Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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  • Article
    Seçici Enternasyonalizmden Askeri İzolasyona ABD Dış Politikasında Türkiye (1918-1923)
    (Istanbul University Press, 2025) Papuççular, H.
    This article examines the United States’ approach toward Türkiye during the Turkish National Struggle and how that approach evolved over time. The study presents four key findings regarding America’s relationship with the Turkish War of Independence. First, it reveals that President Woodrow Wilson’s post-1918 perspective on the region was primarily shaped by the Armenian mandate, reflecting a sectarian preference. This demonstrates the selective nature of Wilson’s internationalist ideals. Second, the condition of non-Muslim minorities in Anatolia remained a significant concern for the U.S. even after Wilson’s presidency. However, unlike the Wilson era, the U.S. largely refrained from intervention, limiting itself to observation. This non-interventionist stance is closely linked to the broader trend of military-political isolation in U.S. foreign policy during the period, when commercial interests were prioritized in international affairs. Third, the growing success of the Turkish national movement gradually compelled the United States to adopt a more pragmatic policy toward Ankara, driven by its own economic and commercial interests. Lastly, the article highlights the intense efforts of various actors with often conflicting agendas-such as relief missions, business circles, and lobbying groups-to influence U.S. policy. The article also analyzes Ankara’s view of the United States as part of a broader balancing strategy against Britain and France. In this context, Türkiye’s relationship with the United States offers valuable insights into the nature of early Republican diplomacy. © 2025, Istanbul University Press. All rights reserved.
  • Article
    Glyphosate and AMPA-Induced Apoptosis and Epigenetic Alterations in HepG2 Cells: Upregulation of p53-BAX-CASP Pathways
    (Elsevier Ltd, 2025) Mehtiyev, T.; Guler, Z.R.; Aktan, E.; Ozden, S.
    Glyphosate and its metabolite aminomethylphosphonic acid (AMPA) are environmental contaminants with potential toxic effects. This study aimed to investigate apoptosis and epigenetic alterations induced by glyphosate and AMPA in HepG2 cells. The IC50 values for glyphosate and AMPA were 6.19 mM and 8.13 mM, respectively, following 24 h exposure; mechanistic assays were conducted at sub-cytotoxic concentrations (50–500 μM). Annexin V/PI flow cytometry revealed that AMPA significantly increased early apoptosis (up to 116 %, p < 0.001), while glyphosate elevated late apoptosis (up to 145 %, p < 0.001). Gene expression analysis showed significant upregulation of p53 (≥1.49-fold), BAX (≥1.82-fold), CASP3 (≥1.37-fold), and CASP9 (≥1.83-fold), with no significant change in BCL2. Epigenetic analysis indicated that both glyphosate and AMPA increased global DNA methylation, with fold changes ranging from 1.43 to 1.62-fold at concentrations of 100–250 μM (p < 0.05). DNA methyltransferase genes DNMT1 (≥2.44-fold), DNMT3A (≥1.65-fold), and DNMT3B (≥1.65-fold) were upregulated. Additionally, histone modification profiling showed elevated levels of H3K27me3, H3K9me3, and H3K9ac (p < 0.05), alongside increased expression of G9a (≥1.64-fold), EZH2 (≥2.14-fold), SETD1B (≥2.15-fold), HAT1 (≥2.40-fold), and SIRT1 (≥2.57-fold), and downregulation of SUV39H1 (≥0.27-fold). These findings reveal the molecular mechanisms of glyphosate and AMPA toxicity, linking apoptosis to epigenetic alterations and enhancing understanding of their risks. © 2025 Elsevier Ltd
  • Conference Object
    A Unique Web 3 Product-NFT Usage in Healthcare
    (Institute of Electrical and Electronics Engineers Inc., 2025) Unozkan, H.
