Early Detection of Lower Adherence to Long-Term E-Diary Recording: A Checkpoint to Target Early Educational Intervention in Seasonal Allergic Rhinitis
| dc.contributor.author | Dramburg, S. | |
| dc.contributor.author | Hernandez Toro, C. J. | |
| dc.contributor.author | Grittner, U. | |
| dc.contributor.author | Tripodi, S. | |
| dc.contributor.author | Arasi, S. | |
| dc.contributor.author | Acar Sahin, A. | |
| dc.contributor.author | Matricardi, P. M. | |
| dc.date.accessioned | 2026-02-10T14:54:37Z | |
| dc.date.available | 2026-02-10T14:54:37Z | |
| dc.date.issued | 2026 | |
| dc.description.abstract | Background: Digital symptom monitoring via e-Diary apps can support the diagnosis and management of chronic diseases with trigger-induced exacerbations such as pollen allergies. Attrition is a major challenge for continuous e-Diary usage with an unsupervised approach. Objective: To investigate adherence to e-Diary reporting, its early determinants and predictors in a blended care setting among pollen allergic patients with heterogeneous cultural backgrounds. Methods: The @IT.2020 observational multicenter study recruited patients with diagnosed seasonal allergic rhinitis from seven Southern European/Mediterranean countries. Baseline characteristics were investigated through questionnaires, skin prick tests and serum specific IgE measurements. The study doctors asked patients to record their allergy symptoms via e-Diary (AllergyMonitor, TPS) daily during the clinically relevant season of pollination and increased mould concentrations. Results: Among 815 patients (467 adults, 348 children), the average prescribed e-Diary recording period was 106 (SD 47.1) days, with an average completion rate of 75.2% (SD 21.2%). Children (>= 10 years) filled 73.8% (95% CI 68.1-79.4) of prescribed days without parental support. We identified a stable 'higher' and a more variable 'lower' adherence cluster. Adherence was weakly associated with disease severity, but not with age, gender, country, education or digital literacy. Short-term (first 3 weeks) adherence was strongly associated with long-term adherence (partial R-2 = 0.387, p < 0.001), with 87.6% of lower adherent patients remaining poorly adherent beyond 3 weeks. Conclusion: In a blended care setting, adherence to e-Diary compilation among pollen allergic patients is high, irrespective of age and cultural background. Early identification of lower adherence is possible and might inform early interventions to improve patient adherence. | en_US |
| dc.description.sponsorship | Euroimmun Medizinische Labordiagnostika [118583] | en_US |
| dc.description.sponsorship | S.A. was supported by the EAACI Fellowship Award of the European Academy of Allergology and Clinical Immunology. P.M.M. is funded by the Deutsche Forschungsgesellschaft (DFG) (MA47/2-1). This investigator-initiated observational study has been supported by an unrestricted grant from Euroimmun Medizinische Labordiagnostika AG, Grant/Award Number: 118583. The Informatics Platform AllergyCARD and the app AllergyMonitor have been kindly provided by TPS Software Production. | en_US |
| dc.identifier.doi | 10.1111/cea.70203 | |
| dc.identifier.issn | 0954-7894 | |
| dc.identifier.issn | 1365-2222 | |
| dc.identifier.scopus | 2-s2.0-105028331330 | |
| dc.identifier.uri | https://doi.org/10.1111/cea.70203 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14627/1416 | |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley | en_US |
| dc.relation.ispartof | Clinical and Experimental Allergy | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Adherence | en_US |
| dc.subject | Allergic Rhinitis | en_US |
| dc.subject | Allergy Symptoms | en_US |
| dc.subject | Chronic Diseases | en_US |
| dc.subject | E-Diary | en_US |
| dc.subject | Patient Education | en_US |
| dc.subject | Patient-Reported Outcomes | en_US |
| dc.subject | Remote Monitoring | en_US |
| dc.subject | Reporting Behaviour | en_US |
| dc.title | Early Detection of Lower Adherence to Long-Term E-Diary Recording: A Checkpoint to Target Early Educational Intervention in Seasonal Allergic Rhinitis | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.scopusid | 57204144153 | |
| gdc.author.scopusid | 57201900696 | |
| gdc.author.scopusid | 12759777500 | |
| gdc.author.scopusid | 7003279868 | |
| gdc.author.scopusid | 35774363100 | |
| gdc.author.scopusid | 57216737502 | |
| gdc.author.scopusid | 55897886600 | |
