PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8

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Safety and Efficacy of Depatuxizumab Mafodotin Monotherapy or in Combination With Temozolomide in Patients With/Without EGFR-Amplified Recurrent Glioblastoma: A Systematic Review
(Lippincott Williams & Wilkins, 2025) Moghib, Khaled; Hassan, Malak A.; Eljadid, Ghaith Y.; Salomon, Izere; Algazar, Mansour A.; Abu Arafeh, Muhannad Wael; Ibrahim, Ismail A.
This study aimed to assess the safety and efficacy of depatuxizumab mafodotin as a monotherapy or in combination with temozolomide in patients with recurrent epidermal growth factor receptor (EGFR)-amplified glioblastoma multiforme, focusing on overall survival (OS) and progression-free survival (PFS). A comprehensive literature search was conducted across PubMed, Cochrane Library, Web of Science, and Scopus databases up to August 2024. Randomized controlled trials (RCTs) and observational studies were included, comparing depatuxizumab mafodotin alone or with temozolomide in patients with and without EGFR amplification. Data extraction encompassed participant demographics, treatment regimens, and clinical outcomes. Of 102 screened publications, 10 RCTs and cohort studies involving 1431 patients met the inclusion criteria. The included studies examined depatuxizumab mafodotin as a standalone therapy and in combination with other agents, revealing OS ranging from 5 to 14 months and considerable variability in PFS. While depatuxizumab mafodotin shows the potential to improve survival outcomes, the heterogeneity in results highlights the need for further research. Future studies should refine patient selection criteria and explore alternative therapeutic combinations, such as depatuxizumab mafodotin with gemcitabine or cisplatin, to optimize treatment strategies.
Ultrasound Measurements of Pelvic Floor and Diaphragm Muscles in Chronic Obstructive Pulmonary Disease Patients With Urinary Incontinence
(Springer London Ltd, 2025) Balaban, Mehtap; Dusgun, Elif Sena; Nur, Hifziye Pervin; Lalecan, Nida; Sertcelik, Umran Ozden; Celenay, Seyda Toprak
BackgroundThe precise manner in which morphological properties of pelvic floor muscles (PFMs) and diaphragm muscle in Chronic Obstructive Pulmonary Disease (COPD) patients with Urinary Incontinence (UI) are affected remains unclear.AimThis study aimed to compare the ultrasound measurements of PFMs and diaphragm muscle in COPD patients with and without UI.MethodsThirty COPD patients with UI [UI group, age: 61.00 (42.00-70.00) years, body mass index: 27.86 (20.20-54.69) kg/m2] and thirty COPD patients without UI [N-UI group, age: 64.00 (47.00-70.00) years, body mass index: 27.11 (20.30-35.94) kg/m2] were included. The PFMs contaction assessment and diaphragm muscle morphological properties were evaluated using the Logiq S7/Expert ultrasound device. The percentage of change in thickness of diaphragm muscle, known as the diaphragm thickening fraction index (DTFI), was also calculated.ResultsIt was found that the PFMs contraction (p = 0.018) and DTFI (p = 0.016) values were significantly lower in the UI group compared to the N-UI group. No significant differences were observed in the diaphragm thickness score during the inspiration (p = 0.973) and expiration (p = 0.233) between the groups.ConclusionsPatients with COPD and UI exhibited diminished the PFMs contaction severity and DTFI compared to those with COPD but no UI. It should be considered that UI comorbidity in COPD may negatively affect PFMs contaction severity and diaphragm muscle morphological properties.
Burn Rehabilitation: Evaluation of Physiotherapists' Knowledge and Awareness Levels
(Elsevier Sci Ltd, 2025) Seyyah, Mine; Akkurt, Mustafa Ferit; Yilmaz, Nergis
Objective: The aim of this study was to evaluate the level of knowledge and awareness of physiotherapists working in Turkey about burn rehabilitation. Method: This was a cross-sectional study conducted between March and June 2025 and data were collected using Google Form. A total of 324 people were included in the study. The level of knowledge and awareness of the participants about burn rehabilitation was evaluated with 28 questions created by taking expert opinion. Results: While 25.6 % of participants had experience in burn rehabilitation, only 1.2 % frequently encountered burn patients. Although 60.5 % had taken courses on burn rehabilitation, only 15.1 % considered their knowledge sufficient. Correct response rates to key knowledge questions were 78.7 % for exercise applicability, 79.6 % for timing, 54.6 % for the most common burn type in Turkey, 35.8 % for edema management, and 13 % for pressure garment duration, revealing gaps in clinical knowledge. Additionally, 92.9 % believed early physiotherapy improves recovery, and 98.4 % reported positive effects on quality of life. Discussion: Our results indicate that although most physiotherapists had taken courses on burn rehabilitation, their knowledge remains insufficient, whereas their awareness is high, underscoring the need for targeted training and certification programs.
