TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9

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Determining the Type 2 Diabetes Risks and Healthy Lifestyle Behaviors of First Year University Students (Vol 6, Pg 420, 2022)
(Dokuz Eylul Univ inst Health Sciences, 2023) Eroglu, Nermin; Temiz, Gamze
Citation - WoS: 6
Citation - Scopus: 6
beta Vulgaris L. Var. Cicla Improves Memory Deficits in Intracerebroventricular Streptozotocin Injected Rats: Role on Neuroinflammation
(Marmara Univ, 2021) Ertas, Busra; Topal, Fadime; Gulhan, Rezzan; Yanardag, Refiye; Sacan, Ozlem; Sener, Goksel
Alzheimer's disease is a challenging disease for patients due to progressive loss of cognition and behavioral disorders. Disruption of cholinergic transmission and neuroinflammation are the most important mechanisms underlying cognitive damage. Beta vulgaris L. var. cicla (BV) has been reported to have various pharmacological effects associated with its rich antioxidant content. In addition, anti-cholinesterase and antiinflammatory activities of BV have been demonstrated in vitro. The aim of this study is to elucidate the therapeutic effect of BV against cognitive impairment, reduction in cholinergic transmission and neuroinflammation caused by intracerebroventricular (ICV) administration of streptozotocin (STZ). STZ was administered bilaterally at a dose of 3 mg/kg via ICV to rats, and BV treatment at a dose of 2 g/kg for 21 days was administered orally to STZ-induced animals. After behavioral tests, AChE activity, TNF-alpha and IL-1 beta levels were measured in hippocampus and cortex tissues excised from decapitated animals. Novel object recognition and passive avoidance test showed that the treatment of BV reverted the ICV-STZ induced memory dysfunctions in rats. Furthermore, increased AChE levels in the hippocampal and cortical tissues of STZ-induced rats were significantly reduced with 21 days of BV treatment. In conclusion, these results confirm that STZ administration caused cholinergic hypofunction, neuronal inflammation and cognitive dysfunction in rats, and BV therapy significantly inhibited these changes with its potential neuroprotective activity.
Citation - Scopus: 2
Platanus Orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage
(Marmara University, 2022) Ayaz Adakul, B.; Şen, A.; Şener, T.E.; Erdoğan, Ö.; Çevik, Ö.; Eker, P.; Şener, G.
The aim of this study is to determine whether Platanus orientalis (PO) which has anti-inflammatory, antioxidant and diuretic properties and used in the treatment of kidney stones as traditional folk medicine, will reduce or prevent the stone formation in the urinary system. To simulate the urolithiasis model 0.75% ethylene glycol (EG) and 1% ammonium chloride (AC) were applied to Sprague-Dawley rats. The rats were divided into four groups (n=8). The control group was given standard drinking water for 5 weeks. EG group received 0.75% EG in their drinking water containing 0.75% EG and 1% AC. PO extract (100 mg/kg) was given orally for 5 weeks to the preventive group and for last 2 weeks to the therapeutic group, respectively. At the end of experiment, 24-hour urine and kidney samples were obtained. In urine samples, calcium and citrate levels were decreased and oxalate level was increased in the EG group. In kidney samples myeloperoxidase, caspase-3, N-acetyl-β-glycosaminidase (NAG) activities, malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), tumor necrosis factor-α and interleukin-1β levels were increased while superoxide dismutase activity and glutathione levels were decreased in the EG group. These biochemical parameters returned to control levels in both PO treatment groups. Histological findings also correlate with these results. Our findings are suggested that PO treatments is effective in both preventive and therapeutic groups. © 2022 Marmara University Press.
