TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9

Browse

Now showing 1 - 14 of 14

Design and Implementation of a Low Cost and Portable Tactile Stimulator Br
(Tubitak Scientific & Technological Research Council Turkey, 2022) Kazma, Coskun; Levent, Vecdi Emre; Cardak, Merve; Aydin, Nizamettin; Bilgisayar Mühendisliği Bölümü
When central nervous system has a problem, somatic area I and II respond to stimulation differently. Therefore, it is possible to identify some of the central nervous diseases when somatosensory on the fingertip is stimulated and responses are recorded and analyzed. We designed a system to stimulate the mechanoreceptors on fingertips. It is composed of a mechanical system for fingertip stimulation, an embedded controller, a control computer, and a software to control overall operation. During test, mechanoreceptors are stimulated according to the test protocols. Individuals' answers are recorded to be evaluated by the developed software. In this study, several design approaches for embedded controller were also examined and an FPGA based controller with the same functionality but higher performance was implemented. A test procedure was performed on 51 individuals at the department of pediatric psychiatry in a hospital, to investigate whether the sex has an effect on attention deficit and hyperactivity disorder.
Determination of Post-Earthquake Trauma Level and Investigation of the Relationship with Physical Activity Status
(Turkish Physiotherapy Association, 2025) Tosun, Anil; Yılmaz, Nergis; Luque, Demet Tekın De Las Penas; Fizyoterapi Ve Rehabilitasyon Bölümü
Amaç: Çalışmanın amacı; 06 Şubat 2023’te meydana gelen Pazarcık-Elbistan merkezli depremler sebebiyle kişilerde oluşan travma düzeyinin, kişinin fiziksel aktivite durumu ile ilişkisini incelemektir. Aynı zamanda, kişilerde deprem sonrası ağrı varlığının sorgulanması ve bu durumun travma düzeyi ile ilişkisini ortaya koymaktır. Yöntem: Veriler çevrimiçi olarak Google formları aracılığıyla toplandı, 18-65 yaş arası 388 gönüllü katılımcı (299 kadın, 89 erkek) çalışmaya dahil edildi. Katılımcıların genel özelliklerini belirlemek için “Sosyodemografik Bilgi Formu”, travma düzeyini değerlendirmek için “Deprem Sonrası Travma Düzeyini Belirleme Ölçeği” (DSTDBÖ) ve fiziksel aktivite durumlarını belirlemek için “Uluslararası Fiziksel Aktivite Anketi Kısa Formu” (IPAQ-KF) kullanıldı. Bulgular: Deprem bölgesinde bulunma durumuna göre DSTDBÖ genel puan ortalamaları arasında anlamlı fark saptandı (p<0,001). Deprem bölgesinde bulunan 126 kişinin DSTDBÖ genel puan ortalaması 57,66±19,87 iken, bölgede bulunmayan 262 kişinin ortalaması 49,00±18,49 olarak bulundu. Spearman korelasyon analiziyle deprem bölgesinde olan ve olmayan bireylerin IPAQ-KF toplam puanları, DSTDBÖ alt faktör ve toplam puanları arasındaki ilişki incelenmiş olup sadece “Bilişsel Yapılandırma” alt faktörü ile IPAQ-KF toplam puanları arasında anlamlı bir ilişkiyi yansıtmayan negatif zayıf ilişki bulundu (deprem bölgesinde olanlar için Spearman korelasyon katsayı değeri =-0,18, p=0,042). Ve deprem sonrası ağrı yaşayan bireylerin DSTDBÖ puanları, ağrı yaşamayanlardan daha yüksek olarak saptandı (p=0,000). Sonuç: Bu çalışma ile deprem sonrası travma düzeyinin, fiziksel aktivite ile negatif ilişki gösterdiği belirlendi. İnaktif bireyler daha yüksek travma düzeylerine sahipken, minimal aktif bireylerde travma düzeyleri daha düşük bulundu. Bu bulgular, deprem sonrası fiziksel aktivitenin artırılmasının travma düzeylerini azaltmada etkili bir strateji olabileceğini göstermektedir. Bu alanda daha fazla araştırma, eğitim ve proje çalışmalarının yapılması gerekmektedir.
