TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9

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Citation Count: 0
The Relation of The Duration of Work in Dentists With Postural Problems, Range of Motion and Pain
(Bezmialem Vakif Univ, 2020) Tekin, Demet; Koksal, Mesut; Terapi ve Rehabilitasyon Bölümü
Objective: The aim of this study is to determine the relationship between cervical and lumbar range of motions, pain and postural problems with the time spent in the occupation in dentists. Methods: A total of 56 dentists (27 males, 29 females), participated in this research as a volunteer (age=29.55 +/- 9.5 years). Firstly, the participants were divided into 3 groups according to the working years in their life and the time spent at unit during the day; they were also divided into 2 groups according to the intermittent or uninterrupted working conditions during the day. Cervical and lumbar joint range of motions were measured to determine limitations. The McGill pain scale survey was used to evaluate the pain. Kruskal Wallis and Mann-Whitney U tests with a posthoc Bonferroni test were used for all statistical analyses. Results: It was seen that the cervical and lumbar joint range of motions decreased, and the postural deformities in the spine and knee were observed and the level of pain increased significantly in comparatively to the excess of the time spent in the profession. However, in the analysis according to the time spent at the unit during the day, only the decrease in the range of motion of the regions was determined with the increase of the time spent at the unit during the day. Conclusion: With the increase in the working years in the dentists, it was revealed that the limitation of the range of motion increased and posture disorders and pain were formed. It is thought that all these problems will be caused by working in non-ergonomic environments for a long time. In this respect, it is important to include experts in the field of physiotherapy in the courses given under the name of preventive medicine. As a result, it can be said that the health problems encountered with the increase in time spent in the profession have increased.
Citation Count: 0
The Effect of Training on Stress and Coping With Stress in Patients Receiving Infertility Treatment
(Cukurova Univ, Fac Medicine, 2020) Eroğlu, Nermin; Temiz, Gamze; Hemşirelik Bölümü
Purpose: This study was planned and applied semi-experimentally to examine the effect of education given to patients receiving infertility treatment on stress and coping with stress. Materials and Methods: The study is semi-experimental. It was held between May 2017 and January 2018 with individuals who applied to a foundation hospital in Istanbul province for IVF treatment. The sample was made up of 40 infertile individuals. The data were collected by the researcher through face-to-face interview method. Training was given after pretesting. Post-test was performed one month after the training. Results: The pre-education stress scale of middle school graduates of infertile women was higher, this difference disappeared after education, and there was a statistically significant difference between the infertility stress and coping scale subscale mean scores. As the use of active ignoring, active struggling and passive ignoring coping methods of women, the use of the methods of coping with the infertility subscale scores increased, the infertility stress subscale scores increased.. Conclusion: In this study, the relationship between infertility and stress research was investigated and it was concluded that the treatment process and results are an important source of stress in patients. According to the results obtained, it is recommended to determine the stress level and methods of coping with stress, and provide training and counseling on patients who apply to the hospital for infertility treatment.
Citation Count: 0
Determining the Effect of Urbanization on the Vegetation of Gurun District (sivas) Based on Biotope Mapping and Vegetation Analysis
(Istanbul Univ-cerrahapasa, 2020) Bozkurt, Selvinaz Gülçin; Akkemik, Unal; Kose, Nesibe
Urbanization is one of the strongest negative effects on vegetational change within and around a city. In this study, it is aimed to determine the flora and vegetational changes within and around the city based on the identification and mapping of the biotopes which show differences in terms of ecologic factors met in Gurun district center and its vicinity and which are suitable for Corine biotope classification. First, 13 main biotope types are classified. In the biotopes, total 666 plant taxa were identified, 84 of which were endemic. Vegetation of the biotopes was determined, and then similarity levels of main biotopes are calculated according to the similarity coefficient method of Sorensen. Accordingly, while the similar areas are health facilities and agricultural areas the most different ones are parks and sports areas and drainage areas. The results emphasize the similarity levels of vegetation in biotopes and the negative effect of human intervention in the study area. As a result, with its rich natural structure, vegetation covers and endemism rate, the district of Gurun has significant natural biotopes and it is suggested that biotope classification should be considered in determining vegetation change and urban planning.