Citation - WoS: 2
Obesity Risk Factors in Turkish Preschool Children: a Cross-Sectional Study
(Cukurova Univ, Fac Medicine, 2022) Ozkaya, Sebnem Ozgen; Ozkaya, Volkan; Garipagaoglu, Muazzez
Purpose: The present study aims to identify the potential risk factors - pre and post-pregnancy, children's, parental, and environmental factors - concerning obesity in Turkish preschool children.Materials and Methods: The cross-sectional study was conducted with 538 children aged 3-5 and their mothers in 25 private and public kindergartens using a face-to-face survey. Demographic, anthropometric, nutrition, sleep, and physical activity information during pregnancy, infancy, and preschool periods were evaluated. Two-day food records and anthropometric measurements of the children were collected.Results: The prevalence of overweight and obesity in preschool children was found to be 27.0%. Among the 28 potential risk factors examined, pre-pregnancy obesity (odds ratios (OR):1.108, confidence interval (CI): 1.042-1.179), post-pregnancy obesity (OR:4.350, CI: 2.053-9.217), caffeine intake >200 mg/day during pregnancy (OR:1.588, CI:1.031-2.446), father with obesity (OR: 1.089, CI: 1.027-1.155), enrolling a private rather than a public kindergarten (OR: 2.093, CI:1.298-3.376), fast eating (OR:3.355, CI: 1.175-9.583 min), short lunch duration (OR:0.966, CI:0.934-0.998), daily sleep of <10 hours (OR:2.522, 1.439-4.421), and finally screen time of >2 hours/day (OR:1.560, CI:1.012-2.405) were found to be significantly correlated with obesity in preschool children.Conclusion: Parental obesity, caffeine intake during pregnancy, eating speed, daily sleep, and screen time were determined as obesity risk factors in Turkish preschool children. Identifying maternal and child risk factors in early childhood, regulating lifestyle and obesogenic environment can be protective against obesity.
Radioprotective Effect of Resveratrol for Early and Late Ionizing Radiation-Induced Damages on Colon and Rectum in Rats
(Marmara Univ, 2023) Beceren, Ayfer; Aydemir, Sezgin; Atasoy, Beste Melek; Esin, A. K.; Ercan, Feriha; Sener, T. Emre; Sener, Goksel
Radiotherapy, which is routinely used to treat a wide range of oncological disorders, primarily affects the malignant tissue in the targeted area, but also have negative effects in the surrounding tissues. Pelvic radiotherapy causes early and late effects on the colon and rectum. Resveratrol (RVT) has been revealed to have a number of pharmacological effects in a variety of experimental models and clinical circumstances, therefore it has piqued the interest of scientists in recent years. In this study, we aimed to investigate the potential protective effects of resveratrol (RVT), a strong antioxidant, anti-inflammatory and anti-mutagenic agent, against toxicity of colonic and rectal tissues seen in the early and late stages after pelvic radiation. The treatment durations of the current study were designed as one week and ten weeks interval by following radiation exposure. Sprague Dawley rats were divided into 5 groups (8 animals/group) as the control, radiation-early effects (Rd-E), radiation-late effects (Rd-L), and RVT-treated Rd-E (Rd-E+RVT) and RVT-treated Rd-L (Rd-L+RVT) groups. Ionizing radiation was performed to the pelvic area that covers colon and rectum in single fraction of 20 Gy in a linear accelerator using with 6 MV photon energy. RVT was orally administered (10 mg/kg/day) immediately following the radiation exposure and continued daily for 1 and 10 weeks for early and late groups, respectively. Pelvic radiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and 8-hydroxydeoxyguanosine were increased in both Rd-E and Rd -L groups in the colon and rectum tissues. Additionally, light microscopic evaluations (H & E staining) revealed degeneration of epithelium and inflammatory cell infiltration in the colonic and rectal tissues in radiation groups. RVT treatment reversed all conducted biochemical parameters and ameliorated histomorphological changes following early and late effects of pelvic radiation in tissues. In conclusion, resveratrol may be a candidate as a radioprotector for normal tissues during and after radiotherapy.