The Effect of 3d Modeling on Family Quality of Life, Surgical Success, and Patient Outcomes in Congenital Heart Diseases: Objectives and Design of a Randomized Controlled Trial
(Turkish J Pediatrics, 2024) Sumengen, Aylin Akca; Ismailoglu, Abdul Veli; Ismailoglu, Pelin; Gumus, Terman; Celiker, Alpay; Namlisesli, Deniz; Cakir, Gokce Naz
Background. Understanding the severity of the disease from the parents' perspective can lead to better patient outcomes, improving both the child's health -related quality of life and the family's quality of life. The implementation of 3 -dimensional (3D) modeling technology in care is critical from a translational science perspective. Aim. The purpose of this study is to determine the effect of 3D modeling on family quality of life, surgical success, and patient outcomes in congenital heart diseases. Additionally, we aim to identify challenges and potential solutions related to this innovative technology. Methods. The study is a two -group pretest -posttest randomized controlled trial protocol. The sample size is 15 in the experimental group and 15 in the control group. The experimental group's heart models will be made from their own computed tomography (CT) images and printed using a 3D printer. The experimental group will receive surgical simulation and preoperative parent education with their 3D heart model. The control group will receive the same parent education using the standard anatomical model. Both groups will complete the Sociodemographic Information Form, the Surgical Simulation Evaluation Form - Part I -II, and the Pediatric Quality of Life Inventory (PedsQL) Family Impacts Module. The primary outcome of the research is the average PedsQL Family Impacts Module score. Secondary outcome measurement includes surgical success and patient outcomes. Separate analyses will be conducted for each outcome and compared between the intervention and control groups. Conclusions. Anomalies that can be clearly understood by parents according to the actual size and dimensions of the child's heart will affect the preoperative preparation of the surgical procedure and the recovery rate in the postoperative period.
The Effect of Vitamin D and Paricalcitol on Protein Disulfide Isomerase
(Marmara University, 2025) Koksal, Murat; Şekerler, Turgut; Şener, Azize; Temel Eczacılık Bilimleri Bölümü
Protein disulfide isomerase (PDI), a multifunctional protein plays an important role as oxidoreductase, isomerase and chaperone in the cell. Prior studies have identified PDI is highly expressed in many different cancer types and presented as a new potential target for cancer treatment. Here, we investigated vitamin D and its analogue paricalcitol in silico interaction of the human PDI and inhibition of PDI reductase activity in vitro. We observed a non-covalent mechanism where the main skeleton of the vitamin D3 ans paricalcitol sturcture is located at the hydrophobic site in the b' domain of PDI and forms a hydrogen bond with a residue (His138) in tihs domain. They also form multiple weak hydrophobic interactions with various chemical groups of the b' subunit. For the first time, we demonstrate that 1,25-dihydroxyvitamin D3 (1a,25(OH)2 vitamin D3) and paricalcitol inhibit the PDI reductase activity in vitro and their IC50 values are 20.79±1.43 nmol/L and 32.83±3.15 nmol/L respectively. The two compounds can also block the denistrosation activity of PDI.
Citation - WoS: 4
Citation - Scopus: 4
Evaluation of Psychosocial Outcomes of Living Liver Donors in Liver Transplantation
(Aves, 2022) Ordin, Yaprak Sarigol; Seren, Arzu Kader Harmanci; Karayurt, Ozgul; Kul, Gulay Aksu; Kilic, Murat; Bozoklar, Cemal Ata; Tokat, Yaman; Hemşirelik Bölümü
Background: The purpose of this study was to evaluate the risk factors affecting psychosocial outcomes of living liver donors after liver transplantations. Methods: This was a descriptive, cross-sectional study. The sample consisted of living liver donors followed by 2 liver transplantation centers in 2 private hospitals in 2 different provinces, between August 2017 and October 2019. All the living liver donors were contacted without a time frame after donation and all the participants were evaluated once. The Beck Depression Scale, SF-36, General Self-Efficacy Scale, and Perceived Available Support Scale were used to collect data. The t-test, Kruskal-Wallis test, Mann-Whitney U-test, and Pearson correlation analysis were used for data analysis. Results: The mean age of the patients was 34.31 +/- 8.22 years. There was a positive, weak correlation between age and physical function. Gender, marital status, financial status, and education levels significantly affected physical components, social function, vitality, depression, and self-efficacy scores. High depression levels negatively affected the physical component, self-efficacy, and social support scores of the living liver donors. High self-efficacy positively affected social support. Conclusion: The study revealed that gender, marital status, employment status, and education levels were associated with psychosocial outcomes. The financial status was the main factor affecting each psychosocial variable. Financial status needs to be assessed in detail before and after the operation.
