Early Detection of Lower Adherence to Long-Term E-Diary Recording: A Checkpoint to Target Early Educational Intervention in Seasonal Allergic Rhinitis
| dc.contributor.author | Dramburg, S. | |
| dc.contributor.author | Hernandez Toro, C. J. | |
| dc.contributor.author | Grittner, U. | |
| dc.contributor.author | Tripodi, S. | |
| dc.contributor.author | Arasi, S. | |
| dc.contributor.author | Acar Sahin, A. | |
| dc.contributor.author | Matricardi, P. M. | |
| dc.date.accessioned | 2026-02-10T14:54:37Z | |
| dc.date.available | 2026-02-10T14:54:37Z | |
| dc.date.issued | 2026 | |
| dc.description.abstract | Background: Digital symptom monitoring via e-Diary apps can support the diagnosis and management of chronic diseases with trigger-induced exacerbations such as pollen allergies. Attrition is a major challenge for continuous e-Diary usage with an unsupervised approach. Objective: To investigate adherence to e-Diary reporting, its early determinants and predictors in a blended care setting among pollen allergic patients with heterogeneous cultural backgrounds. Methods: The @IT.2020 observational multicenter study recruited patients with diagnosed seasonal allergic rhinitis from seven Southern European/Mediterranean countries. Baseline characteristics were investigated through questionnaires, skin prick tests and serum specific IgE measurements. The study doctors asked patients to record their allergy symptoms via e-Diary (AllergyMonitor, TPS) daily during the clinically relevant season of pollination and increased mould concentrations. Results: Among 815 patients (467 adults, 348 children), the average prescribed e-Diary recording period was 106 (SD 47.1) days, with an average completion rate of 75.2% (SD 21.2%). Children (>= 10 years) filled 73.8% (95% CI 68.1-79.4) of prescribed days without parental support. We identified a stable 'higher' and a more variable 'lower' adherence cluster. Adherence was weakly associated with disease severity, but not with age, gender, country, education or digital literacy. Short-term (first 3 weeks) adherence was strongly associated with long-term adherence (partial R-2 = 0.387, p < 0.001), with 87.6% of lower adherent patients remaining poorly adherent beyond 3 weeks. Conclusion: In a blended care setting, adherence to e-Diary compilation among pollen allergic patients is high, irrespective of age and cultural background. Early identification of lower adherence is possible and might inform early interventions to improve patient adherence. | en_US |
| dc.description.sponsorship | Euroimmun Medizinische Labordiagnostika [118583] | en_US |
| dc.description.sponsorship | S.A. was supported by the EAACI Fellowship Award of the European Academy of Allergology and Clinical Immunology. P.M.M. is funded by the Deutsche Forschungsgesellschaft (DFG) (MA47/2-1). This investigator-initiated observational study has been supported by an unrestricted grant from Euroimmun Medizinische Labordiagnostika AG, Grant/Award Number: 118583. The Informatics Platform AllergyCARD and the app AllergyMonitor have been kindly provided by TPS Software Production. | en_US |
| dc.description.sponsorship | European Academy of Allergology and Clinical Immunology; EAACI; Deutsche Forschungsgesellschaft, (MA47/2–1); Euroimmun Medizinische Labordiagnostika AG, (118583) | |