Metaverse Kapsamında Oyun-içi Reklam Uygulamaları: Sandbox Alpha 2 Örneği
(2022) Güdüm, Sinem; Doğan, Ece
Günümüzde üretüketici (prosumer), yeni dijital gelir modelleri ile çevrimiçi kazanç sağlamak için fırsatlar yaratmada katılımcı bir rol üstlenmekte ve ‘Metaverse’ aracılığıyla sanal dünyadaki daldırmalı (immersive) deneyimlere kucak açmaktadır. Bu gelişmelerin yanı sıra Metaverse, üretüketici (prosumer) için çeşitli riskler de barındırmaktadır. Çalışmada, söz konusu risklerin yanı sıra sanal topluluk temelli tüketici davranışları ve Metaverse kapsamında blok zincir teknolojisine dayalı reklam olanakları incelenmiştir. Bu bağlamda, Metaverse üzerinde devam eden SandBox Alpha Test 2, sınırlı bir vaka çalışması olarak ele alınmış ve test yayının ilk gününden son gününe kadar toplanan veriler analiz edilmiştir. Test aşamasındaki oyunda çalışmayan ya da hatalı link gibi teknik sorunlarla karşılaşılması ve sanal platformun çok geniş olması çalışmanın kısıtları olarak verilebilmektedir. Bunları en aza indirmek için, iki araştırmacı çalışmayı hem gündüz hem de gece olmak üzere daha uzun bir süre zarfı boyunca yürütmüştür. Araştırmanın sonucunda SandBox platformunun; NFT pazarlama, Direct 2 Avatar uygulamaları, “oynayarak kazan / earn to play” özelliği ve SandCoin kullanımı çerçevesinde; kullanıcılara güvenilir oyun-içi alışveriş imkanı sağlarken, aynı zamanda da kazanç elde etmelerine imkan verdiği saptanmıştır.
Validity and Reliability of the Symptom-Management Self- Efficacy Scale for Breast Cancer Related To Chemotherapy
(Galenos Publ House, 2022) Semiz, Demet; Saglam Aksut, Rabia
Objective: Since breast cancer (BC) is one of the most common cancer types among women, it is very important for nurses to assess symptom-management and self-efficacy of patients during chemotherapy treatment. This study was carried out to examine the validity and reliability of the symptom-management self-efficacy scale for BC related to chemotherapy. Methods: The study sample of this methodological research consisted of 248 women receiving chemotherapy treatment due to breast cancer in a public hospital in Istanbul between November 2017 ans March 2018. Translation-back translation method was used to assess the language validity of the scale. Kaiser-Mayer-Olkin and Bartlett's tests were applied to evaluate the sampling adequacy and the suitability of the data for factor analysis. Results: The content validity of the Turkish form was 0.912; Cronbach alpha coefficient of the scale was 0.905. The factor loads of all the items belonging to the scale were above 0.40, and explained variance for the scale was as follows; 16,284 for the problem-solving sub-dimension; 13,517 for the sub-dimension of managing problems in emotional and interpersonal relationships, and total explained variance of the scale was found to be 46,944. For this reason, no items were removed from the scale and the scale was accepted as having 3 sub-dimensions as it was in the original. Conclusion: Findings obtained from this study showed that the Turkish version of the scale was valid and reliable and could be used in research and clinical practice in Turkey.
Determining the Type 2 Diabetes Risks and Healthy Lifestyle Behaviors of First Year University Students
(Dokuz Eylul Univ inst Health Sciences, 2022) Eroglu, Nermin; Temiz, Gamze
Introduction: The present study was planned and carried out as a descriptive and cross-sectional study for determining the Type 2 diabetes risks and healthy lifestyle behaviors of first year university students. Material and Methods: The study was carried with 185 students at a foundation university in Istanbul during the dates of November-December 2019. The data were acquired online via Student Information Form, Type 2 Diabetes Questionnaire (FINDRISK) and Healthy Lifestyle Behaviors Scale. Results: The mean age of the students in the study was 19.79 +/- 2.47 years, 53.5 % (n=99) were male, 29.7 % (n=55 previously graduated from another university, 62.1 % (n=115) were students and it was determined that 50.3 % (n=93) had diabetic relatives. It was observed when the diabetes risk status was examined for all participants that they are in the low risk group due to a FINDRISK total score of <7. Conclusion: The study results emphasize the importance of determining the risk for university students to be diabetic in the next decade, putting forth the individuals with high risk and moving onto the next stage for diagnosis. In addition, it has been determined that the level of knowledge of students may have a positive impact on their healthy lifestyle behaviors.
