Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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Synergistic Effects of Amniotic Membrane and Human Milk Exosomes on Burn Wound Healing
(Elsevier Ltd, 2025) Isık, F.; Tufan, E.; Sivas, G.G.; Ak, E.; Muhan, A.; Sener, G.; Tunali-Akbay, T.
Background: Thermal burns are one of the most common burns. Studies are ongoing to develop synthetic or biological wound dressings to ensure painless and scarless healing of burn wounds. Objectives: This study aimed to combine the human amniotic membrane with breast milk-based exosomes and investigate their effects on burn wound healing. Methods: 24 Wistar Albino rats weighing 200–250 g and of both genders were used. Rats were divided into control, burn, burn+human amniotic membrane (hAM) and burn+hAM+Exosomes (hAM+Exo) groups. Burn injury was induced by exposing the back of rats to 90 °C water for 10 s. Rats were treated with hAM and hAM+ Exo for seven days after injury. At the end of the 7th day, the skin samples were taken and analyzed biochemically and histologically. TNF-α, IL-1β, type III collagen, malondialdehyde (MDA), glutathione (GSH), total protein, superoxide dismutase (SOD), and tissue factor (TF) activity were determined in skin samples. Results: In the burn group, skin TNF- α levels increased, IL-1β and type III collagen levels decreased. Wound healing therapy reversed these results. In the hAM+Exo group, the TNF- α level was lower, and IL-1β and type III collagen levels were higher than in the hAM group. MDA and total protein levels increased, and GSH, tissue factor, and SOD activities decreased in the burn group. In hAM and hAM+Exo groups, MDA levels decreased, and GSH and SOD activity increased compared to the burn group. The GSH levels were significantly higher in the hAM+Exo group compared to the hAM group. Conclusion: In conclusion, combining exosomes and amniotic membrane induced changes consistent with better wound healing than amniotic membrane alone. © 2025
Corrigendum to “on Clinical Nurses’ Views About Diversities- A Qualitative Study”
(Elsevier Ltd, 2025) Cakir, H.; Harmanci Seren, A.K.
In the original published version of this article, there were unwanted reference links in 2.3. Sample and setting and new references [1], [2] and [3] has been added in the revised version removing the older reference [1]. The original manuscript showed the Introduction, 2.3. Sample and setting and reference [1] as below: Until the beginning of the 20. century, nearly all civilized societies were controlled by upper-class white men. As a result, diverse people from the leading culture were marginalized based on ethnicity, race, religion, language, sex, or sexual orientation. The “Diversity management" concept first emerged in the United States of America (USA) to manage personal and cultural differences among employees. Later, globalization became a worldwide concept parallel with the internationalization of businesses, employees, and clients [1]. Snowball sampling was applied. Inclusion criteria were working in a hospital in Istanbul for at least one year [1], three years or more of professional experience [2], bachelor's or upper degrees in nursing education [3] and working as a staff or a manager nurse [4]. [1] J.L. Bronstein, D.I. Bolnick, “Her joyous enthusiasm for her life-work …”: early women authors in the American naturalist, Am. Nat. 192 (6) (2018) 655–663. The corrected version of Introduction with relevant references and 2.3. Sample and setting are as below: Until the beginning of the 20. century, nearly all civilized societies were controlled by upper-class white men [1]. As a result, diverse people from the leading culture were marginalized based on ethnicity, race, religion, language, sex, or sexual orientation [2]. The “Diversity management” concept first emerged in the United States of America (USA) to manage personal and cultural differences among employees. Later, globalization became a worldwide concept parallel with the internationalization of businesses, employees, and clients [3]. Snowball sampling was applied. Inclusion criteria were: 1. working in a hospital in Istanbul for at least one year, 2. three years or more of professional experience, 3. bachelor's or upper degrees in nursing education 4. and working as a staff or a manager nurse. [1] Judy, R. W., & d'Amico, C. (1997). Workforce 2020: Work and workers in the 21st century. Hudson Institute, Herman Kahn Center, PO Box 26–919, Indianapolis, IN 46226; tele. [2] Penaluna, B. E., Arismendi, I., Moffitt, C. M., & Penney, Z. L. (2017). Nine proposed action areas to enhance diversity and inclusion in the American Fisheries Society. Fisheries, 42(8), 399–402. [3] Hiranandani, V. (2012). Diversity management in the Canadian workplace: Towards an antiracism approach. Urban Studies Research, 2012(1), 385806. The authors apologize for the errors. © 2025 The Author(s)
Novel Triazole-Urea Hybrids as Promising EGFR Inhibitors: Synthesis, Molecular Modeling and Antiproliferative Activity Studies Against Breast Cancer
(Elsevier B.V., 2025) Ture, A.; Gulcan, M.M.; Dingis Birgül, S.İ.; Erdogan, O.; Erdogan, O.; Oz Tuncay, F.; Kucukguzel, I.
