Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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Safety and Efficacy of Colchicine in COVID-19 Treatment: Systematic Review and Meta-Analysis
(Elsevier Australia, 2025) Nada, Ahmed Hosney; Ibrahim, Ismail A.; Asar, Nada Khalid; Qenawy, Abdulrahman; Mohammed, Mariam M.; Wagdy, Mohamed; Farouk, Heidi Sherif
Background: Colchicine is an anti-inflammatory drug used for the treatment of gout and other autoinflammatory conditions. Several trials reported promising results of the efficacy of colchicine in Covid-19 due to its anti-inflammatory properties. However, applying these results to clinical settings remains the subject of ongoing research. Methods: We performed a systematic review and meta-analysis on the efficacy and safety of colchicine in the treatment of Covid-19. PubMed, Cochrane Library, Web of Science, and Scopus were searched for relevant studies. The primary outcomes were 28-day mortality, invasive mechanical ventilation, non-invasive mechanical ventilation, and ICU admissions. The risk ratio was used to compare effectiveness between the two groups. Subgroup analysis was done for C-reactive protein and duration of hospitalization. Results: 17 randomized controlled trials with a total of 25478 patients were included. The overall Risk ratio didn't favor any of the two groups in terms of 28-day mortality (RR = 1.03, 95 % CI [0.93:1.15], P = 0.58), non-invasive mechanical ventilation (RR = 0.81, 95 % CI [0.44:1.48], P = 0.49), ICU admission (RR = 0.89, 95 % CI [0.56:1.41], P = 0.62). The overall mean difference (MD) did not show statistical significance between both groups in terms of C- reactive protein (CRP) (mg/dl) (MD = −1.21, 95 % CI [-2.42:0.01], P = 0.05), lactate dehydrogenase (LDH) (U/L) (MD = 50.95, 95 % CI [-92.07: 193.98], Ferritin (ng/ml) (MD = 128.08, 95 % CI [51.97:204.18], P = 0.001), ICU length of stay (MD = −0.09, 95 % CI [-0.34:0.15], P = 0.45) and duration of hospitalization (MD = −0.41, 95 % CI [-1.56:0.73], P = 0.48). Conclusion: In Covid-19 treatment, colchicine didn't result in significant benefits in terms of clinical outcomes. More large-scale randomized clinical trials with standardized dosages and long-term follow-up are needed for further investigation into the colchicine effect. © 2025 Elsevier B.V., All rights reserved.
Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin
(Turkish Chemical Society, 2025) Karaman Ersoy, Şeyda; Akyüz, Merve; Başkan, Kevser Sözgen
Quercetin (QUE) is the most active compound in the flavone family, commonly found in the leaves, fruits, and flowers of many plants. The separation of QUE from various plant matrices has been a key research area due to its antioxidant, anti-inflammatory, antiviral, and antitumor properties. In this study, the conditions for synthesizing MMIPs and their use in QUE recovery were examined. Iron (II) chloride tetrahydrate (FeCl2·4H2O) and iron (III) chloride hexahydrate (FeCl3·6H2O) were used to prepare magnetic nanoparticles, and Fe3O4 was synthesized. Tetraethyl orthosilicate (TEOS) was used to coat the resulting Fe3O4 surface with silica. [3-(methacryloxy)propyl] trimethoxysilane (γ-MPS) was used to functionalize the surface of the formed Fe3O4@TEOS structure. The synthesis was carried out using QUE as the template molecule; tetrahydrofuran (THF), ethanol (EtOH), and a solvent mixture of acetone and acetonitrile (ACN) (3:1, v/v) served as porogen solvents; acrylamide (AM), methacrylic acid (MAA), and 4-vinylpyridine (4-VP) were used as functional monomers; ethylene glycol dimethacrylate (EDMA) served as the cross-linker, and 2,2’-azobisisobutyronitrile (AIBN) was used as the initiator at different molar ratios (T:M:CrL, 1:4:20, 1:8:20, and 1:8:40). The recognition and selectivity properties of these polymers were evaluated based on absorbance values at 370 nm obtained through equilibrium assays, which used QUE solutions prepared in THF, ACN, and 50% (v/v) EtOH solvent mixtures at different ratios. It was established that the magnetic imprinted polymer prepared with a 50% (v/v) EtOH solvent mixture and molar ratios of 1:8:40 (QUE:4-VP:EDMA) exhibited the highest adsorption capacity and imprinting factor. Using the prepared QUE-MMIP, QUE was recovered with 33% efficiency from red onion peel extract. © 2025 Elsevier B.V., All rights reserved.
