Prevalence of Colistin-Resistant Klebsiella Pneumoniae Isolates in Turkey Over a 20-Year Period: a Systematic Review and Meta-Analysis

dc.authorscopusid 57226442170
dc.authorscopusid 57199149860
dc.authorscopusid 8669926200
dc.contributor.author Kahraman Kilbas, E.P.
dc.contributor.author Kilbas, I.
dc.contributor.author Ciftci, I.H.
dc.date.accessioned 2025-06-11T20:13:46Z
dc.date.available 2025-06-11T20:13:46Z
dc.date.issued 2025
dc.department Fenerbahçe University en_US
dc.department-temp [Kahraman Kilbas E.P.] Department of Medical Laboratory Techniques, Health Services Vocational School, Fenerbahce University, Istanbul, 34758, Turkey; [Kilbas I.] Medical Microbiology Doctorate Program, Institute of Health Sciences, Istanbul University, Istanbul, 34093, Turkey; [Ciftci I.H.] Department of Medical Microbiology, Faculty of Medicine, Sakarya University, Sakarya, 54100, Turkey en_US
dc.description.abstract Klebsiella pneumoniae is one of the leading causes of healthcare-associated infections and poses challenges in its treatment owing to its high antibiotic resistance. The development of resistance to colistin, which is used as a last resort, has become a major public health problem worldwide. This study was planned according to the PRISMA guidelines and included studies reporting the prevalence of colistin-resistant K. pneumoniae in Turkey between 2004 and 2024 through a systematic literature review. A total of 28 original research articles were included in the meta-analysis. Data were analyzed using the SPSS and CMA software. The pooled colistin resistance of a total of 8916 K. pneumoniae strains from 28 studies included in this meta-analysis was found to be 1.63% (95% CI: 1.51–3.12). Colistin resistance increased significantly over time. A higher resistance rate was detected in the strains tested using the EUCAST guidelines and broth microdilution method. The year of the study and validation methods contributed to the heterogeneity observed in the studies. This meta-analysis reveals that colistin-resistant K. pneumoniae strains have increased over time in Turkey. Current data show that colistin resistance is not only a laboratory finding but has become a crisis, requiring urgent action in terms of hospital infection management and patient safety. Regional and global measures should be taken to ensure the appropriate use of antibiotics to control the development of resistance. © 2025 by the authors. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.3390/microorganisms13050974
dc.identifier.issn 2076-2607
dc.identifier.issue 5 en_US
dc.identifier.pmid 40431147
dc.identifier.scopus 2-s2.0-105006791635
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.3390/microorganisms13050974
dc.identifier.volume 13 en_US
dc.identifier.wos WOS:001496354000001
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Multidisciplinary Digital Publishing Institute (MDPI) en_US
dc.relation.ispartof Microorganisms en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject Epidemiology en_US
dc.subject Gram-Negative Bacteria en_US
dc.subject Healthcare-Associated Infections en_US
dc.subject Multidrug Resistance en_US
dc.title Prevalence of Colistin-Resistant Klebsiella Pneumoniae Isolates in Turkey Over a 20-Year Period: a Systematic Review and Meta-Analysis en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication

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