Breast cancer is the second leading cause of mortality among women globally. In this study, novel promising urea derivatives containing a 4-phenyl-5-sulphanylidene-4,5-dihydro-1H-1,2,4-triazole group were synthesized and evaluated for their biological activities against breast cancer. The cytotoxicity and apoptotic profiles of these compounds were assessed on the MCF7 breast cancer cell line and the L929 fibroblast cell line. Compound 5c exhibited the strongest anticancer activity against MCF7 cells with an IC50 value of 56.97±4.22 µM, while it showed significantly lower cytotoxicity against L929 cells (IC50 = 1651±18.39 µM). Compound 5c also induced early apoptosis in MCF7 cells, with an apoptosis rate of 18.40% and 5.28%, respectively. Additionally, the EGFR inhibitory activities of the synthesized compounds were evaluated, with compound 5i demonstrating the most potent EGFR inhibition, showing an IC50 value of 35.1 nM. These results suggest that compound 5c likely exerts its anticancer effects through mechanisms other than EGFR inhibition, while compound 5i has significant potential as an effective EGFR inhibitor. Molecular modeling studies were conducted to suggest putative binding interactions of compounds 5d, 5e and 5i with wildtype hEGFR. Further studies are warranted to explore their activity against other cancer types. © 2025 Elsevier B.V.
TiO2@ZIF-8 Hybrid as a Type II Heterojunction Photocatalyst:Adsorption/Photocatalytic Properties, Kinetics, and Effect of Humidity
(Springernature, 2025) Okte, A. Neren; Tuncel, Duygu
TiO2@ZIF-8 hybrid and its humidified forms are synthesized as type 2 heterojunction systems using a facile sol-gel method at different relative humidity (RH) conditions. The hybrids' surface characteristics and optical properties are thoroughly examined, followed by investigations into adsorption capacities and photocatalytic activities using anionic-methyl orange (MO) and cationic-methylene blue (MB) dyes. TiO2@ZIF-8 hybrid generates a mesoporous structure with a higher surface area (135.6 m2 g-1) than bare TiO2 (40.1 m2 g-1). Band gap energies of TiO2@ZIF-8 (3.00 eV) and humidified hybrids (2.95-2.91 eV) decrease compared to the individual phases of TiO2 (3.08 eV) and ZIF-8 (4.9 eV). XPS analysis verifies the electron donation from ZIF-8 to TiO2. Adsorptions of MO and MB differ depending on the affinities of MO or MB's functional groups on the TiO2@ZIF-8 and humidified hybrids. TiO2@ZIF-8 demonstrates 98.7% MO and 89.5% MB degradations within 100 min irradiation. Dark adsorption studies follow Langmuir model with Langmuir constants of KL = 0.445 L mg-1 for MO in the presence of TiO2@ZIF-8 and KL = 0.409 L mg-1 for MB in the presence of TiO2@ZIF-8 (84% RH). Meanwhile, pseudo-second-order kinetic model is applicable for dark experiments with rate constants of k2 = 0.918 g mg-1 min-1 for MO in the existence of TiO2@ZIF-8 and k2 = 0.917 g mg-1 min-1 for MB in the existence of TiO2@ZIF-8 (84% RH). Under irradiation, TiO2@ZIF-8 (84% RH) has higher first-order rate constant 'k' values for both MO (0.0134 min-1) and MB (0.0146 min-1) relative to that of TiO2@ZIF-8 (0.0129 min-1 for MO and 0.0112 min-1 for MB). Based on Langmuir-Hinshelwood model, TiO2@ZIF-8 (84% RH)) shows the highest adsorption coefficients (K) of 0.164 L mg-1 for MO and 0.192 L mg-1 for MB and rate constants (k) of 0.197 mg L-1 min-1 for MO and 0.182 mg L-1 min-1 for MB. Notably, the hybrids maintain high stability and photocatalytic efficiency after four consecutive degradation cycles, highlighting their potential for sustainable environmental remediation.