Women’s Self-Transcendence Levels After a Cesarean Birth and Its Contributing Variables
(Jordan University of Science and Technology, 2025) Abushaikha, Lubna A.; Abdel Razeq, Nadin M.; Abushaikha, Fadwa A.
Background: A Cesarean birth has significant implications for women’s physical and psychological health. However, limited studies have explored self-transcendence, as a measure of well-being, and its contributing variables during the postpartum period. Purpose: This study aimed to determine the levels of self-transcendence among women after a Cesarean birth and to explore the contribution of demographic and obstetric variables. Methods: This descriptive correlational study used a convenient sample of 232 women (aged 19-49 years) who completed questionnaires in teaching and private hospitals. Results: Overall, 55% (n=128) of women had high levels of self-transcendence, with a mean score of 45.8 (SD=6.1) out of 60. Self-transcendence was negatively correlated with the number of Cesarean births (r=-0.21, p < 0.001). Higher self-transcendence levels were found among women who gave birth at private hospitals (rpb= 0.41, p < 0.001). Conclusion: A Cesarean birth can be an opportunity for self-transcendence and psychological well-being for women, depending on demographic and obstetric variables. Implications for Nursing: The findings of this study may inform healthcare professionals, especially maternity nurses, in understanding psychological dimensions associated with Cesarean birth. © 2025 Elsevier B.V., All rights reserved.
Emergency Department Nurses’ Knowledge and Practices Related to Extravasation Injuries of Non-Cytotoxic Medications
(Turkish Association of Trauma and Emergency Surgery, 2025) Kuğu, Emre; Akyüz, Nuray
BACKGROUND: Extravasation of non-cytotoxic medications can lead to serious complications such as pain, tissue necrosis, limb loss, and even death. This descriptive cross-sectional study aims to assess the knowledge levels of emergency department (ED) nurses regarding extravasation incidents involving non-cytotoxic medications and to highlight the importance of effective management and prevention. METHODS: The study was conducted in the EDs of three hospitals in Istanbul, Türkiye, between November 19, 2020 and December 31, 2020. A total of 100 ED nurses participated in the study. Inclusion criteria required nurses to be working full-time in the EDs during the study period and to provide written and verbal consent. The study utilized a survey to assess sociodemographic characteristics, knowledge of non-cytotoxic medications (e.g., epinephrine), symptoms of extravasation, prevention strategies, and intervention practices. RESULTS: The mean age of the nurses was 29.43 years, with 57% female and 73% holding a bachelor’s degree. Among participants, 52% had 0-3 years of ED experience. Ninety-one percent reported not receiving education on extravasation after graduation, and 82% indicated no extravasation protocol was in place at their workplace. Knowledge about non-cytotoxic medications causing extravasation significantly increased with ED experience (p=0.035). Nurses in units with an extravasation protocol had significantly higher knowledge levels (p=0.007). Female nurses demonstrated better knowledge of extravasation symptoms than male nurses (p=0.012). Nurses with a bachelor’s or higher degree had significantly better knowledge than others (p=0.015). The knowledge rate for the extravasation care protocol was 64%, with the most recognized protocol item being “immediately stop the infusion” (97%) and the least recognized being “aspirate the medication not to exceed 3-5 mL” (33%). Strong correlations were found between non-pharmacological factors and knowledge of non-cytotoxic medications (r=0.601; p<0.001), as well as between knowledge of extravasation care protocols and non-pharmacological factors (p<0.001). CONCLUSION: The study highlights the need for targeted education and the establishment of institutional protocols for managing and preventing extravasation in EDs. Nurses' knowledge significantly impacts their adherence to prevention and care protocols. To ensure patient safety, it is important to provide ongoing education and implement evidence-based intervention protocols for the management of extravasation in ED settings. © 2025 Elsevier B.V., All rights reserved.
