Scopus İndeksli Yayınlar Koleksiyonu
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Article Citation Count: 0Synthesis, Molecular Modeling, Anti-Cancer and Cox-1/2 Inhibitory Activities of Novel Thiazolidinones Containing Benzothiazole Core(Bangladesh Pharmacological Society, 2024) Kulabas, N.; Guven, C.T.; Duracik, M.; Bingol Ozakpinar, O.; Kucukguzel, I.In this study, new 1,3-thiazolidin-4-one derivatives containing arylmethylene groups in the 5-position were obtained from 6-(trifluoromethoxy)-1,3-benzo-thiazol-2-amine (riluzole). Synthesized compounds were characterized by spectral data and elemental analysis. In vitro, cytotoxic activities of the synthesized molecules were evaluated against the human lung cancer (A549) and human prostate cancer (PC-3) cell lines. Compounds were also tested on mouse embryonic fibroblast cells (NIH/3T3) to determine selectivity. Ten target compounds 3-12 were also screened for their COX-1 and COX-2 inhibitory activities. Of these compounds, 4 showed the highest COX-2 inhibition at 10 μM. Molecular docking calculations were performed to understand the binding interactions of compounds with COX-1 and COX-2 proteins. In silico studies of the tested compounds represented important binding modes that may be responsible for their anti-cancer activity via selective inhibition of the COX-2 enzyme. ADMET predictions were conducted to assess the drug-like properties of the novel compounds. © 2024, Bangladesh Pharmacological Society. All rights reserved.Article Citation Count: 0Dodder (cuscuta Sp.) Extract Prevents Cognitive Deficits in a Rat Model of Hepatic Encephalopathy(Kare Publishing, 2024) Albayrak, O.; Hatipoglu, B.N.; Ozbeyli, D.; Sen, A.; Koyuncuoglu, T.; Cevik, O.; Sener, G.OBJECTIVE: In our study, the protective effect of dodder plant extract against encephalopathy induced by cholestatic liver disease model was investigated. METHODS: Spraque Dawley rats were used in the study. For the cholestatic liver disease model, the bile duct ligation (BDL) was applied. The groups were determined as control, Cuscuta sp. (CUS), BDL and BDL + CUS. Double ligation was performed in the bile duct in the BDL groups. For the applications, saline (SF) was administered to the control and BDL groups for 28 days while 250 mg/ kg of Cuscuta sp. extract was given by oral gavage to the CUS and BDL + CUS groups. At the end of the experiment, cognitive evaluations were made by applying new object recognition and Morris water maze tests. After these tests, blood-brain barrier (BBB) measurements were made in half of the groups. In the other half of the groups, brain tissue samples were taken by decapitation and transforming growth factor-beta (TGF-β), 8-hydroxydeoxyguanosine (8-OHdG) and sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) measurements were made in the tissues. Histological examinations of the tissues were also performed. RESULTS: Cognitive performance was low, and BBB permeability was found to be increased in the group with bile duct ligation. In addition, TGF-β and 8-OHdG levels were increased in tissues, while Na+/K+-ATPase enzyme activity was suppressed. Treatment with Cuscuta sp. increased cognitive performance and decreased BBB permeability. Other biochemical parameters examined were significantly (p<0.05–0.001) reversed and supported by histological findings. CONCLUSION: Our findings in the study suggest that dodder plant may be beneficial for the protection of cognitive performance and brain tissue in encephalopathy caused by cholestasis. © 2024, Kare Publishing. All rights reserved.Article Citation Count: 0Child And Adolescent Mindfulness Measure Turkish Validity And Reliability Study;(Galenos Publishing House, 2024) Bilaç, Ö.; Dikeç, G.; Akyol, C.K.; Kale, M.K.; Sapmaz, Ş.Y.; Kandemir, H.; Aydemir, Ö.Objectives: The number of studies on mindfulness in children and adolescents has rised in recent years, and it is crucial to evaluate the mindfulness-based interventions applied with standardized measurement tools. This aim of this study was to make the Turkish language validity and reliability of the Child and Adolescent Mindfulness Measure (CAMM), which can be used in children and adolescents about mindfulness, which has been very well-liked in recent years, and which has validity and reliability in many languages, and to bring it into our language for the ages of 9-18. Materials and Methods: The total sample of the current study consisted of 156 children and adolescents, 48 of whom were children and adolescents with any mental disorderdiagnosis according to Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5). One hundred eight of them did not have any mental disorders diagnosis according