Recent Progress on Apoptotic Activity of Triazoles

dc.authorscopusid 56612061400
dc.authorscopusid 55894906300
dc.authorwosid Küçükgüzel, Ş.Güniz/AAQ-8954-2021
dc.contributor.author Cikla-Suzgun, P.
dc.contributor.author Kucukguzel, S. G.
dc.date.accessioned 2025-01-11T13:01:30Z
dc.date.available 2025-01-11T13:01:30Z
dc.date.issued 2021
dc.department Fenerbahçe University en_US
dc.department-temp [Cikla-Suzgun, P.] Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34854 Istanbul, Turkey; [Kucukguzel, S. G.] Fenerbahce Univ, Vocat Sch Hlth Serv, TR-34758 Istanbul, Turkey en_US
dc.description.abstract Apoptosis is often called programmed cell death and is defined as a self-directed cell destruction process. It is different from necrosis due to the activation of caspases during this process. Apoptosis is directly related to cancer progression and plays a vital role in carcinogenesis; all cytotoxic drugs and radiation therapy programs initiate apoptosis in tumor cells. Today, studies show that heterocyclic compounds that contain triazole functionality have anticancer activities; triazoles are 5 membered rings, which contain two carbon and three nitrogen atoms. Therefore, many researchers have synthesized these small active compounds as target structures and evaluated their apoptotic activities. The present review describes recent medicinal aspects of triazoles as anticancer agents that have been reported during the past few years. We hope that the bioactivity of triazole derivatives will be beneficial for the rational design of a new generation of small molecule drugs. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citation 5
dc.identifier.doi 10.2174/1389450122666210208181128
dc.identifier.endpage 1900 en_US
dc.identifier.issn 1389-4501
dc.identifier.issn 1873-5592
dc.identifier.issue 16 en_US
dc.identifier.pmid 33563153
dc.identifier.scopus 2-s2.0-85121954796
dc.identifier.scopusquality Q2
dc.identifier.startpage 1844 en_US
dc.identifier.uri https://doi.org/10.2174/1389450122666210208181128
dc.identifier.uri https://hdl.handle.net/20.500.14627/132
dc.identifier.volume 22 en_US
dc.identifier.wos WOS:000711465400004
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Bentham Science Publ Ltd en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 5
dc.subject Apoptosis en_US
dc.subject Triazole en_US
dc.subject Cancer en_US
dc.subject Caspase-8 en_US
dc.subject Caspase-3 en_US
dc.subject Bcl-2 en_US
dc.subject Cytochrome C en_US
dc.title Recent Progress on Apoptotic Activity of Triazoles en_US
dc.type Review en_US
dc.wos.citedbyCount 5
dspace.entity.type Publication

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