| dc.description.sponsorship | S.A. was supported by the EAACI Fellowship Award of the European Academy of Allergology and Clinical Immunology. P.M.M. is funded by the Deutsche Forschungsgesellschaft (DFG) (MA47/2–1). This investigator-initiated observational study has been supported by an unrestricted grant from Euroimmun Medizinische Labordiagnostika AG, Grant/Award Number: 118583. The Informatics Platform AllergyCARD and the app AllergyMonitor have been kindly provided by TPS Software Production. This study was supported by an unrestricted educational grant from Euroimmun (code 118583). We thank all participants and the entire study team. We remember our esteemed colleague Giovanni Battista Pajno who passed away on April 11, 2022, and whose remarkable work has contributed significantly to this project, but also to research in allergology and immunology in general. Open Access funding enabled and organized by Projekt DEAL. | |
| dc.description.sponsorship | Euroimmun Medizinische Labordiagnostika; EAACI; European Academy of Allergology and Clinical Immunology; Deutsche Forschungsgemeinschaft, DFG; European Academy of Allergy and Clinical Immunology, EAACI; Deutsche Forschungsgesellschaft, (MA47/2–1); Euroimmun Medizinische Labordiagnostika AG, (118583) | |
| dc.identifier.doi | 10.1111/cea.70203 | |
| dc.identifier.issn | 0954-7894 | |
| dc.identifier.issn | 1365-2222 | |
| dc.identifier.scopus | 2-s2.0-105028331330 | |
| dc.identifier.uri | https://doi.org/10.1111/cea.70203 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14627/1416 | |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley | en_US |
| dc.relation.ispartof | Clinical and Experimental Allergy | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Adherence | en_US |
| dc.subject | Allergic Rhinitis | en_US |
| dc.subject | Allergy Symptoms | en_US |
| dc.subject | Chronic Diseases | en_US |
| dc.subject | E-Diary | en_US |
| dc.subject | Patient Education | en_US |
| dc.subject | Patient-Reported Outcomes | en_US |
| dc.subject | Remote Monitoring | en_US |
| dc.subject | Reporting Behaviour | en_US |
| dc.title | Early Detection of Lower Adherence to Long-Term E-Diary Recording: A Checkpoint to Target Early Educational Intervention in Seasonal Allergic Rhinitis | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Delgado, Luis/0000-0003-2375-9071 | |
| gdc.author.id | GOKSEL, Ozlem/0000-0003-1121-9967 | |
| gdc.author.id | Pereira, Ana Margarida/0000-0002-5468-0932 | |
| gdc.author.scopusid | 57204144153 | |
| gdc.author.scopusid | 57201900696 | |
| gdc.author.scopusid | 12759777500 | |
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| gdc.author.wosid | Bregu, Blerina/Gry-7196-2022 | |
| gdc.author.wosid | Dramburg, Stephanie/Aam-8340-2020 | |
| gdc.author.wosid | Acar Şahi̇n, Aydan/Kyr-7379-2024 | |
| gdc.author.wosid | Arasi, Stefania/K-2858-2018 | |
| gdc.author.wosid | Delgado, Luis/L-8035-2013 | |
| gdc.author.wosid | Mazon, Angel/Abg-8016-2020 | |
| gdc.author.wosid | Grittner, Ulrike/I-2026-2019 | |
| gdc.author.wosid | Pereira, Ana Margarida/K-3343-2014 | |
| gdc.author.wosid | Papadopoulos, Nikolaos/ABE-1774-2021 | |
| gdc.author.wosid | Uguz, Ulas/GLR-6217-2022 | |
| gdc.coar.access | open access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.description.department | Fenerbahçe University | en_US |
| gdc.description.departmenttemp | [Dramburg, S.; Hernandez Toro, C. J.; Arasi, S.; Hoffmann, T. M.; Potapova, E.; Matricardi, P. M.] Charite Univ Med Berlin, Dept Pediat Resp Care Immunol & Intens Care Med, Berlin, Germany; [Hernandez Toro, C. J.; Grittner, U.] Charite Univ Med Berlin, Inst Biometry & Clin Epidemiol, Berlin, Germany; [Tripodi, S.; Di Rienzo Businco, A.; Sfika, I.; Villella, V.] Sandro Pertini Hosp, Pediat Allergy Unit, Rome, Italy; [Tripodi, S.] Policlin Casilino, Allergolol Serv, Rome, Italy; [Arasi, S.] Bambino Gesu Childrens Res Hosp