Effectiveness of Non-Invasive Vagal Nerve Stimulation in Parkinson's Disease: a Comprehensive Systematic Review And<i> Meta</I>-analysis

dc.authorid Yousef, Obai/0009-0001-5832-3780
dc.authorid Abouelmagd, Moaz/0000-0002-0511-2429
dc.authorscopusid 58781741300
dc.authorscopusid 59352253800
dc.authorscopusid 59287713600
dc.authorscopusid 55991060800
dc.authorwosid Ibrahim, Ismail/KLC-4059-2024
dc.authorwosid Abouelmagd, Moaz/LZE-5886-2025
dc.contributor.author Abouelmagd, Moaz Elsayed
dc.contributor.author Yousef, Obai
dc.contributor.author Ibrahim, Ismail A.
dc.contributor.author Elshahat, Ahmed
dc.date.accessioned 2025-02-10T18:42:28Z
dc.date.available 2025-02-10T18:42:28Z
dc.date.issued 2025
dc.department Fenerbahçe University en_US
dc.department-temp [Abouelmagd, Moaz Elsayed] Cairo Univ, Fac Med, Cairo, Egypt; [Yousef, Obai] Tartous Univ, Fac Med, Tartus?, Syria; [Ibrahim, Ismail A.] Fenerbahce Univ, Fac Hlth Sci, Istanbul, Turkiye; [Ibrahim, Ismail A.] Lomza State Univ Appl Sci, Fac Hlth Sci, Lomza, Poland; [Elshahat, Ahmed] Al Azhar Univ, Fac Med, Cairo, Egypt en_US
dc.description Yousef, Obai/0009-0001-5832-3780; Abouelmagd, Moaz/0000-0002-0511-2429 en_US
dc.description.abstract Background: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by movement impairments. Vagus nerve stimulation (VNS) is a non-invasive brain stimulation technique that has shown promise in treating various neurological conditions, including PD. This systematic review aimed to evaluate the existing evidence on the efficacy of nVNS in managing PD symptoms. Methods: A comprehensive literature search was conducted to identify relevant studies published up to July 2024. The included studies investigated the effect of nVNS on various PD motor symptoms. The quality of studies was assessed using the Cochrane Risk of Bias 2 (ROB-2) and NIH tool for RCTs, single-arm studies, and case series studies respectively. Statistical analysis was conducted using Review Manager version 5.4.1 with outcomes expressed as Mean differences (MD) with 95% confidence intervals (CI). Results: The systematic review included eight randomized controlled trials (RCTs), one single-arm study, and one case series, encompassing a total of 217 patients with PD. The review revealed that nVNS in increasing Freezing of Gait (FOG) in PD (p = 0.04). However, no significant differences were found in UPDRS-III (p = 0.19 and p = 0.89 for on and off-medication conditions, respectively), UPDRS-II (p = 0.9), UPDRS-I (p = 0.46), Time Up and Go (p = 0.61), stand time (p = 0.87), walking speed (p = 0.22), or step length measured in meters (p = 0.8). Interestingly, a significant improvement was observed in step length measured in centimetres (p = 0.0005). No study reported serious adverse effects associated with nVNS treatment. Conclusion: Our finding suggests a potential benefit of nVNS in reducing FOG in PD, but did not demonstrate a significant improvement in other motor symptoms. Larger, longer follow-up studies are needed to confirm the effect nVNS on PD management. PROSPERO number: CRD42024574822. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citation 0
dc.identifier.doi 10.1016/j.jocn.2024.111016
dc.identifier.issn 0967-5868
dc.identifier.issn 1532-2653
dc.identifier.pmid 39733649
dc.identifier.scopus 2-s2.0-85213509493
dc.identifier.scopusquality Q3
dc.identifier.uri https://doi.org/10.1016/j.jocn.2024.111016
dc.identifier.uri https://hdl.handle.net/20.500.14627/786
dc.identifier.volume 133 en_US
dc.identifier.wos WOS:001401666100001
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Elsevier Sci Ltd en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject Vns en_US
dc.subject Vagal Nerve Stimulation en_US
dc.subject Parkinson'S Disease en_US
dc.title Effectiveness of Non-Invasive Vagal Nerve Stimulation in Parkinson's Disease: a Comprehensive Systematic Review And<i> Meta</I>-analysis en_US
dc.type Review en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication

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