The Moderating Role of Gender in Perceived Discrimination Levels and Political Participation of Turkish Women
(Walter de Gruyter Gmbh, 2025) Ozkilicci, Gokce; Yamaner, Onur
This study explores the relationship between women's political participation, perceived discrimination, and gender dynamics in Turkey. Political participation embodies an individual's aspiration to influence societal transformation and contribute to decision-making processes that shape communities. However, women's engagement in these processes has long been hindered by deeply rooted societal norms and systemic barriers. The primary objective of this research is to examine how perceived discrimination impacts women's political participation and to assess whether gender perceptions moderate this relationship. Data were collected from 313 female university students aged 18-58, utilizing the Political Participation Scale, Gender Perception Scale, and Perceived Discrimination Index. The results demonstrated a significant positive correlation between perceived discrimination and political participation, with gender perception acting as a key moderator. Women with stronger gender equality beliefs were more likely to recognize discrimination and engage in political activities. These findings emphasize the critical role of cultural, educational, and institutional strategies in enhancing women's political visibility and addressing systemic barriers. The study provides a robust foundation for developing egalitarian policies to promote women's active participation in politics, fostering a more inclusive democratic landscape.
The Effect of Compulsory Citizenship Behaviors on Subjective Vitality Among Nurses
(Wiley, 2025) Elibol, Esengul; Yildiz, Bora; Seren, Arzu Kader Harmanci
Aim The study aims to assess the extent of compulsory citizenship behaviors (CCBs) and their impact on the nurses' subjective vitality based on self-determination theory. Background CCBs are harmful to both nurses and organizations. These behaviors mean employees are expected to perform additional tasks outside their job descriptions. Although CCBs are highlighted within the recent nursing literature, empirical evidence of their effects is lacking. Methods This is descriptive cross-sectional research. The study included 244 staff nurses using a convenience sampling method who worked in two hospitals in Istanbul. Data were collected via a survey consisting of a personal information form, the compulsory citizenship scale, and the subjective vitality scale. STROBE guidelines were followed when reporting the study. Descriptive statistical analyses, independent samples t-test, one-way ANOVA test, Pearson's correlation, and hierarchical simple linear regression analyses were used. Results The participants' mean scores for compulsory citizenship and subjective vitality were 3.34 out of 5 (SD = 1.05) and 4.15 out of 7 (SD = 1.36), respectively. Nurses' compulsory citizenship scores significantly differed according to their education level, income, and sector. Their subjective vitality scores statistically differed according to their income levels. Regression analysis revealed that CCBs were significant negative predictors of subjective vitality (beta = -0.22, p < 0.01). Conclusion By examining the CCBs and subjective vitality relationship, the current study extended the existing knowledge by drawing attention to the destructive and harmful effects of CCBs on positive psychological sources of nurses' subjective vitality. CCBs negatively predicted subjective vitality. Clinical Relevance Organizational factors such as CCBs, which leads to a lack of autonomy, affect nurses' well-being, thus affecting care quality and patient safety. As the International Council of Nurses mentioned, "Nurses cope with many physical, mental, emotional, and ethical challenges. It is essential that we address these challenges in a way that supports their overall health". In this regard, managers and policymakers in hospitals should develop preventive cautions for CCBs. However, in-service training activities should be carried out to increase awareness about the harmful effects of CCBs on nurses' psychological well-being.