Measuring Shoulder Abduction Strength Using 2 Different Dynamometers: Comprehensive Intrarater and Interrater Reliability and Validity
(2025) Atli, Ecenur; Topaloglu, Mahir; Hoşbay, Zeynep Y.; Razak Özdinçler, Arzu
Objective: The purpose of this study is to investigate the intrarater and interrater reliability of handheld dynamometer (HHD) measurements in assessing isometric muscle strength of the shoulder abductors and to compare these results with those obtained using a fixed dynamometer (FD). Methods: The study involved 25 voluntary participants, all over the age of 18, asymptomatic (with no injuries in the upper extremity), and not engaged in overhead sports. The participants were evaluated twice by 2 di!erent testers who were experienced in orthopedic rehabilitation, at 90 degrees of shoulder abduction in the scapular plane. On the first measurement day, Tester 1 performed measurements using both HHD and FD, while on the second measurement day, both testers used only the HHD. A 3- to 7-day interval separated the 2 measurement sessions. Paired-samples t-tests were used to evaluate the systematic bias between the testers. Spearman's rank correlation coe"cient, intraclass correlation coe"cient, standard error of measurement, and minimal detectable change were calculated. The statistical significance level was accepted as P < .05. Results: Data from 22 participants (15 women, 7 men; mean age: 23.00 ± 3.19 years) were analyzed, as 3 individuals did not attend the final assessment. A strong correlation (r=0.772) was found between Tester 1's HHD measurements and FD, while a similarly strong correlation (r=0.748) was observed for Tester 2's HHD measurements. Excellent intrarater reliability (intraclass correlation coe"cient [ICC]=0.941) was found between Tester 1's measurements, and excellent interrater reliability (ICC=0.889) was found between testers. Conclusion: Handheld dynamometer has demonstrated excellent interrater and intrarater reliability and high validity for assessing shoulder abductor muscle strength in research and clinical use. Since the muscle strength of testers using the HHD may influence the results, the FD may be a more appropriate option when the study population is stronger than the testers. Studies involving di!erent clinical populations and testers with varying experience levels are needed to improve the relevance of the results. Level of Evidence: Level III, Diagnostic Study. This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
STS: AI-Driven Smart Test Scenario Generation Tool
(Institute of Electrical and Electronics Engineers Inc., 2025) Bağlum, Cem; Yayan, Uǧur
One of the most critical steps in the software testing lifecycle, test scenario generation, reduces process efficiency due to its high time and resource requirements. As an innovative solution to this issue, the Smart Test Scenario Tool (STS) has been developed. Smart Test Scenario Tool (STS) enhances contextual accuracy and automation in test scenario generation by analyzing documents in xlsx, py, cpp, txt, and docx formats using large language models. This approach minimizes time loss, and the risk of errors encountered in traditional manual testing processes while transforming test procedures into a context-driven and systematic framework, offering an innovative contribution to the literature. Strengthened with a Streamlit interface, MongoDB-supported database management, and Ollama integration, the system enables the test scenario generation process, a critical component of the software testing cycle, to be conducted more efficiently and reliably. The validity of the study was confirmed through two distinct projects, the first implemented in Python and the second in C++. © 2025 Elsevier B.V., All rights reserved.
Psychometric Evaluation of the Person-Centred Climate Questionnaire – Staff Version
(BioMed Central Ltd., 2025) Arici, Furkan Cihat; Harmanci Seren, Arzu Kader; Edvardsson, Jan David
Background: Valid and reliable instruments are needed to assess person-centredness that serve as quality care indicators. Person-Centred Climate Questionnaire – staff version is an interculturally used tool to evaluate person-centredness in clinical settings. This study aimed to examine the psychometrics of the tool in the Turkish language. Methods: This was a methodological study involving a sample of 140 nurses. One of the researchers collected data using the Turkish version of the questionnaire-staff version in a private hospital in Istanbul. After performing the language validity steps, the researchers analysed the content validity ratios of the items and the questionnaire’s content validity index, and they performed exploratory and confirmatory factor analysis to validate the construct. The internal consistency of the subdimensions and the questionnaire was determined utilising a Cronbach’s Alpha test. Results: The content validity ratios of the items ranged from 0.84 to 1, and the correlation coefficients ranged from 0.50 to 0.69. The three-factor structure accounted for 70.40% of the total variance. The items’ standardised factor loads were between 0.501 and 1.140. The Cronbach’s alpha consistency value was 0.90. Conclusion: The staff version of the questionnaire is an adequately valid and reliable instrument in the Turkish language. © 2025 Elsevier B.V., All rights reserved.