The Use of Probiotics in the Treatment and Prophylaxis of Various Diseases in Turkiye: a Systematic Review
(Bilimsel Tip Yayinevi, 2023) Kilbas, Elmas Pinar Kahraman; Altindis, Mustafa
The aim of this study is to analyze the available information on the use of probiotics containing different microorganisms, singly or in combination, in order to investigate the effect of probiotics on the treatment, prophylaxis and microbiota of various diseases. In addition to Pubmed, Google Scholar, SCOPUS, EMBASE, Cochrane Library of Systematic Reviews, CINAHL, AMED, Turkish Medline electronic da- tabases, the gray literature was searched to cover the years 2004-2021. Randomized controlled studies (RCTs) included in the specified selection criteria were brought together. RCTs were evaluated using the Cochrane risk of bias tool. Of the 32 RCTs included in total, only yeast (Saccharomyces spp.) was administered in fourteen, only Lactobacillus spp. in six, Bifidobacterium spp. only in four, and probiotic supplementation containing more than one bacterial strain in six. Only 10/32 of the included studies fully reported the probiotic strain, and 22/32 reported only at the species level. In all nine studies using probiotics for the treatment of diarrhea, probiotics were reported to shorten the duration of diarrhea and length of hospital stay. Four of the five studies reporting the use of probiotics in the treatment of necrotizing enterocolitis reported that probiotics were not effective in reducing the incidence of necrotizing enterocolitis, but could improve nutritional tolerance. In two of the four RCTs investigating the use of probiotics in the treatment of Helicobacter pylori infec- tion, it was stated that the side effects associated with eradication therapy decreased. In both studies conducted for prophylaxis, it was reported that probiotics prevent antibiotic-associated diarrhea. This study shows that probiotics have positive results for the treatment indications and prophylaxis of various diseases. For the sustainability of these health benefits and the safe administration of probiotics, more research is needed that includes strain information and side effect reports.
Nonviolent Communication in Lifelong Education
(Hacettepe Univ, 2023) Baban, Ece; Erdinc, Ece Dogan
In today's world, the increase of othering and xenophobia with acts of violence, along with the changes that consume resources due to climate changes such as wars, irregular migration movements, famine and thirst, are an important necessity for understanding nonviolent communication and its application in the field of lifelong education. This requirement brought the problem of "adult education" to the agenda and accelerated the studies on the lifelong learning approach. In addition, key messages developed by UNESCO and the European Commission defined the characteristics that the lifelong learning approach should have. Within the scope of the study, the concept of nonviolent communication explained, and the "Make a Gesture Your Opponent" campaign, which includes nonviolent communication training for Turkey Football Federation first league teams, examined. Within the scope of the study, the "Make a Gesture to Your Opponent" campaign was determined as a case study. Accordingly, the official website of the campaign was examined. As a result of the analysis carried out in line with the key messages, the nonviolent communication approach that the "Make a Gesture Your Opponent" project wanted to instill in its participants shows how important education is in all areas of life.