Evaluation of the Barriers to Maintenance 4.0 for the Textile Industry via Pythagorean Fuzzy SWARA
(MDPI, 2025) Turan, Hakan; Buyukselcuk, Elif Caloglu
Maintenance 4.0 studies have become a focus for managers and employees when developing effective and efficient maintenance policies. In this study, the barriers to Maintenance 4.0 applications in the textile industry are investigated, and these barriers are weighted using the Stepwise Weight Assessment Ratio Analysis (SWARA) method based on Pythagorean fuzzy numbers. Solutions to address these barriers are presented. As a result of this study, Organizational and Managerial emerged as the most important main criterion. Operational was identified as the second most significant main criterion, followed by Technical Competence. Data-Related and Cybersecurity ranked fourth in terms of importance. On the other hand, Human Resources and Training and Financial were found to be the least important main criteria. These two criteria received lower importance scores compared to the others, with Financial being the criterion with the lowest overall significance. Sensitivity analyses were performed for six different scenarios by changing the importance weights of the decision-makers. The ranking of the criteria only slightly changed with the weights; this means that the results obtained in Case 1 are robust and reliable. Even in Case 6, where the expert weight ratios were completely reversed, the results did not change significantly. This highlights an important point regarding the reliability of the assessment.
Lactobacillus Rhamnosus GG Alleviates Bisphenol-A Induced Oxidative Stress in Serum
(Marmara Univ, Fac. Pharmacy, 2025) Dede, Pinar; Ede-Pazarbas, Seren; Dorucu, Dogancan; Sener, Goksel; Tunali-Akbay, Tugba
The objective of this investigation was to identify changes in the serum oxidant-antioxidant balance of rats exposed to bisphenol A (BPA) and to investigate the impact of Lactobacillus rhamnosus GG (LGG) administration on those changes. Twenty-four rats (Wistar Albino, 250-300 grams, male) were divided into control, BPA, and BPA+LGG groups with an equal number of rats. BPA and LGG were applied to the rats in the relevant groups for six weeks, five days each week. Six weeks later, the blood samples were withdrawn and serum samples were prepared. Total oxidant and antioxidant status (TAS), glutathione, and lipid peroxidation determinations were determined in serum samples, and the oxidative stress index was calculated. BPA exposure decreased serum total antioxidant status and increased serum total oxidative status, oxidative stress index, and lipid peroxidation level compared to the control group. LGG administration improved the increased serum oxidative stress caused by BPA. Administration of LGG to BPA-treated rats reversed oxidative stress-induced changes. In conclusion, administration of Lactobacillus rhamnosus GG to rats for 30 consecutive days prevented oxidative stress in serum caused by bisphenol A.