to DSM-5, who had only periodic problems or were brought for counseling. Results: In the reliability analysis of the scale, the Cronbach’s alpha coefficient was found to be 0.76 for the whole scale. In test-retest reliability two weeks apart, the two measurements have a strong correlation between the measurements (r=0.634 p<0.0001). Conclusion: In conclusion, our findings show that the Turkish version of the CAMM is a valid and reliable measurement tool for the 9-18 age group. © 2024, Galenos Publishing House. All rights reserved.Article Citation Count: 0Ensemble-Based Alzheimer's Disease Classification Using Features Extracted From Hog Descriptor and Pre-Trained Models(Sakarya University, 2024) Muzoğlu, N.; Akbacak, E.Alzheimer's Disease is the most common type of dementia and is a progressive, neurodegenerative disease. The disease worsens over time, and the patient becomes bedridden, unable to move or understand what is happening around him. The main concern of medicine is to slow down the progression of the disease for which no treatment has yet been developed. Artificial intelligence studies have achieved significant success in detecting many diseases. In this study, an artificial intelligence-based approach that uses MR images of the early stage of Alzheimer's Disease to detect the disease at an early stage is presented. Initially, a new dataset was created through the application of the fuzzy technique, thereby expanding the feature space. Then, an ensemble learning-based hybrid deep learning model was developed to reduce the misclassification rate for all classes. The features derived from the inception module, residual modules, and histogram of oriented gradients descriptor are subjected to classification through bagging and boosting algorithms. The proposed model has surpassed many state-of-the-art studies by achieving a high success rate of 99.60% in detecting Alzheimer's disease in its early stages. © 2024, Sakarya University. All rights reserved.Article Citation Count: 0Bibliometric Analysis of Publications on Stigmatization in Psychiatric Nursing Literature(Kare Publishing, 2024) Dikeç, G.; Sarıtaş, M.; Oban, V.Objectives: In the past two decades, the number of publications on stigma has increased in the literature. This study aimed to conduct a bibliometric analysis of publications related to stigmatization in the psychiatric nursing literature. Methods: In this study, a search was performed on the PubMed database on September 11, 2022, with the Medical Searching Terms “(Stigmatization [Title OR Abstract] OR Social Stigma [Title OR Abstract]) OR (Stigma [Title OR Abstract] OR Stereotyping [Title OR Abstract] OR Discrimination [Title OR Abstract]) AND (Psychiatric Nursing [Title OR Abstract] OR Nursing [Title OR Abstract]).” Between 1990 and 2022, 10,571 studies published in English, available in full text, and published in journals indexed with SCI, SSCI, and ESCI were found. Results: The number of published articles reached the highest number in 2020, with an increase of 4.05 times in 30 years; it was determined that 92.8% of the publications were of the descriptive study, and Happell was the most productive author in this field. Frequently, articles were published in the Journal of Psychiatric and Mental Health Nursing (n=762), Journal of Psychosocial Nursing and Mental Health Services (n=550), International Journal of Mental Health Nursing (n=480), Issues in Mental Health Nursing (n=445), and Journal of Advanced Nursing (n=429). It was determined that the top five most frequently repeated keywords were humans, female, psychiatric nursing, male, and adult, respectively. Conclusion: The findings obtained from this study can provide information about the number of publications, research types, researchers, and institutions, as well as give ideas for new research strategies in psychiatric nursing literature. Establishing cooperation between institutions and authors can guide psychiatric nurses in creating projects to reduce stigma. © 2024 by Journal of Psychiatric Nursing-Available.Article Citation Count: 0Occupation-Based Intervention for Instrumental Activities of Daily Living in People With Disabilities: a Single-Blinded Randomised Controlled Trial(MA Healthcare Ltd, 2024) Akyurek, G.; Aydoner, S.; Ceyhan, I.Background/aims Instrumental activities of daily living are meaningful and purposeful activities that contribute meaning to people's lives and reflect their values and cultures in the community. This study investigated the effects of an occupation-based intervention for instrumental activities of daily living on stress levels, quality of life, and participation in instrumental activities of daily living in