Nursing Students Thoughts and Knowledge Levels About Global Warming
(Marmara Univ, inst Health Sciences, 2024) Gür, Kamer; Kolac, Nurcan; Çalık, Kesver Burcu; Nirgiz, Cansu; Doğan, Rıdvan
Objective: The aim of this study is to determine nursing students’ thoughts and knowledge levels about global warming. Methods: This descriptive study was conducted with 236 nursing students studying at the faculty of health sciences of a state university between May and July 2022. Data were collected using a Sociodemographic Form, the Global Warming Questionnaire. Independent Samples t-test, One-Way ANOVA were used to evaluate the data. Results: Ninety-seven percent of the students stated that global warming was a public health issue. Students’ mean score on the global warming knowledge scale was 90.02±8.76. There was a significant difference between the mean scale score participating in activities on the subject, having received information/education on environment, climate change aside from undergraduate education, wanting to become a member of an environmental non-governmental organization, and school year (p <.05). Conclusion: Participants’ knowledge level about global warming was above the average value of the scale. However, they still needed information, greater sensitivity to participate in environmental non-governmental organizations, global warming activities. For all these reasons, it is recommended that nursing students increase their knowledge and sensitivity during their undergraduate education, learn ways to combat the adverse effects of climate change, put them into practice.
Citation - WoS: 5
The Psycho-Social Effect of The Earthquake on Women in The Eartquake, One of The Disadvantaged Groups: a Qualitative Research
(Mehmet Akif Ersoy Univ, 2023) Aydin, Gulsen Cetin; Aytac, Serpil
Disasters are natural events that vary in severity and impact depending on the location. Disasters damage buildings, products, crops, the environment, people, animals, in short, everything animate and inanimate, and cause living beings to lose their lives regardless of time and place. Individuals are psychologically affected negatively by disasters such as earthquakes. The aim of this study is to evaluate the psycho-social impact of the earthquake that occurred in Kahramanmaras in southeast Turkey on February 6, 2023, on women, one of the disadvantaged groups, in Turkey. As a result of the research, it was understood that the last earthquake disaster in Turkey had a significant impact on women, and how important psychological resilience is in being prepared for disasters. According to the results of the research, it was seen that women had difficulties in coping with the problems they faced during and after the earthquake, they faced stress/depression/anxiety, burnout and the regional conditions had a significant impact on this process. In this direction, it was observed that the earthquake negatively affected the women participating in the research, causing their psychological health disorders and causing depression symptoms.
Evaluation of Growth in Children Aged One- Two Years: a Cross- Sectional Study
(Istanbul Univ, 2022) Guldemir, Hilal Hizli; Simsek, Tugce; Garipagaoglu, Muazzez
Objective: The study was conducted to evaluate growth in children aged 1-2 years. Methods: In this study conducted with 302 children and their mothers, data on children and their families were obtained using a questionnaire. Z-scores were determined by measuring the weight and height of the children, and these were compared with percentile curves developed for Turkish children. Energy and macronutrient consumption were determined by taking a daily food consumption record for each child. Results: The average age, birth weight and height of children were 18.6 +/- 3.2 months, 3.2 +/- 0.5 kg and 50.0 +/- 2.3 cm, respectively. Their current weight and height were determined as 11.4 +/- 1.6 kg and 80.6 +/- 6.5 cm. It was observed that 85.6% of the children had normal body weight, 69.5% normal BMI and 56.2% normal height z score. It has been determined that body weight and height z-scores are higher in girls compared to boys (22.1%, 32.6% and 24.7% respectively in + 2SD). Body weights of children with high monthly income were also found to be significantly higher (15.6% in + 2SD, p=0.038). Conclusions: It has been concluded that the standards, gender and the economic status of the family in this age period are effective on childrens' growth.