Effectiveness of Vibration in Reducing Pain and Improving Satisfaction During Subcutaneous Injections: A Randomized Crossover Clinical Trial
(Taylor & Francis Ltd, 2025) Yildirim, Dilek; Kugu, Emre
AimThe pain experienced during and after the injection may cause discomfort and lead individuals to develop a negative perception toward future injections. This study aimed to evaluate the impact of vibration stimulation on pain induced by subcutaneous injections and patient satisfaction.MethodsThis was a prospective, randomized, single-blind, crossover study design. Data were collected from 85 patients. Vibration and non-vibration subcutaneous anticoagulant injections were administered randomly by the same investigator following a standardized procedure. Pain and satisfaction were evaluated by a study-blind investigator using the Visual Analogue Scale immediately after the injection. Data were analyzed using descriptive statistics, the Student's t-test, paired sample test, and a generalized linear mixed model.ResultsA total of 175 injections were analyzed. It was found that the pain level of patients was lower when vibration was applied (4.06 +/- 1.68 vs. 5.32 +/- 2.19, p = 0.004). Additionally, patient satisfaction was higher when vibration was used (7.17 +/- 1.71vs. 5.97 +/- 2.46, p = 0.011).ConclusionThe results of this study demonstrated that vibration was effective in reducing the pain associated with subcutaneous anticoagulant injections and in increasing patient satisfaction. Vibration can be used as a method to alleviate pain from subcutaneous anticoagulant injections and enhance patient satisfaction. Clinically, this suggests that incorporating vibration during subcutaneous injections can be a simple, non-pharmacological strategy to improve patient comfort and adherence to therapy.
Investigating the Personal and Professional Variables That Predict Discrimination Attitudes Among Nurses and Physicians
(Wiley, 2025) Tekin, Suat; Seren, Arzu Kader Harmanci
Introduction: Healthcare professionals are expected to provide holistic care to their patients without discrimination based on factors such as religion, language, age, gender, and race. Design: It is a cross-sectional descriptive study. Aim: The study aimed to examine the discriminatory attitudes of nurses and physicians working in hospitals in Sanliurfa and to define whether the personal and professional variables predict discriminatory attitudes among them. Methods: The STROBE reporting method, which is one of the EQUATOR guidelines, was followed. Data were collected from a total of 376 physicians and nurses through online platforms between March and June 2020 via the information form and the Discrimination Attitude Scale. Results: The discriminatory attitudes of the nurses and physicians participating in the study were above average. The total discriminatory attitudes scores of the participants varied according to sex, income levels, profession, hospital experience, and unit (p < 0.05). In addition, sex, profession and unit variables predicted the total discriminatory attitudes of nurses and physicians (p < 0.05). Conclusion: Although nurses' and physicians' discriminatory attitudes scores were generally higher, the highest mean score was in the subscale "discrimination against other nationalities." Sex, profession, and unit variables predicted the total discriminatory attitudes of nurses and physicians. Further quantitative and qualitative research is needed to understand the reasons for the highest discriminatory attitudes towards other nationalities among healthcare professionals, to overcome this issue. Clinical Relevance: Nursing or healthcare managers, as well as policymakers, may consider the predictive variables when staffing and training nurses and physicians working in similar regions and conditions.