    Non-fungible tokens (NFTs) have gained immense popularity and value in recent years. After the Web 3 revolution, many new products have been constructed based on smart contracts or powerful software agreements. One of the most exciting products of Web 3 is NFT, with their increasing popularity, high volatility, and significant price movements making them popular in trading activities. Although many people, investors and researchers perceive NFTs as a trading product, the smart contract and metadata, both of which make up of NFT structure, offer valuable support for the big data storage and processing fields. In recent years, researchers have proposed different uses of NFTs in healthcare systems to improve the quality of services by using NFTs' versatile data storage architecture. In this study, the capability of NFTs in the storage of health data is investigated, the usage and usage proposals of NFTs in health are examined, and probable usage areas in health sciences are evaluated. The uniqueness of this study is, using NFTs as the dead parental data storage in which the metadata does not need to be mitigated, but the stored data is very valuable for doctors to assess the genetic illnesses comes from parental DNAs. © 2025 IEEE.
  • Article
    Protective Effects of Cuscuta Sp. Against Cardiorenal Injury in Bile Duct-Ligated Rats
    (Istanbul University Press, 2025) Hatipoglu, B.N.; Ozbeyli, D.; Sen, A.; Cevik, O.; Ercan, F.; Albayrak, O.; Sener, G.
    Objective: Bile duct ligation (BDL) obstructs bile flow, resulting in bile and toxic substances buildup that causes liver damage. This study investigated the protective effects of Cuscuta sp. methanol extract (CUS) against cardiorenal injury in bile duct-ligated rats. Materials and Methods: Rats were categorised into four groups: Control (C), CUS, BDL, and BDL+CUS. The C and BDL groups received saline, whereas the other groups received oral 250 mg/kg CUS. After 28 days, blood, kidney, and heart tissue samples were collected for biochemical and histological analyses. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), direct bilirubin (DB), and total bilirubin (TB) levels were analysed to determine liver function, while Transforming growth factor-beta (TGF-β) and hydroxyproline (HYP) levels were evaluated for fibrosis, and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels alongside Na+/K+-ATPase activity were analysed to assess oxidative stress and membrane injury in the heart and renal tissues. Results: AST, ALT, DB, and TB levels were significantly elevated in the BDL group compared with the C group; however, the levels were distinctly lower in the BDL+CUS group than in the BDL group. Additionally, in both tissues, TGF-β, HYP, and 8-OHdG levels were higher in the BDL group than in the C group, but decreased in the BDL+CUS group, with Na+/K+-ATPase activity being lower in BDL group compared with the C group and significantly increased in BDL+CUS group. Conclusion: CUS has protective effects against oxidative damage and offers antioxidant and anti-inflammatory benefits against cholestasis-induced tissue injury. © 2025. Hatipoglu, B. N., Ozbeyli, D., Sen, A., Cevik, O., Ercan, F., Albayrak, O., Ede Pazarbasi, S., Kanpalta Mustafaoglu, F. & Sener, G.
  • Article
    Efficacy of Different Exercises in Women With Fibromyalgia Syndrome: a Randomised Controlled Trial
    (Clinical and Experimental Rheumatology S.A.S., 2025) Şevgin, Ö.; Buğday, B.; Baykara, R.A.; Günendi, G.; Akkurt, B.; Atasoy, H.; Karamancıoğlu, B.
    The objective of this study was to evaluate the impact of aerobic exercise, resistance exercise combined with aerobic exercise, and yoga exercises combined with aerobic exercise on pain and disease activity in patients with fibromyalgia syndrome (FM). Methods The study population comprised 60 individuals with FM who met the inclusion criteria. The participants were randomly assigned to one of three groups. The first group underwent aerobic exercise (n=20), the second group combined aerobic exercise with yoga (n=20), and the third group engaged in aerobic and resistance exercise (n=20). All exercise interventions were conducted for a total of 12 weeks. Disease activity was evaluated using the Fibromyalgia Impact Questionnaire (FIQ), while pain status was assessed with the Melzack-Melzack Pain Questionnaire (MMPQ). All assessments were conducted before and following the completion of the exercise programme. The clinical trial number of this study is NCT06006494. Results The measurements of the aerobic exercise and yoga group were significantly lower than those of the aerobic and resistance exercise group. A statistically significant difference was observed between the groups in terms of post-treatment MMPQ scores. The measurements of the aerobic exercise and yoga group were significantly lower than those of the aerobic exercise only and aerobic and resistance exercise groups. No statistically significant difference was observed between the post-treatment MMPQ scores of the aerobic and aerobic resistance exercise groups. Conclusion The combination of aerobic exercise and yoga is more efficacious in the treatment of FM than aerobic exercise alone or a combination of resistance exercises and aerobic exercise. © Copyright CliniCal and ExpErimEntal rhEumatology 2025.
