 5 years ago. The data collection process was performed by the researchers. The interviews were recorded and transcribed. The data collected in accordance with the phenomenological approach were processed using guided content analysis.ResultsIn the interview with the participants, whose mean age was 21.86 +/- 2.03 years and 66.7% of those were female, 6 themes were listed as positive and negative experiences of students in diabetes management in the university environment, general nutritional preferences, nutritional attitudes in non-routine and social environments, regular nutrition and quality of campus life, nutrition during the exercise/sports period, university support and students' expectations from the environment and explained by their sub-dimensions.ConclusionThe change in living conditions with the transition to campus life, the new social environment, individualization and academic responsibilities make diabetes self-management a challenging, complex and supportive process. This study might guide the enhancement of university students' living conditions with diabetes.
Synthesis of Novel Thiazole/Thiadiazole Conjugates of Fluoroquinolones as Potent Antibacterial and Antimycobacterial Agents
(John Wiley and Sons Inc, 2025) Poyraz Yılmaz, P.; Kulabaş, N.; Bozdeveci, A.; Vagolu, S.K.; Imran, M.; Tatar, E.; Küçükgüzel, İ.
Twenty azole-fluoroquinolone hybrids were designed and synthesized by conjugating thiazole and thiadiazole structures to ciprofloxacin and norfloxacin via a 2-oxoethyl bridge. The structures and purities of the synthesized compounds were proven by spectral techniques. The antimycobacterial effects of target compounds 21–40 were tested against Mycobacterium tuberculosis H37Rv strain. Among the 20 synthesized compounds, 12 exhibited minimal inhibition concentration (MIC) values in the range of 1.56–25 μg/mL. Among the molecules screened for antimycobacterial effects, the most effective was compound 35, a thiadiazole-ciprofloxacin hybrid. The cytotoxic effect of this molecule was found to be lower than the reference drugs, and it was also determined to be a more effective inhibitor than ciprofloxacin and norfloxacin in the DNA-gyrase supercoiling test. The antimicrobial effects of compounds 21–40 were screened by agar-well diffusion and microdilution tests against Gram-positive/negative bacteria, a fast-growing mycobacterium, and two yeast strains. While most of the compounds tested showed antibacterial effects, the most effective fluoroquinolone derivative appeared to be compound 31 with an MIC value of < 0.63 μg/mL against all Gram-negative bacteria tested. Azole-fluoroquinolone hybrids 21–40 did not show any activity against non-pathogenic Lactobacillus species and yeast-like fungi, indicating that they have selective antibacterial and antimycobacterial activity, particularly against Gram-negative bacteria. In silico molecular docking studies were conducted to uncover the interactions between lead compound 35 and the DNA gyrase proteins of M. tuberculosis and S. aureus. Additionally, a 100 ns molecular dynamics simulation was carried out to assess the stability of the complexes formed between compound 35 and both proteins. © 2025 The Author(s). Chemical Biology & Drug Design published by John Wiley & Sons Ltd.
Design and Synthesis of Thiosemicarbazides and 1,2,4-Triazoles Derived From Ibuprofen as Potential Metap (Type II) Inhibitors
(Elsevier Ireland Ltd, 2025) Yilmaz, Ozgur; Biliz, Yagmur; Ayan, Sumeyra; Cevik, Ozge; Karahasanoglu, Mufide; Cotuker, Reyhan; Kucukguzel, S. Guniz
In the present study, a range of novel thiosemicarbazides 4a-i and 1,2,4-triazoles 5a-i derived from ibuprofen, were synthesized. Structural elucidation of these synthesized compounds was performed utilizing a variety of spectroscopic methods, including FTIR, 1H NMR, 13C NMR and HR-MS. The synthesized compounds were tested for cytotoxicity in five different cancer cell lines (cervical cancer (HeLa), human breast cancer (MCF-7), human gastric adenocarcinoma (MKN-45), human metastatic prostate cancer (PC3) and human glioblastoma (U87)). The compounds were compared with healthy cells (NIH-3T3) and the most effective compounds were determined by means of the selectivity index. Thiosemicarbazides derived form ibuprofen 4i and 4d showed anticancer activity, while 1,2,4-triazoles derived form ibuprofen 5b, 5c, 5d, 5e, 5h, 5g showed anticancer activity in HeLa, MCF-7, MKN-45, PC3 and U87 cells. To test the stability of the protein-drug complexes all 18 compounds 4a-i and 5a-i were docked into the active site of the MetAP2 enzyme In general, computational inhibition constants values were correlated with the experimental values. The dynamic behavior of MetAP2-inhibitor complexes was analyzed using all atoms Molecular Dynamic (MD) simulations for 200 ns duration. MD revealed that the drugs bind in the active center of MetAP2 with stable RMSD and RMSF. In conclusion, in-silico results and in-vitro studies suggests that thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen may be novel anticancer drug candidates for treating cervical, breast, prostate, gastric and glioblastoma. Compounds provided induction of apoptotic proteins in the cell by inhibiting MetAP2 enzyme. Furthermore, the potential antioxidant activities of the compounds were evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Among the compounds tested, 4a, 4b, 4e, 4f, 4h, and 4i exhibited values closely resembling the DPPH activity of the standards.