Molecular Characterization of Resistance and Virulence Genes in Enterococcus Faecium Strains Isolated Between 2000-2021; Systematic Review
(Bilimsel Tip Yayinevi, 2022) Kahraman Kilbas, Elmas Pinar; Kilbas, Imdat; Ciftci, Ihsan Hakki
Introduction: The spread of Vancomycin-Resistant Enterococci (VRE) is a major threat in healthcare institutions, especially for patients in the risk group. The aim of this study is to reveal the antibiotic resistance genes, virulence genes and other accompanying factors detected in vancomycin resistant Enterococcus faecium strains isolated from various clinical specimens in different parts of Turkiye. Material and Methods: For this purpose, a systematic search was carried out using different electronic databases between January 2000 and September 2021. A total of 17 studies were evaluated within the scope of systematic review. Results: The vanA gene was detected the most between the years 2000-2007, and no statistically significant difference was found according to the years. The prevalence of the vanB gene was highest between 2008 and 2013, and no statistical difference was found according to the years (p> 0.05). The vanA gene was mostly detected in Eastern Anatolia, Black Sea, Mediterranean and Aegean, vanB Central Anatolia and Southeastern Anatolia regions. No reports related to the vanC gene were found. Since all strains were E. faecium in our study, it is an expected finding that the vanC gene region was never reported. The esp and hyl gene between 2014-2021. Conclusion: The prevalence of resistance and virulence genes among bacteria is a matter of great concern, limiting treatment options. In particular, effective measures should be taken to prevent healthcare-associated VRE infections, and each institution should report its own resistance data.
Investigation of the Synergic Effect of the Colistin/Sulbactam Combination in Carbapenem-Resistant acinetobacter Baumannii Complex Strains With Time-Kill and Checkerboard Methods
(Bilimsel Tip Yayinevi, 2021) Kilbas, Imdat; Hatipoglu, Huseyin; Kilic, Umit; Kahraman Kilbas, Elmas Pinar; Koroglu, Mehmet; Altindis, Mustafa
Introduction: Infections caused by carbapenem-resistant Acinetobacter strains have become very common in recent years, and the most frequently used medicinal treatment is colistin. Combination treatments should also be applied to prevent development of resistance to colistin. This study examines the in vitro synergic effect of the colistin/sulbactam combination in carbapenem-resistant Acinetobacter strains with the time-kill and checkerboard methods. Materials and Methods: Twenty carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex strains, which were isolated from various clinical samples, were included in this study. Strains were identified with mass spectrometry, and antibiotic sensitivity results were determined with the VITEK 2 (R) system. The in vitro effect and synergic activity of the colistin, sulbactam, and colistin/sulbactam combination on the carbapenem-resistant strains were determined using the time-kill and checkerboard methods. Seventeen strains were examined with the time-kill method, and twenty strains were examined using the checkerboard method. The fractional inhibitory concentration index of strains was calculated for detection of synergic effect. Results: Using the time-kill method applied on the colistin/sulbactam combination showed that the combination had a synergic effect on all 17 strains, while sulbactam alone did not have a bactericidal effect in the studied concentrations. When applying the checkerboard method, it was determined that the colistin/sulbactam combination had a synergic effect on 17 of the strains (85%) and an additive effect on 3 strains (15%), sulbactam had a low effect alone (15%), and colistin was effective on all strains. Conclusion: Study results indicated that the colistin/sulbactam combination had a high level of synergic effect on all studied strains using both methods.
Relationship Between Coronaphobia, Cognitive Functions, Sleep Quality, and Diet Quality in Older Adults During Covid-19
(Galenos Publ House, 2024) Balci, Leyla Atas; Polat, Selda; Coskunsu, Dilber Karagoezoglu; Altuncevahir, Ilayda; Koc, Bilge Meral; Ozkul, Ecenur
Objective: The relationship between the quality of diet and sleep, cognitive function, and fear related to coronavirus disease-2019 (COVID-19) among older adults in Turkey during the pandemic remains unclear. This study aimed to investigate the correlation between diet quality, cognitive function, sleep quality, and levels of coronaphobia in individuals aged 65 and above, to understand the impact of COVID-19. Materials and Methods: Sleep quality, diet quality, coronaphobia, and cognitive status of 72 older individuals were evaluated using the Pittsburgh sleep quality index, healthy eating index 2010, Montreal cognitive assessment scale, and coronavirus-19 phobia scale, respectively. Results: The participants had poor diet quality (54.2%), poor sleep quality (62.5%), obesity (41.7%), higher levels of coronaphobia, and cognitive impairment. There was a moderate negative relationship between sleep quality and coronaphobia and between cognitive status and coronaphobia (p <= 0.00); and a weak positive relationship between diet quality and cognitive status (p<0.05). However, no relationship was found between sleep quality and diet quality, and between coronaphobia and diet quality (p>0.05). Conclusion: Our study highlights the significant challenges faced by older adults during the COVID-19 pandemic, including poor nutrition quality, sleep disturbances, coronaphobia, and cognitive impairment. Our findings suggest a potential interplay between nutrition quality, sleep patterns, and cognitive function among older adults, with those experiencing coronaphobia exhibiting additional cognitive and sleep-related concerns. We advocate the implementation of targeted interventions aimed at mitigating cognitive impairment, addressing nutritional deficiencies, and improving sleep quality among older adults, irrespective of COVID-19 infection status, to enhance overall well-being during these challenging times.