| gdc.author.wosid | Bregu, Blerina/Gry-7196-2022 | |
| gdc.author.wosid | Dramburg, Stephanie/Aam-8340-2020 | |
| gdc.author.wosid | Acar Şahi̇n, Aydan/Kyr-7379-2024 | |
| gdc.author.wosid | Arasi, Stefania/K-2858-2018 | |
| gdc.author.wosid | Delgado, Luis/L-8035-2013 | |
| gdc.author.wosid | Mazon, Angel/Abg-8016-2020 | |
| gdc.description.department | Fenerbahçe University | en_US |
| gdc.description.departmenttemp | [Dramburg, S.; Hernandez Toro, C. J.; Arasi, S.; Hoffmann, T. M.; Potapova, E.; Matricardi, P. M.] Charite Univ Med Berlin, Dept Pediat Resp Care Immunol & Intens Care Med, Berlin, Germany; [Hernandez Toro, C. J.; Grittner, U.] Charite Univ Med Berlin, Inst Biometry & Clin Epidemiol, Berlin, Germany; [Tripodi, S.; Di Rienzo Businco, A.; Sfika, I.; Villella, V.] Sandro Pertini Hosp, Pediat Allergy Unit, Rome, Italy; [Tripodi, S.] Policlin Casilino, Allergolol Serv, Rome, Italy; [Arasi, S.] Bambino Gesu Childrens Res Hosp IRCCS, Dept Pediat Med, Pediat Allergol Unit, Rome, Italy; [Acar Sahin, A.; Pinar, N. M.] Ankara Univ, Fac Sci, Dept Biol, Ankara, Turkiye; [Aggelidis, X.; Makris, M.] Natl & Kapodistrian Univ Athens, Univ Hosp Attikon, Dept Dermatol & Venereol 2, Allergy Unit, Athens, Greece; [Barbalace, A.; Caminiti, L.; Pajno, G.; Panasiti, I.] Univ Messina, Dept Pediat, Allergy Unit, Messina, Italy; [Bourgoin, A.; Charpin, D.; Dimier, C.; Verdier, V.] Aix Marseille Univ, La Timone Hosp, APHM, Dept Pneumonol & Allergy, Marseille, France; [Bregu, B.; Lame, B.; Mesonjesi, E.; Priftanji, A.] Med Univ Tirana, Dept Allergol & Clin Immunol, UHC Mother Teresa, Tirana, Albania; [Brighetti, M. A.; Travaglini, A.] Tor Vergata Univ, Dept Biol, Rome, Italy; [Caeiro, E.] Univ Evora, MED Mediterranean Inst Agr Environm & Dev, Evora, Portugal; [Caeiro, E.] Univ Evora, CHANGE Global Change & Sustainabil Inst, Inst Adv Studies & Res, Evora, Portugal; [Caeiro, E.] Portuguese Soc Allergol & Clin Immunol, Lisbon, Portugal; [Caglayan Sozmen, S.] Fenerbahce Univ, Istanbul, Turkiye; [Couto, M.] Hosp CUF Trindade, Immunoallergol, Porto, Portugal; [Delgado, L.; Pereira, M.] Univ Porto, Fac Med, Dept Pathol, Basic & Clin Immunol Unit, Porto, Portugal; [Delgado, L.; Fonseca, J. A.; Pereira, A. M.; Pereira, M.] Univ Porto, Fac Med, RISE Hlth, Porto, Portugal; [Delgado, L.; Fonseca, J. A.; Pereira, A. M.] Inst & Hosp CUF Porto, Allergy Unit, Porto, Portugal; [Dimou, M. V.; Papadopoulos, N. G.] Univ Athens, Athens Gen Childrens Hosp P&A Kyriakou, Allergy Dept, Pediat Clin 2, Athens, Greece; [Goksel, O.] Ege Univ, EgeSAM Ege Univ Translat Pulm Res Ctr, Div Immunol Allergy & Asthma, Fac Med,Dept Pulm Med, Izmir, Turkiye; [Hernandez, D.] Hosp La Fe, Dept Allergy, Hlth Res Inst, Valencia, Spain; [Jang, D. T.; Llusar, R.; Mazon, A.; Nieto, A.] Childrens Hosp La Fe, Inst Hlth Res La Fe, Pediat Allergy & Pneumol Unit, Valencia, Spain; [Kalpaklioglu, F.] Kirikkale Univ, Sch Med, Dept Immunol & Allerg Dis, Kirikkale, Turkiye; [Ozturk, A.] Koc Univ, Sch Med, Dept Pulm Med, Div Allergy & Immunol, Istanbul, Turkiye; [Pahus, L.] Aix Marseille Univ, INSERM, INRA 1260, U1263,APHM,CIC 1409,C2VN, Marseille, France; [Papadopoulos, N. G.] Univ Manchester, Royal Manchester Childrens Hosp, Div Infect Immun & Resp Med, Manchester, England; [Pellegrini, E.] ARPA Reg Agcy Environm Protect, Dept Reggio Calabria, Calabria, Italy; [Pelosi, S.] TPS Prod Srl, Rome, Italy; [Psarros, F.] Athens Naval Hosp, Allergy Dept, Athens, Greece; [Sackesen, C.] Koc Univ, Sch Med, Div Pediat Allergy, Istanbul, Turkiye; [Suarez, J.] Univ Oviedo, Dept Biol Organisms & Syst, Area Bot, Oviedo, Spain; [Thibaudon, M.] Reseau Natl Surveillance Aerobiol, Brussieu, France; [Travaglini, A.] Italian Aerobiol Assoc, Italian Aerobiol Monitoring Network, Rome, Italy; [Uguz, U.] Ege Univ, Fac Sci, Dept Biol, Izmir, Turkiye; [Xepapadaki, P.] Natl & Kapodistrian Univ Athens, Allergy Dept, Pediat Clin 2, Athens, Greece; [Yazici, D.] Koc Univ, Cellular & Mol Med, Grad Sch Hlth Sci, KUTTAM, Istanbul, Turkiye; [Yazici, D.] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland; [Matricardi, P. M.] Charite Univ Med Berlin, Inst Allergol, Berlin, Germany; [Matricardi, P. M.] Free Univ Berlin, Berlin, Germany; [Matricardi, P. M.] Humboldt Univ, Berlin, Germany; [Matricardi, P. M.] Fraunhofer Inst Translat Med & Pharmacol ITMP, Allergol & Immunol, Berlin, Germany | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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