Effects of Nighttime Eating Behavior on Cardiometabolic Health and Sleep: A Crossover Study
(Elsevier B.V., 2025) Kesgin, Yavuz E.; Hasbal, Nuri Baris; Çopur, Sidar; Incir, Said; Kurtulus, Ozlem; Genc, Candan; Kanbay, Asiye
Background and aims: The impact of night-eating behavior (NEB) on metabolic health remains underexplored, particularly in healthy populations. We have hypothesized that NEB adversely affects metabolic parameters, liver function, and sleep via circadian disruption and neurohormonal alterations. Methods and results: In this single-center crossover study, sixteen healthy adults (aged 18–35 years) with no comorbidities, no medication use, and a body mass index between 18 and 30 kg/m2 participated in two one-week dietary regimens: regular eating (no food after 7:30 p.m.) and nighttime eating (≥25 % of daily caloric intake consumed after 9:30 p.m.). Clinical, biochemical, neurohormonal, and respiratory polygraphy data were obtained following each dietary period. The mean age of participants was 27 ± 4 years. After adjusting for multiple comparisons, nighttime eating behavior (NEB) was associated with significant increases in albuminuria (p = 0.003), serum phosphate (p < 0.001), fasting triglycerides (p = 0.039), and C-reactive protein (CRP; p = 0.01). NEB also elevated serum leptin (p = 0.007), ghrelin (p < 0.001), cortisol (p = 0.041), fibroblast growth factor 21 (FGF-21; p < 0.001), and cytokeratin-18 (p < 0.001), while significantly decreasing melatonin levels (p < 0.001). Sleep study results demonstrated significant increases in the apnea-hypopnea index (AHI; p < 0.001), supine AHI (p < 0.005), oxygen desaturation (7 % ± 2 % vs. 11 % ± 3 %; p < 0.001). Conclusion: NEB significantly affects neurohormonal profiles and sleep-related respiratory metrics in healthy individuals, indicating potential adverse effects on cardiometabolic health during short-term evaluation in healthy subjects. © 2025 Elsevier B.V., All rights reserved.
A Randomized Trial of Cervical Stabilization Exercise Training via Telerehabilitation for Migraine
(W.B. Saunders, 2025) Dusgun, Elif Sena; Karahan, Nesrin; Toprak Çelenay, Şeyda
Purpose: To compare the effects of cervical stabilization exercise training via telerehabilitation (CSET-T) in addition to standard treatment on pain, forward head posture, cervical mobility, muscle performance, functional status, sleep quality, and quality of life in individuals with migraine in comparison to the standard treatment alone. Methods: The control group (n = 20) received standard treatment alone (medication+recommendations). The stabilization group (n = 20) was given CSET-T in addition to standard treatment 3 days a week for 8 weeks. Pain characteristics were assessed by using a pain diary, whereas forward head posture and cervical mobility were measured using a goniometer, cervical muscle performance (CMP) by using a pressure biofeedback unit, functional status by using the Migraine Disability Assessment Scale (MIDAS), sleep quality by using the Jenkins Sleep Scale (JSS), and quality of life by using the Headache Impact Test-6 (HIT-6). Results: Given the group-time interaction, it was found that pain frequency, intensity, duration, MIDAS, JSS, and HIT-6 scores decreased more significantly in the stabilization group when compared to the control group (p < .05). Moreover, the craniovertebral angle, cervical range of motions, and CMP values increased significantly more in the stabilization group (p < .05). It was found that there was no statistically significant difference between the groups in terms of compliance with standard treatment (p = .665). Conclusions: The study revealed that CSET-T in addition to standard treatment is superior to standard treatment alone in reducing pain, improving forward head posture, cervical mobility, muscle performance, functional status, and quality of life in individuals with migraine. © 2025 Elsevier B.V., All rights reserved.