  • Book Part
    Military Coups and Military Disengagement
    (Springer International Publishing, 2023) Eldem, T.
  • Book Part
    Global Cyberspace Security and Critical Information Infrastructure Protection
    (Springer International Publishing, 2023) Eldem, T.
  • Book Part
    VR Headset Selection Via Codas Based on Pythagorean Fuzzy Set
    (IGI Global, 2024) Büyükselçuk, E.C.
    Thanks to the developing technology, innovative activities emerge in the education sector, as in every sector. Contrary to traditional teaching and learning methods, novel models have started to be used in the education sector with the opportunities offered by virtual reality (VR), augmented reality (AR) or mixed reality (MR) technologies used in many different sectors. In this study, a model developed for use in the education sector in Turkey, which is named MEB-VR, has been introduced and the solution of a problem encountered in this model has been discussed. MEB-VR has been developed especially for applied and laboratory courses. The problem of determining the best headsets to be used in the model, in which the VR-based education approach is adopted, has been tried to be solved in this study. For this purpose, the most suitable VR headset was determined using the combinative distance based assessment (CODAS) method based on circular pythagorean fuzzy sets (C-PFS). © 2025, IGI Global. All rights reserved.
  • Article
    Evaluation of Hopelessness, Decision Regret and Desire for Retransplantation in Patients With Graft Loss After Kidney Transplantation
    (Elsevier, 2025) Akinci, Naile; Toprak, Cagla
    Aim: In this descriptive study, it was aimed to evaluate hopelessness, decision regret, and desire to be transplanted again in patients who developed graft loss after kidney transplantation. Material and Method: The study sample consisted of all patients who developed graft loss after kidney transplantation between January 2017 and February 2021 in a private hospital in XXX, who met the inclusion criteria and volunteered for the study. "Patient Information Form", 'Beck Hopelessness Scale' and 'Decision Regret Scale' were used as data collection tools in the study. Findings: It was determined that participants experienced a moderate level of hopelessness after graft rejection (13.370 +/- 4.379) while the average scores on the decision regret scale were generally high (66.435 +/- 18.213). Regarding the desire to be transplanted again, it was observed that the majority of the participants (52.2 %) did not want to be transplanted again. According to the results of the correlation analysis, there was a significant correlation between hopelessness and decision regret scores (p* < 0.05) while there was no significant correlation with the desire to be transplanted again (p > 0.05). In addition, hopelessness (p = 0.034) scores of individuals who were not employed were significantly higher than those who were employed, and both hopelessness (p = 0.000) and decision regret (p = 0.048) scores of those without religious belief were significantly higher than those with religious belief. Conclusion: The findings of the study emphasize the critical importance of monitoring and psychological support processes before and after kidney transplantation. Understanding the emotional processes individuals experience after kidney transplant graft loss is important for the development of psychological support and intervention strategies.
