TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9

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Citation - WoS: 1
Citation - Scopus: 1
A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts
(Marmara University, 2025) Sen, Ali; Servı, Hüseyın; Barak, Timur Hakan; Tekin, Fethullah; Şener, Azize; Marzi, Mahdi; Gülmez, Gizem
Plants are the significant global interest as alternative treatment sources with their biologically activecompounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobialproperties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemicalcompositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC)contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showedthe highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. TheMIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714;2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies haveshown that TPC was 100.60±5.06, 127.90±0.30, 69.01±0.30 mg GAE /g extract; TFC was 80.07±0.15, 25.35±0.0, 16.58±0.31mg KE/g and TTC was 217.30±6.05,172.40±2.17, 126.30±4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 inparticular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategiesand potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also apreliminary study for future studies.
Acute Serious Hepatitis of Unknown Cause in Children
(Galenos Publishing House, 2022) Kılbaş, E.P.K.; Altındiş, M.
On April 5, 2022, an increase in cases of acute hepatitis of unknown etiology was reported in previously healthy children under the age of 10 in the United Kingdom. Since there is no link between these patients, called acute non-HepA-E hepatitis, and viral hepatitis agents (hepatitis A, B, C, D, and E), the possible etiology, and pathogenesis of this emergency is being investigated. One of the alarming features of this epidemic is the high requirement for liver transplantation in a fraction of the cases. In cases other than hepatitis A, B, C, D, and E, a case definition is made by looking at a series of clinical pictures, including serum transaminase levels and age. As of August 26, 2022, 513 cases of acute hepatitis have been reported in Europe and 1,010 globally. Adenovirus was detected in 75% of cases tested in the UK, but data for other countries are still lacking. The role of other etiologic agents is still under investigation. The exact disease pathogenesis has not yet clear. Evidence of human-to-human transmission of the disease remains unclear. Epidemiological studies are critical in clarifying the uncertainties regarding the existence of links between the cases reported to date. Continuing the national and international surveillance activities of the countries in an organized manner is the most basic issue required for the elimination of the epidemic. Copyright © 2022 Tehran University of Medical Sciences.
Adaptation of Caregivers' Task Scale for Multiple Sclerosis To Turkish Society: Validity and Reliability Study
(Dokuz Eylul Univ inst Health Sciences, 2022) Eroglu, Nermin; Tosun, Anil Tekeoglu
Objectives: This study was planned and carried out methodologically to adapt the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS) to Turkish society. Methods: A methodological research. The study was conducted with caregivers of individuals with multiple sclerosis who presented to the neurology clinic of a university hospital between June 2019 and September 2020. The validity and reliability study of the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS) was performed with a total of 142 individuals, which is more than 5 times the number of items on the scale (24 items). Results: The validity of the CTiMSS was evaluated with language validity, construct validity (CFA), and content validity. The reliability coefficient of the internal consistency analysis (Cronbach's Alpha) was found to be extremely high (0.97). Item-total correlation of the scale was examined, and accordingly, no items were removed from the scale. The scale was administered to 30 patients at a two-week interval to analyze test-retest reliability and time-dependent invariance. Conclusion: The CTiMSS, which was adapted to Turkish society to evaluate the tasks of individuals providing care for individuals with multiple sclerosis, is a valid and reliable tool. We recommend that it should be administered to different groups and cultures to increase its evidence value. CTiMSS is an appropriate measurement tool to determine the duties of caregivers of individuals with multiple sclerosis.
Brain in Metabolic Syndrome Model: the Effect of Exercises and Caloric Restriction
(Marmara Univ, 2022) Alev-Tuzuner, Burcin; Genc-Kahraman, Nevin; Ipekci, Hazal; Ustundag, Unsal Veli; Tunali-Akbay, Tugba; Emekli-Alturfan, Ebru; Yarat, Aysen
Caloric restriction (CR) and exercise (EX) have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX and/or CR in metabolic syndrome (MeS) induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10% fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX and/or CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control (C) group. These parameters reduced significantly in the metabolic syndrome with caloric restriction (MeS+CR) group, and more significantly in the metabolic syndrome with exercise and caloric restriction group (MeS+EXCR), compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeS+CR group, and MeS+EXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeS+EXCR group.