people with disabilities. Methods A total of 18 people with different types of disabilities (intervention group n=9, control group n=9) were recruited. The occupation-based intervention took place in 45-minute sessions, with a total of 16 sessions held twice a week for 8 weeks. The measurement tools used were the Lawton-Brody Instrumental Activities of Daily Living Scale and the Waisman Activities of Daily Living Scale to evaluate activities of daily living, the Mini-Mental State Examination to examine cognitive status, the 36-item Short Form Survey questionnaire to assess quality of life, the Perceived Stress Scale to examine stress level, and the Community Integration Questionnaire to evaluate participation in the community were used. Results After 8 weeks, there were significant improvements in performance and participation in instrumental activities of daily living, stress and quality of life in the intervention group intervention group had significant increases in instrumental activities of daily living (z=−2.6, P=0.008), vitality (z=−0.5, P=0.041), role emotional (z=−2.7, P=0.008), role physical (z=−2.3, P=0.020), general health (z=−3.3, P=0.001) and participation (z=−1.3, P=0.023). There were also significant reductions in stress (z=−2.8, P=0.005) and bodily pain (z=−3.2, P=0.001) scores compared to the control group conclusions The occupation-based intervention reduced the stress levels of people with a range of disabilities and increased their ability to perform activities of daily living], participation in activities of daily living and improved their quality of life. Implications for practice Occupational therapists could use occupation-based interventions to reduce the stress levels of people with disabilities and increase their performance and participation in activities of daily living and improve their quality of life. © 2024 MA Healthcare Ltd.Conference Object Citation Count: 0Transaction Types in Cryptocurrencies(Institute of Electrical and Electronics Engineers Inc., 2024) Uysal, T.; Unozkan, H.The cryptocurrency ecosystem has witnessed an explosive growth, and this study delves into the mechanisms that fuel this expansion. Focusing on airdrops, staking, farming, and coin burning, the research analyzes a vast dataset of transactions from the Ethereum and Binance Networks. This analysis sheds light on the strategic use of these tools by highlighting transactions that engage users and distribute rewards (e.g., airdrops, staking). Furthermore, the study investigates farming as a method to enhance market efficiency by providing liquidity, and coin burning as a strategy to manage token supply and potentially increase value through scarcity. While effective utilization of these mechanisms can bolster token value and project success, regulatory challenges remain. Ultimately, this study aims to raise public awareness of cryptocurrency transaction types and the associated risks. Although many researchers have studied illicit flows on cryptocurrency transactions, in literature we haven't confronted with any study regarding transaction types. By analyzing over 107 million transaction records, the research presents the distribution of these transaction types. With the analysis of the transaction types, the definitions of them, the statistical outputs from the more than 107 million transaction records from ERC20 and BEP20 blockchain systems and the analysis of some specific token types such as Pancake Swap and Shiba, this research is the first study to present an academic approach with statistical analysis. This study can provide investors with knowledge that safeguard them from the potential pitfalls of cryptocurrency transactions. Also, this study presents some basic statistics so as to understand main patterns of different types of transactions. © 2024 IEEE.Article Citation Count: 0Patterns Before Recognition: the Historical Ascendance of an Extractive Empiricism of Forms(Springer Nature, 2024) Üstün, B.This article explores the complex convergence between cybernetics and Gestalt theory and its influence on the concept of pattern recognition. It finds a departure in the analogous ways each discipline extends their core frameworks toward social and anthropological objects. However, this shared ground is not without tensions. In the post-war American context, what is formalizable and realizable in mechanical structures has a certain explanatory authority—even if often misplaced-- concerning perception and human intelligence. Cultural patterns feed into mechanical recognition of patterns, exemplifying “extractive empiricism” or the process of outsourcing experiential processes to mechanical systems. This mode of “proof” is also