Unraveling the Potential of Stem Cell Therapy in Motor Neuron Disease: A Narrative Review
(Bentham Science Publ, 2025) Essa, Syed Muhammad; Khosa, Noor Ahmed; Kakar, Amanullah; Ozturk, Basar; Ibrahim, Ismail A.; Haq, Noman
Motor neuron disorders (MNDs), including ALS, are deadly neurodegenerative conditions that cause progressive motor neuron degeneration. With neuroprotection and the potential for neuron regeneration employing MSCs, ESCs, iPSCs, and NSCs, stem cell treatment presents a viable alternative to current medicines, which only control a limited number of symptoms. Following PRISMA criteria, this narrative review methodically screened 1248 records from the Cochrane, Web of Science, PubMed, and Scopus databases. Following a thorough screening process, 22 studies, including preclinical models and 19 clinical trials, were analysed to assess the therapeutic mechanisms, safety, and efficacy of stem cell therapies for MNDs. Mesenchymal stem cell (MSC) therapy has shown a promising safety profile and possible therapeutic efficacy in ALS, with no substantial transplant-related toxicity noted. ALS functional rating scale-revised (ALSFRS-R) scores and forced vital capacity (FVC) assessments from clinical trials, such as those evaluating autologous bone marrow-derived MSCs, demonstrated stabilisation in ALS development. Studies have also emphasised as to how immunomodulation and neurotrophic factors play a part in MSC-based therapies. Recent data indicate that repeated intrathecal MSC injection could extend the duration of therapeutic advantages. Clinical trials have shown safety and early efficacy signals for motor neurons produced from embryonic stem cells (ESCs), especially using AstroRx (R). This suggests that ESCs could be a viable option for regenerative medicine. Nonetheless, issues, like host integration and differentiation optimisation, still exist. Although clinical translation is still in its early stages, induced pluripotent stem cells (iPSCs) and their derivatives provide disease modelling and patient-specific therapeutic applications. Stem cell therapy holds promise for treating MND, with MSCs leading the way in current trials. It is necessary to enhance ESC- and iPSC-based techniques to tackle integration issues. To ensure long-term safety and efficacy, therapies must be developed using standardised protocols, patient stratification, optimised delivery, and large-scale studies.
Comprehensive Bibliometric Analysis of Characteristics, Patterns, and Causes of Retractions in Pediatric Literature
(Springer, 2025) Abo-Elnour, Dina Essam; Helal, Mohamed Mohsen; Albalasy, Abdulrahman Ahmed; Abdul-Hafez, Hamza A.; Abdelkader, Ahmed; El-Sherbini, Eman Raafat; Amer, Samar A.
This study aimed to systematically identify the key characteristics of retracted articles in pediatric literature and explore the patterns and reasons of pediatric retraction from 1995 to 2024. We searched PubMed and Retraction Watch databases to identify all retracted publications in the field of pediatrics. After the screening process, data were extracted into Excel. Statistical analysis was conducted using Jamovi and Excel. A correlation matrix was used for the important retraction-related factors. After screening, 590 unique retracted pediatric articles were included, with most of them, 572 (96.9%), having retraction notices available; 516 (87.5%) published as open access; 433 (73.4%) from Asia-mostly China; 348 (59%) retracted by the publisher; 301 (51.0%) published by Hindawi; 275 (46.6%) observational studies; and 221 (37.5%) retracted due to misconduct. Articles with four authors showed the highest retraction rate, and the retraction rate generally decreased as the number of authors increased. Most retractions occurred in 2023. The most common pediatric age group included in the retracted papers was children. The median H-index of authors of retracted papers was 8 for first authors and 10 for senior authors. The median time from submission to acceptance of retracted papers was 50 days and that from publication to retraction was 15 months. Additionally, time to retraction was positively correlated with the journal's impact factor (r = 0.106, p = 0.015) and the citation count (r = 0.213, p < 0.001) but showed no significant correlation with time to acceptance (r = - 0.019, p = 0.675). Conclusion: The increasing number of retracted pediatric papers reflects a growing concern with a complex pattern and various determinants. Researchers and publishers should adopt strong regulations and guidelines to improve the integrity of scientific research, especially pediatric research.
In Vitro Investigation of the Effects of Octenidine Dihydrochloride on Nasal Septum Squamous Carcinoma Cells
(MDPI, 2025) Ciftci, Ihsan Hakki; Ozkan, Asuman Deveci; Erman, Gulay; Kilbas, Elmas Pinar Kahraman; Koroglu, Mehmet
Background/Objectives: The aim of this study was to investigate the cytotoxic, genotoxic, apoptotic, and anti-inflammatory effects of the antiseptic agent octenidine dihydrochloride (OCT-D) on the RPMI-2650 cell line derived from human nasal mucosa in vitro. Methods: RPMI-2650 cells and Human Umbilical Cord Endothelial Cells (HUVECs) were treated with various concentrations of OCT-D (0.00625-0.4%) for 12 and 24 h. Cell viability was assessed using the WST-1 assay, while DNA damage was assessed using the comet and micronucleus (MN) assays. Apoptotic activity was determined using Annexin V flow cytometry and fluorescence microscopy. Intracellular reactive oxygen species (ROS) levels were measured, and inflammatory cytokines (IL-1 beta, IL-6, TNF-alpha, and IFN-gamma) were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The mRNA expression of genes associated with apoptosis, oxidative stress, and inflammation was analyzed using RT-PCR. Results: OCT-D caused dose- and time-dependent cytotoxicity, and RPMI-2650 cells showed greater resistance compared to HUVECs. While a strong apoptotic response was observed in HUVECs, RPMI-2650 cells exhibited limited apoptosis. OCT-D was found to cause dose-dependent DNA damage and an increase in MN in both cell lines. OCT-D significantly reduced cytokine levels and ROS production in both cell types. RT-PCR results supported its anti-inflammatory and antioxidant effects at the molecular level. Conclusions: In conclusion, this study demonstrated that OCT-D exhibited minimal cytotoxic and apoptotic effects in RPMI-2650 cells, but affected vascular structure by inducing apoptosis in endothelial cells. These findings provide important evidence that OCT-D can be used as a potential adjunctive agent in nasal treatments, and these data need to be supported by preclinical and clinical studies.