Cross-Cultural Adaptation, Validity, and Reliability of the Turkish Version of the Cumberland Ankle Instability Tool for Athletes
(Human Kinetics Publ Inc, 2025) Yazgan, Elif Aleyna; Coskunsu, Dilber Karagozoglu; Ozdincler, Arzu Razak
Context: To cross-cultural translate the Cumberland Ankle Instability Tool (CAIT) to Turkish version (CAIT-T) and to evaluate the validity, reliability, and cutoff score of CAIT-T for Turkish athletic population. Design: The English version of CAIT was translated to CAIT-T based on a guideline of cross-cultural adaptation. Fifty-two athletes with chronic ankle instability and 63 athletes without chronic ankle instability were included in the study. Construct validity was evaluated with correlations between the CAIT-T, Turkish version of Foot Ankle Ability Measure (FAAM-T), and Numeric Rating Scale. CAIT-T was completed twice by each participant at 7 to 10 days intervals to assess test-retest reliability based on the intraclass correlation coefficient, whereas Cronbach alpha evaluated internal consistency. Discriminative validity and content validity of the CAIT-T also evaluated. Results: In construct validity, strong positive correlation was found between CAIT-T and Numeric Rating Scale perceived ankle instability (rho = -.771, P<.001), as well as moderate negative correlations with FAAM-T-activities of daily living and FAAM-T-sports (rho = -.448, P < .001 and rho = -0.541, P < .001, respectively). The CAIT-T demonstrated strong test-retest reliability (intraclass correlation coefficient score of .98) with a good internal consistency (Cronbach alpha: .85). Receiver operating characteristic curve showed a cutoff score of 26.5 (Youden index: 0.78, sensitivity: 0.57, specificity: 0.90.5). No ceiling or floor effects were observed. Conclusions: CAIT-T is a valid and reliable questionnaire for the assessment of chronic ankle instability in the Turkish athletic population.
Unraveling Hepatic Consequences of Intrauterine Growth Restriction and Catch-Up Growth: Insights From Histological, Biochemical and Metabolomic in Rats
(Univ Basque Country Upv-Ehu Press, 2025) Esrefoglu, Mukaddes; Selek, Sahabettin; Koktasoglu, Fatmanur; Bayindir, Nihan; Hekimoglu, Emine-Rumeysa; Kirmizikan, Seda; Bekiroglu, Somer
Intrauterine growth restriction (IUGR) is increasingly recognized as a significant risk factor for metabolic disorders in adulthood. Employing a multi-faceted approach encompassing histopathological, immunohistochemical, biochemical, Western-blotting, and metabolomics analyses, this study aimed to elucidate potential metabolite markers of IUGR, and catch-up growth-related metabolic disturbances and the underlying metabolic pathways implicated in IUGR pathogenesis. This study cohort comprised 54 male siblings from 20 Sprague-Dawley female young rats. On the 19th day of gestation, half of the pregnant rats underwent bilateral uterine artery ligation, while the remaining half underwent a simulated surgical intervention involving solely peritoneal incisions. Blood and liver samples were collected from the pups after attaining catch-up growth at the postnatal weeks 2, 4, and 8. IUGR rats exhibited a spectrum of changes including histological abnormalities, altered apoptosis rates, oxidative stress markers, and mitochondrial energy metabolism. Metabolomic analysis revealed dysregulation in multiple metabolic pathways encompassing galactose, propanoate, glycerolipid, cysteine, methionine, and tyrosine metabolism, among others. Notably, disturbances were observed in butanoate, glutathione metabolism, as well as glycolysis/gluconeogenesis. Our metabolomics analysis provides insights into the potential disease susceptibility of individuals born with IUGR, including obesity, diabetes, heart failure, cancer, mental retardation, kidney and liver diseases, and cataracts. These findings underscore the intricate interplay between intrauterine conditions and long-term metabolic health outcomes, highlighting the need for further investigation into preventive and therapeutic strategies aimed at mitigating the risk of metabolic diseases in individuals with a history of IUGR.