  • Article
    Investigating the Relationship Between Caregiver Burden and Quality of Life in Burn Care
    (Elsevier Sci Ltd, 2025) Seyyah, Mine; Reyhanioglu, Duygu Aktar; Kardas, Ayse Sena Yumbul
    Aim: This study aimed to examine the relationship between caregiver burden and quality of life among primary caregivers of burn survivors receiving inpatient treatment in an acute care setting. Methods: This cross-sectional descriptive and correlational study included 53 primary caregivers of hospitalized burn patients, recruited from the Burn Care Unit of a tertiary hospital in Turkey between August 2022 and January 2023. Participants were aged 18 or older, identified as the primary caregiver, and able to communicate in Turkish. Individuals with psychiatric disorders were excluded. Data were collected through face-to-face structured interviews using the Zarit Burden Interview (ZBI) and the Short Form Health Survey (SF-36), in which higher scores indicate better quality of life. Descriptive statistics, Pearson correlation, and linear regression were used to analyze the data. Results: The caregivers had a mean age of 38.75 +/- 10.76 years; 71.7 % were female, and 50.9 % had completed only primary education. The average caregiving duration was 10.6 days. The mean ZBI score was 22.54 +/- 15.11, indicating moderate burden. Demographic variables did not significantly affect caregiver burden (p > .05). A moderate negative correlation was found between caregiver burden and their emotional (r = -0.367, p = .007), psychological (r = -0.313, p = .023), and physical functioning (r = -0.355, p = .009) subdomains of the SF-36. Conclusion: A inverse relationship was observed between caregiver burden and caregiver quality of life, especially in emotional, psychological, and physical functioning domains. Although demographic factors were not influential, lower quality of life was associated with greater caregiver burden.
  • Article
    Effects of Motor Imagery Adding To Physiotherapy and Rehabilitation Program in Children With Duchenne Muscular Dystrophy: Does It Make a Difference
    (Elsevier Sci Ltd, 2025) Umut, Gulsena Utku; Ozdincler, Arzu Razak; Ulug, Fitnat; Guler, Serhat; Saltik, Sema
    Introduction/background: The study aims to investigate the effects of the MI (Motor Imagery) program applied in addition to the PTR (Physiotherapy and Rehabilitation) program on gait and balance in children with DMD (Duchenne Muscular Dystrophy). Methods: The 38 boys with DMD were included in the study and randomized into two groups: the PTR group (mean age: 7.96 +/- 1.94 years) and the MI + PTR group (mean age: 9.03 +/- 1.71 years). In the PTR group, the PTR program was administered 2 days/week for 8 weeks, and in the MI + PTR group, the MI program was administered 5 days/week in addition to the PTR program. Groups were assessed by the Brooke Lower Extremity Functional Classification Scale, Modified Pediatric Mini Mental Scale, Movement Imagery Questionnaire (MIQc), Kinovea (R) Software Program, Timed Up & Go Test (TUG), Timed Function Tests (TFT), Two-Minute Walk Test (2MWT), and Motor Function Measure (MFM-32). Results: As a result of the study, in PTR Group, TFT-Stairs descending (p = 0.049) was improved. In MI + PTR Group, Kinovea (R) Software Program-Walking Speed (p = 0.003), 2MWT (p = 0.037), TFT-Stair descend and 10-m walk (respectively; p = 0.001; p = 0.039), and MFM-32-D1 (p = 0.036) were improved. According to the comparison between groups, the groups were not superior to each other (p > 0.05). Discussion/conclusion: Although the MI program applied in addition to the PTR program contributes to improvements in walking speed, walking distance, and functional performance in children with DMD, it does not demonstrate superiority over the PTR program alone.
  • Article
    Sensory Processing Skills and School Functions in School-Aged Children With Attention Deficit Hyperactivity Disorder: a Gender-Based Analysis
    (Routledge Journals, Taylor & Francis Ltd, 2025) Ceyhan, Irem; Akyurek, Gokcen
    Sensory processing skills are important for school functioning, learning and school participation. Children with attention deficit hyperactivity disorder (ADHD) may need additional support in the school context. This study aims to assess sensory processing skills and school functions in children with ADHD, focusing on gender differences. We included 118 children of whom 57 had ADHD and 61 were typically developing peers. Sensory processing skills were assessed with the Sensory Integration and Praxis Test subtests (Postrotary Nystagmus, Standing Walk and Balance, Bilateral Motor Coordination), and school functioning was evaluated using the School Function Assessment. Results showed that children with ADHD had worse sensory processing skills and school function, regardless of gender (p < 0.05). In girls with ADHD, Bilateral Motor Coordination emerged as a significant predictor across some sub-parameters of school functioning (Participation: p = 0.022; task supports: p = 0.020; physical tasks: p = 0.012). In boys, balance was particularly significant predictor of physical (p = 0.008) and cognitive functioning (p = 0.008). Boys with ADHD had more difficulty than girls in cognitive/behavioral task adaptations, setup and cleaning, and eating/drinking. Recognizing gender differences among these children is essential for health professionals to deliver more effective and individualized support interventions.