Citation - WoS: 5
Citation - Scopus: 6
An Integrated Methodology Proposal for Sustainable Fashion: Understanding and Examining Criteria Affecting the Second-Hand Clothes Shopping
(Gazi Univ, Fac Engineering Architecture, 2022) Usta, Saliha Karadayi; Kadaifci, Cigdem; Endüstri Mühendisliği Bölümü
Sustainable fashion is an important movement that offers numerous benefits in the long run by questioning the actual needs of the consumer, selecting the natural fabrics, preferring the brands providing ethical working conditions for the employees, using the acquired clothes as long as possible, repairing when necessary, and recycling into yarn when the lifetime is over, or transforming into a new product by changing the function of the items. In this context, the most active role of consumers is to prefer quality products that can last for many years and to extend the time of the products remaining in use, especially through the purchase and sale of second-hand clothes. While current papers provide roadmaps based on conceptual details, and consumer perception and attitude, there is no comprehensive study in second-hand shopping practices specific to clothing. Hence, the aim of this study is proposing an integrated methodology to understand the criteria that consumers pay attention in second-hand clothes shopping platforms as a tool that makes sustainable fashion possible via literature review, individual interviews and text mining, to determine the weights of these criteria according to their importance via Step-Wise Weight Assessment Ratio Analysis (SWARA) methodology, and to compare the prominent platform alternatives via Weighted Aggregated Sum Product Assessment (WASPAS) technique. The criteria weights vary depending on the sustainability awareness of consumers, and on the generation gap.
Lactobacillus Rhamnosus GG Alleviates Bisphenol-A Induced Oxidative Stress in Serum
(Marmara University, Faculty of Pharmacy, 2025) Şener, Göksel; Tunali-Akbay, Tugba; Dorucu, Dogancan; Ede-Pazarbasi, Seren; Dede, Pınar; Eczacılık Meslek Bilimleri Bölümü; Eczane Hizmetleri Bölümü
The objective of this investigation was to identify changes in the serum oxidant-antioxidant balance of rats exposed to bisphenol A (BPA) and to investigate the impact of Lactobacillus rhamnosus GG (LGG) administration on those changes. Twenty-four rats (Wistar Albino, 250-300 grams, male) were divided into control, BPA, and BPA+LGG groups with an equal number of rats. BPA and LGG were applied to the rats in the relevant groups for six weeks, five days each week. Six weeks later, the blood samples were withdrawn and serum samples were prepared. Total oxidant and antioxidant status (TAS), glutathione, and lipid peroxidation determinations were determined in serum samples, and the oxidative stress index was calculated. BPA exposure decreased serum total antioxidant status and increased serum total oxidative status, oxidative stress index, and lipid peroxidation level compared to the control group. LGG administration improved the increased serum oxidative stress caused by BPA. Administration of LGG to BPA-treated rats reversed oxidative stress-induced changes. In conclusion, administration of Lactobacillus rhamnosus GG to rats for 30 consecutive days prevented oxidative stress in serum caused by bisphenol A.