Citation Count: 0
Investigation of the Synergic Effect of the Colistin/Sulbactam Combination in Carbapenem-Resistant acinetobacter Baumannii Complex Strains With Time-Kill and Checkerboard Methods
(Bilimsel Tip Yayinevi, 2021) Kahraman Kılbaş, Elmas Pınar; Hatipoglu, Huseyin; Kilic, Umit; Kahraman Kilbas, Elmas Pinar; Koroglu, Mehmet; Altindis, Mustafa; Tıbbi Hizmetler ve Teknikler Bölümü
Introduction: Infections caused by carbapenem-resistant Acinetobacter strains have become very common in recent years, and the most frequently used medicinal treatment is colistin. Combination treatments should also be applied to prevent development of resistance to colistin. This study examines the in vitro synergic effect of the colistin/sulbactam combination in carbapenem-resistant Acinetobacter strains with the time-kill and checkerboard methods. Materials and Methods: Twenty carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex strains, which were isolated from various clinical samples, were included in this study. Strains were identified with mass spectrometry, and antibiotic sensitivity results were determined with the VITEK 2 (R) system. The in vitro effect and synergic activity of the colistin, sulbactam, and colistin/sulbactam combination on the carbapenem-resistant strains were determined using the time-kill and checkerboard methods. Seventeen strains were examined with the time-kill method, and twenty strains were examined using the checkerboard method. The fractional inhibitory concentration index of strains was calculated for detection of synergic effect. Results: Using the time-kill method applied on the colistin/sulbactam combination showed that the combination had a synergic effect on all 17 strains, while sulbactam alone did not have a bactericidal effect in the studied concentrations. When applying the checkerboard method, it was determined that the colistin/sulbactam combination had a synergic effect on 17 of the strains (85%) and an additive effect on 3 strains (15%), sulbactam had a low effect alone (15%), and colistin was effective on all strains. Conclusion: Study results indicated that the colistin/sulbactam combination had a high level of synergic effect on all studied strains using both methods.
Citation Count: 1
International Cybersecurity Norms and Responsible Cyber Sovereignty
(Istanbul Univ, Fac Law, 2021) Eldem, Tuba; Siyaset Bilimi ve Uluslararası İlişkiler Bölümü
Initially envisioned as a free and open communication space between people, free from state regulation and intervention, cyberspace has become a fundamental subject of national and global politics over the last decade. Allegedly state-sponsored cyber operations against Estonia in 2007, Georgia in 2008 and Iran in 2010 played an important role in turning cybersecurity into a national and international security issue. Although the development of cyber diplomacy and international cybersecurity law were left behind the militarization of cyberspace, nevertheless, there have been many international initiatives to adopt international cybersecurity norms in the past decade. Within the framework of the life cycle model of the norms developed by Martha Finnemore and Kathryn Sikkink (1998), this article aims to shed light on the emergence of international cybersecurity norms by focusing on the negotiations held at the First Committee of the United Nations for more than twenty years. The article argues that those negotiations held under the First Committee dealing with disarmament and international security issues indicate the first stage of the formation of international rules related to cyberspace, and the negotiations to be completed under the UN Open-Ended Working Group in 2021 is critical for the transition of international cybersecurity norms from the first to the second stage.
Citation Count: 1
Molecular Modelling Studies To Suggest Novel Scaffolds Against Sars-Cov Target Enzymes
(Marmara Univ, 2021) Küçükgüzel, Şükriye Güniz; Kucukguzel, S. Guniz; Akdemir, Atilla; Eczacılık Meslek Bilimleri Bölümü
In this study, molecular modelling study of previously synthesized compounds against SARS-CoV-2 target enzyme was performed. A subset of 156 compounds from an in-house database has been subjected to molecular modelling studies against the SARS-CoV-2 ADP-ribose phosphatase (ADRP, NSP3), Papain-like protease (PLpro), and uridine specific endoribonuclease (NSP15) enzymes. We have identified one compound that is expected to inhibit the SARS-CoV-2 ADRP enzyme and one compound that is expected to inhibit the NSP15 enzyme.
Citation Count: 0
Inequality and the Import Demand in Turkey
(Istanbul Univ, 2021) Özbay Daş, Zühal; Ekonomi ve Finans Bölümü
The study aims to see whether the long-run relation between inequality and import demand exists in Turkey. The Autoregressive Distributed Lag (ARDL) cointegration technique is used in this study to estimate the long-run relationships between real imports, income, relative price, real exports, and inequality for the period 1982-2015. The results revealed that the income elasticity of imports is greater than one as the literature suggests. The sign of the coefficient of relative price and its magnitude is also compatible with the literature, while it is not statistically significant. However, the results further reflect that inequality is positively associated with real imports in Turkey contrary to assumptions of the relation between inequality and imports that is found to be negative for lower income countries in some studies. Short-run coefficients reflect that real income and relative prices are associated with real imports, whereas exports and not surprisingly, inequality variables are not in the short-run. The coefficient of income parameter is less in magnitude in the short-run but still greater than one. However, the sign of the coefficient of the relative price turns out to be positive in the short-run.