evident in cybernetic and cognitive psychological strategies toward Gestalt theory, leaving a significant legacy for contemporary machine learning approaches. By examining the early interactions between these rival paradigms, known for their quest for generalization, and disentangling their source status, this inquiry contributes to understanding the broad conceptual possibilities of pattern recognition beyond its narrow confines in engineering perspectives and machine learning discourse. © 2024, The Author(s).Article Citation Count: 0The Effect of Myrtus Communis L. Extract on Nephrolithiasis Model in Rats(Kare Publishing, 2024) Ertas, B.; Dorucu, D.; Gulerturk, O.; Sen, A.; Cevik, O.; Cetinel, S.; Sener, G.OBJECTIVE: Nephrolithiasis is a common urological disease that can lead to renal failure. Oxidative stress has been shown to be a contributing factor for nephrolithiasis and many agents have been studied to prevent and treat oxidative stress-related nephrolithiasis and renal damage. Myrtus communis (MC) extract has been shown to be an important antioxidant in different animal models. In this study, MC extract was administered preventively or therapeutically to rats with kidney stones, and its effectiveness was investigated. METHODS: Wistar albino rats were divided into four groups (n=8); control (C), ethylene glycol (EG), EG+preventive MC, and EG+curative MC groups. The nephrolithiasis model was created by adding 0.75% EG to drinking water for 8 weeks. Ultimately, 24-hour urine was collected to measure calcium, citrate, and creatinine levels. After decapitation, kidney tissues were harvested for histological analyses, measurement of osteopontin and 8-hydroxydeoxyguanosine (8-OHdG) levels, and N-acetyl-β-glucosaminidase (NAG), myeloperoxidase (MPO) and caspase-3 activities. RESULTS: In 24-hour urine samples, calcium, citrate and creatinine levels were decreased in the EG group, while oxalate levels were increased and in treatment groups these parameters returned to control levels. MPO, 8-OHdG, caspase-3 and NAG activity were significantly increased in tissue and these changes were reversed in both MC groups. Histological findings also supported the biochemical parameters. CONCLUSION: MC can reduce oxidative stress and histopathological changes in kidney tissues in rat nephrolithiasis model when used as either a preventive or therapeutic agent. If supported with further clinical trials, MC might have clinical implications in preventing oxidative renal cell injury and ultimately kidney stone formation. © 2024 by Istanbul Provincial Directorate of Health.Article Citation Count: 0Nurse Unemployment in the Country Which Has Nursing Shortage: Investigation of the Reasons in the Aspect of Nurses(Informa UK Ltd, 2024) Soydaş, K.; Harmancı Seren, A.K.Turkey is the country which has serious nursing shortage. However, still there are many nurses unemployed and looking for an appropriate job. Therefore, this descriptive study aimed to examine unemployment reasons among nurses in Turkey. The study collected data from 266 unemployed nurses through an online questionnaire included demographic, socioeconomic, professional, and working characteristics, job expectations, and reasons for unemployment. Descriptive statistics were used in data analysis. The study findings revealed that the nurses thought they were unemployed due to a lack of information exchange between educational institutions and health labor markets, low wages, and intense workload. © 2024 Taylor & Francis Group, LLC.Article Citation Count: 0Effects of Computer-Based Balance Exercises on Balance, Pain, Clinical Presentation and Nerve Function in Patients With Diabetic Peripheral Neuropathy: a Randomized Controlled Study(International Society of Musculoskeletal and Neuronal Interactions, 2024) Reyhanıoglu, D.A.; Yıldırım, G.; Sengun, I.Ş.; Kara, B.Objective:To evaluate the use of a computer-based biodex balance exercise system (BBS) on balance, neuropathic pain, clinical presentation and nerve function in patients with diabetic peripheral neuropathy (DPN). Methods: A total of 32 participants with DPN were randomly assigned in a 1:1 ratio to an intervention group (IG) or control group (CG). The IG performed exercises using the BBS twice weekly for 8 weeks, while CG were informed regarding diabetes self-management. At baseline and after study completion, participants underwent balance (postural stability and fall risk) and neuropathic pain assessment (DN4 questionnaire) and were screened using the Michigan Neuropathy Screening Instrument and nerve conduction test. Results: Among the baseline participants, 14 in the IG and 13 in the CG completed the study. Balance training improved