  • Article
    Empowering a Mother of Children With Autism: a Case Report on the Impact of Tele-Occupational Performance Coaching on Parent-Child Relationships, Maternal Self-Efficacy, and Occupational Performance
    (Routledge Journals, Taylor & Francis Ltd, 2025) Bektas, Selen Aydoner; Bumin, Gonca
    This case report aimed at tele-occupational performance coaching to empower the mother of a child with autism spectrum disorder by enhancing occupational performance, parent-child relationships, and maternal self-efficacy. Over 8 weeks, the intervention addressed goals collaboratively identified by the mother, including self-care, productivity, and leisure-related tasks. Results revealed clinically significant improvements, with a two-point increase in Canadian Occupational Performance Measure scores for both performance and satisfaction. Significant score increases were also obtained on the Parent-Child Relationship Scale and the Early Intervention Parenting Self-Efficacy Scale. The findings underscore the effectiveness of tele-occupational performance coaching in enhancing family dynamics and parental capabilities while emphasizing the potential of telehealth as a scalable and accessible modality for delivering family-centered occupational therapy. Future research should expand on these findings by incorporating diverse populations and assessing long-term outcomes.
  • Article
    The Effect of Mirror Therapy on Spasticity in Adult Patients With Stroke: a Systematic Review and Meta-Analysis
    (Taylor & Francis Ltd, 2025) Tosun, Anil Tekeoglu; Isiklar, Cagdas; Yeldan, Ipek
    Objective This study aims to investigate the effects of Mirror Therapy (MT) on spasticity and related parameters in stroke patients Methods A systematic review was performed in databases PubMed, Web of Science, Science Direct, Cochrane, and Scopus databases for published RCTs (Randomized Controlled Trials) from the date of each database's inception to May 2021. Modified Ashworth Scale (MAS) in adult patients with stroke compared to conventional therapy, sham, and additional therapy control were included. Physiotherapy Evidence Database Scale was used to assess the methodological quality of each study. Results The overall effect of MT on MAS was statistically significant and beneficial when studies were analyzed in terms of both upper and lower extremities (p < 0.001). MT demonstrated a large and beneficial overall effect on the Brunnstrom Assessment compared to conventional therapy (p < 0.001). The overall impact of MT on Fugl-Meyer Assessment (FMA) was large and statistically significant (p < 0.001). However, a meta-analysis of three studies using the 10-meter walk test showed that the overall effect of MT was not statistically significant (p = 0.258). Conclusion This systematic review and meta-analysis demonstrates reductions in upper and lower extremity spasticity and improved motor recovery with MT, both isolated and combined with other treatments, in adults with stroke. PROSPERO registration number CRD42021255154.
  • Article
    Life and Stigma Experiences of Individuals With Substance Use Disorder: a Qualitative Study
    (Turkish Green Crescent Soc, 2025) Albal, Esra; Dikec, Gul; Umut, Gokhan
    This study aimed to determine the life and stigma experiences of individuals with substance use disorder who received inpatient treatment in an adult detoxification center. Data for this qualitative phenomenological study were collected in Istanbul between April and December 2023. The data were analyzed using Colazzi steps. A total of 26 individuals with substance use disorder were interviewed. The content analysis identified three main themes. The initial topic discussed was the effect of substance use on individuals' lives. The sec-ond theme discussed was stigmatization. The final theme addressed coping with stigmatization. The study revealed that participants experienced negative emotions, including regret, guilt, and shame, due to stigmatization, exclusion, and discrimination. Substance use treatment should not only focus on pharmacotherapy but also the psychological and social needs of the individual. Furthermore, to address negative attitudes in society, mental health professionals could inform families and disseminate anti-stigma programs.