The Therapeutic Role of Ginseng in Promoting Hippocampal Neurogenesis and Ameliorating Cognitive Function Following Whole Brain Radiotherapy in Rats
(Springer/Plenum Publishers, 2025) Sahin, Sevim; Bayindir, Nihan; Ertas, Busra; Ceylan, Cemile; Elibol, Birsen; Ozkan, Alper; Sener, Goksel
Whole-brain radiotherapy (WBRT) is a prevalent technique for managing multiple intracranial metastases, however, the cognitive damage in long-term survivors due to WBTR is a critical concern that impacts patients' quality of life. Panax ginseng, a bioactive compound recognized for its neuroprotective benefits, also enhances cognitive functions, including memory and learning. This study aims to examine the potential protective effects of Panax ginseng supplementation on cognitive dysfunction and the levels of neurogenesis-related proteins in the hippocampus of rats that underwent WBRT, which was delivered as 3 fractions of 6 Gy (total dose 18 Gy) using a linear accelerator. Thirty-six male Sprague-Dawley rats were divided into three groups: radiation, ginseng treatment, and control. After 60 days of Panax ginseng administration (100 mg/kg), behavior tests (Morris water maze and novel object recognition) were performed, followed by western blot analysis of the hippocampus. Results indicated that Panax ginseng supplementation ameliorated radiation-induced cognitive impairments. Additionally, western blot analyses revealed that Panax ginseng promoted neuronal recovery and neuroplasticity processes in the hippocampus, simultaneously exhibiting a neuroprotective mechanism by reducing apoptosis and neurotoxicity markers. Panax ginseng ameliorates cognitive dysfunction after WBRT by enhancing neurogenesis and diminishing cell death in the hippocampus.
Effectiveness of Individual Psychoeducational Interventions for Caregivers of Stroke Patients: A Systematic Review and Meta-Analysis
(Springer/Plenum Publishers, 2025) Kelani, Hesham; Ali, Hossam Tharwat; Naeem, Ahmed; Salamah, Hazem Mohamed; Ismail, Ali; Younes, Youmna Atef; Khandelwal, Priyank
Stroke is a major cause of disability, and patients who suffer strokes have limited mobility and functional tasks, necessitating daily reliance on caregivers. However, caregivers of stroke patients often experience depression and anxiety, negatively impacting their mental health and reducing their quality of life. Psychoeducational interventions may be a solution to support the well-being of stroke caregivers. This study is performed to assess the overall effectiveness of individual psychoeducational interventions for caregivers of stroke patients. A thorough search of Scopus, PubMed, Web of Science, and Cochrane databases was performed for published studies in English up to June 2023. Clinical trials assessing the efficacy of psychoeducational interventions on quality of life, depression, or care burden among stroke caregivers compared to usual care were included. A total of 18 clinical trials, 16 randomized clinical trials (RCTs), and two non-RCTs, with a total of 2007 patients, were included. The study's pooled results revealed a significant increase in the quality of life in the group receiving psychoeducational interventions compared to the comparison group (SMD = 0.34, 95% CI 0.13-0.55, p value = 0.002), while no significant difference was found in terms of depression (SMD = - 0.05, 95% CI - 0.23 to 0.14, p value = 0.62) or caregiver burden (SMD = - 0.61, 95% CI - 1.65 to 0.44, p value = 0.25). Psychoeducation programs should be considered as a supportive intervention to improve quality of life in caregivers; however, their impact on depression and caregiver burden remains inconclusive. However, further studies with a larger sample size are needed to confirm the results.
Beyond Age: Understanding How Mindful Eating and Food Label Reading Shape Generational Differences in Health Outcomes – A Cross-Sectional Study
(BioMed Central Ltd, 2025) Altınok, Ö.; Yalcin, B.; Deniz, M.Ş.; Çelikayar, M.N.; Sevdin, S.; Bingül, B.Ç.; Garipaǧaoǧlu, M.