Reflection Coefficient Prediction in Triple-Layer Microwave Absorbers: A Machine Learning Perspective
(Institute of Electrical and Electronics Engineers Inc., 2025) Nas, Abdurrahim; Kankilic, Sueda; Karpat, Esin
Electromagnetic absorbers prevent the reflection and transmission of electromagnetic waves. Electromagnetic absorbers have a wide range of applications from military to medical applications. In these areas, absorber designs have different importance in terms of parameters such as reflection coefficient, selected material and thickness. Many difficulties are encountered to achieve the optimal design. In this paper, we propose a machine learning regression method for three-layer microwave absorber architecture to obtain the optimum parameters, overcome the difficulties and speed up the process. The material and thickness of each layer are used as parameters to feed the models and the reflection coefficient is estimated using these parameters. Predictions are made with various regression algorithms. These algorithms are KNeighbors Regression, Random Forest Regressor, XGBoost Regression, CatBoost Regressor, AdaBoost Regressor which uses similarities between observations, Gradient Boosting Regressor which is tree based or boosted tree based algorithms, Linear Regression which uses a linear model, Partial Least Squares Regression which uses cross decomposition, Gaussian Process Regressor which uses statistical distribution, Stochastic Gradient Descent Regressor which uses a linear model to reduce empirical loss to predict an output. Mean square error (MSE), mean absolute error (MAE), root mean square error (RMSE), R-squared (R2) are used with the predictions of each model to obtain the metrics for the analysis of the results. The predicted values and actual values of the metrics are used to compare the regression algorithms used in the research. After the comparison, our observations show that in most cases CatBoost Regressor is better than other models used in the research. In general, it is observed that most of the machine learning regression algorithms used in this paper can be used to predict the reflection coefficient of three-layer microwave absorbers as output and input parameters used in the research. © 2025 Elsevier B.V., All rights reserved.
Synthesis, Molecular Modeling, Anti-Cancer and COX-1/2 Inhibitory Activities of Novel Thiazolidinones Containing Benzothiazole Core
(Bangladesh Pharmacological Society, 2024) Kulabas, Necla; Guven, Cansu Tamniku; Duracık, Merve; Bingol Ozakpinar, Ozlem; Küçükgüzel, İlkay
In this study, new 1,3-thiazolidin-4-one derivatives containing arylmethylene groups in the 5-position were obtained from 6-(trifluoromethoxy)-1,3-benzo-thiazol-2-amine (riluzole). Synthesized compounds were characterized by spectral data and elemental analysis. In vitro, cytotoxic activities of the synthesized molecules were evaluated against the human lung cancer (A549) and human prostate cancer (PC-3) cell lines. Compounds were also tested on mouse embryonic fibroblast cells (NIH/3T3) to determine selectivity. Ten target compounds 3-12 were also screened for their COX-1 and COX-2 inhibitory activities. Of these compounds, 4 showed the highest COX-2 inhibition at 10 μM. Molecular docking calculations were performed to understand the binding interactions of compounds with COX-1 and COX-2 proteins. In silico studies of the tested compounds represented important binding modes that may be responsible for their anti-cancer activity via selective inhibition of the COX-2 enzyme. ADMET predictions were conducted to assess the drug-like properties of the novel compounds. © 2024 Elsevier B.V., All rights reserved.
The Perceptions of Generation Z University Students About Their Futures: A Qualitative Study
(Multidisciplinary Digital Publishing Institute (MDPI), 2023) Dikeç, Gül; Öztürk, Simge; Taşbaşı, Neslihan; Figenergül, Damla; Güler, Bilal Buğrahan
This study explored the future-oriented perceptions of Generation Z students in a foundation university. This study was conducted using qualitative research and a phenomenological design. The study sample consisted of 11 university students over the age of 18 who agreed to participate in the study. Data were collected online through individual interviews in Türkiye. Colaizzi’s phenomenological analysis method was used in the data analysis. The content analysis determined three main themes and eleven sub-themes. The first theme was the students’ knowledge acquisition about the “current situation of the country.” Under this theme were four sub-themes: economic problems, the immigrant situation, the education and justice system, and the country’s agenda. In the second theme, students shared their opinions about “being a student in the country.” This theme included economic impossibilities, their participation in limited social activities, and housing problems. In the last theme, “future anxiety,” the sub-themes of the students were found to include experiences hopelessness versus hope. Uncertainty caused anxiety, as did going abroad, finding a job, and improving themselves. It was determined that the participants were worried about the current situation in the countries they lived in during this period due to economic problems; while some were hopeful about the future, some were hopeless and would go abroad. This study might contribute to the literature on determining the future-oriented perceptions, possible stressors and hope levels of Generation Z university students in Türkiye. Additionally, intervention programs can be developed for the management these stressors to protect the mental health of Generation Z university students. On the other hand, it is necessary to protect the mental health of young people, who are the adults of the future, and to create policies for the youth of this country where social opportunities are maintained. © 2024 Elsevier B.V., All rights reserved.
