Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7
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Article Visual Tracking Efficiency across Different Spacing Widths: A Text-Free Eye-Tracking Study(Routledge Journals, Taylor & Francis Ltd, 2026) Akyurek, Gokcen; Akcay, Arif; Aydoner Bektas, SelenThis study examined how spatial spacing influences visual tracking efficiency using a novel text-free eye-tracking paradigm designed to minimize the influence of reading-related processes. Twenty participants visually followed straight, curved, and angular paths with five different widths (0.5-3 cm), while eye movements were recorded using a Tobii Eye Tracker T120. Results showed that narrow angular paths (0.5-1 cm) were associated with significantly higher fixation counts and longer fixation durations compared to wider angular paths and other paths. For angular paths, fixation counts differed significantly between 0.5 cm and 2.5 cm (p = .005), and between 0.5 cm and 3 cm (p = .003). Total fixation counts and total fixation durations were significantly greater for angular paths than for straight and curved paths. The findings indicate that narrower spatial constraints increase visual-perceptual load and reduce oculomotor fluency, whereas moderate spacing (approximately 2.5 cm) facilitates smoother visual guidance. The results are limited to visual tracking and oculomotor control within constrained geometric layouts and do not reflect reading behavior. The study highlights the utility of text-free visual tracking tasks for isolating low-level perceptual and oculomotor processes and informing future research on spatial layout and visual guidance in digital environments.Article Women’s Biopsychosocial Experiences Following Embryo Transfer: A Qualitative Study(Elsevier Masson, Corp Off, 2026) Baltacı, Nurşah Boylu; Aslan, Ergül; Coşkun, MervePurpose: This study explored the physical, psychological, and social experiences of women during the waiting period following embryo transfer (ET) in In Vitro Fertilization (IVF) and provides recommendations regarding psychosocial support needs. Materials and methods: A descriptive phenomenological design with thematic analysis was used. Semi-structured telephone interviews (30-45 min) were conducted with 29 women who underwent ET at a private IVF center in Istanbul from April to July 2025. Data were coded and analyzed using MAXQDA 24, and themes and subthemes were identified. Results: Participants had a mean age of 32.8 years, infertility duration of 2.8 years, 2.2 of IVF attempts, and 2.5 ETs. Most women were employed (69%), 72% had no previous pregnancies, and 86% had undergone multiple IVF attempt. Four main themes emerged in the thematic analysis: physical effects, psychological effects, social effects, and coping strategies. Subthemes varied by marital duration, previous IVF experience, and number of ETs; effects were stronger among women with multiple ETs. Conclusion: Women experience multidimensional challenges following ET and adopt various coping strategies. Physical changes disrupt daily life, emotional fluctuations stem from uncertainty and anxiety, and partner/social support and trust in healthcare professionals are critical for mitigating anxiety and improving quality of life and treatment adherence.Article Virtual Reality-Based Rehabilitation for Upper Extremity Recovery after Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials(Taylor & Francis Ltd, 2026) Ozturk, BasarBackground: Stroke often results in upper extremity motor impairments, limiting functional independence. Conventional rehabilitation, while effective, faces challenges such as low engagement and high resource demand. Virtual reality (VR)-based rehabilitation may promote neuroplasticity through immersive and repetitive training. Objectives: To systematically evaluate randomized controlled trials (RCTs) assessing the effectiveness of VR-based rehabilitation on upper extremity motor recovery in stroke patients, and to explore the impact of system type, stroke chronicity, and intervention dosage. Methods: Following PRISMA 2020 guidelines (PROSPERO: CRD420251065021), a systematic search was conducted in PubMed, Scopus, Web of Science, and CENTRAL for RCTs published between 2010 and March 2025. Studies included adult stroke survivors receiving VR interventions targeting upper limb recovery. A random-effects meta-analysis calculated standardized mean differences (SMDs), and risk of bias was assessed using RoB 2.0. Results: Twenty-four RCTs (n = 1,627) were included. Meta-analysis of 21 studies showed a moderate effect favoring VR (SMD = 0.58; 95% CI: 0.38-0.78; p < 0.001; I-2 = 62%). Immersive VR, chronic stroke, and higher intervention doses (>600 min) showed stronger effects. Conclusions: VR-based rehabilitation significantly enhances upper extremity motor function post-stroke. Immersive systems and sufficient dosage yield optimal outcomes, supporting VR as a valuable adjunct to conventional therapy.Article Turkish Translation and Cultural Adaptation of the Test of Ideational Praxis(SAGE Publications Ltd, 2026) Asqarova, Sevda; May-Benson, Teresa; Sagliyan, Mustafa; Balikci, Aymen; Sirma, Gamze CaglaIntroduction: The Test of Ideational Praxis is a performance-based assessment designed to identify ideational praxis difficulties in children aged 