PubMed İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8
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Article Telerehabilitation Transforms Recovery: Elevating Outcomes for Lower Limb Amputees(Wolters Kluwer Health, 2026) Ozturk, BasarBackground: Telerehabilitation provides a viable alternative for individuals facing barriers to in-person rehabilitation because of transportation issues and physical limitations. It enables remote monitoring and guidance, allowing patients to continue rehabilitation at home. Objective: This study aimed to assess the effectiveness of a telerehabilitation program in improving physical and psychological outcomes for lower limb amputees and to evaluate adherence to a home-based exercise program delivered via video. Study design: A randomized controlled trial. Methods: Sixty participants with lower limb amputations were randomized to an experimental group (telerehabilitation) or a control group (standard care). The intervention involved a 4-week supervised phase followed by a 4-week unsupervised phase. Primary outcomes were physical capacity, measured by the Six-Minute Walk Test (6MWT), and psychological status, assessed using the Hospital Anxiety and Depression Scale. Secondary outcomes included adherence rates and patient satisfaction. Results: The experimental group showed significant improvements in 6MWT distance and Hospital Anxiety and Depression Scale scores compared to the control group. The mean 6MWT distance increased by 20% from baseline to the end of the supervised phase (P < 0.01) and was maintained during the unsupervised phase. Anxiety and depression scores significantly decreased (P < 0.05). Adherence was higher during the supervised phase (85%) but dropped during the unsupervised phase (60%). Conclusions: Telerehabilitation significantly improved physical and psychological outcomes for lower limb amputees. High adherence during the supervised phase emphasizes the importance of clinician support, whereas strategies are needed to sustain long-term engagement during the unsupervised phase.Article 1,2,4-Triazole Conjugates as HEGFR Inhibitors: Synthesis, Anticancer Evaluation, and in Silico Studies(Wiley-V C H Verlag GmbH, 2026) Bulbul, Bahadir; Kulabas, Necla; Gurboga, Merve; Ozakpinar, Ozlem Bingol; Cakmak, Ummuhan; Tuncay, Fulya Oz; Kucukguzel, IlkayA series of novel 1,2,4-triazole-acetamide derivatives was synthesized and evaluated for anticancer and hEGFR inhibitory activity. The compounds were obtained via multistep synthesis and characterized by spectroscopic methods. Cytotoxicity was tested against PC-3, MCF-7, A549, and K562 cell lines. Compounds <bold>18</bold>, <bold>19</bold>, and especially <bold>24</bold> showed notable antiproliferative effects, with compound <bold>24</bold> exhibiting higher selectivity and potency than gefitinib. It also induced apoptosis and inhibited migration in A549 and PC-3 cells, while selectively promoting invasion in PC-3, suggesting EMT-related behavior. In vitro kinase assays revealed compound <bold>20</bold> as the most potent hEGFR inhibitor (IC50 = 43.8 +/- 1.3 nM). Molecular docking and 200 ns molecular dynamics simulations confirmed its stable interaction with EGFR, particularly involving Cys797. These findings highlight compounds <bold>20</bold> and <bold>24</bold> as promising candidates for further development as EGFR-targeted anticancer agents.Article The Relationship Between Spiritual Well-Being, Resilience, and Adherence Among Patients Receiving Hemodialysis Treatment in Türkiye(Springer, 2026) Bulbul, Elif; Sukut, Ozge; Dikec, GulThis study examined the relationship between spiritual well-being, resilience, and adherence of hemodialysis patients and the factors affecting them. The data were collected from 182 hemodialysis patients receiving treatment in a dialysis center who met the inclusion criteria by purposive sampling method in Istanbul. The data were collected with the patient description questionnaire, which measures patient sociodemographic characteristics and characteristics related to the medical diagnosis, the Spiritual Well-Being Scale, the Brief Resilience Scale, and the End-Stage Renal Failure-Adherence Questionnaire. Gender, educational status, employment status, and mean age of patients were found to be correlated with psychological resilience. Marital status, employment status, cohabitants, and mean age of patients were found to be correlated with spiritual well-being. Gender, number of weekly dialysis sessions, and dialysis competencies were found to be correlated with hemodialysis patients' adherence to their treatment. Hemodialysis patients' adherence was positively correlated with both the faith subscale of spiritual well-being and psychological resilience. According to regression analysis, gender and resilience explained 12.8% of the total variance of adherence. This study determined that resilience is an essential factor in increasing the adherence of hemodialysis patients.Article Turkish Translation and Cross-Cultural Adaptation of the Pelvic Floor Dysfunction-SENTINEL Screening Tool: A Methodological Study(Springer London Ltd, 2025) Celenay, Seyda Toprak; Dusgun, Elif Sena; Arslan, Mesut; Kaya, Derya OzerIntroduction and Hypothesis To translate and perform cultural adaptation of the Pelvic Floor Dysfunction-SENTINEL (PFD-SENTINEL) screening tool into Turkish and to establish its reliability and validity for female athletes. Methods The study included 200 female athletes (mean age 22 +/- 4 years). The translation of the PFD-SENTINEL, which comprised the symptoms related to PFD and item sections related to general risk factors and sports-related risk factors, was performed in accordance with international recommendations. The