Consensus Paper on Candida Auris by Türkiye EKMUD, ID-IRI, THSK of Ministry of Health of the Republic of Türkiye, KLIMUD, TMC, TARD, and TYBD
(Tubitak Scientific & Technological Research Council Turkey, 2025) Agalar, Canan; Erdem, Hakan; Cag, Yasemin; Arda, Bilgin; Balik, Recep; Bastug, Aliye; Arikan Akdagli, Sevtap
Candida auris is an emerging fungal pathogen that has become a critical global health concern due to its high antifungal resistance and potential to cause nosocomial outbreaks. Since its initial identification in Japan in 2009, C. auris has spread rapidly, posing significant treatment challenges across various healthcare settings worldwide. The biofilm formation ability of C. auris enhances its resilience against disinfectants and antifungal agents, complicating infection control in healthcare environments. This consensus report was developed by a collaboration between several Turkish medical societies including the Turkish Society of Infectious Diseases and Clinical Microbiology Specialty (EKMUD), the Turkish Society of Anesthesiology and Reanimation (TARD), the Turkish Intensive Care Society (TYBD), the Infectious Diseases-International Research Initiative (ID-IRI), the Clinical Microbiology Specialist Society (KLIMUD), the Turkish Microbiology Society (TMC), and the Public Health Institution of T & uuml;rkiye (PHIT) under the Ministry of Health. The report provides a comprehensive overview of C. auris and its management, with a focus on the epidemiology, antifungal resistance mechanisms, recommendations for diagnostic and therapeutic challenges, infection control and prevention measures, and surveillance of C. auris. This consensus report aims to establish standardized diagnostic protocols, improve national surveillance systems, and promote effective infection control measures to mitigate C. auris-related health risks in T & uuml;rkiye. It also offers comprehensive national recommendations and addresses the need for interinstitutional collaboration, improve public health, and strengthen the healthcare response to this pathogen.
Effect of Progressive Muscle Relaxation on Postoperative Pain in Laparoscopic Living Kidney Donors: A Randomized Controlled Trial
(BMC, 2025) Akinci, Naile
Aim This study aimed to evaluate the effect of progressive muscle relaxation on postoperative pain in laparoscopic living kidney donors. Design This was a randomized controlled, single-blind trial. This study was conducted in accordance with the CONSORT statement. Methods This study was conducted between January and September 2023 and included 62 patients (study group = 31, control group = 31) who met the inclusion criteria and underwent laparoscopic living donor nephrectomy in the transplant service of a private hospital in Istanbul province. A power analysis was performed to calculate the sample size and the power of the study (G*Power 3.1). Study data were collected using a patient information form, a postoperative patient follow-up and evaluation form to record the total number of bolus requests and administrations via of boluses with the PCA device and additional analgesic needs, and the Visual Analog Scale (VAS). The data obtained in the study were analyzed on the SPSS 22.0 statistical software. Results Additional analgesic requirements did not differ significantly between groups where progressive muscle relaxation exercises were applied and the VAS score and bolus requirement were significantly lower than in the control group (p < 0.05). Anxiety levels were also significantly reduced in the experimental group compared to both their pre-test scores and the control group (p < 0.05). Although the time to resume oral intake did not differ significantly between the groups (X-2 = 5.020; p = 0.170 > 0.05), the time to start mobilization was significantly earlier in the experimental group (X-2 = 8.808; p = 0.012 < 0.05). As a result of the study, it was found that progressive muscle relaxation exercises reduced postoperative pain, bolus requirements, and anxiety in patients undergoing living donor nephrectomy. Additionally, these exercises facilitated earlier mobilization following surgery.
The Effect of Combined Core Training Intervention on Ball Throwing Velocity and Jump Performance in Competitive Young Female Handball Players
(Iermakov S.S., 2025) Akalp, Ugur; Pinar, Salih; Pinar, Yeliz
Background and Study Aim Handball is a dynamic team sport that requires a combination of technical, tactical, and physical abilities. Among the key physical components, throwing velocity and vertical jump performance are essential for successful gameplay. These skills rely not only on upper and lower limb strength but also on core muscle function. The aim of this study is to investigate the impact of a combined core training intervention on ball throwing velocity and vertical jump performance in young competitive female handball players. Material and Methods A total of 28 young female handball players ((X) over bar = 17.21 +/- 0.74 years, 169 +/- 5 cm body height, 62.07 +/- 7.43 kg body weight) participated in the study. They were divided into an experimental group (EG = 14) and a control group (CG = 14). Both groups underwent a pretest to assess ball throwing velocity and vertical jump performance. After the initial measurements, the CG followed a standard training regimen. The EG completed an intervention program comprising six combined core exercises, performed three times per week for eight weeks. The same measurements were repeated after the program. A 2x2 repeated measures ANOVA was used to determine differences between EG and CG. The main effects of time (pretest and posttest), group, and the time*group interaction were evaluated. Results No changes were observed in the ball throwing velocity or jump performance of the CG between pretest and posttest. However, significant improvements were found in the EG for both ball throwing velocity and vertical jump performance (F = 47.467, p <.001, eta(2) =.646). Conclusions Designing core training programs in a sport-specific manner plays a significant role in developing athletes who require both general and specialized training.
