Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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New Diclofenac Hydrazones: Design, Synthesis, in Silico Studies and Anticancer Evaluation Against Breast Cancer
(Elsevier B.V., 2026) Birgül, K.; Oktay, L.; Bekci, H.; Çıkla-Süzgün, P.; Durdagi, S.; Küçükgüzel, Ş.G.
Breast cancer remains one of the most prevalent and lethal malignancies among women, highlighting the urgent need for novel therapeutic strategies that can overcome resistance mechanisms. The p38α mitogen-activated protein kinase (MAPK14) plays a key role in inflammation-associated oncogenic signaling, making it an attractive molecular target for drug development. In this study, a novel series of diclofenac-based hydrazone derivatives (4a–4o) were designed, synthesized, and characterized using FT-IR, ¹H- and ¹³C-NMR spectroscopy, thin-layer chromatography, and elemental analysis. Computational target profiling using SwissTargetPrediction identified MAPK14 as the primary predicted target. Molecular docking against the MAPK14 crystal structure (PDB ID: 1WBS) revealed high binding affinities (–11.41 to –8.34 kcal/mol), supported by MM/GBSA free energy calculations and molecular dynamics simulations, which confirmed stable ligand–protein interactions through hydrogen bonding with Asp168 and Glu71. In vitro cytotoxicity assays on MCF-7 (luminal A) and MDA-MB-231 (triple-negative) breast cancer cell lines demonstrated low-micromolar IC₅₀ values, with compounds 4c, 4d, and 4e showing the strongest activity (2.1–4.5 µM), surpassing the reference drug Tamoxifen. Overall, the results indicate that diclofenac hydrazones represent promising candidates anticancer properties through MAPK14 inhibition, providing a foundation for the development of next-generation therapeutics against breast cancer. © 2025 Elsevier B.V.
Turning Human Resource Analytics Into Actionable Strategies
(IGI Global, 2025) Khan, Shad Ahmad; Koy, A.; Rani, C.; Kansra, P.; Kajla, T.
In today's data-driven workplace, the ability to harness unstructured text data is reshaping how organizations manage their human capital. Natural Language Processing (NLP) empowers HR professionals to extract insights from employee communications, feedback, and performance reviews, turning qualitative input into strategic decision-making tools. By improving areas such as recruitment, engagement, and retention, NLP enhances both employee experiences and organizational efficiency. Its application bridges the gap between traditional HR practices and advanced analytics, enabling more informed, proactive, and people-centered approaches. This integration of technology and human insight marks a transformative shift in the way businesses understand and support their workforce. Turning Human Resource Analytics Into Actionable Strategies emphasizes transforming raw textual data into actionable intelligence that enhances recruitment processes, improves employee engagement strategies, and optimizes organizational decision-making. It explores innovative approaches to effectively understand, manage, and leverage human capital in today's data-driven business environment. Covering topics such as forecasting workforce needs, job satisfaction, and recommendation systems, this book is an excellent resource for HR managers, recruiters, performance managers, employee engagement professionals, business leaders, data analysts, professionals, researchers, scholars, academicians, and more. © 2026 by IGI Global Scientific Publishing. All rights reserved.
The Futures of New Diplomatic History in a Shifting International Order
(Brill Academic Publishers, 2025) Papuccular, H.
This essay reflects on the agenda of globalizing diplomatic history as put forward in the manifesto “Provincializing ‘New’ Diplomatic History.” It first emphasizes that the Manifesto overlooks key structural dynamics, such as the transformation of the global order. These structural shifts have the potential to significantly influence the trajectories of global diplomatic history. This signifies that the suggestion for global diplomatic history is not merely an epistemic endeavor, but one that must also grapple with the politics of writing global – diplomatic – history in an age of rising disconnections and in an increasingly post-Western world order. Second, the essay points out that New Diplomatic History remains useful in many contexts, even if in a somewhat parochial form, because in many non-Western settings, it still represents a nascent approach to study diplomatic history. Thus, it still holds the potential to generate novel contributions to the historiography of diplomacy. © Hazal Papuççular, 2025 |
The Foundation of the Turkish Republic Under Atatürk 1923-38
(Taylor and Francis, 2025) Papuccular, H.