postural stability (overall, p<0.001), fall risk (p<0.001), neuropathic pain (p=0.01) and symptoms (p<0.001), and clinical presentation (p=0.02), but not nerve function, within the IG. At follow-up, IG displayed significantly improved stability (p<0.001) and fall risk (p=0.02) and decreased neuropathic symptoms (p=0.01) compared to the CG. Conclusion: Computer-based balance exercises improve balance, pain, and clinical presentation of DPN, but not nerve function, in patients with DPN. ClinicalTrials.gov ID: NCT05255497. © 2024, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.Book Part Citation Count: 0Green jobs in green transformation story(IGI Global, 2024) Alkan, B.Governments around the world are enacting green recovery and transition programs in collaboration with international agencies. Their coordinated efforts attempt to balance economic growth with environmental preservation, emphasizing that for a sustainable and green future the green transformation is an urgent requirement. The employment component of the green transformation has significant social and economic repercussions. Depending on how prepared countries are for the transition process, skill adaptation and the creation of new job opportunities can provide socioeconomic benefits. "Green jobs" are discussed in the chapter as an important part of the transition strategy to a green economy. The chapter outlines what a "green job" is and is not, presents the connection between employment and skills, and emphasizes the relevance of green jobs in the transition process. © 2024, IGI Global. All rights reserved.Conference Object Citation Count: 0Unet3D Based Next Frame Prediction;(Institute of Electrical and Electronics Engineers Inc., 2024) Akbacak, E.The concept of next-frame prediction, which is predicting the subsequent frames using historical frames' spatial and temporal properties, is indispensable in computer vision. There are various application of frame prediction such as predicting a future event in autonomous vehicles, predicting patient falls in biomedical engineering, and reducing the amount of data transmitted in video transmission. Deep learning applications in this field are the focus of the most effective methods. Especially CNN-LSTM, Convolutional LSTMs, and GAN-supported deep learning methods are very common. This study proposes the inflated 3D Unet encoder-decoder model, which is not yet used for the next-frame prediction problem. The proposed model predicts both the next frame and the subsequent frames. Experimental results have shown that the proposed method gives better results than CNN-LSTM and Convolutional LSTMs. © 2024 IEEE.Letter Citation Count: 0Developmental Care in İran: an Approach To Optimal Utilization of Nursing Care Aimed at Reducing Long-Term Complications in Preterm Neonates(Elsevier Ltd, 2024) Akbari, N.We have carefully reviewed the article titled ‘Developmental Care in Iran: An Approach to Optimal Utilization of Nursing Care Aimed at Reducing Long-term Complications in Preterm Neonates' with great interest. The author provides valuable insights into the correlation between developmental care and the mitigation of long-term complications, and we commend their efforts in shedding light on this crucial aspect. This letter aims to articulate our concerns regarding certain issues identified in the publication. While common and observed in various publications, these concerns have the potential to introduce bias into the study, as indicated by various research findings. Our perspective, supported by a range of research publications, suggests that addressing these issues is essential to uphold the integrity and reliability of the study. © 2024 Neonatal Nurses AssociationArticle Citation Count: 1A Systematic Review And Meta-analysis Of The Prevalence, Risk Factors, Agents And Laboratory Diagnosis Of Vulvovaginal Candidiasis İn Türkiye;(Refik Saydam National Public Health Agency (RSNPHA), 2024) Kilbaş, İ.; Kilbaş, E.P.K.; Çİftçİ, İ.H.Objective: Vulvovaginal candidiasis (VVC) is the most common superficial mycosis among women, and it is estimated that 75% of women experience at least one in their lifetime, and about 40-50% have a second exposure. This study aims to determine the prevalence, risk factors, etiological factors and laboratory diagnosis of VVC in Türkiye. Methods: In the study, original scientific articles for the reporting of VVC epidemiological features published in English and Turkish languages in national and international databases (PubMed, Embase, Scopus, Google Scholar, Web of Science and Turkish Medline) between January 1995 and December 2021 were searched. Electronic databases were searched using various combinations