  • Article
    Evaluation of the Neuroprotective Effects of Korean Ginseng Root Extract in an Experimental Model of Multiple Sclerosis
    (Marmara Univ, Fac Medicine, 2025) Donmez, Muhammet Oguzhan; Sener, Goksel; Akbay, Tugba Tunali; Sivas, Guzin Goksun; Akakin, Dilek; Unlu, Hilal; Goren, Mehmet Zafer
    Objective: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterised by demyelination. The aim of this study was to evaluate the neuroprotective effects of Korean ginseng root extract (KGE) using a cuprizone-induced demyelination model. Materials and Methods: C57BL/6 mice were divided into control, demyelination and remyelination groups and each group was treated with KGE. Demyelination was induced with 0.2% cuprizone in the diet for four weeks. KGE (100 mg/kg) was administered by gavage during or after the cuprizone exposure. Body weight, food and water intake, and motor performance parameters were investigated. In addition, glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD) malondialdehyde (MDA), oligodendrocyte transcription factor-2 (OLIG2) and myelin basic protein (MBP) levels were measured in brain samples, while MBP and glial fibrillary acidic protein (GFAP) expression was assessed by immunohistochemistry and myelin status was examined using Luxol Fast Blue staining. Results: Korean ginseng root extract prevented myelin loss, promoted remyelination, and improved motor performance. It reduced oxidative stress by increasing GSH, GST, and SOD levels while decreasing MDA. KGE also suppressed demyelination by reducing astrogliosis and restoring OLIG2 and MBP levels. Conclusion: Korean ginseng root extract exhibits neuroprotective properties during demyelination and promotes remyelination, highlighting its therapeutic potential for MS.
  • Article
    Assessment of Cross-Cultural Adaptations and Patient-Reported Outcome Measures Relevant To Shoulder Disorders in Turkish: a Systematic Review Using the Cosmin Methodology
    (Public Library Science, 2025) Isiklar, Cagdas; Sirma, Gamze Cagla; Turgut, Elif
    Background There are many shoulder assessment outcome measures in the literature that have been studied for validity and reliability. However, there is no study examining the Turkish-adapted patient outcome measures (PROMs) on the shoulder according to the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist. In addition, there is a small number of studies that carry out this examination on the shoulder internationally. Determining the most appropriate questionnaires for clinical use will also be an important guide in patient evaluation by filling the gap in both literature and clinical aspects.Objective Our aim in this study is to identify the valid and reliable Turkish scales used to evaluate shoulder pain and disability, to reveal how compatible these scales are with the aspects of study quality and psychometric quality according to COSMIN criteria list.Methods A systematic search was performed in the following electronic databases: MED-LINE, Web of Science (WOS), EMBASE, SCOPUS, and ULAKBIM were searched from inception to September 2024.Results A total of 2890 articles were found in the databases. Four articles were included additionally without a search. Then, after eliminating the duplicates, 2231 articles were included based on the title and abstract search. 63 articles were included in full-text review. After the full-text review, according to our criteria, 29 articles were included in the systematic review. According to the assessment by the COSMIN checklist, 28 articles received the final classification of "inadequate". Only 1 article (UCLA-Tr) received the final classification of "adequate".Conclusion There is a wide range of Turkish PROMs available for the shoulder, with only one fully meeting COSMIN methodology criteria. However, this does not imply that other PROMs lack clinical utility. Future studies should focus on refining PROMs by incorporating MCID and PASS scores and prioritizing their responsiveness to enhance their clinical relevance. Additionally, variations in PROM performance across different patient populations highlight the need for context-specific evaluations to ensure their applicability in diverse clinical settings.Trial registration PROSPERO registration number: CRD42022298425.