Canlı Karaciğer Donör Adaylarında Hepatosteatozun Saptanmasında Biyopsi, Bilgisayarlı Tomografi ve Manyetik Rezonans Görüntülemenin Karşılaştırılması
(2021) Sokmen, Bedriye Koyuncu; Şahin, Tolga; Koçak, Erdem; Oral, Alihan
Amaç: Karaciğer donöründe hepatosteatoz (HS) varlığı, karaciğer transplantasyonu sonuçları üzerinde olumsuz etkilere sahiptir. Bu nedenle, donörde HS’nin tespiti, nakil öncesi dönemde hayati önem taşımaktadır. Bu çalışmanın amacı, canlı karaciğer donör adaylarında HS’nin saptanmasında karaciğer biyopsisi ve radyolojik yöntemlerin etkinliğini karşılaştırmaktır. Gereç ve Yöntem: Demiroğlu Bilim Üniversitesi’ne karaciğer transplantasyonu için donör adayı olarak kabul edilen 226 sağlıklı birey çalışmaya dahil edildi. Donörlerin demografik, histopatolojik, laboratuvar ve görüntüleme bulguları retrospektif olarak incelendi. Donörlerin bilgisayarlı tomografi (BT) ve manyetik rezonans görüntüleme (MRG) taramaları geriye dönük olarak yeniden değerlendirildi ve karaciğer yağ ölçümleri kaydedildi. Bulgular: Hastaların %39’u (88) kadın, %61’i (138) erkekti. Çalışma popülasyonunda ortalama yaş 34,3±8,7 yıl, ortalama ağırlık 78,0±12,6 kg, ortalama boy 169,1±9,6 cm ve ortalama vücut kitle indeksi 27,2±4,0 idi. Karaciğer biyopsisinde donörlerin %42’sinde <%5 HS vardı ve donörlerin %58’inde >%5 HS vardı. Hem BT hem de MRG, HS saptamada biyopsi ile anlamlı korelasyon gösterdi (p<0,05). Sonuç: Çalışmamızda MRG’nin BT kadar biyopsi ile ilişkili olduğu ve HS’nin saptanmasında rahatlıkla kullanılabileceği bulunmuştur. Karaciğer donörlerinde MRG kullanımı, iyonizan radyasyon içermemesinden dolayı nakil öncesi donör için daha uygun bir yöntem olabilir.
The Challenges Experienced by International Nursing Students in Nursing Education: a Qualitative Study
(Ataturk Univ, 2024) Elmali Simsek, Hulya; Karali, Ece; Arslan, Gunay
Objective: The study aimed to determine the challenges experienced by international nursing undergraduate students during their education period. Methods: A phenomenological research design was used. The study was conducted with 20 international nursing students enrolled in a foundation university in T & uuml;rkiye. Colaizzi's phenomenological data analysis method was employed in the study. Results: Based on the study's results, three main themes, 'Learning in a different environment', 'Challenges', 'Solution-Non Solution' and 'System difference, Language problems in clinical practice, Broad nursing curriculum, Facilitators, Language barrier, Feeling homesick, Racism and discrimination, Housing difficulties, Lack of funding, Instant solution, Failing to find a solution sub-themes themes were created. Conclusion: It has been observed that students experience different environments, uncertainties, and various challenges, and that these situations directly affect their education and success. To that end, both the institutions they receive education and the academicians must support the students in various ways.