Citation Count: 2
Therapeutic Effects of Momordica Charantia L. Ethanolic Extract on Acetic Acid-Induced Ulcerative Colitis in Rats
(Istanbul University Press, 2021) Şener, Göksel; Sen, A.; Aykac, A.; Terali, K.; Cilingir-Kaya, O.T.; Senkardes, I.; Sener, G.; Eczacılık Meslek Bilimleri Bölümü
Objective: This study aims to investigate the effect of Momordica charantia L. (MoC) ethanolic extract on ulcerative colitis (UC) and was explored in vitro and in vivo. Materials and Methods: The rats were divided into control (C), saline-treated colitis (AA), MoC extract-treated colitis (AA+MoC), and sulfasalazine (SS)-treated colitis (AA+SS) groups. Colitis was induced by acetic acid. MoC extract, SS or saline were given to the related groups for 3 days. Interleukine-1β, malondialdehyde, glutathione levels, myeloperoxidase activity, bax/bcl-2 ratio, caspase-9 and caspase-3 levels were measured in colon and macroscopic and histopathologic examinations were done. Total phenolic/flavonoid content and biological activity of MoC were evaluated by in vitro analysis. Results: Compared to the control group, with acetic acid application interleukin-1β levels, myeloperoxidase activity, malondialdehyde levels, bax/bcl-2 ratio, caspase-9 and caspase-3 levels were significantly upregulated, while glutathione levels were significantly decreased in the AA group. In contrast, MoC and SS treatments reduced interleukin-1β, malondialdehyde levels, myeloperoxidase activity, bax/bcl-2 ratio, and caspase-9 and caspase-3 levels. Glutathione levels increased upon MoC or SS treatment. Increased macroscopic and microscopic scoring with AA improved with MoC or SS treatment, but the MoC or SS treated groups had higher score values than the control. Also, in vitro results showed that MoC exhibited 2,2-diphenyl-1- picrylhydrazyl and 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid radical scavenging activity as well as significant antilipoxygenase activity. In addition, MoC extract showed a potent anti-inflammatory activity compared to standard indomethacin. Conclusion: Our biochemical, in vitro and histopathologic analysis indicate that MoC is likely to prove beneficial in UC therapy. © 2021 European Journal of Biology. All rights reserved.
Citation Count: 2
Effects Of Exercise And Calorie Restriction On Brain And Testis İn Natural Aging Model;
(Istanbul University Press, 2021) Hakgüder, U.; Üstündağ, Ü.V.; Tüzüner, B.A.; Genç, N.; İpekci, H.; Özçelik, R.; Emekli-Alturfan, E.
The aim of our study was to examine the effects of exercise and calorie restriction on various tissue damage and antioxidant parameters in the brain and testis of rats in a natural aging model. For this purpose, male Sprague-Dawley rats were the control group (C), the elderly (A), the elderly with calorie restriction (ACR), the elderly who were exercised (AE) and the elderly who were exercised with calorie restriction (ACRE), they were divided into 5 groups. The control group was composed of three-month-old animals. The other group consisted of 15-month-old rats. Exercise and calorie restriction were applied for 6 weeks. At the end of the experiment, lipid peroxidation (LPO), nitric oxide (NO), glutathione (GSH) levels and superoxide dismutase (SOD), catalase (CAT), glutathione-S-trans-ferase (GST) and tissue factor (TF) were determined in brain and testicular tissues homogenates. As a result of the study, the A group’s brain and testis LPO, NO levels and TF activity increased, GSH levels and SOD, CAT and GST activities decreased, when compared to the C group. As a result of our study, an increase in oxidant damage was observed with TF activity in the brain and testis in the natural aging model, and positive effects of exercise and calorie restriction on the antioxidant levels in the brain were determined, especially in aging. © 2021, Istanbul University Press. All rights reserved.