Background: The increasing prevalence of obesity and diet-related chronic diseases poses a considerable threat to public health. Consequently, understanding generational differences in dietary behaviors has gained growing importance. This study aims to examine the direct and indirect effects of generational cohort on anthropometric indicators and self-rated diet quality (SRDQ), mediated through mindful eating and food label reading attitudes. Method: This cross-sectional design study involved 2725 participants from Generations X (n = 786), Y (n = 933), and Z (n = 1006) living in Istanbul, Türkiye. Participants’ sociodemographic characteristics and anthropometric measurements, including body mass index (BMI), waist circumference (WC), and waist–hip ratio (WHR), were recorded. Data on SRDQ were collected, alongside responses to the Mindful Eating Questionnaire and the Food Label Reading Attitude Scale. Descriptive statistics, one-way analysis of variance, and chi-square tests were applied to the data. The direct and indirect effects of generation groups were analyzed using structural equation modeling. Results: Increasing mindful eating scores were associated with higher label reading attitude and SRDQ scores, while they were related to lower anthropometric risk indicators. Higher label reading attitudes showed an association with reduced WHR and increased SRDQ. Generation Z participants reported significantly lower scores for mindful eating, label reading attitude, anthropometric measures, and SRDQ than Generation X participants. Lower mindful eating scores were related to increased BMI among Generation Z, whereas lower label reading attitude scores were positively associated with WC and WHR. Furthermore, poor mindful eating and label reading attitudes and the combined effects of low mindful eating and label reading attitudes were linked to lower SRDQ. Conclusion: Poor mindful eating and label reading attitudes in Generation Z may threaten long-term health sustainability and increase the risk of developing chronic diseases. Combining generation-specific public health strategies with interventions aimed at improving nutritional literacy and mindful eating habits from an early age could enhance individual and societal health outcomes. © 2025 Elsevier B.V., All rights reserved.
Effects of an Adapted Dance Exercise Program on Trunk Control, Balance and Functional Mobility in Children and Adolescents with Cerebral Palsy: Randomized Controlled Study
(Taylor & Francis inc, 2025) Yekdaneh, Asena; Arman, Nilay
Aims: The study aimed to investigate whether an 8-week adapted dance exercise program (ADEP), delivered in addition to conventional physiotherapy, would improve trunk control, balance, functional mobility, and quality of life (QoL) in children and adolescents with cerebral palsy (CP) compared with conventional physiotherapy alone. Methods: Thirty participants with CP (Gross Motor Function Classification System Level I - II) were randomly assigned to the ADEP group (n = 15) or the control group (n = 15). Both groups received conventional physiotherapy, while the ADEP group additionally performed physiotherapist-choreographed dance exercises accompanied by music, twice a week for 8 weeks. Outcomes included the Trunk Control Measurement Scale (TCMS) for trunk control, the Pediatric Balance Scale (PBS) for balance, the Timed Up and Go (TUG) for functional mobility, and the Pediatric Outcomes Data Collection Instrument (PODCI) for QoL. Results: The ADEP group showed significantly greater improvements than the control group in TCMS-Total (Delta = 10.53 vs 3.50, p < .001), TCMS-selective motor control (Delta = 6.00 vs 1.42, p < .001), TCMS-dynamic sitting balance (Delta = 7.53 vs 2.28, p < .001), and PODCI-Global scores (Delta = 4.61 vs -1.71, p < .001). Both groups improved in PBS and TUG, but between-group differences were not significant. Effect sizes indicated large improvements in trunk control in favor of the ADEP group. Conclusions: An 8-week ADEP program, when combined with conventional physiotherapy, produced clinically meaningful gains in trunk control and QoL in children and adolescents with CP. These findings support the use of dance-based rehabilitation as a feasible and engaging adjunct to physiotherapy.