Citation - WoS: 1
Chatgpt as a Solution To Emotional Loneliness: a New Tool for Interpersonal Communication
(Marmara Univ, Fac Communication, 2024) Sarioglu, Elif Basak; Guregen, Esra Pelin
Loneliness stands as one of the most pervasive and universal health issues in contemporary society. This study, conducted within the scope of emotional loneliness, delves into the nuances of loneliness, understanding its origin and how it manifests in individuals. In the research where students from the Faculty of Communication of a foundation university in Istanbul were chosen as the sample, the data collected through in-depth interviews, a qualitative data collection tool, were analyzed using content analysis method. This phenomenological research design aimed to assess participants' attitudes toward utilizing a chatbot (ChatGPT) as a tool to combat emotional loneliness. Despite their generally positive disposition and strong tendency to anthropomorphize, participants were found to approach the use of ChatGPT with caution. The majority harbored negative judgments about ChatGPT and technological tools meeting emotional and social needs. However, a significant portion believes that the widespread adoption of ChatGPT and similar tools for socialization is imminent in the near future. Concerns predominantly revolve around mistrust in artificial intelligence technologies' ability to meet emotional needs and the potential harms they could inflict on socio-cultural life, with ethical issues forming another major theme. Notably, when expressing their apprehensions, participants frequently referenced artificial intelligence representations in popular culture, such as films, series, and games.
Chelsea Yoğun Bakım Fiziksel Değerlendirme Aracı’nın (CPAx-TR) Türkçe Versiyonunun Güvenirliği ve Geçerliği
(2025) Pehlivan, Esra; Baydılı, Kürşad Nuri; Uyaroğlu, Mehmet Burak; Koyutürk, Gamze; Parlak, Hakan
Amaç: Yoğun bakım ünitelerinde (YBÜ), hastaların fonksiyonel durumunu değerlendirme klinik karar verme açısından kritik roldedir. Chelsea Kritik Bakım Fiziksel Değerlendirme Aracı (CPAx), YBÜ hastalarında fonksiyonel durumu değerlendirmek için geliştirilmiş, geçerliliği kanıtlanmış bir araçtır. Çalışmanın amacı; CPAx aracının Türkçeye kültürlerarası uyarlamasını yapmak ve yoğun bakım hastalarında geçerlik ve güvenirliğini değerlendirmektir. Gereç ve Yöntem: Çeviri ve geri çeviri yöntemi ile Türkçe’ye uyarlanan araç, yoğun bakım ünitesinde yatan 60 hastaya uygulanmıştır. Güvenirlik analizi kapsamında, iç tutarlılık Cronbach’s alpha katsayısı ile değerlendirilmiştir. Yapı geçerliği kapsamında faktör Analizi kullanıldı. Kriter geçerliği kapsamında ise, CPAx aracı ile Fiziksel Fonksiyon YBÜ Testi (P-FIT) arasında Pearson korelasyon analizi yapılmıştır. Bulgular: Aracın iç tutarlılığı yüksek bulunmuş, Cronbach’s alpha değeri 0,960 olarak hesaplanmıştır. Madde-toplam puan korelasyonlarının tamamı 0,30’un üzerinde çıkmıştır. Açımlayıcı faktör analizi sonucunda, tüm maddelerin tek faktörde toplandığı görülmüştür. Doğrulayıcı faktör analizinde modelin iyi uyum gösterdiği belirlenmiştir (CMIN/df=1,207; CFI=0,993; NFI=0,959; GFI=0,907; RMSEA=0,059). Ayrıca, P-FIT ile yapılan korelasyon analizinde güçlü bir pozitif ilişki bulunmuştur (r = 0.892; p Sonuç: CPAx-TR’nin YBÜ hastalarında işlevselliği değerlendirmede kabul edilebilir düzeyde geçerlik ve güvenirlik gösterdiği tespit edilmiştir.
Determination of Age- and Gender-Specific Reference Values for Different Functional Tests with or without Cognitive Dual-Task in Young Adults: An Observational Study
(Turkey Assoc Physiotherapists, 2025) Analay Akbaba, Yildiz; Emirza Cilbir, Cigdem; Poyraz Isleyen, Tugce; Evrendilek, Halenur; Gungor Eroglu, Nazli; Asena Yekdaneh, Aye; Gungor, Feray
Purpose: To determine the age-and gender-specific reference values for the five functional tests performed with or without cognitive dual-task in young adults. Methods: In this cross-sectional observational study, a total of 107 participants were divided into four subgroups based on gender and age: females 18-25 years (G1), and 26-35 years (G2), and males 18-25 years (G3), and 26-35 years (G4). Participants completed the timed up and go test (TUG), 4 meter gait speed test, 10 meter walk test (10MWT), timed 25-foot walk test, and 1 minute sit-to-stand test (1MSTS) with and without dual-tasks. The mean value of each test was recorded. Results: Significant differences were observed in some functional tests. TUG was longer in G1 compared to G2 (p=0.019), 10MWT dual-task performance differed between G1 and G3 (p=0.041), and 1MSTS and 1MSTSdual scores were higher in G3 compared to G4 (p=0.044 and p=0.035, respectively). All dual-task conditions led to decreased performance compared to single-task conditions (p<0.001) Conclusion: The dual-task added to the performance tests changes the time, speed, and number of repetitions in healthy individuals, and these effects may vary according to age and gender. These reference values can guide clinical assessments of dual-task performance in this population.