severity of PFD symptoms was assessed with the Pelvic Floor Distress Inventory-20 (PFDI-20). Psychometric analyses consisted of assessing the following: internal consistency reliability using the Kuder-Richardson-20 (KR-20) coefficient, construct validity using confirmatory factor analysis, and criterion validity. Results The reliability was acceptable for the PFD-SENTINEL items assessed using the KR-20, at 0.581, indicating moderate internal consistency. All fit indices except standardized root mean square residual indicated a perfect fit for the final models. Criterion validity was supported by positive correlations between the PFD-SENTINEL symptom score and the PFDI-20 score (r = 0.724, p < 0.001) and between the PFD-SENTINEL item score and the PFIQ-20 scores (r = 0.334; p < 0.001). Conclusions The Turkish version of the PFD-SENTINEL is a reliable and valid instrument to screen for PFD in female athletes.Article Citation - WoS: 1Citation - Scopus: 1A Bibliometric Analysis of Nursing Research in the Field of Refugee Health Between 1980 and 2024(John Wiley and Sons Inc., 2025) Öztürk, Gizem; Dikeç, Gül; Harmanci Seren, Arzu KaderAim: This study aimed to examine the bibliographic characteristics of publications on refugees in the nursing field. Design: A bibliometric analysis design was adopted for the study. Sample: Included the articles scanned in the Web of Science Core Collection database. The study excluded the other databases and gray literature. Measurements: The 2120 articles published between 1980 and 2024 that met the inclusion criteria were analyzed using Bibliometrix in RStudio, VOSviewer, and Microsoft Excel software. Results: The majority of publications were published in 2024. The United Kingdom, the United States, Canada, and Australia have the highest publications, citations, and international cooperation. Additionally, “mental health” is one of the most frequently used keywords in studies. Conclusions: The increased migration rates and the growing need for healthcare for refugees underscore the importance of investing in nursing research within this field. Nurses and researchers should establish partnerships and share best practices with leading countries. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 1Citation - Scopus: 1Sensory Processing Skills and School Functions in School-Aged Children With Attention Deficit Hyperactivity Disorder: a Gender-Based Analysis(Routledge Journals, Taylor & Francis Ltd, 2025) Ceyhan, Irem; Akyurek, GokcenSensory processing skills are important for school functioning, learning and school participation. Children with attention deficit hyperactivity disorder (ADHD) may need additional support in the school context. This study aims to assess sensory processing skills and school functions in children with ADHD, focusing on gender differences. We included 118 children of whom 57 had ADHD and 61 were typically developing peers. Sensory processing skills were assessed with the Sensory Integration and Praxis Test subtests (Postrotary Nystagmus, Standing Walk and Balance, Bilateral Motor Coordination), and school functioning was evaluated using the School Function Assessment. Results showed that children with ADHD had worse sensory processing skills and school function, regardless of gender (p < 0.05). In girls with ADHD, Bilateral Motor Coordination emerged as a significant predictor across some sub-parameters of school functioning (Participation: p = 0.022; task supports: p = 0.020; physical tasks: p = 0.012). In boys, balance was particularly significant predictor of physical (p = 0.008) and cognitive functioning (p = 0.008). Boys with ADHD had more difficulty than girls in cognitive/behavioral task adaptations, setup and cleaning, and eating/drinking. Recognizing gender differences among these children is essential for health professionals to deliver more effective and individualized support interventions.Article Perceived Stress and Performance of Daily Activities Among Emergency Healthcare Workers During the COVID-19 Pandemic(Sage Publications Ltd, 2025) Yücel, Hülya; Bektas, Selen AydonerBackground: During the COVID-19 pandemic, healthcare workers were exposed to intense stress in the emergency departments and sudden changes in their daily lives. Objective: The study aimed to investigate the impact of the pandemic on performance and participation in the activities of daily living, personal lives, and overall well-being of the healthcare workers in an emergency department. Methods: Seventy-eight people working in an emergency department of a university hospital (100% of those eligible) participated in the study during June-July 2022. A self-report survey, cross-sectional design was used to collect data. Participants completed the Perceived Stress Scale-10 (PSS) and the Canadian Occupational Performance Measure (COPM). Independent sample t-tests, Pearson correlation, and multiple regression analysis were used for statistical analysis. Results: There was a significant negative correlation between PSS and COPM Performance (r = −0.524) as well as between PSS and COPM Satisfaction (r = −0.508), indicating that higher levels of stress were associated with lower performance and satisfaction. In addition, work-related factors, including working experience, daily working hours, and time available for rest at work, were significantly associated with PSS, COPM Performance, and Satisfaction (p < 0.05). The strongest multivariate associations (p = 0.001) were found between lacking time to rest at work and PSS (direct) and COPM Performance and Satisfaction (inverse). Conclusion: The stress experienced by emergency healthcare workers during COVID-19 negatively impacted their performance, daily activities, personal lives, and well-being. A potential implication is that policy-makers addressing work-related factors and implementing regulations could improve the well-being of these workers in their professional practices. