Effects of Adding Respiratory Training To Osteopathic Manipulative Treatment on Exhaled Nitric Oxide Level and Cardiopulmonary Function in Patients With Pulmonary Arterial Hypertension

dc.authorid Naci, Baha/0000-0003-3764-2421
dc.authorid Demir, Rengin/0000-0002-2901-2967
dc.authorscopusid 57217004238
dc.authorscopusid 7006161415
dc.authorscopusid 57310612300
dc.authorscopusid 55364192200
dc.authorscopusid 6603550419
dc.authorwosid Sinan, Umit/A-7003-2017
dc.contributor.author Naci, Baha
dc.contributor.author Demir, Rengin
dc.contributor.author Onder, Omer O.
dc.contributor.author Sinan, Umit Yasar
dc.contributor.author Kucukoglu, Mehmet Serdar
dc.contributor.other Fizyoterapi Ve Rehabilitasyon Bölümü
dc.date.accessioned 2025-01-11T13:01:46Z
dc.date.available 2025-01-11T13:01:46Z
dc.date.issued 2022
dc.department Fenerbahçe University en_US
dc.department-temp [Naci, Baha; Demir, Rengin; Sinan, Umit Yasar; Kucukoglu, Mehmet Serdar] Istanbul Univ Cerrahpasa, Inst Cardiol, Dept Cardiol, Istanbul, Turkey; [Naci, Baha] Fenerbahce Univ, Fac Hlth Sci, Div Physiotherapy & Rehabil, Istanbul, Turkey; [Onder, Omer O.] Istanbul Hlth & Technol Univ, Fac Hlth Sci, Div Physiotherapy & Rehabil, Istanbul, Turkey en_US
dc.description Naci, Baha/0000-0003-3764-2421; Demir, Rengin/0000-0002-2901-2967 en_US
dc.description.abstract Limited research exists regarding nonpharmacologic management of pulmonary arterial hypertension (PAH), except for exercise training. The objective of this study was to investigate the effects of osteopathic manipulative treatment (OMT) alone and combined with respiratory training on fractional exhaled nitric oxide (FeNO), and cardiopulmonary function in patients with PAH. This single-blind, prospective, randomized controlled study included 54 patients with PAH who were randomly allocated to OMT, combined intervention, and control groups. The OMT group (n = 16) and combined intervention group (n = 16) received OMT and yoga respiratory training plus OMT, respectively, twice a week for 8 weeks. The control group (n = 16) received no intervention. All patients undertook an educational lecture. FeNO level, pulmonary function, 6-minute walk distance (6MWD), maximal inspiratory and expiratory pressures, and handgrip strength were assessed at baseline and 8 weeks. Combined intervention and OMT groups significantly improved all outcome measures after 8 weeks of treatment (p 0.01), except mean forced expiratory flow between 25% and 75% of forced vital capacity, which did not change in the OMT group (p 0.05). The control group showed significant deteriorations in 6MWD, inspiratory and peripheral muscle strength, and pulmonary function except peak expiratory flow at 8 weeks (p <0.05). The combined intervention group revealed significantly greater improvements of FeNO, 6MWD, respiratory and peripheral muscle strength, and pulmonary function except mean forced expiratory flow between 25% and 75% of forced vital capacity compared with the OMT group (p <0.05). All outcomes significantly improved in both intervention groups versus the control group (p <0.05). Our study demonstrated that adding respiratory training to OMT provided further benefit to FeNO level and cardiopulmonary function compared with OMT alone and that the OMT might be a useful and safe intervention for patients who cannot attend cardiac rehabilitation programs. (c) 2021 Elsevier Inc. All rights reserved. (Am J Cardiol 2022;162:184-190) en_US
dc.description.sponsorship Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa (Istanbul, Turkey) [TDK-2018-31147] en_US
dc.description.sponsorship This work was supported by the Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa (Istanbul, Turkey) as project number TDK-2018-31147. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citation 1
dc.identifier.doi 10.1016/j.amjcard.2021.09.023
dc.identifier.endpage 190 en_US
dc.identifier.issn 0002-9149
dc.identifier.issn 1879-1913
dc.identifier.pmid 34706819
dc.identifier.scopus 2-s2.0-85117766062
dc.identifier.scopusquality Q2
dc.identifier.startpage 184 en_US
dc.identifier.uri https://doi.org/10.1016/j.amjcard.2021.09.023
dc.identifier.uri https://hdl.handle.net/20.500.14627/178
dc.identifier.volume 162 en_US
dc.identifier.wos WOS:000731300600027
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Excerpta Medica inc-elsevier Science inc en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 2
dc.subject [No Keyword Available] en_US
dc.title Effects of Adding Respiratory Training To Osteopathic Manipulative Treatment on Exhaled Nitric Oxide Level and Cardiopulmonary Function in Patients With Pulmonary Arterial Hypertension en_US
dc.type Article en_US
dc.wos.citedbyCount 2
dspace.entity.type Publication
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