of “vaginal yeast infection”, “vaginal candidiasis”, “vulvovaginal candidiasis Turkey”, “candidal vaginitis”, “Candida vaginitis”, “vaginal candidosis”, “Candida species”, “epidemiology” key terms. Results: The mean prevalence of VVC in adult women was found to be 57.91% in all of the 28 included studies, and 68.21% in the 2-18 age group. Considering the causative distribution, the most common Candida albicans (54.76%), Candida glabrata (24.04%), other Candida species (12.29%), Candida krusei (3.68%), Candida kefyr (3.37%), and Candida tropicalis (2.07%) positivity has been reported. In the included studies, the most common predisposing factors of the patients were pregnancy (35.71%) and diabetes (35.71%). When the articles were examined according to the year they were published and the provinces, it was seen that the prevalence of Candida did not differ significantly (p>0.05). In the studies, VITEK®2 (bioMérieux, Marcy l’Etoile, France) automatic identification system (15), Germ tube (7) and CHROMagar (7) diagnostic methods were used to identify strains. As a result of the meta analysis, it was determined that there was a high level of heterogeneity among studies (I2=95.28). Conclusion: As a result of our meta-analysis study, the prevalence of VVC was found to be high in women and children in Turkey. In addition, it was determined that non-albicans species increased in the etiology of VVK. It has been observed that the incidence of C. glabrata species in the etiology of VVC has increased since 1999. Considering that VVK infection increases the susceptibility to other sexually transmitted diseases, as well as the risk of preterm birth and congenital cutaneous candidiasis in pregnant women, it is essential to raise awareness of patients on issues such as treatment follow-up and protection from the disease. © (2024), (Refik Saydam National Public Health Agency (RSNPHA)). All Rights Reserved.Article Citation Count: 0Perfusion-Mri for Differentiating Cerebral Metastatic Lesions and Gliomas: an Evidence-Based Review(Elsevier Sci Ltd, 2025) Azab, Mohammed A.; El-Gohary, Nour; Atallah, Oday; Shama, Mohsen; Ibrahim, Ismail A.Background: Lesions affecting the brain are variable and have multiple pathologies. Brain metastasis is a common entity of lesions that can be misleading in diagnosis. Brain metastasis affects the patient's life and survival in about 40% of cases; all patients with metastatic brain lesions are indicated for surgery, so proper diagnosis is crucial for each patient. Non-invasive diagnosis is a promising way to confirm the diagnosis of cerebral metastatic lesions for patients who are not indicated for surgery for medical reasons. To our knowledge, this is the first evidence-based review article regarding utilizing perfusion-MRI for approaching cerebral metastatic lesions. Methods: A comprehensive database search on PubMed/Medline, Scopus and Google Scholar was done by the relevant keywords. Eligibility of articles was done by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cochrane risk of bias assessment tool was used to determine the risk of bias among the included studies. Results: From 2989 articles, only 31 studies were eligible for the qualitative synthesis. A comprehensive summary of the included study was made according to population, intervention, comparator and outcomes (PICO) method. Conclusions: Diagnosing cerebral metastases, categorizing subtypes, and monitoring their response to treatment is a challenging endeavor for neurosurgeons, neuroradiologists, and oncologists. Technological advances in MRI software as perfusion-based MRIs are designated to facilitate diagnosis and follow-up for patients with cerebral metastases.Review Citation Count: 0Effectiveness of Postoperative Cephalosporins in Reducing Urinary Tract Infections and Other Parameters Following Transurethral Resection of the Prostate: a Systematic Review and Meta-Analysis(Mosby-elsevier, 2025) Hafez, Wael; Al-Obeidat, Feras; Rashid, Asrar; Venkatachalapathi, Arun Kumar; Massaod, Amr; Albaha, Ziad; Cherrez-Ojeda, Ivan[No Abstract Available]Article Citation Count: 0Plasma-Exchange Therapy in Acute Immune-Mediated Neuropathy: Effects on Muscle Strength and Functional Outcomes(Amaltea Medical Publishing House, 2024) Khosa, N.A.; Essa, S.M.; Zarak, M.S.; Zarkoon, A.U.H.; Ibrahim, I.A.; Mumtaz, T.Background and objectives. This study explores the impact of plasma exchange therapy (TPE) on muscle strength and functional outcomes in patients with acute immune-mediated neuropathy. Materials and methods. We retrospectively analyzed clinical data from patients diagnosed with acute immune-mediated neuropathy at the Department of Neurology, Bolan University