Determination of Post-Earthquake Trauma Level and Investigation of the Relationship with Physical Activity Status
(Turkish Physiotherapy Association, 2025) Tosun, Anil; Yılmaz, Nergis; Luque, Demet Tekın De Las Penas
Amaç: Çalışmanın amacı; 06 Şubat 2023’te meydana gelen Pazarcık-Elbistan merkezli depremler sebebiyle kişilerde oluşan travma düzeyinin, kişinin fiziksel aktivite durumu ile ilişkisini incelemektir. Aynı zamanda, kişilerde deprem sonrası ağrı varlığının sorgulanması ve bu durumun travma düzeyi ile ilişkisini ortaya koymaktır. Yöntem: Veriler çevrimiçi olarak Google formları aracılığıyla toplandı, 18-65 yaş arası 388 gönüllü katılımcı (299 kadın, 89 erkek) çalışmaya dahil edildi. Katılımcıların genel özelliklerini belirlemek için “Sosyodemografik Bilgi Formu”, travma düzeyini değerlendirmek için “Deprem Sonrası Travma Düzeyini Belirleme Ölçeği” (DSTDBÖ) ve fiziksel aktivite durumlarını belirlemek için “Uluslararası Fiziksel Aktivite Anketi Kısa Formu” (IPAQ-KF) kullanıldı. Bulgular: Deprem bölgesinde bulunma durumuna göre DSTDBÖ genel puan ortalamaları arasında anlamlı fark saptandı (p<0,001). Deprem bölgesinde bulunan 126 kişinin DSTDBÖ genel puan ortalaması 57,66±19,87 iken, bölgede bulunmayan 262 kişinin ortalaması 49,00±18,49 olarak bulundu. Spearman korelasyon analiziyle deprem bölgesinde olan ve olmayan bireylerin IPAQ-KF toplam puanları, DSTDBÖ alt faktör ve toplam puanları arasındaki ilişki incelenmiş olup sadece “Bilişsel Yapılandırma” alt faktörü ile IPAQ-KF toplam puanları arasında anlamlı bir ilişkiyi yansıtmayan negatif zayıf ilişki bulundu (deprem bölgesinde olanlar için Spearman korelasyon katsayı değeri =-0,18, p=0,042). Ve deprem sonrası ağrı yaşayan bireylerin DSTDBÖ puanları, ağrı yaşamayanlardan daha yüksek olarak saptandı (p=0,000). Sonuç: Bu çalışma ile deprem sonrası travma düzeyinin, fiziksel aktivite ile negatif ilişki gösterdiği belirlendi. İnaktif bireyler daha yüksek travma düzeylerine sahipken, minimal aktif bireylerde travma düzeyleri daha düşük bulundu. Bu bulgular, deprem sonrası fiziksel aktivitenin artırılmasının travma düzeylerini azaltmada etkili bir strateji olabileceğini göstermektedir. Bu alanda daha fazla araştırma, eğitim ve proje çalışmalarının yapılması gerekmektedir.
