Gold Nanoparticle/Silk Fibroin-Based Nanofiber Enhances Skin Regeneration

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Date

2025

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Oxford University Press

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Abstract

Objectives The aim of this study was to determine the wound-healing potential of gold nanoparticles and silk fibroin-based nanofiber produced by green chemistry. Methods The electrospinning method was used to prepare the nanofiber. Twenty rats were exposed to a 7-day treatment period and another 20 rats were exposed to a 21-day treatment period. Rat groups were control, silver, silk fibroin, and silk + gold nanoparticle groups for each period. The effect of the gold nanoparticle/silk fibroin-based nanofiber was examined in skin samples by using biochemical and histological analysis. In biochemical analysis, skin oxidant and antioxidant parameters were determined. Key findings Parameters indicating skin damage returned to their previous levels 7 and 21 days after the wound formation using gold nanoparticle/silk fibroin-based nanofiber. Gold nanoparticle/silk fibroin-based nanofiber initiated hair follicle formation at the wound site and accelerated the re-epithelialization process. Conclusions It was found that the nanofiber prepared by adding gold nanoparticles to silk fibroin had better wound-healing properties than silk fibroin nanofibers without gold nanoparticles. © 2025 Elsevier B.V., All rights reserved.

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Keywords

Antioxidant Effect, Gold Nanoparticles, Nanofiber, Silk Fibroin, Wound Dressing, Ketamine, Xylazine, Fibroin, Gold, Fibroins, Gold, Antioxidant, Gold Nanoparticle, Ketamine, Nanofiber, Silk Fibroin, Xylazine, Fibroin, Gold, Metal Nanoparticle, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Antioxidant Activity, Article, Biochemical Analysis, Biocompatibility, Controlled Study, Electrospinning, Epithelization, Female, Fourier Transform Infrared Spectroscopy, Male, Morphology, Nonhuman, Rat, Scanning Electron Microscopy, Skin Defect, Tensile Strength, Transmission Electron Microscopy, Wistar Rat, X Ray Diffraction, Animal, Chemistry, Drug Effect, Injury, Metabolism, Regeneration, Skin, Sprague Dawley Rat, Wound Healing, Animals, Fibroins, Gold, Male, Metal Nanoparticles, Nanofibers, Rats, Rats, Sprague-Dawley, Re-Epithelialization, Regeneration, Skin, Wound Healing

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Q2

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Q2

Source

Journal of Pharmacy and Pharmacology

Volume

77

Issue

8

Start Page

1085

End Page

1096
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