Why Do Nurses Transfer from Private Hospitals to Public Hospitals in Turkiye? A Descriptive Cross-Sectional Survey Study Considering Working Conditions, Compulsory Citizenship, Presenteeism, and Burnout
(Wiley, 2025) Turan, Suzan; Seren, Arzu K. Harmanci
This study investigates the reasons behind the transition of nurses from private hospitals to public hospitals in Turkiye, focusing on working conditions, compulsory citizenship behavior, presenteeism, and burnout. The study used a descriptive cross-sectional survey design. The sample consisted of 224 nurses who previously worked in private hospitals and were employed in public hospitals at the time of data collection. Researchers collected data via a questionnaire incorporating demographic questions and validated scales on compulsory citizenship behavior, presenteeism, and burnout. Parametric and nonparametric comparison tests were used to compare participants' experiences in private and public hospitals regarding working conditions. There were statistically significant differences between the groups (p < 0.05). Also, participant nurses' negative organizational behavior experiences scores (compulsory citizenship behavior, presenteeism, and work-related burnout) statistically significantly differed (p < 0.05), considering their scores based on private hospital and public hospital experiences. The study concluded that nurses worked longer and took less leave in private hospitals. Participant nurses also reported that they exhibited more compulsory citizenship presenteeism and experienced a higher rate of work-related burnout while working in private hospitals.
Comparison of HLA-G Levels for Cord Blood Derived-MSC and Wharton's Jelly Derived-MSC
(Walter de Gruyter GmbH, 2025) Abatay Sel, Figen; Erol Bozkurt, Ayse; Karatas, Sule; Suleymanoglu, Mediha; Yasa, Beril; Yasa, Cenk; Savran Oguz, Fatma
Objectives: A special group of stem cells with multipotent and immunomodulatory properties are mesenchymal stem cells (MSCs). Many modulatory factors are thought to mediate immunomodulatory properties of MSCs. One of these modulatory factors is thought to be HLA-G, one of human leukocyte antigens (HLA). This study aimed to compare HLA-G levels in both stimulated and unstimulated of peripheral blood mononuclear cell (PBMC) cultures with "cord blood-MSC" (CB-MSC) and "Wharton's jelly-MSC" (WJ-MSC) at different rates and different incubation periods. Methods: WJ-MSCs were obtained by explant method, and CB-MSCs using Ficoll-paque. They were characterized by flow cytometry. MSCs and PBMCs were directly co-cultured for 24 and 72 h at 1:5 and 1:10, respectively. After incubations, the media were collected and HLA-G levels were measured by ELISA. Results: In the unstimulated group, the highest HLA-G level was found in the PBMC:WJ-MSC-72-1:5 group, while the lowest HLA-G level was found in the PBMC:CB-MSC-72-1:5. When 24-1:5 and 72-1:5 groups were examined, the HLA-G level decreased significantly in CB-MSC groups compared to WJ-MSC, while it increased significantly in the 24-1:10 and 72-1:10 groups (p<0.05). In stimulated groups, the highest HLA-G level was observed in the PBMC:CB-MSC-24-1:5. Conclusions: Our study aimed to evaluate the immunomodulatory effect of MSCs via HLA-G molecule. HLA-G levels changed with different incubation times of two different MSC sources. In this study, we suggest that MSCs as a cell therapy, in particular for immune system-related disease, may be a preliminary in vitro approach to evaluate the immunomodulatory effect via HLA-G.
Dual-Phase Malicious User Detection Scheme for IM-OFDMA Systems Using IQ Imbalance
(Wiley, 2025) Alaca, Ozgur; Althunibat, Saud; Riza Ekti, Ali; Yarkan, Serhan; Miller, Scott L.; Qaraqe, Khalid A.