IRCCS, Dept Pediat Med, Pediat Allergol Unit, Rome, Italy; [Acar Sahin, A.; Pinar, N. M.] Ankara Univ, Fac Sci, Dept Biol, Ankara, Turkiye; [Aggelidis, X.; Makris, M.] Natl & Kapodistrian Univ Athens, Univ Hosp Attikon, Dept Dermatol & Venereol 2, Allergy Unit, Athens, Greece; [Barbalace, A.; Caminiti, L.; Pajno, G.; Panasiti, I.] Univ Messina, Dept Pediat, Allergy Unit, Messina, Italy; [Bourgoin, A.; Charpin, D.; Dimier, C.; Verdier, V.] Aix Marseille Univ, La Timone Hosp, APHM, Dept Pneumonol & Allergy, Marseille, France; [Bregu, B.; Lame, B.; Mesonjesi, E.; Priftanji, A.] Med Univ Tirana, Dept Allergol & Clin Immunol, UHC Mother Teresa, Tirana, Albania; [Brighetti, M. A.; Travaglini, A.] Tor Vergata Univ, Dept Biol, Rome, Italy; [Caeiro, E.] Univ Evora, MED Mediterranean Inst Agr Environm & Dev, Evora, Portugal; [Caeiro, E.] Univ Evora, CHANGE Global Change & Sustainabil Inst, Inst Adv Studies & Res, Evora, Portugal; [Caeiro, E.] Portuguese Soc Allergol & Clin Immunol, Lisbon, Portugal; [Caglayan Sozmen, S.] Fenerbahce Univ, Istanbul, Turkiye; [Couto, M.] Hosp CUF Trindade, Immunoallergol, Porto, Portugal; [Delgado, L.; Pereira, M.] Univ Porto, Fac Med, Dept Pathol, Basic & Clin Immunol Unit, Porto, Portugal; [Delgado, L.; Fonseca, J. A.; Pereira, A. M.; Pereira, M.] Univ Porto, Fac Med, RISE Hlth, Porto, Portugal; [Delgado, L.; Fonseca, J. A.; Pereira, A. M.] Inst & Hosp CUF Porto, Allergy Unit, Porto, Portugal; [Dimou, M. V.; Papadopoulos, N. G.] Univ Athens, Athens Gen Childrens Hosp P&A Kyriakou, Allergy Dept, Pediat Clin 2, Athens, Greece; [Goksel, O.] Ege Univ, EgeSAM Ege Univ Translat Pulm Res Ctr, Div Immunol Allergy & Asthma, Fac Med,Dept Pulm Med, Izmir, Turkiye; [Hernandez, D.] Hosp La Fe, Dept Allergy, Hlth Res Inst, Valencia, Spain; [Jang, D. T.; Llusar, R.; Mazon, A.; Nieto, A.] Childrens Hosp La Fe, Inst Hlth Res La Fe, Pediat Allergy & Pneumol Unit, Valencia, Spain; [Kalpaklioglu, F.] Kirikkale Univ, Sch Med, Dept Immunol & Allerg Dis, Kirikkale, Turkiye; [Ozturk, A.] Koc Univ, Sch Med, Dept Pulm Med, Div Allergy & Immunol, Istanbul, Turkiye; [Pahus, L.] Aix Marseille Univ, INSERM, INRA 1260, U1263,APHM,CIC 1409,C2VN, Marseille, France; [Papadopoulos, N. G.] Univ Manchester, Royal Manchester Childrens Hosp, Div Infect Immun & Resp Med, Manchester, England; [Pellegrini, E.] ARPA Reg Agcy Environm Protect, Dept Reggio Calabria, Calabria, Italy; [Pelosi, S.] TPS Prod Srl, Rome, Italy; [Psarros, F.] Athens Naval Hosp, Allergy Dept, Athens, Greece; [Sackesen, C.] Koc Univ, Sch Med, Div Pediat Allergy, Istanbul, Turkiye; [Suarez, J.] Univ Oviedo, Dept Biol Organisms & Syst, Area Bot, Oviedo, Spain; [Thibaudon, M.] Reseau Natl Surveillance Aerobiol, Brussieu, France; [Travaglini, A.] Italian Aerobiol Assoc, Italian Aerobiol Monitoring Network, Rome, Italy; [Uguz, U.] Ege Univ, Fac Sci, Dept Biol, Izmir, Turkiye; [Xepapadaki, P.] Natl & Kapodistrian Univ Athens, Allergy Dept, Pediat Clin 2, Athens, Greece; [Yazici, D.] Koc Univ, Cellular & Mol Med, Grad Sch Hlth Sci, KUTTAM, Istanbul, Turkiye; [Yazici, D.] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland; [Matricardi, P. M.] Charite Univ Med Berlin, Inst Allergol, Berlin, Germany; [Matricardi, P. M.] Free Univ Berlin, Berlin, Germany; [Matricardi, P. M.] Humboldt Univ, Berlin, Germany; [Matricardi, P. M.] Fraunhofer Inst Translat Med & Pharmacol ITMP, Allergol & Immunol, Berlin, Germany | en_US |
| gdc.description.endpage | 537 | |
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| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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