Evaluating and Comparing Student Responses in Examinations from the Perspectives of Human and Artificial Intelligence (GPT-4 and Gemini)
(BMC, 2025) Domanic, Kubra Yildiz; Baycan, Sukran
BackgroundGenerative Artificial Intelligence (AI) models, such as ChatGPT (GPT-4) and Gemini, offer potential benefits in educational settings, including dental education. These tools have shown promise in enhancing learning and assessment processes, particularly in dental prosthetic technology (DPT) and oral health (OH) programs.ObjectiveThis study aimed to evaluate the accuracy, reliability, and consistency of GPT-4 and Gemini AI models in answering examination questions in dental education. The study focused on multiple-choice questions (MCQs), true/false (T/F) questions, and short-answer questions (SAQs).MethodsAn exploratory study design was used with 30 questions (10 MCQs, 10 T/F, and 10 SAQs) covering key topics in DPT and OH education. ChatGPT and Gemini were tested with the same set of questions on two separate occasions to assess consistency. Responses were evaluated by two independent researchers using a predefined answer key. Data were analyzed using descriptive statistics, the Kappa coefficient for agreement, and the Chi-square test for categorical variables.ResultsChatGPT demonstrated high accuracy in MCQs (90%) and T/F questions (85%) but showed reduced performance in SAQs (60%). Gemini's accuracy ranged between 60% and 70%, with the highest accuracy in SAQs (70%). ChatGPT showed significant consistency across testing dates (Kappa = 0.754; p = 0.001), whereas Gemini's responses were less consistent (Kappa = 0.634; p = 0.001).ConclusionWhile both AI models offer valuable support in dental education, ChatGPT exhibited greater accuracy and consistency in structured assessments. The findings suggest that AI tools can enhance teaching and assessment methods if integrated thoughtfully, supporting personalized learning while maintaining academic integrity.
Multisensory Stimulation by Mothers: Impact on Neonatal Pain and Maternal Anxiety During Heel Blood Collection: A Randomized Controlled Trial
(Springernature, 2025) Akkaya-Gul, Aysenur; Ozyazicioglu, Nurcan; Celikboya-Kabadayi, Ezgi
OBJECTIVE: This study aimed to evaluate the effects of maternal multisensory stimulation on neonatal pain and maternal state anxiety during heel blood collection in neonates. STUDY DESIGN:A randomized controlled trial was conducted from July 2019 to January 2020 in neonatal units, with 80 newborns in intervention(n = 40) and control (n = 40) groups. In the intervention group, mothers provided multisensory stimulation (speech, touch, skin odor, breastfeeding, eye contact), while the control group received routine care. Neonatal Infant Pain Scale (NIPS) and maternal state anxiety inventory were evaluated. RESULTS:NIPS scores and maternal anxiety were significantly lower in the intervention group (p < 0.001). A positive correlation was found between NIPS and maternal anxiety in the intervention group (r = 0.372, p = 0.018). CONCLUSIONS: Maternal multisensory stimulation reduces neonatal pain and maternal anxiety. These findings emphasize the importance of pediatric nurses considering neonatal comfort and maternal emotional well-being during medical procedure. CLINICAL TRIAL REGISTRATION: The protocol for this randomized controlled experimental trial is registered on ClinicalTrials.gov. The clinical trial registration number is https://clinicaltrials.gov; NCT05606458.
Implementation of an AI-Enhanced Motor and Cognitive Intervention: A Case Study in Developmental Delay
(Routledge Journals, Taylor & Francis Ltd, 2025) Bektas, Selen Aydoner; Bumin, Gonca
This study aimed to explore the implementation of an AI-enhanced motor and cognitive intervention for a 7-year-old child with developmental delay. A case study design was employed using an A-B framework (pre-test, intervention, post-test) over 12 weeks. The intervention incorporated AI-based tools such as Lumosity, Just Dance, and Cogmed for tailored motor and cognitive activities. The Bruininks-Oseretsky Test of Motor Proficiency-2 Brief Form (BOT-2 BF) and the Dynamic Occupational Therapy Cognitive Assessment for Children (DOTCA-Ch) were used to evaluate outcomes. Post-intervention, significant improvements were observed in BOT-2 BF and DOTCA-Ch scores, indicating enhanced motor coordination, and cognitive abilities. AI-enhanced interventions demonstrated the potential to address developmental delays by providing adaptive, engaging, and effective therapeutic activities. The findings highlight the feasibility of integrating AI tools into therapy, with implications for broader adoption in addressing developmental challenges. Further research is recommended to explore generalizability and long-term effects.
Effects of the HEP® (Homeostasis-Enrichment Approach in Preterm Infants with Increased Developmental Risk: A Randomized Controlled Study
(Frontiers Media S.A., 2025) Sirma, Gamze Cagla; Zengin Alpozgen, Ayse; Balikci, Aymen
Background and objectives: This study investigated the effectiveness of the Homeostasis-Enrichment-Plasticity (HEP) Approach in preterm infants with increased developmental risk, compared to the Traditional Treatment (TT) intervention for physical and occupational therapy.
