Managing Viral Emerging Infectious Diseases Via Current and Future Molecular Diagnostics

dc.authorid Kahraman Kilbas, Elmas Pinar/0000-0003-1348-625X
dc.authorscopusid 6701700795
dc.authorscopusid 57226442170
dc.authorwosid Altindis, Mustafa/O-8413-2019
dc.authorwosid Kılbaş, Elmas/HRC-3339-2023
dc.contributor.author Kahraman Kılbaş, Elmas Pınar
dc.contributor.author Kilbas, Elmas Pinar Kahraman
dc.contributor.other Tıbbi Hizmetler ve Teknikler Bölümü
dc.date.accessioned 2025-01-11T13:03:49Z
dc.date.available 2025-01-11T13:03:49Z
dc.date.issued 2023
dc.department Fenerbahçe University en_US
dc.department-temp [Altindis, Mustafa] Sakarya Univ, Fac Med, Med Microbiol Dept, TR-54050 Sakarya, Turkiye; [Kilbas, Elmas Pinar Kahraman] Fenerbahce Univ, Vocat Sch Hlth Serv, Med Lab Tech, TR-34758 Istanbul, Turkiye en_US
dc.description Kahraman Kilbas, Elmas Pinar/0000-0003-1348-625X en_US
dc.description.abstract Emerging viral infectious diseases have been a constant threat to global public health in recent times. In managing these diseases, molecular diagnostics has played a critical role. Molecular diagnostics involves the use of various technologies to detect the genetic material of various pathogens, including viruses, in clinical samples. One of the most commonly used molecular diagnostics technologies for detecting viruses is polymerase chain reaction (PCR). PCR amplifies specific regions of the viral genetic material in a sample, making it easier to detect and identify viruses. PCR is particularly useful for detecting viruses that are present in low concentrations in clinical samples, such as blood or saliva. Another technology that is becoming increasingly popular for viral diagnostics is next-generation sequencing (NGS). NGS can sequence the entire genome of a virus present in a clinical sample, providing a wealth of information about the virus, including its genetic makeup, virulence factors, and potential to cause an outbreak. NGS can also help identify mutations and discover new pathogens that could affect the efficacy of antiviral drugs and vaccines. In addition to PCR and NGS, there are other molecular diagnostics technologies that are being developed to manage emerging viral infectious diseases. One of these is CRISPR-Cas, a genome editing technology that can be used to detect and cut specific regions of viral genetic material. CRISPR-Cas can be used to develop highly specific and sensitive viral diagnostic tests, as well as to develop new antiviral therapies. In conclusion, molecular diagnostics tools are critical for managing emerging viral infectious diseases. PCR and NGS are currently the most commonly used technologies for viral diagnostics, but new technologies such as CRISPR-Cas are emerging. These technologies can help identify viral outbreaks early, track the spread of viruses, and develop effective antiviral therapies and vaccines. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citation 3
dc.identifier.doi 10.3390/diagnostics13081421
dc.identifier.issn 2075-4418
dc.identifier.issue 8 en_US
dc.identifier.pmid 37189522
dc.identifier.scopus 2-s2.0-85153745037
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.3390/diagnostics13081421
dc.identifier.uri https://hdl.handle.net/20.500.14627/307
dc.identifier.volume 13 en_US
dc.identifier.wos WOS:000977918800001
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Mdpi en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 9
dc.subject Emerging Viral Infections en_US
dc.subject Pcr en_US
dc.subject Next-Generation Sequencing en_US
dc.subject Crispr-Cas en_US
dc.subject Lamp en_US
dc.title Managing Viral Emerging Infectious Diseases Via Current and Future Molecular Diagnostics en_US
dc.type Review en_US
dc.wos.citedbyCount 8
dspace.entity.type Publication
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