The Effectiveness of Proprioceptive Neuromuscular Facilitation Techniques Versus Conventional Therapy in Patients With Proximal Humerus Fracture: Randomized Controlled Trial
(Taylor & Francis Inc, 2025) Kus, Gamze; Alpozgen, Ayse Zengin; Ozdincler, Arzu Razak; Gungor, Feray; Altun, Suleyman
Background To date, no study has investigated the effectiveness of proprioceptive neuromuscular facilitation (PNF) techniques for patients with proximal humerus fractures (PHF). Objective To compare the effect of PNF, conventional physicaltherapy (CPT) on shoulder passive and active range of motion (ROM), function, muscle strength, pain, kinesiophobia, quality of life (QoL), and patient satisfaction in patients with PHF. Methods A total of 40 patients with PHF were randomly allocated into two groups of CPT and PNF. Both groups received treatment programs three times a week for 6 weeks. The primary measures were shoulder ROM, function, and muscle strength. The secondary measures were pain, kinesiophobia, QoL, and patient satisfaction. Results Forty patients analyzed at the end of the study. There were no statistically significant group-by-time interactions for function, pain, shoulder ROM (active and passive), or muscle strength (p > .05). However, there were statistically significant group-by-time interactions in role limitations due to physical health subscale of the 36-item Short Form Survey (SF-36) in CPT (p = .046, eta(2)(p) = 0.078). In addition, a significant difference was found in patient satisfaction at 3 weeks in CPT (p = .021) but no difference at 6 weeks between groups (p > .05). Conclusion The PNF techniques demonstrated similar outcomes to the CPT in reducing pain, improving function and shoulder ROM, and enhancing quality of life in patients with PHF in short time. According to our findings, PNF techniques are as effective as CPT and can be proposed as a potential adjunctive treatment for patients with PHF. Clinicaltrialnumber NCT05960435
The Effect of Simulation-Based Electroconvulsive Therapy Education on Perception and Knowledge of Nursing Students: a Semiexperimental Study
(Lippincott Williams and Wilkins, 2025) Dikeç, G.; Şan, E.Ö.
Objectives Despite the recognized benefits and safety of electroconvulsive therapy (ECT) for treating mental disorders, negative perceptions persist among both the public and mental health professionals. This stigma is often rooted in historical practices and media portrayals, despite modern advancements in the technique. This study aimed to assess the impact of simulation-based ECT education on nursing students' perceptions and knowledge regarding ECT before and after the procedure. Methods This study was planned to use a single-group pretest and posttest quasi-experimental design with a 3-month follow-up. Simulation-based ECT education involved 1 hour of theoretical instruction followed by hands-on learning using a high-fidelity mannequin. Final-year nursing students enrolled in a psychiatric and mental health nursing course were examined on their knowledge and perceptions of ECT before, immediately after, and 3 months following the intervention. Results Students reported statistically significant improvements in their perception and knowledge levels after participating in the simulation-based ECT education. The results were similar at the 3-month follow-up. Conclusions Simulation-based ECT education can be effectively integrated into both undergraduate and graduate nursing curricula to foster positive perceptions and enhance knowledge about ECT. Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.
Cochleogram-Based Speech Emotion Recognition With the Cascade of Asymmetric Resonators With Fast-Acting Compression Using Time-Distributed Convolutional Long Short-Term Memory and Support Vector Machines
(Mdpi, 2025) Parlak, Cevahir
Feature extraction is a crucial stage in speech emotion recognition applications, and filter banks with their related statistical functions are widely used for this purpose. Although Mel filters and MFCCs achieve outstanding results, they do not perfectly model the structure of the human ear, as they use a simplified mechanism to simulate the functioning of human cochlear structures. The Mel filters system is not a perfect representation of human hearing, but merely an engineering shortcut to suppress the pitch and low-frequency components, which have little use in traditional speech recognition applications. However, speech emotion recognition classification is heavily related to pitch and low-frequency component features. The newly tailored CARFAC 24 model is a sophisticated system for analyzing human speech and is designed to best simulate the functionalities of the human cochlea. In this study, we use the CARFAC 24 system for speech emotion recognition and compare it with state-of-the-art systems using speaker-independent studies conducted with Time-Distributed Convolutional LSTM networks and Support Vector Machines, with the use of the ASED and the NEMO emotional speech dataset. The results demonstrate that CARFAC 24 is a valuable alternative to Mel and MFCC features in speech emotion recognition applications.

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