Citation Count: 7
Protective Effects of Petroselinum Crispum (parsley) Extract Against Methotrexate-Induced Hepatotoxicity
(Istanbul University Press, 2021) Şener, Göksel; Turan, F.B.; Ozbeyli, D.; Yanardag, R.; Sacan, O.; Sener, G.; Eczacılık Meslek Bilimleri Bölümü
Objective: By inhibiting the synthesis of thymidine and purine, and thereby DNA synthesis, Methotrexate (MTX), suppresses the proliferation of cancer cells. It is thought that the side-effect mechanism is related to oxidant molecules derived from MTX metabolism. In this study, we examined whether the Petroselinum crispum extracts (PCr; parsley) of which the antioxidant properties have been previously shown, was protective against MTX induced liver damage. Materials and Methods: Sprague Dawley rats (female/male; 200-250 g) were used. MTX was injected intraperitoneally and PCr extract was given orally. A single dose of 20mg/kg MTX was administered to the groups that were to experience hepatotoxicity. Then, a physiological saline (MTX group) or PCr (2 g/kg, MTX + PCr group) treatment was applied for 5 days. The same treatments were applied to the other groups (control group, PCr group) for 5 days after a single dose saline injection. At the end of the study, the biochemical parameters were examined in the blood and liver tissues taken from animals sacrificed by decapitation. Results: MTX caused a significant increase in malondialdehyde and collagen levels and myeloperoxidase and caspase-3 activities, while glutathione levels were found to have decreased. PCr treatment showed protective efficacy by preventing these increases. Conclusion: It appears that the administration of PCr to MTX treated rats prevented the accumulation of lipid peroxides, inflamatory reactions and depletion of antioxidant glutathione, and thus protected liver tissues against oxidative stress. © 2021 European Journal of Biology. All rights reserved.
Citation Count: 6
Effects of myrtus Communis L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats With a High Fat-Diet
(Galenos Publ House, 2021) Şener, Göksel; Kuru, Dilruba; Sen, Ali; Sener, Goksel; Ercan, Feriha; Yarat, Aysen; Eczacılık Meslek Bilimleri Bölümü
Objectives: Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals. Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor. The data on tissue boron levels are quite lacking. The aim of this novel study was to investigate the effects of Myr and Apo treatment on boron levels and oxidative lens damage in rats fed a high-fat diet (HFD). Materials and Methods: Wistar albino male rats were randomly divided into four groups: the control group, HFD group, HFD + Myr group, and HFD + Apo group. Body weight and blood lipids were determined before and after the experiment. After decapitating the rats, the lenses were removed and homogenized. Catalase (CAT) and superoxide dismutase (SOD) activities and boron, malondialdehyde (MDA), and reduced glutathione (GSH) levels in the lens homogenates were determined. Results: The HFD increased serum triglyceride (p<0.05), total cholesterol level (p<0.001), body weight (p<0.001), and lens MDA levels (p<0.01) and decreased lens GSH (p<0.05) and boron level (p<0.01), SOD (p<0.001), and CAT activity (p<0.001). However, Myr and Apo treatment reduced the rats' body weight (p<0.001), serum triglyceride (p<0.05), and total cholesterol level (p<0.001) and increased lens boron (p<0.01; p<0.001), GSH levels (p<0.05; p<0.01), and CAT activity (p<0.001). Conclusion: Both Myr and Apo may be able to reduce oxidative stress in the lenses of obese rats caused by HFD by increasing boron levels.
Citation Count: 0
Tween Jargon "mean Girls" and Beauty Bullying;
(Cyprus International University, 2021) Güzel, Ebru
The destructive emotions imposed on women by patriarchal ideology, such as dependence on appearance, vanity, narcissism, and competitiveness are also capturing girls; children under the age of 13 sharing adult-looking posts on Instagram under 2 million "tween" tags although it is illegal; cyberbullying and the words used in social media and the interaction of phrases with spoken language are the main problems of tween. In this study, grounded theory and in-depth interviews are used as a qualitative research method, beauty bullying is defined with the movie Mean Girls, and the "tween jargon" that can be clearly seen in social media is reflected in the spoken language. For example, words and abbreviations used by children such as tag, "break my scale", "send ss/dm", "bro/sis", "feno", "efso" are also used in daily language. As a result, the expression of tween jargon with the way of life of these children determines the increase of beauty cyberbullying, competition and language degeneration of this new girl culture. In addition, it is predicted that this study will contribute not only to the corruption of language but also literature in terms of childhood degeneration. © 2021 Cyprus International University. All rights reserved.
