Ethanolic Extract of Cotinus Coggygria Leaves Attenuates Crystalluria and Kidney Damage in Ethylene Glycol-Induced Urolithiasis in Rats

dc.contributor.author Gumru, S.
dc.contributor.author Ozgur, G.
dc.contributor.author Ertas, B.
dc.contributor.author Sen, A.
dc.contributor.author Eker, P.
dc.contributor.author Sener, T.E.
dc.contributor.author Sener, G.
dc.contributor.other Eczacılık Meslek Bilimleri Bölümü
dc.date.accessioned 2025-01-11T13:04:15Z
dc.date.available 2025-01-11T13:04:15Z
dc.date.issued 2023
dc.description.abstract OBJECTIVE: Nephrolithiasis is a common cause of kidney insufficiency. Nephrolithiasis is proven to be the result of various biochemical and inflammatory processes that result in crystal formation and subsequent aggregation. Cotinus coggygria L. (CCog) is a plant extract which has been used as a Turkish remedy for kidney stones. With this study, we planned to evaluate the effects of CCog extract in ethylene glycol (EG)-induced nephrolithiasis model in rats. METHODS: The study group comprised 32 Wistar albino rats which were divided into Control (C), EG, CCog Prophylaxis (CC+EG+CC), and CCog Treatment (EG+CC) groups. Stone formation was induced by adding EG (0.75%) into rat’s drinking water. Normal drinking water was given to Control group for 8 weeks. Throughout the study period of 8 weeks, EG group was given only EG (0.75%) and CC+EG+CC group was given both EG and CCog. In EG+CC group, EG (0.75%) was given for 8 weeks whereas CCog was given for the past 4 weeks. After the 8th week, 24-h urine samples were collected. Rats were then sacrificed and kidney tissue samples were harvested. RESULTS: Metabolites (calcium, citrate) and creatinine in 24 h urine samples were decreased in CC+EG+CC and EG+CC groups. While hyperoxaluria was observed in the EG group, oxalate levels were similar to control levels in the P-CCog and C-CCog groups. The N-acetyl-β-glucosaminidase and myeloperoxidase activities were both increased in EG group and these parameters were significantly decreased on CCog treatment. CONCLUSION: We can conclude that C. coggygria extract can have beneficial effect on lowering concentration of stone-forming metabolites in urine and consequently protect renal tissues from damage due to nephrolithiasis. C. coggygria extract can be considered as a potential prophylactic and therapeutic option in high-risk stone formers. Furthermore, our data confirm ethnobotanical use of CC against nephrolithiasis. © 2023 by Istanbul Provincial Directorate of Health. en_US
dc.identifier.citation 1
dc.identifier.doi 10.14744/nci.2023.29794
dc.identifier.issn 2148-4902
dc.identifier.scopus 2-s2.0-85179368331
dc.identifier.uri https://doi.org/10.14744/nci.2023.29794
dc.language.iso en en_US
dc.publisher Kare Publishing en_US
dc.relation.ispartof Northern Clinics of Istanbul en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Ethylene Glycol, Hyperoxaluria en_US
dc.subject Nephrolithiasis en_US
dc.subject Oxidative Stress en_US
dc.subject Renal Insufficiency en_US
dc.title Ethanolic Extract of Cotinus Coggygria Leaves Attenuates Crystalluria and Kidney Damage in Ethylene Glycol-Induced Urolithiasis in Rats en_US
dc.type Article en_US
dspace.entity.type Publication
gdc.author.id Ozgur, Gunal/0000-0002-3847-0089
gdc.author.institutional Şener, Göksel
gdc.author.scopusid 55313593300
gdc.author.scopusid 57264132500
gdc.author.scopusid 57196052987
gdc.author.scopusid 55250649800
gdc.author.scopusid 56755056800
gdc.author.scopusid 55615347500
gdc.author.scopusid 55615347500
gdc.author.wosid EKER, PINAR/AAI-5216-2021
gdc.author.wosid Özgür, Günal/JRY-6435-2023
gdc.author.wosid Ertas, Busra/IQS-8337-2023
gdc.author.wosid Sener, Tarik/K-2501-2016
gdc.description.department Fenerbahçe University en_US
gdc.description.departmenttemp Gumru S., Department of Pharmacology, Marmara University, Faculty of Pharmacy, Istanbul, Turkey; Ozgur G., Department of Urology, Marmara University, Faculty of Medicine, Istanbul, Turkey; Ertas B., Department of Pharmacology, Marmara University, Faculty of Pharmacy, Istanbul, Turkey; Sen A., Department of Pharmacognosy, Marmara University, Faculty of Pharmacy, Istanbul, Turkey; Eker P., Department of Biochemistry, Health Sciences University, Istanbul, Turkey; Sener T.E., Department of Urology, Marmara University, Faculty of Medicine, Istanbul, Turkey; Sener G., Department of Pharmacology, Fenerbahce University, Faculty of Pharmacy, Istanbul, Turkey en_US
gdc.description.endpage 744 en_US
gdc.description.issue 6 en_US
gdc.description.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
gdc.description.scopusquality Q4
gdc.description.startpage 734 en_US
gdc.description.volume 10 en_US
gdc.description.woscitationindex Emerging Sources Citation Index
gdc.description.wosquality N/A
gdc.identifier.pmid 38328729
gdc.identifier.trdizinid 1242699
gdc.identifier.wos WOS:001126875300017
gdc.scopus.citedcount 1
gdc.wos.citedcount 0
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