Materials and methods: Twenty-nine preterm infants (adjusted age, 4-10 months) were randomly assigned to two groups: the HEP Approach group and the TT group. The Peabody Developmental Motor Scales-2 (PDMS-2), Test of Sensory Functions in Infants (TSFI), and Beck Anxiety Inventory (BAI) were administered pre-and post-intervention. The intervention was implemented weekly for 12 weeks.
Results: The baseline characteristics of the infants were similar. At the end of the treatment, a significant time effect was observed in motor skills and sensory functions across both groups, with improvements in all PDMS-2 and TSFI subtests (p < 0.05). Significant time x group interactions showed greater improvements in the HEP Approach group compared to the TT group for Fine Motor Quotient: F = 10.818, p = 0.003; Gross Motor Quotient: F = 5.691, p = 0.024; and Total Motor Quotient: F = 21.109, p < 0.001. For TSFI, the HEP Approach group showed greater improvements in Adaptive Motor Functions (F = 13.794, p = 0.001), Visual-Tactile Integration (F = 7.410, p = 0.011), and Total score (F = 11.316, p = 0.002). No significant time*group interactions were found for Reactivity to Tactile Deep Pressure, Ocular Motor Control, and Reactivity to Vestibular Stimulation (p > 0.05). Parental anxiety, measured by BAI, decreased significantly in both groups (F = 8.72, p = 0.006), but no significant time x group interaction was found (p > 0.05), indicating similar reductions in both groups. Conclusion: The HEP Approach demonstrated superior outcomes compared to the TT intervention in improving motor skills and sensory functions in preterm infants, while both interventions reduced caregiver anxiety.
'I Feel Like the Burden of the World Is on My Shoulders': A Phenomenological Qualitative Study on the Life Experiences of Adult Children of Parents with Schizophrenia
(BMC, 2025) Pehlivan Saribudak, Tugba; Dag, Zeynep; Ozturk, Ayse; Dikec, Gul
BackgroundStudies investigating the experiences of adult children of parents with schizophrenia (ACPS) are limited, and no qualitative study examining this issue in T & uuml;rkiye has been previously conducted. This study aimed to examine the life experiences of ACPS providing primary care.MethodsThis phenomenological qualitative study was conducted with 14 ACPS in acute clinics of a regional psychiatric hospital in Istanbul between March and August 2024. Data were collected through in-depth interviews and analyzed using Colaizzi's seven-step analysis method.ResultsData analysis revealed five main themes: (1) Difficult beginning of life, (2) Being a caregiver without receiving care, (3) Emotional storm, (4) Disruption of the flow of life, and (5) Coping. The study found that adult children who cared for their parents could not remember their childhood, had to grow up early without parents, and experienced violence. Adult children had difficulty carrying the burden of care, experienced various emotions at the same time, and care disrupted their lives. They were both using adaptive and maladaptive coping methods.ConclusionsThis study determined that ACPS experienced significant childhood stressors and difficulties providing care in adult life that changed the flow of their daily lives while challenging their ability to cope. Psychiatric nurses have essential tasks to support ACPS in coping with difficult life experiences and reducing their care burdens. They should inform ACPS about schizophrenia, regularly monitor their mental health, and implement initiatives that will protect or improve their mental health.Clinical trial registrationNot applicable.
Machine Learning Model for Predicting Multidrug Resistance in Clinical Escherichia Coli Isolates: A Retrospective General Surgery Study
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Tolan, H.K.; Aydın, İ.; Tanyildizi-Kökkülünk, H.; Karakuş, M.; Akkaya, Y.; Kaya, O.; Işman, F.K.
Background/Objectives: Escherichia coli is one of the leading causes of surgical site infections (SSIs) and poses a growing public health concern due to its increasing antimicrobial resistance. High rates of extended-spectrum beta-lactamase (ESBL) production among E. coli strains complicate treatment outcomes and emphasize the need for effective surveillance and control strategies. Methods: A total of 691 E. coli isolates from general surgery clinics (2020–2025) were identified using MALDI-TOF MS. Antibiotic susceptibility data and patient variables were cleaned, encoded, and used to predict resistance using the Random Forest, CatBoost, and Naive Bayes algorithms. SMOTE addressed class imbalance, and model performance was assessed through various validation methods. Results: Among the three machine learning models tested, Random Forest (RF) showed the best performance in predicting antibiotic resistance of E. coli, achieving median accuracy, precision, recall, and F1-scores of 0.90 and AUC values up to 0.99 for key antibiotics. CatBoost performed similarly but was less stable with imbalanced data, while Naive Bayes showed lower accuracy. Feature importance analysis highlighted strong inter-antibiotic resistance links, especially among β-lactams, and some influence of demographic factors. Conclusions: This study highlights the potential of simple, high-performing models using structured clinical data to predict antimicrobial resistance, especially in resource-limited clinical settings. By incorporating machine learning into antimicrobial resistance (AMR) surveillance systems, our goal is to support the advancement of rapid diagnostics and targeted antimicrobial stewardship approaches, which are essential in addressing the growing challenge of multidrug resistance. © 2025 by the authors.