Mekanik Boyun Ağrılı Bireylerde Alt Ekstremite Posterior Plan Kaslarına Foam Roller İle Uygulanan Miyofasyal Gevşetme Tekniğinin Akut Etkisi
(2021) Alkan, Mirsad; Besen, Kardelen; Coşkunsu, Dilber Karagözoğlu; Güler, Dilara; Fizyoterapi Ve Rehabilitasyon Bölümü
Amaç: Myers tarafından tanımlanan fasyal\rzincirlerden biri olan Süperfisyal arka zincir\r(SAZ) ayak parmaklarından başlayıp supraorbital\rçıkıntıya kadar uzanan fasyal bir\rbanttır. SAZ öne eğilme (fleksiyon) hareketini\rlimitleyen ya da işlev bozukluğunda aşırı\rarkaya eğilme hareketine (ekstansiyon) sebep\rolan, primer olarak sagital planda postürü ve\rhareketi sağlayan başlıca zincirdir. Sağ ve\rsol tarafta olmak üzere iki SAZ vardır ve iki\rtaraf arasında etkileşim olduğundan dolayı\rdengesizliklerin gözlemlenip düzeltilmesi\rgerekir. Bu çalışmada aktif komponentler\rarası etkileşimi değerlendirmek için; Mekanik\rBoyun Ağrılı bireylerde Hamstring ve\rGastroknemius kaslarına uygulayarak Foam\rRoller (FR) Self Miyofasyal Gevşetme (SMG)\rtekniğinin servikal bölge Eklem Hareket\rAçıklığı’na (EHA), ağrıya ve kas kuvvetine\rolan akut etkisi araştırılmıştır.
Post Challenge Effects of Ozg-38.61.3 Gamma Irradiated SARS-CoV Vaccine on Organ Protection in Transgenic Mouse Model
(Marmara University, Institute of Health Sciences, 2025) Telci, Dilek; Akpınar, Gürler; Tuğlu, Mehmet İbrahim; Ovalı, Ercüment; Oztatlıcı, Hulya; Şahin, Fikrettin; Demir, Sevda
Objective: Coronavirus disease 2019 (COVID-19) is an infectious outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) and virus-related deaths are increasing day by day. For this reason, vaccine studies and their urgent use are of great importance to prevent the pandemic. In this study, multi-organ damages caused by SARS-CoV-2 virus in human- angiotensin-converting enzyme type 2 (ACE2) transgenic mice and the protective effects of OZG-38.61.3 gamma irradiated SARS-CoV-2 vaccine against viral damage were investigated. Methods: For this purpose, transgenic K18-hACE2 BALB/c mice were randomly allocated into 4 groups, negative control group (NC), positive control group (PC, SARS-CoV-2 infected), and 2 different doses of OZG-38.61.3 vaccine (Challenge 1, dose of 10 13 and Ch2, 10 14 viral particle after SARS-CoV-2 infection). After the administrations, lung, heart and kidney tissues were examined by histopathological, immunohistochemical and TUNEL analysis. Results: Our results showed that the vaccine doses decreased the apoptosis, oxidative stress and inflammation parameters caused by virus in lung, heart, and kidney tissues. It was also found that the vaccine protected the expressions of tight junction proteins in the kidneys. Conclusion: According to our findings, it is suggested that the OZG-38.61.3 can be an effective and protective vaccine that can be safely used against the SARS-CoV-2 virus.
Citation - WoS: 2
Citation - Scopus: 2
Preparation and Application of Caffeic Acid Imprinted Polymer
(Tubitak Scientific & Technological Research Council Turkey, 2023) Ersoy, Seyda K. A. R. A. M. A. N.; Tutem, Esma; Baskan, Kevser SoeZGEN; Apak, Resat; Temel Eczacılık Bilimleri Bölümü
In the present study, molecularly imprinted polymers were synthesized using caffeic acid (CA) as a template molecule and then used for the extraction of CA and chlorogenic acid (CLA) from complex matrices. Syntheses were carried out in tetrahydrofuran as porogenic solvent using 4-vinyl pyridine, methacrylic acid, acrylamide, and 1-vinyl imidazole as monomers, ethylene glycol dimethacrylate as crosslinker and 2,2'-azobisisobutyronitrile as initiator. In polymerization processes, different ratios of the template:monomer:crosslinker (T:M:CrL) were used to obtain the most suitable polymer. Caffeic acid:4-vinylpiridine:ethylene glycol dimethacrylate's 1:4:16 mole ratio of MIP was determined as the most convenient polymer for CA recognition. In addition, nonimprinted polymers (NIPs) without templates were prepared. Dynamic and static adsorption tests were applied to determine the absorption features of the NIPs and CA-MIPs. Separation and purification studies of CA and CLA were performed with molecular imprinted solid phase extraction (MISPE) application. All steps of MISPE (loading, washing, elution) were optimized by HPLC analysis.