of Medical Sciences, Baluchistan, from January 2016 to December 2021. Results. The study, comprising 141 patients with various neurological disorders, underscores the efficacy of plasma exchange therapy in improving muscle strength and functional outcomes, particularly in Guillain-Barré Syndrome (GBS). Notably, after four weeks of treatment, a significant proportion of patients demonstrated improved mobility, with 51.8% able to walk without assistance. However, despite the positive response to therapy, a small percentage (2.8%) experienced unfavorable outcomes marked by expiration. Additionally, the study identifies significant associations between treatment outcomes and patient characteristics, such as the number of plasma exchange cycles and diagnosis (p <0.05), emphasizing the importance of personalized treatment approaches in managing neurological disorders. Conclusions. Our findings underscore the effectiveness of plasma exchange in enhancing muscle strength and functional outcomes in acute immune-mediated neuropathy, particularly GBS. © 2024, Amaltea Medical Publishing House. All rights reserved.Article Citation Count: 0Does Prolotherapy Have an Effect on the Care of Pressure Injuries? a Pilot Study(Elsevier Sci Ltd, 2025) Eroglu, Nermin; Kokkiz, Rukiye; Eroglu, Hatice Eda; Kocoglu, HasanBackground: This study contributes to wound healing with prolotherapy in people with pressure injuries. The study was planned and conducted as a randomized controlled trial to determine the effect of prolotherapy on the care of pressure injuries. Methods: The study was carried out with patients with pressure injuries in the intensive care unit of a city hospital between April and June 2023. A power analysis was performed, and the sample size was calculated as 20 patients, including 10 in the intervention and 10 in the control group. The patients in the experimental group were given wound care with gelofusine as prolotherapy in the morning and evening for three days, and the injury site was covered with a sterile sponge and fixation tape. The patients in the control group were treated with saline in the morning and evening for three days. In both groups, the wound width, depth, and length were measured and evaluated prior to each intervention for three days. Results: In the study, a significant difference was found between the mean ages of the participants in the experimental and control groups (p < 0.05). The decrease in width measurements in the experimental group was found to be statistically significant compared to the previous measurements, while the increase in width measurements in the control group was significant compared to the previous measurements (p < 0.05). Depth measurements decreased statistically significantly in the experimental group, while they increased significantly in the control group compared to previous measurement values (p < 0.05). Conclusion: In conclusion, it was determined that the administration of gelofusine for pressure injuries as prolotherapy in the experimental group may be more effective in wound healing than saline treatment applied in the control group. Further studies are warranted.Article Citation Count: 0Populist Securitization of Migration: the Anti-Immigrant Zafer Party Example in Türkiye(Routledge Journals, Taylor & Francis Ltd, 2025) Ozoflu, Melek Aylin; Uyar, Merve Hazer Yigit; Altintop, Apak Kerem; Uyar, CanAlthough T & uuml;rkiye is the largest refugee-hosting country in the world, the Zafer Party's (ZP) (English: Victory Party) discourse on migration as the pioneer representative of the European-style anti-immigrant right party example has been under-studied. To address this gap, this research examines the discursive practices of the ZP through the lens of populist securitization. It focuses on revealing how the ZP employs a people-centred appeal to securitization, explaining how the people are located within its populist discourse as a threatened object of reference and actor. In this way, it empirically contributes to the burgeoning literature bridging between populism and securitization theory. To this end, it conducts an extensive qualitative frame analysis of the party's manifesto, programme, press releases, public speeches uttered by party leader & Uuml;mit & Ouml;zda & gbreve;. The time frame of the research is designated as starting from the establishment of the ZP, i.e. 26 August 2021, to the Presidential and Parliamentary Elections in T & uuml;rkiye, i.e. 14 May 2023. The paper finds out that ZP combines populist and nationalist appeals by creating vertical (down/up) and horizontal (in/out) antagonisms, exhibiting parallels with similar tendencies in its European counterparts.