Citation Count: 5
beta Vulgaris L. Var. Cicla Improves Memory Deficits in Intracerebroventricular Streptozotocin Injected Rats: Role on Neuroinflammation
(Marmara Univ, 2021) Şener, Göksel; Topal, Fadime; Gulhan, Rezzan; Yanardag, Refiye; Sacan, Ozlem; Sener, Goksel; Eczacılık Meslek Bilimleri Bölümü
Alzheimer's disease is a challenging disease for patients due to progressive loss of cognition and behavioral disorders. Disruption of cholinergic transmission and neuroinflammation are the most important mechanisms underlying cognitive damage. Beta vulgaris L. var. cicla (BV) has been reported to have various pharmacological effects associated with its rich antioxidant content. In addition, anti-cholinesterase and antiinflammatory activities of BV have been demonstrated in vitro. The aim of this study is to elucidate the therapeutic effect of BV against cognitive impairment, reduction in cholinergic transmission and neuroinflammation caused by intracerebroventricular (ICV) administration of streptozotocin (STZ). STZ was administered bilaterally at a dose of 3 mg/kg via ICV to rats, and BV treatment at a dose of 2 g/kg for 21 days was administered orally to STZ-induced animals. After behavioral tests, AChE activity, TNF-alpha and IL-1 beta levels were measured in hippocampus and cortex tissues excised from decapitated animals. Novel object recognition and passive avoidance test showed that the treatment of BV reverted the ICV-STZ induced memory dysfunctions in rats. Furthermore, increased AChE levels in the hippocampal and cortical tissues of STZ-induced rats were significantly reduced with 21 days of BV treatment. In conclusion, these results confirm that STZ administration caused cholinergic hypofunction, neuronal inflammation and cognitive dysfunction in rats, and BV therapy significantly inhibited these changes with its potential neuroprotective activity.
Citation Count: 2
Data Mining the City: User Demands Through Social Media
(Konya Technical Univ, Fac Architecture & design, 2021) Levent, Vecdi Emre; Levent, Vecdi Emre; Bilgisayar Mühendisliği Bölümü
Purpose Information technologies are commonly used in architectural and urban design. The use of these technologies providing support at every stage of the design opens up different perspectives for designers and users. The aim of the study is to obtain user demands for green spaces of a specific district by mining data through social media and to detect the actual green spaces of the same district using applications developed for this purpose. User demands for design decisions and applications of green spaces and the current situation of the study area are evaluated. Design/Methodology/Approach The research is firstly realized through social media, and data obtained from Twitter is analysed in order to evaluate user demands for parks and green spaces of Atasehir district in Istanbul City. Secondly, all green areas in the same district are detected by using digital maps. Two applications are specifically designed for this research; Tweet Grabber is used for user sentiment analysis on social media and Map Grabber is processed for extraction of green spaces via maps. The total area of the green spaces is compared with the desired area of open and green spaces per user. Findings The user demands and thoughts obtained in the study about the green spaces of the district are compatible with the actual situation of green spaces. It is observed that the users are mostly dissatisfied with the adequacy of green spaces. Designers, politicians, municipalities and all stakeholders can benefit from the obtained user expectations and feedback. Interpreting user demands by mining data through social media enables user participation in design decisions. This research method can be supportive and adaptive in related issues of design for the cities, enabling user participation in architectural and urban design. Research Limitations/Implications Parks and green spaces of Atasehir district of Istanbul are taken as a case study. Twitter is chosen for mining of data in social media based on parameters such as keywords and location. Social/Practical Implications The impact and support of users in design decisions can be clearly demonstrated by advanced information technologies. Mining data through social media and developed applications will contribute to design decisions and policies for architectural and urban spaces. Originality/Value Tweet Grabber and Map Grabber applications are developed for this research in order to get text based and image based data. The research includes a unique case study for mining data through social media on a specific design issue and target location.
Citation Count: 5
RELATIONSHIP OF DAILY TIME SPENT OUTDOORS WITH SLEEP QUALITY AND EMOTIONAL WELL-BEING AMONG COMMUNITY-DWELLING OLDER ADULTS DURING COVID-19 RESTRICTIONS
(Gunes Kitabevi Ltd Sti, 2021) Karagözoğlu Coşkunsu, Dilber; Balci, Leyla Atas; Cinar, Fadime; Coskunsu, Dilber Karagozoglu; Tanriover, Sezin Hatice; Uluengin, Mehmet Bengu; Fizyoterapi Ve Rehabilitasyon Bölümü
Introduction: Given the recent constraints imposed due to the ongoing COVID-19 pandemic and the importance of the daily light-dark cycle for entraining the human circadian system, it is possible to state that the elderly are likely to be at serious risk of experiencing sleep-related problems. Whilst reduced or limited time outdoors, and thus, exposure to diurnal bright light appear to be detrimental to sleep and emotional well-being in old age, further research is required to confirm this relationship. Materials and Method: To build on earlier work, a two-week study was conducted in a sample of 79 community-dwelling older adults recruited by using snowball sampling method. Throughout the study, the participants were allowed to be outdoors from 10.00 a.m. to 1.00 p.m. on weekdays. Whilst the participants were performing their daily habitual activities, they were asked to keep an activity diary and report on their sleep quality and emotional wellbeing using two questionnaires. Results: The results demonstrated that participants' daily time spent outdoors (49.13 minutes on average) positively correlated with their perceived sleep quality and emotional well-being at various - but significant - levels (p<0.05). Moreover, significant negative correlations were identified between participants' sleep quality and experienced emotional disturbances (p<0.001). Conclusion: Based on the research findings, it is reasonable to conclude that spending momentary periods outdoors may have adverse consequences for the elderly. To maintain a healthy sleep-wake cycle and alleviate related emotional problems in old age, increasing outdoor time and diurnal bright light exposure should be encouraged.