  • Article
    NADPH Oxidase-2 Inhibitor Apocynin Attenuates High-Fat Diet-Induced Kidney and Bladder Injury
    (Marmara Univ, Fac Medicine, 2025) Kanpalta Mustafaoglu, Fatma; Ertas, Busra; Sener, Goksel; Ercan, Feriha
    Objective: This study aimed to evaluate the effects of NADPH oxidase-2 (NOX-2) inhibitor apocynin (APC) on high-fat diet (HFD)induced renal and bladder injury. Materials and Methods: Wistar albino rats were divided into 4 groups: Control, HFD, HFD+dimetyl sulfoxide (DMSO), and HFD+APC. Rats in HFD, HFD+DMSO, and HFD+APC groups were fed with HFD for sixteen weeks. In the last 4 weeks of the experiment, either DMSO or APC (25 mg/kg, dissolved in DMSO) was applied to the HFD+DMSO or HFD+APC groups. Lipid profiles and leptin values were measured in blood serum. Renal and bladder oxidant/antioxidant parameters, histological changes in the tissues, NOX-2-, nuclear factor kappa B (NF-& kgreen;B)-immunopositive and apoptotic cells were evaluated. Results: At the end of the experiment, leptin, cholesterol, and triglyceride levels were higher and high-density lipoprotein levels were lower in the HFD and HFD+DMSO groups compared to controls. In these experimental groups, an increase in malondialdehyde, 8-hydroxy-deoxyguanosine and myeloperoxidase levels and a decrease in glutathione levels, as well as an increase in collagen, NOX-2-and NF & kgreen;-B-immunopositive and apoptotic cells were found. Also, a deterioration in kidney and bladder morphology was observed. All these biochemical and histopathological findings improved in the HFD+APC group. Conclusion: High-fed diet causes renal and bladder injury by increasing NOX-2 activity and inflammation via oxidative stress. APC might alleviate tissue injury by inhibiting oxidative stress.
  • Article
    The Relationship Between Health Literacy and Healthy Lifestyle Behaviors of Women With Preeclampsia
    (Assoc Medica Brasileira, 2025) Kolcu, Merve; Akturk, Nur Bahar Kuru; Ozturk, Gizem; Akkus, Mine
    OBJECTIVE: The aim of this studywas to explore the relationship between the levels of health literacy and healthy lifestyle behaviors in women with preeclampsia. This research was planned as a descriptive relational study. METHODS: The data were collected from 251 pregnant women with preeclampsia who were admitted to a training and research hospital between February and July 2024. The Patient Information Form, Health Literacy Scale, and Healthy Lifestyle Behaviours in Pregnancy Scale were used for data collection. RESULTS: The mean Health Literacy Scale total score of the women was 76.25 +/- 14.48, and the mean Healthy Lifestyle Behaviours in Pregnancy Scale total score was 110.17 +/- 17.57. A moderate positive correlation was found between the mean total scores of the scales (r=0.365, p<0.05). CONCLUSION: As health literacy levels increased amongwomen diagnosed with preeclampsia, the level of healthy lifestyle behaviors also increased. It would be beneficial to integrate the topic of health literacy into prenatal care and pregnancy preparation classes.
  • Article
    Avatar: a Film at the Center of the Feminine Other
    (Univ Pittsburgh, Univ Library System, 2025) Dereboyu, Pelin Guregen; Guzel, Ebru; Olaru, Gabriela Oana; Ayberk, Erhan
    This study analyzes James Cameron's 2009 film Avatar from the perspective of the feminine other through deconstruction. In the movie, nature and the Na'vi people are depicted as feminine, while modern man and the science, technology, and military power he represents are portrayed as masculine. Although it critiques the colonialist structure of modernity, the film's narrative structure and character portrayals indicate that it reproduces the superiority of Western-centered ideology and the masculine mind. The study analyzes how the film's narrative and character representations implicitly support masculine centrism. The analysis reveals how nature and marginalized cultures are romanticized and presented in the film and how the notion that the feminine can only survive by adopting masculine traits is processed in the subtext. Grounded in a conceptual and theoretical framework, this research focuses on the sustainability of the patriarchal capitalist system and gender politics while critically examining how cinema reconstructs ideological structures through the narratives in the film.