Sports Injuries of the Sternoclavicular Joint
(Springer Science+Business Media, 2025) Uluçay, C.; Yilmaz, B.
The sternoclavicular joint (SCJ) is the primary joint connecting the upper limb to the axial skeleton. It is a saddle-shaped diarthrodial joint comprised of a large clavicular head and a small fossa on the manubrium sterni. The SCJ plays a crucial role in facilitating a wide range of shoulder movements, allowing for clavicle rotation and abduction. Despite its relatively small size and limited bony locking, the SCJ requires robust ligaments to maintain stability and withstand substantial forces. Particularly in sports like football, martial arts, and soccer, direct and indirect traumas can easily lead to injuries in this joint. SCJ injuries are relatively common, and they often complicate other shoulder injuries. Because of the strength of its ligaments, dislocations of this joint are rare, accounting for less than 1% of all dislocations. However, posterior dislocations, although infrequent, can be life-threatening. In this chapter, we will provide a brief overview of the anatomy, patterns of injury, imaging techniques, and treatment options related to the SCJ. © 2025 Springer Nature Switzerland AG.
Ultrasound Measurements of Pelvic Floor and Diaphragm Muscles in Chronic Obstructive Pulmonary Disease Patients With Urinary Incontinence
(Springer London Ltd, 2025) Balaban, Mehtap; Dusgun, Elif Sena; Nur, Hifziye Pervin; Lalecan, Nida; Sertcelik, Umran Ozden; Celenay, Seyda Toprak
BackgroundThe precise manner in which morphological properties of pelvic floor muscles (PFMs) and diaphragm muscle in Chronic Obstructive Pulmonary Disease (COPD) patients with Urinary Incontinence (UI) are affected remains unclear.AimThis study aimed to compare the ultrasound measurements of PFMs and diaphragm muscle in COPD patients with and without UI.MethodsThirty COPD patients with UI [UI group, age: 61.00 (42.00-70.00) years, body mass index: 27.86 (20.20-54.69) kg/m2] and thirty COPD patients without UI [N-UI group, age: 64.00 (47.00-70.00) years, body mass index: 27.11 (20.30-35.94) kg/m2] were included. The PFMs contaction assessment and diaphragm muscle morphological properties were evaluated using the Logiq S7/Expert ultrasound device. The percentage of change in thickness of diaphragm muscle, known as the diaphragm thickening fraction index (DTFI), was also calculated.ResultsIt was found that the PFMs contraction (p = 0.018) and DTFI (p = 0.016) values were significantly lower in the UI group compared to the N-UI group. No significant differences were observed in the diaphragm thickness score during the inspiration (p = 0.973) and expiration (p = 0.233) between the groups.ConclusionsPatients with COPD and UI exhibited diminished the PFMs contaction severity and DTFI compared to those with COPD but no UI. It should be considered that UI comorbidity in COPD may negatively affect PFMs contaction severity and diaphragm muscle morphological properties.