Determining the Type 2 Diabetes Risks and Healthy Lifestyle Behaviors of First Year University Students
(Dokuz Eylul Univ inst Health Sciences, 2022) Eroglu, Nermin; Temiz, Gamze
Introduction: The present study was planned and carried out as a descriptive and cross-sectional study for determining the Type 2 diabetes risks and healthy lifestyle behaviors of first year university students. Material and Methods: The study was carried with 185 students at a foundation university in Istanbul during the dates of November-December 2019. The data were acquired online via Student Information Form, Type 2 Diabetes Questionnaire (FINDRISK) and Healthy Lifestyle Behaviors Scale. Results: The mean age of the students in the study was 19.79 +/- 2.47 years, 53.5 % (n=99) were male, 29.7 % (n=55 previously graduated from another university, 62.1 % (n=115) were students and it was determined that 50.3 % (n=93) had diabetic relatives. It was observed when the diabetes risk status was examined for all participants that they are in the low risk group due to a FINDRISK total score of <7. Conclusion: The study results emphasize the importance of determining the risk for university students to be diabetic in the next decade, putting forth the individuals with high risk and moving onto the next stage for diagnosis. In addition, it has been determined that the level of knowledge of students may have a positive impact on their healthy lifestyle behaviors.
Determining the Type 2 Diabetes Risks and Healthy Lifestyle Behaviors of First Year University Students (Vol 6, Pg 420, 2022)
(Dokuz Eylul Univ inst Health Sciences, 2023) Eroglu, Nermin; Temiz, Gamze
Digital Travel Memories: a Comparison of Physical and Online Travel Experiences in the Terms of Recollection
(Marmara Univ, Fac Communication, 2022) Eyrek, Aysun
The study aims to undertake a comparison of physical and online travel experiences in terms of their recollection and the differences between each experience. Digitalization of travel is explained as visiting a place virtually by means of digital devices instead of visiting it physically. In the first part of the research, in which both qualitative and quantitative research methods were used, the viewer comments written under two most-viewed walking tour videos on YouTube were examined by using sentiment and text analysis which are among the social network analysis methods. In the second of the research, focus groups study are conducted with qualitative and experimental design. The focus groups consist of participants who visited the two cities (selected as sample) either physically (control groups) or online (experimental group). In the sentiment analysis, it was concluded that the positive and neutral sentiment expressions were higher than negative expressions, and in the text analysis individuals approached the online walking tours as a travel experience., In the focus groups research, it was observed that the use of natural sounds, the high visual quality in the videos are effective on individual's recollection of their travel in the online travel experiences. The content of the memories of physical travel experiences is usually about human interactivity and social life. In both travel experiences, it was determined that the information obtained by the individuals about the place through the media strengthens the recall of the images of their travel experiences.
Citation - WoS: 10
Citation - Scopus: 11
The Effect of cotinus Coggygria L. Ethanol Extract in the Treatment of Burn Wounds
(Marmara Univ, 2022) Erta, Busra; Okuyan, Betul; Sen, Ali; Ercan, Feriha; Onel, Huseyin; Goger, Fatih; Sener, Goksel
The overall aim of the present research is to evaluate for the first time the curative effect of Cotinus coggygria leaves on burn injury in an experimental burn model along with its anti-inflammatory and antioxidant activity potential. Also, phenolic compounds of C. coggygria were characterised by LC-MS/MS. Wistar albino rats weighing 200-250 g were exposed to 90 degrees C bath for 10 s to induce burn injury, involving 30% of the total body surface area. In the treatment groups, 5% C. coggygria ethanol extract was applied topically as a cream immediately after the burn. Blood and skin tissue samples were taken after decapitation at the 4th and 48th hours following the burn procedure. Interleukin 1-beta (IL-1 beta) and tumour necrosis factor (TNF-alpha) were determined in serum samples, and hydroxyproline, prostoglandin E2 (PGE2), and myeloperoxidase (MPO) activity and 8-hydroxy-2'-deoxy-guanosine (8-OHdG) levels were determined in skin tissue samples. Increased levels of serum cytokines were decreased with C. coggygria treatment in both periods. MPO activity, prostaglandine (PGE2), and 8-OhdG levels increased, while hydroxyproline levels decreased due to burn damage. On the other hand, these parameters were returned to its normal levels with C. coggygria treatment. In addition, the tissue histology of animals treated with C. coggygria showed a complete epithelialization with increased collagenation. As a result, C. coggygria may be an alternative treatment approach for burns-induced skin damage and wounds.