Citation - WoS: 3
Citation - Scopus: 4
Qualitative and Artificial Intelligence-Based Sentiment Analysis of Turkish Tweets Related To Schizophrenia
(Turkiye Sinir ve Ruh Sagligi dernegi, 2023) Dikec, Gul; Oban, Volkan; Usta, Mirac Baris; Hemşirelik Bölümü
Objective: The aim of this study was to qualitatively examine Turkish tweets about schizophrenia in respect of stigmatization and discrimination within a one-month period and to conduct emotional analysis using artificial intelligence applications. Method: Using the keyword 'schizophrenia,' Turkish tweets were gathered from the Python Tweepy application between December 19, 2020 and January 18, 2021. Features were extracted using the Bidirectional Encoder Representations from Transformers (BERT) method and artificial neural networks and tweets were classified as positive, neutral, or negative. Approximately 5% of the tweets were qualitatively analyzed, constituting those most frequently liked and retweeted. Results: The study found that, of the total of 3406 schizophrenia-related messages shared in Turkey over a period of one-month, 2996 were original, and were then retweeted a total of 1823 times, and liked by 25,413 people. It was determined that 63.4% of the tweets shared about schizophrenia contained negative emotions, 28.7% were neutral, and 7.71% expressed positive emotions. Within the scope of the qualitative analysis, 145 tweets were examined and classified under four main themes and two sub-themes; namely, news about violent patients, insult (insulting people in interpersonal relationships, insulting people in the news), mockery, and information. Conclusion: The results of this study showed that the Turkish tweets about schizophrenia, which were emotionally analyzed using artificial intelligence were found often to contain negative emotions. It was also seen that Twitter users used the term schizophrenia, not in a medical sense but to insult and make fun of individuals, frequently shared the news that patients were victims or perpetrators of violence, and the messages shared by professional branch organizations or mental health professionals were primarily for conveying information to the public.
Citation - WoS: 8
Citation - Scopus: 6
RELATIONSHIP OF DAILY TIME SPENT OUTDOORS WITH SLEEP QUALITY AND EMOTIONAL WELL-BEING AMONG COMMUNITY-DWELLING OLDER ADULTS DURING COVID-19 RESTRICTIONS
(Gunes Kitabevi Ltd Sti, 2021) Sansal, Kenan Eren; Balci, Leyla Atas; Cinar, Fadime; Coskunsu, Dilber Karagozoglu; Tanriover, Sezin Hatice; Uluengin, Mehmet Bengu; Fizyoterapi Ve Rehabilitasyon Bölümü
Introduction: Given the recent constraints imposed due to the ongoing COVID-19 pandemic and the importance of the daily light-dark cycle for entraining the human circadian system, it is possible to state that the elderly are likely to be at serious risk of experiencing sleep-related problems. Whilst reduced or limited time outdoors, and thus, exposure to diurnal bright light appear to be detrimental to sleep and emotional well-being in old age, further research is required to confirm this relationship. Materials and Method: To build on earlier work, a two-week study was conducted in a sample of 79 community-dwelling older adults recruited by using snowball sampling method. Throughout the study, the participants were allowed to be outdoors from 10.00 a.m. to 1.00 p.m. on weekdays. Whilst the participants were performing their daily habitual activities, they were asked to keep an activity diary and report on their sleep quality and emotional wellbeing using two questionnaires. Results: The results demonstrated that participants' daily time spent outdoors (49.13 minutes on average) positively correlated with their perceived sleep quality and emotional well-being at various - but significant - levels (p<0.05). Moreover, significant negative correlations were identified between participants' sleep quality and experienced emotional disturbances (p<0.001). Conclusion: Based on the research findings, it is reasonable to conclude that spending momentary periods outdoors may have adverse consequences for the elderly. To maintain a healthy sleep-wake cycle and alleviate related emotional problems in old age, increasing outdoor time and diurnal bright light exposure should be encouraged.