Citation Count: 0
Space as a Source of Alienation in the Context of Migration Debates
(Yildiz Technical Univ, Fac Architecture, 2022) Ulubay, Serhat; Onal, Feride
Migration is one of the main agenda items of the time we live in. Migration mobility, which is defined as an act of displacement in its basic meaning corresponds to a process affecting many dynamics. It does not seem possible to make an overarching immigration definition due to the reasons for its emergence, the effect it creates on the social structure and the difference in its results. The phenomenon of immigration existing in the literature with definitions closer to its essential sense such as 'spatial mobility', 'act of displacement', 'transition from one place to another with the intention of settlement' does not contain the content of an absolute border crossing action. Crossing a border does not end the act of migration, but immigrants encounter ethnic, religious, social, class and many other thresholds and borders. For this reason, migration is not just an act of displacement. Immigrants migrate to places, cultures, social structures, life and many other aspects of new geographies. Social elements and spaces established with daily lives are one of the thresholds faced by the immigrant. Immigrants are stuck between the places in their geographies and the places and lifestyles in their new places where they came through immigration. This contrast manifests itself as soon as they step into a new geography and this situation transforms into an element of oppression for immigrants. The migration does not only correspond to the loss of physical spaces, but also to the dissipation of all social and daily life. For that reason, Arent, Heidegger and Blanchot define migrations of the current time period is independent of a physical displacement, alienation from the social and daily life acts to which one belongs and estrangement of the individual from his own essence. Alienation of one's own self, identity and sociality, drags them into an everlasting migration. For this reason, Blanchot emphasises that immigration starts as soon as the immigrant gets used to the places where he/she migrates, not when he/she fails to get used to the places. It is worth remembering that the space cited here has abstract content as well as concrete construction activity. Space according to Lefebvre exists as a product of the cultural, social and historical acts of societies. For this reason, it is specific to a community. It incorporates not only a concreteness, but also the mentality containing the traces of communities. Space represents a critical threshold in debates about immigration. For immigrants, space is both the grounds fin- establishing a sense of belonging and preserving their own identity, as well as the source of alienation and mental migration. This contrast is discussed in the study through Derrida's "hospitality" statement and the concepts of spatial memory and belonging. Immigrant according to Derrida, encounters a sovereign power defining itself as the owner of the place, in other words, the host, in the geography where he migrated. The host offers a place to the immigrant, whom he/she sees as a guest, and hosts him/her in his home. In fact, the landlord defines where, how and in what way he or she will live, together with the space and draws limits to him/ her. That he/she presents his/her way of life to the immigrant as if it were a rule that he/she must abide by. This style of presentation is a kind of imposition, because it doesn't contain any preference option in it: "I host you in my home. Welcome to my home, save to adhere my language, tradition, lifestyle, laws and rules". This language of life that the immigrant does not recognise and is not familiar with, is an act of mental 'violence perpetrated against him/her. This act of violence takes place through space. Although the immigrant loses his/her place by experiencing a physical migration, he/she brings all the acts of his social and daily life with him/her through his memory. These acts kept in the memory, stands out as the founding elements of the space in the new lands. Immigrants attempt to create their own spaces and lives through their memories instead of venues and lifestyles offered to them. For this reason, space is also the opposite of mental migration and alienation as the preservation of ego and identity. The space, in the migration actions that took place in the current time period, on one hand, is the main actor of eternal immigration and on the other hand protecting identity. The immigrant is stuck between the space offered to him/her and his/her actions and spatial memory in the new lands he/she has come from. The study aims to examine the situation of the immigrant, to question the source of alienation and (main) migration over this sense incorporated by the space.