Aqueous Parsley (Petroselinum Crispum) Extract Ameliorated Methotrexate-Induced Brain and Small Intestine Damage in Rats
(Ankara Univ, 2025) Dursun, Ercan; Karaoglu, Sumeyye Yilmaz; Sivas, Guzin Goksun; Tufan, Elif; Sacan, Ozlem; Yanardag, Refiye; Akbay, Tugba Tunali
Methotrexate (MTX) is a widely used antiarthritic and chemotherapeutic agent known to cause damage to various tissues. This study investigated the potential protective effects of parsley extract against MTX-induced brain and intestinal tissue damage. Sprague-Dawley rats were divided into control, control + parsley, MTX, and MTX + parsley. MTX (20 mg/kg, i.p.) was administered to the MTX and MTX + parsley groups. The control + parsley, and MTX + parsley groups were administered 2 g/kg parsley extract by oral gavage for five consecutive days. After the fifth day, brain and small intestinal tissues were taken. Total protein, nitric oxide, lipid peroxidation, glutathione levels, tissue factor, superoxide dismutase, and glutathione S-transferase activities were determined in these tissues. The protein profiles of the tissues were evaluated using SDS polyacrylamide gel electrophoresis. Parsley administration caused a decrease in lipid peroxidation levels in both tissues of the MTX group. On the other hand, glutathione level, glutathione-Stransferase, and superoxide dismutase activities were found to be increased. On the other hand, parsley decreased the nitric oxide level which was increased in the intestinal tissues of the MTX group. There was no significant change in brain nitric oxide level and tissue factor activity between groups. MTX and parsley administration altered protein expression, leading to the appearance or disappearance of specific bands in intestinal and brain tissues. In conclusion, parsley alleviated MTX-induced damage in brain and intestinal tissues by reducing lipid peroxidation and modulating antioxidant defenses.
Turkish Validity and Reliability Study of the Kidney Transplant Understanding Tool (K-TUT) in Kidney Transplant Recipients
(Elsevier, 2025) Akinci, Naile; Genc, Kadriye Nilay; Toprak, Cagla
Aim: The study was conducted methodologically to evaluate the validity and reliability of the KTUT scale in kidney transplant recipients. Material and Method: The population of the study consisted of kidney transplant patients at a private hospital group in Istanbul, while the sample comprised patients who met the inclusion criteria and volunteered for the study. Based on ten times the number of scale items, 220 individuals were included in the sample to prevent data loss and to ensure high representativeness. In the study, data collection tools such as the "Patient Information Form" and the "KTUT" scale were employed. The test-retest study was repeated two weeks later with 50 participants. The participants in the retest were not included in other tests of the scale. Findings: The overall content validity index of the scale (S-CVI/Ave) was found to be 0.93. According to the experts' opinions, the content validity of the scale is high, and the majority of the items have been deemed appropriate for the measurement purpose. The internal consistency reliability coefficient of the scale (Cronbach's Alpha) was calculated as 0.789. This threshold indicates that the scale possesses an acceptable level of reliability for use at the group level. In addition, the results of the study reveal that the scores of the K-TUT scale show a significant difference in the 27 % lower and 27 % upper groups. Conclusion: As a result of the study, the K-TUT scale has been shown to reliably distinguish knowledge levels and to be an effective measurement tool in the field of kidney transplant. It is thought that using the Turkish version of the K-TUT to evaluate the knowledge levels of kidney transplant recipients will contribute to evaluation of developed programs and the improvement of patients' treatment processes.
Seçici Enternasyonalizmden Askeri İzolasyona ABD Dış Politikasında Türkiye (1918-1923)
(Istanbul Univ, 2025) Papuccular, Hazal
This article examines the United States' approach toward T & uuml;rkiye during the Turkish National Struggle and how that approach evolved over time. The study presents four key findings regarding America's relationship with the Turkish War of Independence. First, it reveals that President Woodrow Wilson's post-1918 perspective on the region was primarily shaped by the Armenian mandate, reflecting a sectarian preference. This demonstrates the selective nature of Wilson's internationalist ideals. Second, the condition of non-Muslim minorities in Anatolia remained a significant concern for the U.S. even after Wilson's presidency. However, unlike the Wilson era, the U.S. largely refrained from intervention, limiting itselfto observation. This non-interventionist stance is closely linked to the broader trend of military-political isolation in U.S. foreign policy during the period, when commercial interests were prioritized in international affairs. Third, the growing success of the Turkish national movement gradually compelled the United States to adopt a more pragmatic policy toward Ankara, driven by its own economic and commercial interests. Lastly, the article highlights the intense efforts of various actors with often conflicting agendas-such as relief missions, business circles, and lobbying groups-to influence U.S. policy. The article also analyzes Ankara's view of the United States as part of a broader balancing strategy against Britain and France. In this context,T & uuml;rkiye's relationship with the United States offers valuable insights into the nature ofearly Republican diplomacy.