Safe Drug Administration in Pediatric Nursing Education: A Quasi-Experimental Design Study
(Ataturk Univ, 2023) Onturk, Zehra Kan; Sanci, Yagmur; Hemşirelik Bölümü
Objective: This study was carried out to determine the correlation between the performance of students who received simulation-based pediatric nursing education and their self-confidence regarding safe drug administrations during simulation.Methods: The study was conducted in pretest and posttest quasi-experimental design and carried out on a sample group (n =39) based on criteria established at the Nursing Department of a foundation university. Students were subjected to a simulation of "Drug Management in Children" within the scope of the pediatric nursing course. The researchers collected data through a check-list, a self-confidence scale, and tests (pretest and posttest) used in the simulation application on "Drug Management in Children."Results: The students obtained a mean score of 129.00 +/- 14.36 on the self-confidence scale. The posttest scores of the students were statistically significantly higher than the pretest scores (P = .011). The performance mean score of the students from the simulation checklist for safe drug administrations was 36.28 +/- 6.65. There was no statistically significant correlation between the scores from the self-confidence scale, the pretest, the posttest, and the checklist scores (P> .05).Conclusion: This study underlines the importance of having a suitable level of self-confidence for students' educational gains and also indicated that there was no correlation between self-confidence and performance.
Seçici Enternasyonalizmden Askeri İzolasyona ABD Dış Politikasında Türkiye (1918-1923)
(Istanbul University, 2025) Papuççular, Hazal; Siyaset Bilimi ve Uluslararası İlişkiler Bölümü
Bu makale Millî Mücadele döneminde Amerika Birleşik Devletleri’nin Türkiye’ye yaklaşımını ve bu yaklaşımın zaman içindeki değişimini incelemektedir. Çalışma, Amerika’nın Millî Mücadele ile olan ilişkisine dair dört bulgu ortaya koymak- tadır. Birincisi, 1918 sonrasında Başkan Wilson’ın bölgeye bakışının çoğunlukla Ermenistan mandası üzerinden şekillenip sekteryan bir tercihi yansıttığıdır. Bu durum, başkanın enternasyonalist düşüncelerinde seçici olduğunu göstermektedir. İkincisi, Anadolu’daki gayrimüslimlerin durumunun Wilson’ın başkanlığından sonra da ABD’nin bölgeye bakışındaki önemli unsurlardan biri olmaya devam ettiğidir. Ancak Wilson döneminin aksine, ABD bu meseleleri takiple yetinmiş ve çoğu zaman konuya müdahil olmamıştır. Bu durum, ABD dış politikasında yaşanan askeri-siyasi izolasyon süreci ve bu zaman zarfında dış ilişkilerde ticari çıkarların ön planda olmasıyla yakından ilişkilidir. Üçüncüsü, Türklerin Millî Mücadele’de zamanla artan başarısının da ABD’yi iktisadi ve ticari çıkarları sebebiyle Ankara’ya karşı daha farklı bir politika izlemeye itmesidir. Sonuncusu ise hem gayrimüslimler hem de iktisadi çıkarlar çerçevesinde, yardım misyonları, iş çevreleri, lobi grupları gibi birbiriyle çatışan hedefleri olan çeşitli aktörlerin bu süreçte Amerikan siyasetini etkilemek için yoğun çaba sarf ettiğidir. Makale, Ankara’nın ABD’ye temel bakışının ise İngiltere ve Fransa’ya karşı bir denge oluşturma politikası olarak analiz etmektedir. Bu bağlamda, Türkiye’nin ABD ile olan ilişkileri kuruluş dönemi diplomasisini de iyi bir biçimde yansıtmaktadır.

Browse

Browsing TR-Dizin İndeksli Yayınlar Koleksiyonu by WoS Q "Q4"