3-12. However, Turkish therapists are currently unable to use this tool due to the lack of a linguistically and culturally appropriate version. This study aimed to develop a culturally adapted Turkish version of the Test of Ideational Praxis to support future normative data collection, psychometric evaluations and clinical application.Method: A seven-step process for translation and cross-cultural adaptation was conducted, including forward and backwards translation, expert synthesis, linguistic review, structured therapist evaluations and pre-testing with children. Each step was guided by established literature and best practice guidelines.Findings: The translation and adaptation process was completed successfully with 29 participants, including translators, therapists and 10 typically developing children aged 6-8 years (four girls and six boys). While minor revisions were required during the synthesis and linguistic review phases, the forward translations showed strong semantic and conceptual consistency. Discrepancies observed in the back translation were limited to phrasing and did not affect standardised administration or scoring. Both therapists and children confirmed that the Turkish version was clear, comprehensible and culturally appropriate, with no expressions, instructions or symbolic representations perceived as problematic.Conclusion: The Turkish translation and adaptation of the Test of Ideational Praxis provides a culturally adapted instrument that supports future validation studies and clinical piloting, offering a foundation for both research and practice on ideational praxis development in Türkiye.Article The Practice Environment Scale of the Nursing Work Index Short Form in Turkish: A Psychometric Study(BMC, 2026) Arici, Furkan Cihat; Harmancı Seren, Arzu Kader; Seren, Arzu Kader Harmanci; Ayan, GüzinBackgroundThe work environment is a concept encompassing factors that increase or decrease a nurse's ability to practice the nursing profession competently and provide high-quality care. This study aims to adapt the short form of the Nursing Work Index-Nursing Work Environment Assessment Scale, which is used in many countries to evaluate the nursing work environment, to Turkish.MethodsThe study sample consisted of 711 nurses. For this study, data were collected from the researchers' personal social media accounts (WhatsApp, LinkedIn, and Instagram) between October and December of 2024. The Turkish version of the short form of the Practice Environment Scale from the Nursing Work Environment Index was used to collect the data. After creating the Turkish version of the instrument through translation and back-translation and collecting data, the researchers conducted content validity analyses, construct validity tests, and internal consistency analyses to assess the instrument's psychometric properties.ResultsThe items' content validity ratios were 0.93, and correlation coefficients varied between 0.605 and 0.523. The one structure accounted for 56.122% of the total variance. PES-5 scale findings: chi & sup2;/df 3.76, CFI 0.973, TLI 0.946, SRMR 0.031, RMSEA 0.090, CR 0.62. The standardized factor loadings for the scale items ranged from 0.610 to 0.743. The scale was compatible with its five items and one-factor structure The items' standardized factor loadings ranged from 0.370 to 0.575. The Cronbach's alpha consistency value was 0.804.ConclusionA short form of the practice environment scale of the Nursing Work Index is a valid and reliable tool in Turkish.Book Part The Genetics of Norovirus: Understanding Its Genome and Genogroups(Wiley, 2027) Sharma, Rahul; Kagithala, Naga Rani; Kothamasu, Sasikanth; Srivastava, Shriyansh; Ibrahim, Ismail A.Article Synergistic Anticancer Effects of the PLK1 Inhibitor BI-2536 and β-Glucan in Colon and Gastric Cancer Cells(International Institute of Anticancer Research, 2026) Saraç, Bülent; Joha, Ziad; Takci, Rabia Gökçe; Hacisüleyman, Levent; Şahİnbaş, BurcuArticle Sub-Cytotoxic Mitochondrial Stress in Cardiomyocytes and Whole-Organism Toxicity in C. Elegans Induced by Molnupiravir(SAGE Publications Inc, 2026) Gunaydin-Akyildiz, Aysenur; Keskin, Zehra; Ozhan, Gul; Kuran, Ebru Didem; Gulec, MeltemMany antiviral agents are known to induce off-target mitochondrial toxicity due to the prokaryotic origin of mitochondria. Mitochondrial dysfunction is frequently linked to cardiotoxicity. We aimed to elucidate the mitochondrial toxicity profile of molnupiravir via focusing on mitochondrial dynamics, biogenesis, and oxidative stress in cardiac cells. Mitochondrial function was evaluated by luminometric measurement of ATP (adenosine triphosphate) content, and flow cytometric analysis of mitochondrial membrane potential, and mitochondrial mass. The expression levels of genes involved in mitochondrial fusion-fission were assessed by RT-PCR. In addition, molecular docking analysis was performed to evaluate the interaction between molnupiravir and the dynamin related-protein DRP1. Protein carbonylation was determined as an oxidative stress parameter. Toxicity evaluation was further investigated in Caenorhabditis elegans to support the in vitro findings at the organismal level. Molnupiravir exposure led to a significant dose-dependent reduction in intracellular ATP level and mitochondrial mass, accompanied by increased protein carbonylation. Mitochondrial