Psychological Effects of Robotic Rehabilitation in Individuals With Spinal Cord Injury: A Narrative Review
(BMC, 2025) Ibrahim, Ismail A.; Mounir, Mennatallah M.; Hussein, Omar; Parnian, Nadieh; Sefertas, Ece; Ravanbod, Amin; Arican, Tuna Eren
IntroductionSpinal cord injury (SCI) is associated with severe physical, psychological, and social burdens. Robotic rehabilitation, especially robotic-assisted gait training, is increasingly used to improve functional recovery. Nonetheless, its psychological effects which are key to motivation, compliance, and long-term prognosis have received little scrutiny.MethodsWe conducted a narrative review across five databases (PubMed, Web of Science, Scopus, Cochrane, Embase) from inception to January 2025. Studies were included if they evaluated robotic rehabilitation in SCI and reported psychological outcomes. Findings were synthesized thematically into domains of anxiety/technophobia, motivation/engagement, self-efficacy/dependence, and frustration/quality of life.ResultsRobotic systems frequently improved autonomy, motivation, and self-confidence, which corresponded to less depression and a better quality of life. Nevertheless, negative effects including technophobia, frustration from technological malfunction, and loss of self-efficacy from excessive dependence were found. Patient experiences ranged: empowerment and new optimism were reported by some patients, whereas others experienced the devices as complicated, emotionally alienating, or inadequately adjustable.DiscussionRobotic rehabilitation has a dual psychological effect. On one hand, it encourages engagement and emotional resilience; on the other, it carries risks of interdependence and diminished autonomy. There are ethical issues to be resolved access disparities, data protection, and preserving human connection that require careful management. The inclusion of psychological screening, education of patients, and specific goal-setting within protocols can maximize results.ConclusionRobotic rehabilitation is highly capable of promoting progress after SCI if psychological considerations are completely incorporated into rehabilitation interventions. A multimodal approach that is interdisciplinary and ethically solid is required to achieve optimized functional improvement as well as psychosocial health.
Burn Rehabilitation: Evaluation of Physiotherapists' Knowledge and Awareness Levels
(Elsevier Sci Ltd, 2025) Seyyah, Mine; Akkurt, Mustafa Ferit; Yilmaz, Nergis
Objective: The aim of this study was to evaluate the level of knowledge and awareness of physiotherapists working in Turkey about burn rehabilitation. Method: This was a cross-sectional study conducted between March and June 2025 and data were collected using Google Form. A total of 324 people were included in the study. The level of knowledge and awareness of the participants about burn rehabilitation was evaluated with 28 questions created by taking expert opinion. Results: While 25.6 % of participants had experience in burn rehabilitation, only 1.2 % frequently encountered burn patients. Although 60.5 % had taken courses on burn rehabilitation, only 15.1 % considered their knowledge sufficient. Correct response rates to key knowledge questions were 78.7 % for exercise applicability, 79.6 % for timing, 54.6 % for the most common burn type in Turkey, 35.8 % for edema management, and 13 % for pressure garment duration, revealing gaps in clinical knowledge. Additionally, 92.9 % believed early physiotherapy improves recovery, and 98.4 % reported positive effects on quality of life. Discussion: Our results indicate that although most physiotherapists had taken courses on burn rehabilitation, their knowledge remains insufficient, whereas their awareness is high, underscoring the need for targeted training and certification programs.
Effectiveness of Vibration in Reducing Pain and Improving Satisfaction During Subcutaneous Injections: A Randomized Crossover Clinical Trial
(Taylor & Francis Ltd, 2025) Yildirim, Dilek; Kugu, Emre
AimThe pain experienced during and after the injection may cause discomfort and lead individuals to develop a negative perception toward future injections. This study aimed to evaluate the impact of vibration stimulation on pain induced by subcutaneous injections and patient satisfaction.MethodsThis was a prospective, randomized, single-blind, crossover study design. Data were collected from 85 patients. Vibration and non-vibration subcutaneous anticoagulant injections were administered randomly by the same investigator following a standardized procedure. Pain and satisfaction were evaluated by a study-blind investigator using the Visual Analogue Scale immediately after the injection. Data were analyzed using descriptive statistics, the Student's t-test, paired sample test, and a generalized linear mixed model.ResultsA total of 175 injections were analyzed. It was found that the pain level of patients was lower when vibration was applied (4.06 +/- 1.68 vs. 5.32 +/- 2.19, p = 0.004). Additionally, patient satisfaction was higher when vibration was used (7.17 +/- 1.71vs. 5.97 +/- 2.46, p = 0.011).ConclusionThe results of this study demonstrated that vibration was effective in reducing the pain associated with subcutaneous anticoagulant injections and in increasing patient satisfaction. Vibration can be used as a method to alleviate pain from subcutaneous anticoagulant injections and enhance patient satisfaction. Clinically, this suggests that incorporating vibration during subcutaneous injections can be a simple, non-pharmacological strategy to improve patient comfort and adherence to therapy.