Citation - WoS: 7
Effect of Flurbiprofen Derivative (sgk597) on Cell Proliferation and Apoptosis of Breast Cancer Cell Lines
(Istanbul Univ, Fac Pharmacy, 2022) Atlihan, Irem; Sevinc, Sevgi Kocyigit; Orun, Oya; Yilmaz, Ozgur; Kucukguzel, S. Guniz; Tiber, Pinar Mega
Background and Aims: The incidence of breast cancer is increasing day by day, especially in women. The search for new drugs against breast cancer is the focus of attention in research. Breast cancer and prostate cancer have remarkable biological similarities. Therefore, the 4-(4-chlorophenyl)-3-(1-(2-fluoro-[1,1'-biphenyl]-4-yl)ethyl)-5-((4-fluorobenzyl)thio)-4H-1,2,4-triazole (SGK597) compound that is suppressing cell proliferation in prostate cancer, was studied in MCF-7 breast can-cer and MCF-10A mammary epithelial cell lines. Methods: The WST-8 method was used to determine cell viability and cytotoxicity of SGK597 in MCF-7 and MCF10-A cell lines. The JC-1 test was applied to determine changes in mitochondrial membrane potential. The protein expression levels of Bax, Bcl-2, and c-PARP associated with apoptosis were determined using Western blot analysis.Results: After 24 and 48 hours of incubation of SGK597, the IC50 values were 28.74 pM and 17.28 pM for MCF-7; 65.9 pM and 50.5 pM for MCF-10A, respectively. Mitochondrial membrane potential showed a tendency toward depolarization in MCF-7 cells as a result of increasing concentration of SGK597, while the same tendency was not seen for MCF-10A. As a result of western blot experiments, no increase in the Bax/Bcl-2 ratio and c-PARP expression level was observed, indicating no apoptosis.Conclusion: It was observed that the compound SGK597 suppressed MCF-7 cell proliferation. These results indicate that SGK597 may be a candidate compound for use as an anticancer agent. Keywords: Apoptosis, breast cancer, flurbiprofen, thioether, triazole
Effect of Pilates Exercises on the Body Composition of Fasting Females
(Galenos Publ House, 2022) Batar, Nazli; Kermen, Seda; Sevdin, Sezen; Ersin, Aybuke; Guclu, Duygu
Objective: This study aimed to evaluate the changes in the body composition of individuals who fasted and did Pilates at least twice a week during Ramadan versus those who fasted but did no Pilates. Methods: This was an experimental study conducted on 60 healthy women who were admitted to the Noi Pilates in Istanbul Turkey, which was a private Pilates studio. The study was carried out on 60 grown-up, healthy women between 18 and 65 years of age who fasted in Ramadan 2019, some of whom did Pilates and some who did not. The women involved in the study had been doing Pilates for 6 months prior to Ramadan and did Pilates at least 3 times a week during Ramadan. Results: Significant increases were observed in body mass index (BMI), triceps skin-fold thickness (SFT), muscle mass and fat percentage in the fasting and non-pilates group (p<0.05). Our study found the change in the percentage of triceps SFT and fat in women who did Pilates to be more than those who did not. BMI, muscle mass, waist circumference and hip circumference of women who did Pilates and who did not do Pilates during Ramadan did not differ compared to the first measurements, and neither of the two methods dominated in terms of these variables. Conclusion: While a long period of fasting in Ramadan leads people to inactivity, personalized exercise and nutrition programs planned by experts may result in weight loss, especially for obese and slightly overweight people.
Citation - WoS: 1
The Effect of Training on Stress and Coping With Stress in Patients Receiving Infertility Treatment
(Cukurova Univ, Fac Medicine, 2020) Eroglu, Nermin; Temiz, Gamze
Purpose: This study was planned and applied semi-experimentally to examine the effect of education given to patients receiving infertility treatment on stress and coping with stress. Materials and Methods: The study is semi-experimental. It was held between May 2017 and January 2018 with individuals who applied to a foundation hospital in Istanbul province for IVF treatment. The sample was made up of 40 infertile individuals. The data were collected by the researcher through face-to-face interview method. Training was given after pretesting. Post-test was performed one month after the training. Results: The pre-education stress scale of middle school graduates of infertile women was higher, this difference disappeared after education, and there was a statistically significant difference between the infertility stress and coping scale subscale mean scores. As the use of active ignoring, active struggling and passive ignoring coping methods of women, the use of the methods of coping with the infertility subscale scores increased, the infertility stress subscale scores increased.. Conclusion: In this study, the relationship between infertility and stress research was investigated and it was concluded that the treatment process and results are an important source of stress in patients. According to the results obtained, it is recommended to determine the stress level and methods of coping with stress, and provide training and counseling on patients who apply to the hospital for infertility treatment.