Panax Ginseng Extract Ameliorates Methotrexate-Induced Multi-Organ Damage Via the Regulation of Oxidative Stress
(Marmara Univ, 2023) Macit, Caglar; Ede-Pazarbasi, Seren; Yilmaz-karaoglu, Suemeyye; Tunali-Akbay, Tugba; Karakaya-Cimen, Fatma Bedia; Ercan, Feriha; Sener, Goksel
Oxidative damage plays an important role in organ toxicities caused by methotrexate (MTX). This study aimed to determine the antioxidant effects of Panax ginseng (PxG) extract against MTX-induced liver, lung, ileum and kidney damage. Twenty-four Sprague Dawley male rats (weight 250-300 g) were used in the study. The animals were randomly separated into three groups: a) Control, b) MTX-treated (MTX) and c) MTX+PxG-treated (MTX+PxG) groups. MTX was administered intraperitoneally at 20 mg/kg, as a single dose to MTX and MTX+PxG groups. PxG was administered orally at 100 mg/kg to the MTX+PxG group for five days. Saline was given to the control and MTX groups for 5 days. At the end of the experiment, liver, lung, ileum, and kidney samples were obtained. Malondialdehyde (MDA) and glutathione (GSH) levels, superoxide dismutase (SOD), glutathione-S-transferase (GST) and tissue factor (TF) activities were determined in all tissues. In addition, histological examinations were done through light microscopy. GraphPad Prism 5v. was used for statistics, and p<0.05 were considered significant. Administration of MTX caused severe injury in tissues. Findings showed that MDA level, SOD, and GST activities were significantly normalized in the MTX+PxG group compared to the control group. A significant reduction in GSH level observed in the MTX group was reversed with PxG administration In addition, TF activity and total protein levels were found to be impaired in the MTX group, but TF activity was significantly improved in liver and lung tissues and total protein level was significantly reversed in lung and ileum in MTX+PxG group. The results of histological examinations showed that MTX-induced damage was ameliorated with the PxG administration. In conclusion, this study shows that Panax ginseng, thanks to its antioxidant properties, reversed MTX-induced tissue damage and therefore may be beneficial against side effects in patients undergoing chemotherapy.
The Effects of Chard Extract Against Streptozotocin-Induced Erectile Dysfunction in Rats
(Istanbul Univ, Fac Pharmacy, 2024) Aydin, Mustafa; Sacan, Ozlem; Kabasakal, Levent; Cetinel, Sule; Kadihasanoglu, Mustafa; Kendirci, Muammer; Sener, Goksel
Background and Aims: To analyze the potential therapeutic effects of chard against streptozotocin (STZ) -induced erectile dysfunction (ED) and oxidative damage in the corpus cavernousum in rats. Materials and Methods: In this study, Sprague-Dawley rats (250-300g) were allocated into groups as follows: control, diabetic, diabetic + chard, and diabetic + insulin. In order to induce diabetes, rats were given 65 mg/kg intraperitoneal streptozotocin. Chard extract was given orally at a dose 2 g/kg for 45 days beginning on 15 th days. Sixty days after STZ injection, intracavernosal pressure (ICP) was measured and rats were decapitated. Blood samples were obtained for glucose, asymmetric dimethylarginine (ADMA)levels, and lactate dehydrogenase (LDH) activity while cavernous tissues were taken to analyze luminol and lucigenin chemiluminescence (CL), malondialdehyde and glutathione and along with histological analysis. Results: The results revealed that diabetes caused significant decreases in cavernosal tissue glutathione levels, while luminol and lucigenin CL, and malondialdehyde levels were significantly elevated. Plasma glucose, ADMA levels, and LDH activity were also found to be increased in diabetic group. On the other hand, both chard extract and insulin treatment reversed these biochemical parameters significantly. Furthermore, it was found that the ICP value examined for evaluating erectile functions were lower in the diabetic group, but increased in both treatment groups which were similar to the control values. Conclusion: According to our results, chard extract, similar to insulin, reduced diabetes -induced oxidative damage in cavernosal tissue and protected erectile functions. This effects may be attributed its hypoglycemic and antioxidant properties.