Investigating the Personal and Professional Variables That Predict Discrimination Attitudes Among Nurses and Physicians
(Wiley, 2025) Tekin, Suat; Seren, Arzu Kader Harmanci
Introduction: Healthcare professionals are expected to provide holistic care to their patients without discrimination based on factors such as religion, language, age, gender, and race. Design: It is a cross-sectional descriptive study. Aim: The study aimed to examine the discriminatory attitudes of nurses and physicians working in hospitals in Sanliurfa and to define whether the personal and professional variables predict discriminatory attitudes among them. Methods: The STROBE reporting method, which is one of the EQUATOR guidelines, was followed. Data were collected from a total of 376 physicians and nurses through online platforms between March and June 2020 via the information form and the Discrimination Attitude Scale. Results: The discriminatory attitudes of the nurses and physicians participating in the study were above average. The total discriminatory attitudes scores of the participants varied according to sex, income levels, profession, hospital experience, and unit (p < 0.05). In addition, sex, profession and unit variables predicted the total discriminatory attitudes of nurses and physicians (p < 0.05). Conclusion: Although nurses' and physicians' discriminatory attitudes scores were generally higher, the highest mean score was in the subscale "discrimination against other nationalities." Sex, profession, and unit variables predicted the total discriminatory attitudes of nurses and physicians. Further quantitative and qualitative research is needed to understand the reasons for the highest discriminatory attitudes towards other nationalities among healthcare professionals, to overcome this issue. Clinical Relevance: Nursing or healthcare managers, as well as policymakers, may consider the predictive variables when staffing and training nurses and physicians working in similar regions and conditions.
Logistics Performance and Agricultural Exports: Evidence From Sub-Saharan Africa
(Routledge Journals, Taylor & Francis Ltd, 2025) Vardar, N. Baris; Cifter, Atilla; Delipinar, Gul Esin; Tekelioglu, Mehmet Gurel
This paper investigates the relationship between logistics performance and agricultural exports in Sub-Saharan Africa. Using dynamic panel data from 2012 to 2022, we examine the impact of various components of logistics performance on aggregate agricultural exports. We also analyse how logistics performance affects exports in agricultural subsectors. Our results show that improvements in logistics infrastructure, customs procedures, and international shipping services significantly increase agricultural export performance. The food and live animals subsector benefits the most, followed by crude materials and animal and vegetable oils and fats subsectors. We also find that financial development, foreign direct investment, and world demand are important drivers of agricultural exports in Sub-Saharan Africa. We include institutional quality indicators in our analysis for robustness checks, showing that governance factors also play a significant role in boosting exports. These findings highlight the need for targeted investment in logistics and complementary economic policies, supported by good governance, to harness the region's agricultural export potential and promote sustainable economic development.