The Effect of Vitamin D and Paricalcitol on Protein Disulfide Isomerase
(Marmara University, 2025) Koksal, Murat; Şekerler, Turgut; Şener, Azize
Protein disulfide isomerase (PDI), a multifunctional protein plays an important role as oxidoreductase, isomerase and chaperone in the cell. Prior studies have identified PDI is highly expressed in many different cancer types and presented as a new potential target for cancer treatment. Here, we investigated vitamin D and its analogue paricalcitol in silico interaction of the human PDI and inhibition of PDI reductase activity in vitro. We observed a non-covalent mechanism where the main skeleton of the vitamin D3 ans paricalcitol sturcture is located at the hydrophobic site in the b' domain of PDI and forms a hydrogen bond with a residue (His138) in tihs domain. They also form multiple weak hydrophobic interactions with various chemical groups of the b' subunit. For the first time, we demonstrate that 1,25-dihydroxyvitamin D3 (1a,25(OH)2 vitamin D3) and paricalcitol inhibit the PDI reductase activity in vitro and their IC50 values are 20.79±1.43 nmol/L and 32.83±3.15 nmol/L respectively. The two compounds can also block the denistrosation activity of PDI.
The Effect on Birth Pain and Process of the Freedom of Movement in the First Stage of Labor: a Randomized Controlled Study
(2022) Yıldız, Hatice; Karaman, Özen Esra
Objective: To determine the effect of freedom of movement implemented in the dilatation stage, which is the first stage of labor, on the labor process in pregnant women who will give their first birth. Methods: This study was designed as a randomized controlled trial. The study consisted of 70 primiparous women, including 35 in the study group (SG) and 35 in the control group (CG). Freedom of movement was provided to the study group in the first stage of labor. Data were collected using a Personal Information Questionnaire, a Labor Assessment Form, and the Visual Analog Scale (VAS) for perceived pain. Results: The SG was observed to be walking when dilatations were 4-7 cm and mostly squatting when 8-10 cm (94.2%). The level of effacement, frequency of contraction, and descent of the fetal head were faster (p
Citation - WoS: 5
Citation - Scopus: 5
Effects of myrtus Communis L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats With a High Fat-Diet
(Galenos Publ House, 2021) Yasar, Ruya Kuru; Kuru, Dilruba; Sen, Ali; Sener, Goksel; Ercan, Feriha; Yarat, Aysen
Objectives: Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals. Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor. The data on tissue boron levels are quite lacking. The aim of this novel study was to investigate the effects of Myr and Apo treatment on boron levels and oxidative lens damage in rats fed a high-fat diet (HFD). Materials and Methods: Wistar albino male rats were randomly divided into four groups: the control group, HFD group, HFD + Myr group, and HFD + Apo group. Body weight and blood lipids were determined before and after the experiment. After decapitating the rats, the lenses were removed and homogenized. Catalase (CAT) and superoxide dismutase (SOD) activities and boron, malondialdehyde (MDA), and reduced glutathione (GSH) levels in the lens homogenates were determined. Results: The HFD increased serum triglyceride (p<0.05), total cholesterol level (p<0.001), body weight (p<0.001), and lens MDA levels (p<0.01) and decreased lens GSH (p<0.05) and boron level (p<0.01), SOD (p<0.001), and CAT activity (p<0.001). However, Myr and Apo treatment reduced the rats' body weight (p<0.001), serum triglyceride (p<0.05), and total cholesterol level (p<0.001) and increased lens boron (p<0.01; p<0.001), GSH levels (p<0.05; p<0.01), and CAT activity (p<0.001). Conclusion: Both Myr and Apo may be able to reduce oxidative stress in the lenses of obese rats caused by HFD by increasing boron levels.

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