membrane potential remained slightly increased. Alterations in the expression of genes regulating mitochondrial dynamics suggested an imbalance between fusion and fission processes, while mitochondrial biogenesis-related signaling was progressively suppressed. C. elegans exposed to higher concentrations of the drug (20-500 & micro;M) exhibited significant lifespan reduction at all doses. Molecular docking analysis demonstrated a moderate binding affinity of molnupiravir to DRP1, supporting a potential direct interaction with mitochondrial fission machinery. In conclusion, our results demonstrate that molnupiravir induces mitochondrial stress through oxidative damage, impaired biogenesis, and altered dynamics, emphasizing the need for careful evaluation of mitochondrial safety of molnupiravir in cardiac tissue.Article Telehealth Delivery of the Homeostasis–Enrichment–Plasticity Approach for Premature Infants With Developmental Risks: Exploratory Feasibility Study(JMIR Publications, Inc, 2026) May-Benson, Teresa A.; Demirbag, Izgi-Miray; Sirma, Gamze Cagla; Sozen, Hatice Gulhan; Aracikul Balikci, Ayse Firdevs; Ilbay, Gul; Balikci, AymenBackground: Preterm delivery is an increasing worldwide health concern linked to increased neurodevelopmental risks. Early intervention is crucial for harnessing neuroplasticity to enhance developmental and functional performance outcomes; however, access to early intervention is frequently hindered by logistical, financial, and labor constraints. The Homeostasis-Enrichment-Plasticity (HEP) Approach is a family-centered early intervention model based on enriched environments, designed to improve infants' sensory-motor, cognitive, and socio-emotional development. Objective: This study aimed to assess the feasibility, safety, acceptability, and outcomessensitivity to change of implementing the HEP Approach through telehealth for premature infants at developmental risk. Methods: A pre-post exploratory feasibility study was performed, including 16 preterm infants (aged 4-12 months corrected age), of whom 14 completed the study. The 12-week intervention included weekly remote sessions focused on environmental enrichment, active exploration, and parental guidance. Thefeasibility and acceptability were evaluated using a 24-item questionnaire. Developmental outcomeswere assessed with the Young Children's Participation and Environment Measure, Ages and Stages Questionnaire (ASQ), Alberta Infant Motor Scale, Infant Motor Profile, and Depression Anxiety Stress Scales. Results: High adherence (14/14, 100%) and retention (14/16, 87.5%) rates demonstrated robust feasibility. Parents indicated 86%-100% agreement across all feasible criteria, affirming safety, satisfaction, and acceptability. No adverse incidents were reported. Changes were identified in participation (Young Children's Participation and Environment Measure), motor development (Alberta Infant Motor Scale, Infant Motor Profile, andASQ), communication and social-emotional domains (ASQ), and caregiver well-being (Depression Anxiety Stress Scales) (P<.05). Conclusions: The telehealth implementation of the HEP Approach demonstrated feasibility, safety, and strong acceptance among families, along with quantifiable developmental and psychosocial changes. These initial findings endorse the model's viability as an accessible, family-oriented telehealth framework for infants born preterm. Future randomized controlled and longitudinal studies are necessary to validate intervention efficacy and scalability.Article Synthesis, Experimental and Quantum Mechanical Investigation of the Crystal Structures of Two Triazolyl-Indole Compounds, along with the Evaluation of Their Antioxidant Activity(Elsevier, 2026) Pınar, Deniz; Kurt-Şirin, Özlem; Ulusoy-Güzeldemirci, Nuray; Dincel, Efe Doğukan; Karayel, Arzu; Kuran, Ebru DidemIn this study, two 1,2,4-triazolyl-indole compounds, 5-(1H-indol-3-yl)-4-propyl-2,4 dihydro-3H-1,2,4-triazole-3-thione (3a) and 5-(1H-indol-3-yl)-4-butyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (3b), were synthesized and the structures of these compounds were determined by X-ray diffraction method. These two compounds crystallize in the orthorhombic space groups, Pbca. The structures have been determined by direct methods and refined to R, 0.0459 (3a) and 0.0714 (3b). The molecular and crystal structures are stabilized by two intermolecular hydrogen bond for both molecules. The triazole parts of the molecules are almost perpendicular to propyl and butyl groups. NMR studies was also performed to enhance comprehension of the molecular structure of the compounds. The most stable states of the structures, as determined by both DFT analysis and experimental realizations (X-ray, NMR and FT-IR), are the thione form. Although the thione forms are thermodynamically more stable than the thiol forms (Delta H degrees approximate to-15 kcal/mol), they display higher chemical reactivity, as reflected by their smaller HOMO-LUMO energy gaps (Delta E = 4.374 eV for 3a and 4.377 eV for 3b). In addition, the antioxidant activities of both compounds were evaluated using ABTS, DPPH, and FRAP assays. Although both (3a) and (3b) exhibited measurable radical scavenging and reducing power, their antioxidant capacities were found to be lower than that of the reference compound quercetin.