Unraveling the Potential of Stem Cell Therapy in Motor Neuron Disease: A Narrative Review
(Bentham Science Publ, 2025) Essa, Syed Muhammad; Khosa, Noor Ahmed; Kakar, Amanullah; Ozturk, Basar; Ibrahim, Ismail A.; Haq, Noman
Motor neuron disorders (MNDs), including ALS, are deadly neurodegenerative conditions that cause progressive motor neuron degeneration. With neuroprotection and the potential for neuron regeneration employing MSCs, ESCs, iPSCs, and NSCs, stem cell treatment presents a viable alternative to current medicines, which only control a limited number of symptoms. Following PRISMA criteria, this narrative review methodically screened 1248 records from the Cochrane, Web of Science, PubMed, and Scopus databases. Following a thorough screening process, 22 studies, including preclinical models and 19 clinical trials, were analysed to assess the therapeutic mechanisms, safety, and efficacy of stem cell therapies for MNDs. Mesenchymal stem cell (MSC) therapy has shown a promising safety profile and possible therapeutic efficacy in ALS, with no substantial transplant-related toxicity noted. ALS functional rating scale-revised (ALSFRS-R) scores and forced vital capacity (FVC) assessments from clinical trials, such as those evaluating autologous bone marrow-derived MSCs, demonstrated stabilisation in ALS development. Studies have also emphasised as to how immunomodulation and neurotrophic factors play a part in MSC-based therapies. Recent data indicate that repeated intrathecal MSC injection could extend the duration of therapeutic advantages. Clinical trials have shown safety and early efficacy signals for motor neurons produced from embryonic stem cells (ESCs), especially using AstroRx (R). This suggests that ESCs could be a viable option for regenerative medicine. Nonetheless, issues, like host integration and differentiation optimisation, still exist. Although clinical translation is still in its early stages, induced pluripotent stem cells (iPSCs) and their derivatives provide disease modelling and patient-specific therapeutic applications. Stem cell therapy holds promise for treating MND, with MSCs leading the way in current trials. It is necessary to enhance ESC- and iPSC-based techniques to tackle integration issues. To ensure long-term safety and efficacy, therapies must be developed using standardised protocols, patient stratification, optimised delivery, and large-scale studies.
Comprehensive Bibliometric Analysis of Characteristics, Patterns, and Causes of Retractions in Pediatric Literature
(Springer, 2025) Abo-Elnour, Dina Essam; Helal, Mohamed Mohsen; Albalasy, Abdulrahman Ahmed; Abdul-Hafez, Hamza A.; Abdelkader, Ahmed; El-Sherbini, Eman Raafat; Amer, Samar A.
This study aimed to systematically identify the key characteristics of retracted articles in pediatric literature and explore the patterns and reasons of pediatric retraction from 1995 to 2024. We searched PubMed and Retraction Watch databases to identify all retracted publications in the field of pediatrics. After the screening process, data were extracted into Excel. Statistical analysis was conducted using Jamovi and Excel. A correlation matrix was used for the important retraction-related factors. After screening, 590 unique retracted pediatric articles were included, with most of them, 572 (96.9%), having retraction notices available; 516 (87.5%) published as open access; 433 (73.4%) from Asia-mostly China; 348 (59%) retracted by the publisher; 301 (51.0%) published by Hindawi; 275 (46.6%) observational studies; and 221 (37.5%) retracted due to misconduct. Articles with four authors showed the highest retraction rate, and the retraction rate generally decreased as the number of authors increased. Most retractions occurred in 2023. The most common pediatric age group included in the retracted papers was children. The median H-index of authors of retracted papers was 8 for first authors and 10 for senior authors. The median time from submission to acceptance of retracted papers was 50 days and that from publication to retraction was 15 months. Additionally, time to retraction was positively correlated with the journal's impact factor (r = 0.106, p = 0.015) and the citation count (r = 0.213, p < 0.001) but showed no significant correlation with time to acceptance (r = - 0.019, p = 0.675). Conclusion: The increasing number of retracted pediatric papers reflects a growing concern with a complex pattern and various determinants. Researchers and publishers should adopt strong regulations and guidelines to improve the integrity of scientific research, especially pediatric research.