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 1Citation - Scopus: 1The Effect of Neck Mobilization Vs. Combined Neck and Lumbar Mobilization on Pain and Range of Motion in People With Cervical Disc Herniation: a Randomized Controlled Study(Elsevier, 2025) Ozdincler, Arzu; Aktas, Dogan; Reyhanioglu, Duygu Aktar; Ozturk, Basar; Aktar Reyhanioglu, DuyguBackground: To assess the effectiveness of Kaltenborn-Evjenth Orthopedic Manual Therapy (KEOMT) applied to cervical-only mobilization versus both lumbar and cervical regions on pain intensity and range of motion (ROM) in individuals with cervical disc herniation. Methods: Thirty-three participants were enrolled in the study. The patients were randomly assigned to two groups. Group A received cervical-only KEOMT, while Group B received combined lumbar and cervical KEOMT. Interventions were administered three times a week for four weeks. Pain was measured using the Visual Analog Scale (VAS), ROM was assessed for flexion and lateral flexion, and Neck Pain and Disability Index (NPDI) and Short-Form 36 Health Survey (SF-36) were used for evaluation. Results: In intra-group measurements, a statistically significant difference was observed in all parameters of pain, ROM, disability, and quality of life for the mobilization methods applied in both groups (p < 0.05). Group B demonstrated significantly greater improvements in ROM/flexion, pain, and disability outcomes compared to Group A in inter-group measurements (p < 0.05). Physical and emotional sub-groups of quality of life measures also favored Group B in intergroup analysis (p < 0.05). However, the power values for ROM and quality of life parameters were found to be low. Conclusions: The cervical plus lumbar KEOMT technique is more effective than cervical-only mobilization in improving pain and disability. However, low power values for ROM and quality of life suggest these results may lack clinical significance, warranting further research.Article The Effect of Simulation-Based Electroconvulsive Therapy Education on Perception and Knowledge of Nursing Students: a Semiexperimental Study(Lippincott Williams and Wilkins, 2025) Dikeç, G.; Şan, E.Ö.Objectives Despite the recognized benefits and safety of electroconvulsive therapy (ECT) for treating mental disorders, negative perceptions persist among both the public and mental health professionals. This stigma is often rooted in historical practices and media portrayals, despite modern advancements in the technique. This study aimed to assess the impact of simulation-based ECT education on nursing students' perceptions and knowledge regarding ECT before and after the procedure. Methods This study was planned to use a single-group pretest and posttest quasi-experimental design with a 3-month follow-up. Simulation-based ECT education involved 1 hour of theoretical instruction followed by hands-on learning using a high-fidelity mannequin. Final-year nursing students enrolled in a psychiatric and mental health nursing course were examined on their knowledge and perceptions of ECT before, immediately after, and 3 months following the intervention. Results Students reported statistically significant improvements in their perception and knowledge levels after participating in the simulation-based ECT education. The results were similar at the 3-month follow-up. Conclusions Simulation-based ECT education can be effectively integrated into both undergraduate and graduate nursing curricula to foster positive perceptions and enhance knowledge about ECT. Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.Article The Effects of Pelvic Floor Muscle Training Applied Via Telerehabilitation During the Postpartum Period: a Randomized Controlled Study(Mary Ann Liebert, inc, 2025) Razak Ozdincler, Arzu; Korkmaz Dayican, Damla; Ozyurek, BurcinPurpose: To examine the short- and medium-term effects of pelvic floor muscle training (PFMT) applied via telerehabilitation (TR) on pelvic floor muscle function, pelvic floor symptoms, and quality of life. Methods: Fifty-eight women between the ages of 18 and 35 who were between 6 and 8 weeks postpartum were included. The participants were randomized into the PFMT applied via TR (TR-PFMT) group or the supervised PFMT (S-PFMT) group. The PFMT was performed for 8 weeks, 2 days a week, and 45-50 min a day. The participants' pelvic floor muscle function, pelvic floor symptoms, and quality of life were evaluated with the superficial electromyography, the Pelvic Floor Distress Inventory-20 (PFDI-20), and the Pelvic Floor Impact Questionnaire-7, respectively. Results: Phasic, tonic, and endurance activities of the pelvic floor muscles were significantly higher in both groups immediately after and 8 weeks after the exercise program (all p < 0.05). In addition, total PFDI-20 and all subscales' scores decreased significantly in the TR-PFMT group (all p < 0.05). In the S-PFMT group, total PFDI-20 (p = 0.012) and Urinary Distress Inventory-6 (p = 0.012) scores improved significantly. A significant difference was found between the groups in favor of the TR-PFMT group in terms of total PFDI-20 (p = 0.024; p = 0.024) and Urinary Distress Inventory-6 (p = 0.033; p = 0.040) scores immediately after and 8 weeks after the exercise program. Conclusions: TR-PFMT and S-PFMT improved women's pelvic floor muscle function, pelvic floor symptoms, and quality of life in the short and medium term. Improvement in urinary symptoms was greater after TR-PFMT. TR-PFMT should be considered for postpartum women.