Artificial Intelligence in Nursing Practice: A Qualitative Study of Nurses' Perspectives on Opportunities, Challenges, and Ethical Implications
(BMC, 2025) Bodur, Gonul; Cakir, Hanife; Turan, Suzan; Seren, Arzu Kader Harmanci; Goktas, Polat
BackgroundThe study aims to explore nurses' views on the effects of artificial intelligence (AI) in nursing, focusing on their understanding, practical applications, ethical considerations, and perceived opportunities and threats.MethodsThis qualitative study used semi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\:-$$\end{document}structured interviews to gain comprehensive insights from clinical nurses, adhering to the Standards for Reporting Qualitative Research for methodological rigor. After obtaining ethical approval, researchers conducted semi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\:-$$\end{document}structured interviews with 25 clinical nurses. The interviews explored nurses' perceptions of AI, including its basic concepts, applications in nursing practice, ethical and social implications, and potential benefits and drawbacks.ResultsThe analysis identified four overarching themes: (1) Nurses' Conceptualizations of Artificial Intelligence, (2) Opportunities of AI in Nursing Practice, (3) Threats of AI in Nursing Practice, and (4) Ethical and Psychological Concerns in AI-Based Nursing Practice. The findings revealed that nurses had a foundational understanding of AI and its definitions. They acknowledged both the positive and negative impacts of AI technologies on their practice. Nurses expressed that AI could reduce workload, enhance patient care, and improve efficiency. However, they also articulated significant threats, including concerns over professional redundancy, emotional disconnection in caregiving, de-skilling, and the risk of dehumanizing the healthcare environment. Additionally, ethical and psychological concerns emerged, such as ambiguity in accountability, threats to data security and patient safety, unsuitability in psychiatric care contexts, staff surveillance anxiety, and risks of misuse or systemic bias.ConclusionThe study concluded that while nurses possess a basic understanding of AI, the effective and ethical integration of AI technologies in nursing requires targeted training, institutional preparedness, and robust interdisciplinary collaboration. To ensure AI complements rather than compromises nursing values, it is imperative to equip nurses with skills in digital literacy, ethical reasoning, and critical engagement with AI tools. The findings highlight the necessity of structured education programs and policy development that address both the technological and humanistic dimensions of AI use in healthcare. Future research should actively incorporate patient and public voices to ensure that AI-driven transformations in care remain aligned with the principles of patient-centeredness and human dignity.
Psychometric Properties and Transcultural Adaptation of Turkish Version of the Basel Assessment of Adherence to Immunosuppressive Medication Scale
(Baskent Univ, 2025) Koken, Zeliha Ozdemir; Ordin, Yaprak Sarigol; Seren, Arzu Kader Harmanci
Objectives: This study aimed to translate BAASIS (Basel Assessment of Adherence to Immunosuppressive Medication Scale) into Turkish and to test the psychometric properties of the translated Turkish version of the instrument. Materials and Methods: In this single-center crosssectional study, we included 100 kidney transplant recipients in a university hospital in a western city of Turkiye. The Translation and Cultural Adaptation Report from Professional Society for Health Economics and Outcomes Research was used for the transcultural adaptation of BAASIS to Turkish. We tested the validity of the BAASIS Turkish version by the level of evidence according to the American Educational Research Association guidelines: content validity, internal structure, and relations to other variables. We calculated item-total correlations of the BAASIS Turkish version to examine internal consistency reliability. Results: The content validity index score of BAASIS was calculated as 1.00, indicating agreement between the experts. Exploratory factor analysis evaluated the internal structure of BAASIS, and the coefficients for inter-item correlations ranged from 0.170 to 0.395. The Immunosuppressive Treatment Adherence Scale and the BAASIS nonadherent scores were significantly correlated (r = 0.673, P < .001). The coefficients for item-total correlation analyses ranged from 0.160 to 0.470. Conclusions: The BAASIS Turkish version has acceptable psychometric properties. The scale can be used in clinical practice and research projects in transplantation to assess immunosuppressive medication adherence.

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