Development and Psychometric Properties of the Home Programme Quality Evaluation Tool for Therapists, Clients and Caregivers: A Validity and Reliability Study
(MA Healthcare Ltd, 2025) Akyurek, Gokcen; Bektas, Selen Aydoner; Sipahi, Busra
Background/Aims Home programmes - where rehabilitation activities are carried out in the client's home - are frequently used in the rehabilitation process but there are no standardised measurements to assess preparation, delivery and quality. The aim of this study was to determine the validity and reliability of two different forms - one for therapists and one for client and caregivers - that were developed as part of the Home Programme Quality Evaluation tool. Methods Initially, two 38-item forms were created based on a comprehensive literature review and expert panel evaluation. These forms were piloted with 30 participants from each target group to assess grammatical clarity, comprehensibility and cultural appropriateness. Based on the pilot feedback, minor linguistic adjustments were made, and the refined 38-item forms were then administered to 179 physiotherapists, occupational therapists and speech and language therapists, and 185 clients/caregivers (100 clients, 85 caregivers) for psychometric analyses. Psychometric analyses were conducted to evaluate validity and reliability, including exploratory and confirmatory factor analyses (chi-square/degree of freedom ratio, Goodness-of-Fit Index, Tucker-Lewis Index, Comparative Fit Index, Incremental Fit Index, root mean square error of approximation, standardised root mean square residual and internal consistency (Cronbach's alpha) and test-retest reliability (intraclass correlation coefficient and Pearson correlation). Results Exploratory and confirmatory factor analyses supported a one-factor structure for both forms, resulting in the final 11-item therapist form and 8-item client/caregiver form. The Home Programme Quality Evaluation tool demonstrated a good model fit for both forms (therapist form: chi(2)/df=2.66, goodness-of-fit index=0.909, Tucker-Lewis Index=0.886, standardised root mean square residual=0.060; client/caregiver form: chi(2)/df=3.37, goodness-of-fit index=0.929, Tucker-Lewis Index=0.950, standardised root mean square residual=0.027). Cronbach's alpha was 0.868 for the therapist form and 0.932 for the client/caregiver form. Test-retest reliability revealed strong positive correlations (r=0.994, P<0.001; r=0.998, P<0.001) and excellent stability over time (intraclass correlation coefficient=0.998 and 0.990, respectively). Conclusions The Home Programme Quality Evaluation's therapist and client/caregiver forms were found to have strong validity and reliability. The therapist form can enable therapists to monitor themselves, while the client and caregiver form can help clients or caregivers provide feedback on the home programme. Future studies can explore its application across different clinical populations and rehabilitation settings to further refine and optimise home-based interventions. Implications for practice For allied health professionals, the Home Programme Quality Evaluation tool serves as a practical tool for improving home programme design and implementation. By systematically assessing home programme quality, therapists can identify areas for improvement, ensuring that programmes are clear, feasible and well-integrated into the daily life of clients and their caregivers. Integrating the Home Programme Quality Evaluation tool into routine clinical practice can contribute to more effective rehabilitation outcomes, promoting structured, high-quality home programmes that align with the needs and capabilities of both clients and caregivers.
Google Trend Index as an Investor Sentiment Proxy in Cryptomarket: Nonlinear Relationships With Cryptomarket and Predicting Bitcoin Returns With Machine Learning Approach
(Springer, 2025) Koy, Ayben; Demir, Semra; Colak, Andac Batur
This study investigates the utility of Google trend indices as proxies of investor sentiment, examining their relationships with cryptocurrency market prices and their potential for return prediction. Employing several nonlinear econometric models including the momentum threshold autoregressive AR (MTAR), Kapetanios, Shin, and Snell, and exponential smooth transition autoregressive vector error correction model, the research the relationships between Google trend indices and BTC prices. Additionally, the study evaluates the performance of three developed artificial neural network models in predicting bitcoin returns based on investor sentiment derived from Google trend indices. The findings highlight that the MTAR model effectively captures significant relationships between the variables studied. However, predicting bitcoin returns remains challenging due to their typically small values, which represent the changes between observation points.