Glyphosate and AMPA-Induced Apoptosis and Epigenetic Alterations in HepG2 Cells: Upregulation of p53-BAX-CASP Pathways
(Elsevier Ltd, 2025) Mehtiyev, T.; Guler, Z.R.; Aktan, E.; Ozden, S.
Glyphosate and its metabolite aminomethylphosphonic acid (AMPA) are environmental contaminants with potential toxic effects. This study aimed to investigate apoptosis and epigenetic alterations induced by glyphosate and AMPA in HepG2 cells. The IC50 values for glyphosate and AMPA were 6.19 mM and 8.13 mM, respectively, following 24 h exposure; mechanistic assays were conducted at sub-cytotoxic concentrations (50–500 μM). Annexin V/PI flow cytometry revealed that AMPA significantly increased early apoptosis (up to 116 %, p < 0.001), while glyphosate elevated late apoptosis (up to 145 %, p < 0.001). Gene expression analysis showed significant upregulation of p53 (≥1.49-fold), BAX (≥1.82-fold), CASP3 (≥1.37-fold), and CASP9 (≥1.83-fold), with no significant change in BCL2. Epigenetic analysis indicated that both glyphosate and AMPA increased global DNA methylation, with fold changes ranging from 1.43 to 1.62-fold at concentrations of 100–250 μM (p < 0.05). DNA methyltransferase genes DNMT1 (≥2.44-fold), DNMT3A (≥1.65-fold), and DNMT3B (≥1.65-fold) were upregulated. Additionally, histone modification profiling showed elevated levels of H3K27me3, H3K9me3, and H3K9ac (p < 0.05), alongside increased expression of G9a (≥1.64-fold), EZH2 (≥2.14-fold), SETD1B (≥2.15-fold), HAT1 (≥2.40-fold), and SIRT1 (≥2.57-fold), and downregulation of SUV39H1 (≥0.27-fold). These findings reveal the molecular mechanisms of glyphosate and AMPA toxicity, linking apoptosis to epigenetic alterations and enhancing understanding of their risks. © 2025 Elsevier Ltd
A Unique Web 3 Product-NFT Usage in Healthcare
(Institute of Electrical and Electronics Engineers Inc., 2025) Unozkan, H.
Non-fungible tokens (NFTs) have gained immense popularity and value in recent years. After the Web 3 revolution, many new products have been constructed based on smart contracts or powerful software agreements. One of the most exciting products of Web 3 is NFT, with their increasing popularity, high volatility, and significant price movements making them popular in trading activities. Although many people, investors and researchers perceive NFTs as a trading product, the smart contract and metadata, both of which make up of NFT structure, offer valuable support for the big data storage and processing fields. In recent years, researchers have proposed different uses of NFTs in healthcare systems to improve the quality of services by using NFTs' versatile data storage architecture. In this study, the capability of NFTs in the storage of health data is investigated, the usage and usage proposals of NFTs in health are examined, and probable usage areas in health sciences are evaluated. The uniqueness of this study is, using NFTs as the dead parental data storage in which the metadata does not need to be mitigated, but the stored data is very valuable for doctors to assess the genetic illnesses comes from parental DNAs. © 2025 IEEE.
Protective Effects of Cuscuta Sp. Against Cardiorenal Injury in Bile Duct-Ligated Rats
(Istanbul University Press, 2025) Hatipoglu, B.N.; Ozbeyli, D.; Sen, A.; Cevik, O.; Ercan, F.; Albayrak, O.; Sener, G.