Physical-layer security techniques have contributed to the achievement of various security objectives in an efficient and lightweight manner. Thus, these techniques have been widely considered for limited-resource networks such as Internet of Things networks. Among the different security objectives, malicious user detection by exploiting physical-layer parameters has demonstrated efficient performance. In this work, malicious user detection in the recently proposed index modulation-based orthogonal frequency division multiple access (IM-OFDMA) is addressed. The proposed malicious user detection scheme exploits the hardware impairments, especially the in-phase and quadrature imbalance parameters, for both legitimate and malicious users to design a dual-phase efficient detection scheme. The proposed scheme accounts for the special characteristics of IM-OFDMA transmission that are different from other multiple-access techniques. The performance of the proposed scheme was evaluated considering detection probability and false alarm probability performance metrics. Moreover, closed-form expressions of these metrics were derived for both phases and were validated by Monte Carlo simulation results under different configurations of IM-OFDMA systems.
Turkish Translation and Cross-Cultural Adaptation of the Pelvic Floor Dysfunction-SENTINEL Screening Tool: A Methodological Study
(Springer London Ltd, 2025) Celenay, Seyda Toprak; Dusgun, Elif Sena; Arslan, Mesut; Kaya, Derya Ozer
Introduction and Hypothesis To translate and perform cultural adaptation of the Pelvic Floor Dysfunction-SENTINEL (PFD-SENTINEL) screening tool into Turkish and to establish its reliability and validity for female athletes. Methods The study included 200 female athletes (mean age 22 +/- 4 years). The translation of the PFD-SENTINEL, which comprised the symptoms related to PFD and item sections related to general risk factors and sports-related risk factors, was performed in accordance with international recommendations. The severity of PFD symptoms was assessed with the Pelvic Floor Distress Inventory-20 (PFDI-20). Psychometric analyses consisted of assessing the following: internal consistency reliability using the Kuder-Richardson-20 (KR-20) coefficient, construct validity using confirmatory factor analysis, and criterion validity. Results The reliability was acceptable for the PFD-SENTINEL items assessed using the KR-20, at 0.581, indicating moderate internal consistency. All fit indices except standardized root mean square residual indicated a perfect fit for the final models. Criterion validity was supported by positive correlations between the PFD-SENTINEL symptom score and the PFDI-20 score (r = 0.724, p < 0.001) and between the PFD-SENTINEL item score and the PFIQ-20 scores (r = 0.334; p < 0.001). Conclusions The Turkish version of the PFD-SENTINEL is a reliable and valid instrument to screen for PFD in female athletes.
Unraveling the Persistent Renal Impact of Intrauterine Growth Restriction and Catch-Up Growth: Integrating Morphological Insights with Metabolomic Profiling
(Springer, 2025) Esrefoglu, Mukaddes; Koktasoglu, Fatmanur; Bayindir, Nihan; Cimen, Fatma Bedia Karakaya; Kirmizikan, Seda; Hekimoglu, Emine Rumeysa; Selek, Sahabettin
The study aimed to investigate the long-term effects of IUGR and consequent catch-up growth on metabolic health by using a comprehensive approach that included histopathological, immunohistochemical, biochemical, and metabolomics analyses. Sprague-Dawley pregnant rats either undergo bilateral uterine artery ligation or a sham surgery on the 19th day of gestation. The offspring reached catch-up growth, kidney samples were collected at postnatal weeks 2, 4, and 8 for analysis. IUGR rats exhibited a spectrum of changes including reduced glomeruli number, proliferating cell number, altered oxidative stress markers, various enzymes involved in Krebs cycle, mitochondrial dynamics, and energy metabolism. Examination of the 8-week-old cohort identified a broader spectrum of metabolic alterations, notably in the biosynthesis of phenylalanine, tyrosine, and tryptophan, phenylalanine, tyrosine, glyoxylate, dicarboxylate, pyruvate, alanine, aspartate, and glutamate metabolism, glycolysis/gluconeogenesis and citrate (TCA) cycle. Our metabolomics analysis provides insights into the potential disease susceptibility of individuals born with IUGR, including obesity, diabetes, hypertriglyceridemia, cardiovascular diseases, and mental retardation. These findings underscore the intricate interplay between intrauterine conditions and long-term metabolic health outcomes, highlighting the need for further investigation into preventive and therapeutic strategies to mitigate the risk of metabolic diseases in individuals with a history of IUGR.

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