Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cells in the Treatment of Type 1 and Type 2 Diabetes Mellitus: a Systematic Review and Meta-Analysis

dc.authorid Ibrahim, Ismail/0000-0002-0805-8181
dc.authorid Oteri, Vittorio/0000-0001-5210-8601
dc.authorid Hafez, Wael/0000-0003-1203-0808
dc.authorid Shalabi, Laila/0000-0001-7334-9711
dc.authorwosid Hafez, Wael/Aej-1260-2022
dc.authorwosid Nada, Ahmed/Gqp-7981-2022
dc.authorwosid Shalabi, Laila/Lyo-9528-2024
dc.authorwosid Ibrahim, Ismail/Klc-4059-2024
dc.contributor.author Nada, Ahmed Hosney
dc.contributor.author Ibrahim, Ismail A.
dc.contributor.author Oteri, Vittorio
dc.contributor.author Shalabi, Laila
dc.contributor.author Asar, Nada Khalid
dc.contributor.author Aqeilan, Saja Rami
dc.contributor.author Hafez, Wael
dc.date.accessioned 2025-03-10T21:19:13Z
dc.date.available 2025-03-10T21:19:13Z
dc.date.issued 2025
dc.department Fenerbahçe University en_US
dc.department-temp [Nada, Ahmed Hosney] Benha Univ, Fac Med, Banha, Egypt; [Ibrahim, Ismail A.] Fenerbahce Univ, Fac Hlth Sci, Istanbul, Turkiye; [Oteri, Vittorio] Univ Catania, Garibaldi Nesima Hosp, Dept Clin & Expt Med, Endocrine Unit, Catania, Italy; [Shalabi, Laila] Gharyan Univ, Fac Med, Gharyan, Libya; [Asar, Nada Khalid] Mansoura Univ, Fac Med, Mansoura, Egypt; [Aqeilan, Saja Rami] Univ Jordan, Fac Med, Amman, Jordan; [Hafez, Wael] Natl Res Ctr, Med Res & Clin Studies Inst, Giza, Egypt; [Hafez, Wael] NMC Royal Hosp, Abu Dhabi, U Arab Emirates en_US
dc.description Ibrahim, Ismail; Oteri, Vittorio; Hafez, Wael; Shalabi, Laila en_US
dc.description.abstract Introduction Many patients struggle to control glucose without side effects. Due to their immunomodulatory and regenerative properties, mesenchymal stem cells (MSCs) might treat Diabetes Mellitus (DM). The authors employed this meta-analysis to evaluate the efficacy and safety of umbilical cord MSCs (UCMSCs) for DM management. Methods The PubMed, Cochrane, WOS, Embase, and Scopus databases were searched for randomized controlled trials (RCTs) investigating the effects of UCMSCs on DM (Types 1, 2) till January 2024. Patient demographics, interventions, and outcomes, including glycated hemoglobin (HbA1c%), C-peptide levels, and insulin requirements, were extracted. A comprehensive meta-analysis software was used. Results Eight CTs of 334 patients (172 experimental and 162 controls) were included. UMSCs treatment substantially lowered HbA1c levels (MD = -1.06, 95% CI [-1.27, -0.85], p < 0.00001) with consistent outcomes (i(2) = 0%, p = 0.43). Fasting C-peptide levels were heterogeneous but favored placebo (MD = 0.35, 95% CI [0.15, 0.56], p = 0.0007). In T1D patients, daily insulin requirements decreased considerably (MD = -0.24, 95% CI [-0.29, -0.18], p < 0.00001), with heterogeneity addressed by sensitivity analysis. Conclusion UMSCs therapy reduced HbA1c and insulin requirements, and increased C-peptide levels. Multicenter clinical trials are required to confirm the long-term efficacy and safety of UMSC therapy. en_US
dc.description.sponsorship Global Alliance of Young Researchers en_US
dc.description.sponsorship The authors thank the Global Alliance of Young Researchers for their support and high-quality mentorship. en_US
dc.description.woscitationindex Emerging Sources Citation Index
dc.identifier.doi 10.1080/17446651.2025.2457474
dc.identifier.endpage 117 en_US
dc.identifier.issn 1744-6651
dc.identifier.issn 1744-8417
dc.identifier.issue 2 en_US
dc.identifier.pmid 39905688
dc.identifier.scopus 2-s2.0-85217554150
dc.identifier.scopusquality Q2
dc.identifier.startpage 107 en_US
dc.identifier.uri https://doi.org/10.1080/17446651.2025.2457474
dc.identifier.volume 20 en_US
dc.identifier.wos WOS:001415501000001
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Routledge Journals, Taylor & Francis Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject Diabetes Mellitus en_US
dc.subject Diabetes Type 1 en_US
dc.subject Diabetes Type 2 en_US
dc.subject Umbilical Cord Mesenchymal Stem Cells en_US
dc.subject Efficacy en_US
dc.subject Safety en_US
dc.title Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cells in the Treatment of Type 1 and Type 2 Diabetes Mellitus: a Systematic Review and Meta-Analysis en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication

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