Objective: Bile duct ligation (BDL) obstructs bile flow, resulting in bile and toxic substances buildup that causes liver damage. This study investigated the protective effects of Cuscuta sp. methanol extract (CUS) against cardiorenal injury in bile duct-ligated rats. Materials and Methods: Rats were categorised into four groups: Control (C), CUS, BDL, and BDL+CUS. The C and BDL groups received saline, whereas the other groups received oral 250 mg/kg CUS. After 28 days, blood, kidney, and heart tissue samples were collected for biochemical and histological analyses. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), direct bilirubin (DB), and total bilirubin (TB) levels were analysed to determine liver function, while Transforming growth factor-beta (TGF-β) and hydroxyproline (HYP) levels were evaluated for fibrosis, and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels alongside Na+/K+-ATPase activity were analysed to assess oxidative stress and membrane injury in the heart and renal tissues. Results: AST, ALT, DB, and TB levels were significantly elevated in the BDL group compared with the C group; however, the levels were distinctly lower in the BDL+CUS group than in the BDL group. Additionally, in both tissues, TGF-β, HYP, and 8-OHdG levels were higher in the BDL group than in the C group, but decreased in the BDL+CUS group, with Na+/K+-ATPase activity being lower in BDL group compared with the C group and significantly increased in BDL+CUS group. Conclusion: CUS has protective effects against oxidative damage and offers antioxidant and anti-inflammatory benefits against cholestasis-induced tissue injury. © 2025. Hatipoglu, B. N., Ozbeyli, D., Sen, A., Cevik, O., Ercan, F., Albayrak, O., Ede Pazarbasi, S., Kanpalta Mustafaoglu, F. & Sener, G.
Efficacy of Different Exercises in Women With Fibromyalgia Syndrome: a Randomised Controlled Trial
(Clinical & Exper Rheumatology, 2025) Sevgin, O.; Bugday, B.; Baykara, R. Aydogan; Gunendi, G.; Akkurt, B.; Atasoy, H.; Karamancioglu, B.
Objective The objective of this study was to evaluate the impact of aerobic exercise, resistance exercise combined with aerobic exercise, and yoga exercises combined with aerobic exercise on pain and disease activity in patients with fibromyalgia syndrome (FM). Methods The study population comprised 60 individuals with FM who met the inclusion criteria. The participants were randomly assigned to one of three groups. The first group underwent aerobic exercise (n=20), the second group combined aerobic exercise with yoga (n=20), and the third group engaged in aerobic and resistance exercise (n=20). All exercise interventions were conducted for a total of 12 weeks. Disease activity was evaluated using the Fibromyalgia Impact Questionnaire (FIQ), while pain status was assessed with the Melzack-Melzack Pain Questionnaire (MMPQ). All assessments were conducted before and following the completion of the exercise programme. The clinical trial number of this study is NCT06006494. Results The measurements of the aerobic exercise and yoga group were significantly lower than those of the aerobic and resistance exercise group. A statistically significant difference was observed between the groups in terms of post-treatment MMPQ scores. The measurements of the aerobic exercise and yoga group were significantly lower than those of the aerobic exercise only and aerobic and resistance exercise groups. No statistically significant difference was observed between the post-treatment MMPQ scores of the aerobic and aerobic resistance exercise groups. Conclusion The combination of aerobic exercise and yoga is more efficacious in the treatment of FM than aerobic exercise alone or a combination of resistance exercises and aerobic exercise.
Military Coups and Military Disengagement
(Springer International Publishing, 2023) Eldem, T.
Global Cyberspace Security and Critical Information Infrastructure Protection
(Springer International Publishing, 2023) Eldem, T.
VR Headset Selection Via Codas Based on Pythagorean Fuzzy Set
(IGI Global, 2024) Büyükselçuk, E.C.