Evaluating the Styles of Coping With Stress of Individuals With Multiple Sclerosis During the Covid - 19 Pandemic
(Marmara Univ, inst Health Sciences, 2022) Eroglu, Nermin; Tosun, Anil
Objective: Multiple sclerosis (MS)is among the most influential environmental factors. Quarantine days during Covid-19 outbreak can cause conditions such as anxiety, isolation stress, financial and long-term economic stress, including health concerns.The descriptive study was planned and applied with the aim of examining the impacts of Covid-19 pandemic on the styles of coping with stress of individuals with multiple sclerosis. Methods: The study was carried out on 246 volunteer individuals during April2020-May2020 following the approval of the Turkey MS Association and the briefing provided to the individuals.The data were acquired via Personal Information Form and The Styles of Coping with Stress Scale. Results: The mean age of individuals with MS was 39.41 +/- 9.06 years. Statistically significant increase was found in the sub-dimensions of optimistic and helpless approach with gender, submissive approach with marital status, helpless and submissive approach with education status, helpless, submissive and seeking social support sub-dimensions with working status (p<0.0, p<0.05). Conclusion: It was determined that individuals with MS use the helpless approach and submissive approach most frequently in coping with stress during the Covid-19 pandemic.It was determined that those living with their families mostly use the optimistic approach and selfconfident approach.It is thought that MS associations will be effective in coping with stress in reducing symptoms and social and physical support through informative meetings, home visits, psychotherapies, yoga and organized trainings.
Opinions of Students in the Field of Health on Distance Education During the Covid-19 Pandemic: a Cross-Sectional Study
(Galenos Publ House, 2024) Kaya, Gizem; Karaca, Anita; Beji, Nezihe Kizilkaya
Objective: It is important to determine the opinions and preferences of students about distance education as its use is becoming more and more prevalent because of the Coronavirus disease-19 (COVID-19) pandemic. It was aimed to determine the opinions of students in the field of health about distance education during the COVID-19 pandemic. Methods: This was a cross-sectional, descriptive study which was conducted at the Faculty of Health Sciences of a foundation university in stanbul. The data were obtained from 476 students who were studying at the Faculty of Health Sciences of a university between June and July 2021, using a Student Information Form and Student Opinions on Distance Education Survey. Results: When asked their opinions on distance education, most described that face-to-face education was more useful than distance education (65.1%) and that having practical lessons with distance education negatively affected their learning (61.1%). Conversely, most of the students expressed that they could listen to the parts of the lessons they did not understand again (93.1%), could listen to the lessons they missed (90.3%), and that distance education provided them with the convenience of taking lessons wherever internet access was available (76.7%). Conclusion: The results indicated that students did not have considerable problems during distance education, they benefited from the advantages of distance education and were generally satisfied with it. In relation to the problems experienced during the pandemic, we recommend to take measures especially for applied lessons, to continue to benefit from the advantages of distance education by combining it with formal education in appropriate lessons, and to make necessary improvements by evaluating the opinions of students on a departmental basis.

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