Exercise Improves Testicular Morphology and Oxidative Stress Parameters in Rats With Testicular Damage Induced by a High-Fat Diet

dc.authorid Kolgazi, Meltem/0000-0003-4820-1904
dc.authorid Ercan, Feriha/0000-0003-2339-5669
dc.authorid Sener, Goksel/0000-0001-7444-6193
dc.authorscopusid 57201334006
dc.authorscopusid 39161700400
dc.authorscopusid 14045293900
dc.authorscopusid 55662834600
dc.authorscopusid 6701314738
dc.authorscopusid 7006979286
dc.authorwosid Ozakpinar, Ozlem/ACB-1160-2022
dc.authorwosid Kolgazi, Meltem/J-6786-2015
dc.authorwosid Ercan, Feriha/A-1655-2018
dc.contributor.author Şener, Göksel
dc.contributor.author Ozakpinar, Ozlem Bingol
dc.contributor.author Kolgazi, Meltem
dc.contributor.author Sener, Goksel
dc.contributor.author Arbak, Serap
dc.contributor.author Ercan, Feriha
dc.contributor.other Eczacılık Meslek Bilimleri Bölümü
dc.date.accessioned 2025-01-11T13:00:56Z
dc.date.available 2025-01-11T13:00:56Z
dc.date.issued 2022
dc.department Fenerbahçe University en_US
dc.department-temp [Elmas, Merve Acikel; Arbak, Serap] Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkey; [Ozakpinar, Ozlem Bingol] Marmara Univ, Fac Pharm, Dept Biochem, Istanbul, Turkey; [Kolgazi, Meltem] Acibadem Univ, Dept Physiol, Sch Med, Istanbul, Turkey; [Sener, Goksel] Fenerbahce Univ, Vocat Sch Hlth Serv, Istanbul, Turkey; [Ercan, Feriha] Marmara Univ, Dept Histol & Embryol, Sch Med, Istanbul, Turkey en_US
dc.description Kolgazi, Meltem/0000-0003-4820-1904; Ercan, Feriha/0000-0003-2339-5669; Sener, Goksel/0000-0001-7444-6193 en_US
dc.description.abstract Obesity and male infertility are problems that affect population. Exercise is a nonpharmacological way to reduce the negative health effects of obesity. The purpose of this study was to examine the effects of exercise on hormone levels, blood-testis barrier, and inflammatory and oxidative biomarkers in rats that became obese due to a high-fat diet (HFD). Male rats received a standard diet (STD group) or a HFD (HFD group) for 18 weeks. During the final 6 weeks of the experiment, swimming exercises (1 h/5 days/week) were given to half of these animals (STD + EXC and HFD + EXC groups). Finally, blood and testicular tissues were analysed by biochemical and histological methods. Body weight, leptin, malondialdehyde, interleukin-6, TNF-alpha and myeloperoxidase levels, apoptotic cells and DNA fragmentation were increased, and testis weight, insulin, FSH, LH, testosterone, glutathione and superoxide dysmutase levels, proliferative cells, ZO-1, occludin, and gap junction protein Cx43 immunoreactivity were decreased in the HFD group. All these hormonal, morphological, oxidative and inflammatory biomarkers were enhanced in the HFD + EXC group. It is thought that exercise protected testicular cytotoxicity by regulating hormonal and oxidant/antioxidant balances and testicular function, inhibiting inflammation and apoptosis, as well as preserving blood-testis barrier. en_US
dc.description.sponsorship Acibadem Mehmet Ali Aydinlar University Scientific Research Project Committee [2016/05/01]; Marmara University Scientific Research Project Committee [SAG-CDRP-131016-0443]; Scientific and Technological Research Counsil of TurkeyTUBITAK [216S280] en_US
dc.description.sponsorship Acibadem Mehmet Ali Aydinlar University Scientific Research Project Committee, Grant/Award Number: 2016/05/01; Marmara University Scientific Research Project Committee, Grant/Award Number: SAG-CDRP-131016-0443; Scientific and Technological Research Counsil of TurkeyTUBITAK, Grant/Award Number: 216S280 en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citation 8
dc.identifier.doi 10.1111/and.14600
dc.identifier.issn 0303-4569
dc.identifier.issn 1439-0272
dc.identifier.issue 11 en_US
dc.identifier.pmid 36146902
dc.identifier.scopus 2-s2.0-85138700075
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.1111/and.14600
dc.identifier.uri https://hdl.handle.net/20.500.14627/87
dc.identifier.volume 54 en_US
dc.identifier.wos WOS:000856573900001
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 11
dc.subject Blood Testis Barrier en_US
dc.subject Exercise en_US
dc.subject High-Fat Diet en_US
dc.subject Oxidative Stress en_US
dc.subject Ultrastructure en_US
dc.title Exercise Improves Testicular Morphology and Oxidative Stress Parameters in Rats With Testicular Damage Induced by a High-Fat Diet en_US
dc.type Article en_US
dc.wos.citedbyCount 10
dspace.entity.type Publication
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