In Vitro Investigation of the Effects of Octenidine Dihydrochloride on Nasal Septum Squamous Carcinoma Cells
(MDPI, 2025) Ciftci, Ihsan Hakki; Ozkan, Asuman Deveci; Erman, Gulay; Kilbas, Elmas Pinar Kahraman; Koroglu, Mehmet
Background/Objectives: The aim of this study was to investigate the cytotoxic, genotoxic, apoptotic, and anti-inflammatory effects of the antiseptic agent octenidine dihydrochloride (OCT-D) on the RPMI-2650 cell line derived from human nasal mucosa in vitro. Methods: RPMI-2650 cells and Human Umbilical Cord Endothelial Cells (HUVECs) were treated with various concentrations of OCT-D (0.00625-0.4%) for 12 and 24 h. Cell viability was assessed using the WST-1 assay, while DNA damage was assessed using the comet and micronucleus (MN) assays. Apoptotic activity was determined using Annexin V flow cytometry and fluorescence microscopy. Intracellular reactive oxygen species (ROS) levels were measured, and inflammatory cytokines (IL-1 beta, IL-6, TNF-alpha, and IFN-gamma) were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The mRNA expression of genes associated with apoptosis, oxidative stress, and inflammation was analyzed using RT-PCR. Results: OCT-D caused dose- and time-dependent cytotoxicity, and RPMI-2650 cells showed greater resistance compared to HUVECs. While a strong apoptotic response was observed in HUVECs, RPMI-2650 cells exhibited limited apoptosis. OCT-D was found to cause dose-dependent DNA damage and an increase in MN in both cell lines. OCT-D significantly reduced cytokine levels and ROS production in both cell types. RT-PCR results supported its anti-inflammatory and antioxidant effects at the molecular level. Conclusions: In conclusion, this study demonstrated that OCT-D exhibited minimal cytotoxic and apoptotic effects in RPMI-2650 cells, but affected vascular structure by inducing apoptosis in endothelial cells. These findings provide important evidence that OCT-D can be used as a potential adjunctive agent in nasal treatments, and these data need to be supported by preclinical and clinical studies.
Recognition of Clove (Eugenia Caryophyllata) Oil Adulteration by Monitoring Phenolic and Antioxidative Fingerprint Markers Utilizing Online HPLC Post Column and Spectrophotometric Assays With Chemometric Analysis
(Springer, 2025) Ersoy, Seyda Karaman; Kaya, Elif Nilay; Celik, Saliha Esin; Senol, Onur; Apak, Resat
This research aims to develop a reliable and versatile methodology for authenticating clove (Eugenia caryophyllata) oil (CLO). Key variables included total antioxidant capacity (TAC), total phenolic content (TPC), quantitative analyses and/or individual antioxidant capacity of fingerprint markers including eugenol (EUG) and tocopherol isomers (alpha-T, gamma-T, and delta-T) using reversed-phase liquid-chromatography (RP-HPLC) with post-column detection. A total of 28 commercial CLO samples (certified as 100% pure and other commercial samples), potential adulterants like vegetable oils (sunflower oil (SFO) and corn oil (CO)), and 14 synthetically adulterated CLO samples blended with varying proportions (ranging from 5 to 50%) of SFO and CO were analyzed. The EUG content and antioxidant capabilities of each marker were ascertained by online RP-HPLC analysis with post column detection utilizing CUPRAC (cupric reducing antioxidant capacity). EUG content in commercial CLO ranged from 1.46 to 98.06 mg g(-1), while TAC ranged between 18.54 and 748.46 mu mol g(-1) Trolox equivalents (TE), as determined by the online HPLC-CUPRAC method. Depending on the type and ratio of adulterating oils, a considerable decrease in the TAC values of virgin CLO was recorded. Classification of the commercial and synthetically adulterated CLOs (total of 42 samples) was performed using partial least square discrimination analysis (PLS-DA) and hierarchical cluster analysis (HCA). Adulteration levels above > 5% were successfully detected with 95% confidence. Thus, the proposed chemometric strategy combining selected chemical markers and TAC data demonstrated high potential for authenticating CLO. This technique provides a more focused investigation alternative for determining the authenticity and quality of commercial CLO.