Citation Count: 0
Molecular Characterization of Resistance and Virulence Genes in Enterococcus Faecium Strains Isolated Between 2000-2021; Systematic Review
(Bilimsel Tip Yayinevi, 2022) Kahraman Kılbaş, Elmas Pınar; Kilbas, Imdat; Ciftci, Ihsan Hakki; Tıbbi Hizmetler ve Teknikler Bölümü
Introduction: The spread of Vancomycin-Resistant Enterococci (VRE) is a major threat in healthcare institutions, especially for patients in the risk group. The aim of this study is to reveal the antibiotic resistance genes, virulence genes and other accompanying factors detected in vancomycin resistant Enterococcus faecium strains isolated from various clinical specimens in different parts of Turkiye. Material and Methods: For this purpose, a systematic search was carried out using different electronic databases between January 2000 and September 2021. A total of 17 studies were evaluated within the scope of systematic review. Results: The vanA gene was detected the most between the years 2000-2007, and no statistically significant difference was found according to the years. The prevalence of the vanB gene was highest between 2008 and 2013, and no statistical difference was found according to the years (p> 0.05). The vanA gene was mostly detected in Eastern Anatolia, Black Sea, Mediterranean and Aegean, vanB Central Anatolia and Southeastern Anatolia regions. No reports related to the vanC gene were found. Since all strains were E. faecium in our study, it is an expected finding that the vanC gene region was never reported. The esp and hyl gene between 2014-2021. Conclusion: The prevalence of resistance and virulence genes among bacteria is a matter of great concern, limiting treatment options. In particular, effective measures should be taken to prevent healthcare-associated VRE infections, and each institution should report its own resistance data.
Citation Count: 0
Evaluation of Promotion Theses of Museologists Prepared Between 1943 and 1973 in Terms of Architectural History
(Yildiz Technical Univ, Fac Architecture, 2022) Bilgen, Cigdem; Urfalioglu, Nur
Works by museologists with different occupations and titles featuring important documents are in the archive of the General Directorate of Cultural Heritage and Museums of T.R. Ministry of Culture and Tourism. Archivers recorded them at the Ministry of Culture's inventory as "promotional thesis" and organised them in 330 files from folders 1 to 34. The General Directorate of Classics and Museums demanded such theses from museologists for promotional purposes. Contents and constructs of dissertations about different fields and subjects featured important references. Therefore, these theses have a characteristic to enlarge the scale of research topics or enhance efforts leading to literature scanning for respective research subjects. Thirty-seven of 330 theses with known dates and authors included important information in architectural history and were investigated in the doctoral thesis study. Such 37 dissertations covering the period 1943-1973 were prepared considering Law on Organization of Museums and Observatories numbered 2530 enacted in TGNA on 23rd June 1934. It is the first legal arrangement in Turkish museology's history to officially register museums as separate institutions causing a leap in Turkish museology as of its effective date. With this law, guidebooks illuminating cities' architectural history written by museologists between 1930s and 1970s and published by the Board of Education and Ministry of Culture were prepared alongside promotional theses - products of Turkish museology's progress. This study illustratively evaluates promotional theses written based on law dated 1934 in architectural history. With the study of the 37 theses, written between 1943 and 1973, detection of another respective thesis in the archive and determination of the relevant legislative link and reasoning behind has gained critical importance. When we look at the selection of the topics of the promotion thesis, we see a great variety and substantiality in the subjects. Additionally, it has been targeted to inspire the researchers who have studied in the fields of the topics of respective thesis and their topics. The subjects in these archive documents are archaeological sites, single building scale, urban history studies and period studies. Within the scope of this article, one example of these topics has been selected. The thesis chosen as an example of archaeological sites is Raci Temizer's thesis entitled "Ayazmayeni Koyu Kayapinar Hoyugu Buluntulari" written in 1952. Another thesis is the subject of a single structure scale and M. Hadi Altay's thesis titled "Revan Kosku", written in 1958. The third thesis is an example of urban history studies titled "Kastamonu Eski Eserler Kilavuzu" and it was written by Ahmet Gokoglu in 1949. The last sample promotion thesis chosen as a period study belongs to the Cengiz Koseoglu. The title of the promotion thesis written in 1970 is "Maras'ta Dulkadiroglu Mimarisi". A detailed text about these theses is included in this article study. In addition, the catalogues of these four sample theses, which have been prepared in accordance with the A3 format in the excel file, have been included in the study. The differentiation of promotion theses in catalogues has been in the form of placing only selected sample pages from the text pages and turning all the images contained in the theses into one or more tables. Due to these catalogues, promotion theses have become more descriptive, and evaluations of these theses have been made in detail in many ways. Consequently, this article also emphasises the benefit of this cataloguing method applied for promotion theses. All theses, just like the other theses in the archive of Cultural Assets and Museums General Directorate, are the product of culture policies that started to be applied in the fields of historical works and museums in the Early Republic Period. As stated in the respective acts of law, the promotion of the museum officials as a result of their scientific works prepared in their workplace museums is very important. In addition, the museum officials' examining the architectural works in their theses, both in a visual and literal way is also very important in showing the significance of the contribution of this work not only to the history of architecture but also art history, restoration, archaeology and any other related fields. The Museum Officials criteria in determining the aims for selecting the topics of their theses from filling the gaps in the literature topics, contributing to the museum they work for or working in the fields of their interest or curiosity, shows not only the great contribution of the theses to the Turkish Museum History but also proves that they were prepared in a way to capture the fields of architecture and art history. This study aims to emphasise the importance of this point as well. In order for researchers and scientists to access the data in the theses and use this data in their own studies, it is necessary to reveal these theses contained in the ministry archive.