Thanks to the developing technology, innovative activities emerge in the education sector, as in every sector. Contrary to traditional teaching and learning methods, novel models have started to be used in the education sector with the opportunities offered by virtual reality (VR), augmented reality (AR) or mixed reality (MR) technologies used in many different sectors. In this study, a model developed for use in the education sector in Turkey, which is named MEB-VR, has been introduced and the solution of a problem encountered in this model has been discussed. MEB-VR has been developed especially for applied and laboratory courses. The problem of determining the best headsets to be used in the model, in which the VR-based education approach is adopted, has been tried to be solved in this study. For this purpose, the most suitable VR headset was determined using the combinative distance based assessment (CODAS) method based on circular pythagorean fuzzy sets (C-PFS). © 2025, IGI Global. All rights reserved.
Evaluation of Hopelessness, Decision Regret and Desire for Retransplantation in Patients With Graft Loss After Kidney Transplantation
(Elsevier, 2025) Akinci, Naile; Toprak, Cagla
Aim: In this descriptive study, it was aimed to evaluate hopelessness, decision regret, and desire to be transplanted again in patients who developed graft loss after kidney transplantation. Material and Method: The study sample consisted of all patients who developed graft loss after kidney transplantation between January 2017 and February 2021 in a private hospital in XXX, who met the inclusion criteria and volunteered for the study. "Patient Information Form", 'Beck Hopelessness Scale' and 'Decision Regret Scale' were used as data collection tools in the study. Findings: It was determined that participants experienced a moderate level of hopelessness after graft rejection (13.370 +/- 4.379) while the average scores on the decision regret scale were generally high (66.435 +/- 18.213). Regarding the desire to be transplanted again, it was observed that the majority of the participants (52.2 %) did not want to be transplanted again. According to the results of the correlation analysis, there was a significant correlation between hopelessness and decision regret scores (p* < 0.05) while there was no significant correlation with the desire to be transplanted again (p > 0.05). In addition, hopelessness (p = 0.034) scores of individuals who were not employed were significantly higher than those who were employed, and both hopelessness (p = 0.000) and decision regret (p = 0.048) scores of those without religious belief were significantly higher than those with religious belief. Conclusion: The findings of the study emphasize the critical importance of monitoring and psychological support processes before and after kidney transplantation. Understanding the emotional processes individuals experience after kidney transplant graft loss is important for the development of psychological support and intervention strategies.
Investigating the Relationship Between Caregiver Burden and Quality of Life in Burn Care
(Elsevier Sci Ltd, 2025) Seyyah, Mine; Reyhanioglu, Duygu Aktar; Kardas, Ayse Sena Yumbul
Aim: This study aimed to examine the relationship between caregiver burden and quality of life among primary caregivers of burn survivors receiving inpatient treatment in an acute care setting. Methods: This cross-sectional descriptive and correlational study included 53 primary caregivers of hospitalized burn patients, recruited from the Burn Care Unit of a tertiary hospital in Turkey between August 2022 and January 2023. Participants were aged 18 or older, identified as the primary caregiver, and able to communicate in Turkish. Individuals with psychiatric disorders were excluded. Data were collected through face-to-face structured interviews using the Zarit Burden Interview (ZBI) and the Short Form Health Survey (SF-36), in which higher scores indicate better quality of life. Descriptive statistics, Pearson correlation, and linear regression were used to analyze the data. Results: The caregivers had a mean age of 38.75 +/- 10.76 years; 71.7 % were female, and 50.9 % had completed only primary education. The average caregiving duration was 10.6 days. The mean ZBI score was 22.54 +/- 15.11, indicating moderate burden. Demographic variables did not significantly affect caregiver burden (p > .05). A moderate negative correlation was found between caregiver burden and their emotional (r = -0.367, p = .007), psychological (r = -0.313, p = .023), and physical functioning (r = -0.355, p = .009) subdomains of the SF-36. Conclusion: A inverse relationship was observed between caregiver burden and caregiver quality of life, especially in emotional, psychological, and physical functioning domains. Although demographic factors were not influential, lower quality of life was associated with greater caregiver burden.

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