In Vivo and In Silico Evaluation of the Effects of Parsley (Petroselinum Crispum L.) Extract on Small Intestinal Tissue in Scopolamine-Induced Cognitive Dysfunction Model
(Wiley-VCH Verlag GmbH, 2025) Ertik, Onur; Sacan, Ozlem; Sener, Goksel; Pazarbasi, Seren Ede; Yanardag, Refiye
The brain-small intestine connection has become important in neurodegenerative diseases in recent years. In particular, the discovery of the relationship between Alzheimer's disease (AD) and the small intestine and the examination of the effects of AD on this tissue are important in this respect. Our study aimed to understand the effects of the experimentally created AD model in rats on the small intestinal tissue and the protective effect of the extract prepared from parsley leaves (PE). The experimental animals were divided into four groups in the study; Control, Scopolamine (Scop), Scop + PE and Scop + Galantamine (GAL). Oxidative stress parameters and activities of some important enzymes were examined in small intestinal tissues taken as a result of the experimental protocol. Additionally, in silico studies were carried out for bioactive molecules found in parsley leaves using data obtained from in vivo enzyme activity results. It was found that parameters examined for the damaged group, Scop, were reversed by PE and GAL treatment. As a result of in silico studies, it was determined that oxypeucedanin and phylloquinone had higher binding affinity than rutin for acetylcholinesterase (AChE). It has been observed that oxidative damage in the small intestine due to AD can be treated by the PE.
The Therapeutic Role of Ginseng in Promoting Hippocampal Neurogenesis and Ameliorating Cognitive Function Following Whole Brain Radiotherapy in Rats
(Springer/Plenum Publishers, 2025) Sahin, Sevim; Bayindir, Nihan; Ertas, Busra; Ceylan, Cemile; Elibol, Birsen; Ozkan, Alper; Sener, Goksel
Whole-brain radiotherapy (WBRT) is a prevalent technique for managing multiple intracranial metastases, however, the cognitive damage in long-term survivors due to WBTR is a critical concern that impacts patients' quality of life. Panax ginseng, a bioactive compound recognized for its neuroprotective benefits, also enhances cognitive functions, including memory and learning. This study aims to examine the potential protective effects of Panax ginseng supplementation on cognitive dysfunction and the levels of neurogenesis-related proteins in the hippocampus of rats that underwent WBRT, which was delivered as 3 fractions of 6 Gy (total dose 18 Gy) using a linear accelerator. Thirty-six male Sprague-Dawley rats were divided into three groups: radiation, ginseng treatment, and control. After 60 days of Panax ginseng administration (100 mg/kg), behavior tests (Morris water maze and novel object recognition) were performed, followed by western blot analysis of the hippocampus. Results indicated that Panax ginseng supplementation ameliorated radiation-induced cognitive impairments. Additionally, western blot analyses revealed that Panax ginseng promoted neuronal recovery and neuroplasticity processes in the hippocampus, simultaneously exhibiting a neuroprotective mechanism by reducing apoptosis and neurotoxicity markers. Panax ginseng ameliorates cognitive dysfunction after WBRT by enhancing neurogenesis and diminishing cell death in the hippocampus.
Psycho-Social Impact of the Disaster on Employees in Terms of Occupational Health and Safety: The Case of Turkey
(Springer Nature, 2025) Aytac, S.S.; Akalp, H.G.; Bilir, B.O.; Mamaci, M.
The earthquakes that occurred in Maraş, Turkey, on February 6, 2023, with intensities of 7.7 MW and 7.6 MW, deeply affected the lives of millions of people in economic, social and psychological terms within a few seconds and caused loss of life. The aim of this study is to examine the moderator role of disaster preparedness plans in workplaces on the relationship between post-traumatic stress levels and depression, anxiety, stress levels of people who are directly or indirectly exposed to these earthquakes and have an active work life. The data was obtained from a total of 206 blue-collar employees who were actively working in a private company and were directly and indirectly exposed to the effects of the earthquake. In data collection, demographic information form, The Impact of Event Scale-Revised (IES-R) and Depression Anxiety Stress Scale-21 (DASS-21) were used. According to the findings analyzed using structural equation modeling showed that having a disaster preparedness plan in workplaces weakens the strength of the relationship between post-traumatic stress level and depression, anxiety, stress levels. © 2025 Elsevier B.V., All rights reserved.

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