Citation Count: 1
Investigation of the Protective and Therapeutic Efficacy of myrtus Communis Extract in Aluminum Chloride and Dgalactose-Induced Alzheimer's Disease in Rats
(Marmara Univ, 2022) Şener, Göksel; Sen, Ali; Cevik, Ozge; Kadioclu-Yaman, Beril; Ertas, Biiva; Yildiz, Sila; Sener, Goksel; Eczacılık Meslek Bilimleri Bölümü
This study investigated the possible protective and therapeutic effects of Myrtus communis subsp. communis ethanol extract (MC) in aluminum chloride (AlCl3) and D-galactose (D-Gal) induced Alzheimer's disease in rats. MC was orally given to rats as a protective treatment for 90 days and, in other two groups starting from the 60th day MC (100-200 mg/kg) was administered, concomitantly with AlCl3 and D-Gal. Learning and memory functions were evaluated by the behavioral tests. Biological activities of MC treatment were examined in hippocampal tissues by ELISA tests. D-Gal and AlCl3-treated rats showed increased amyloid beta (A ss) and 8-hydroxy-2-deoxyguanosine (8OHdG) levels, acetylcholinesterase activity and decreased neprilysin, Na+-K+ATPase and SOD levels in parallel with a decrease in Novel Object Recognition Test, Morris Water Maze and Passive Avoidance Test scores. On the other hand, MC administration reversed the behavioral impairments and improved learning and memory. Moreover, MC treatment decreased A ss and 8-OHdG levels and acetylcholinesterase activity and increased neprilysin levels, Na+-K+ATPase and SOD levels. Our results suggest that MC has beneficial effects on cognitive and neuronal functions through its anticholinesterase and antioxidant properties.
Citation Count: 1
Time Difference Between Onsets of Lateral and Medial Hamstring Muscles During Gait in Patients With Patellofemoral Pain: a Preliminary Study
(Marmara Univ, inst Health Sciences, 2022) Karagözoğlu Coşkunsu, Dilber; Can, Filiz; Kuchimovs, Shavkat; Akalan, Nazif Ekin; Kilicoglu, I. Onder; Ozturk, Necla; Fizyoterapi Ve Rehabilitasyon Bölümü
Objective: Early activation of lateral hamstrings (LH) relative to medial hamstrings (MH) has been thought to be the cause of abnormal knee abduction and external rotation of the tibia, which affects the orientation of patellar tendon and increases lateral patellofemoral compression. Therefore, early activation of LH relative to MH is considered to have a role in the patellofemoral pain (PFP). The aim of this study was to investigate the time difference between MH and LH onsets in patients with PFP during gait. Methods: Thirteen patients with bilateral PFP (mean age 28.73 +/- 7.44 years) and 13 asymptomatic subjects (mean age 30.47 +/- 6.22 years) were recruited in the study. Gait analysis was performed using the ELITE system (BTS, Milano-Italy) with video cameras (TVC, BTS, Milano-Italy). Participants were requested to walk at a self-selected speed on a force platform, and EMG data were recorded from MH and LH muscles for 10 initial contacts by using TELEEMG (BTS, Milano-Italy). Time difference between the onsets of the MH and LH was calculated for each initial contact by using moving averaging method, then their mean was obtained for each participant. Results: The time difference between onsets of MH and LH was - 26.9 +/- 22.2 ms for PFP subjects and - 11.2 +/- 14.2 ms for control subjects, and LH mainly became activated earlier compared to MH in most of the subjects in both groups. There was a statistically significant difference between the time differences of the groups (p=0.041). Conclusion: Our findings suggest that LH displayed an earlier activation in subjects with PFP compared to control subjects during gait.

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