TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9

Browse

Now showing 1 - 20 of 21

Citation - WoS: 2
Citation - Scopus: 2
Global Health Emergencies During the Pandemic and Their Solutions
(2021) Sencan, Irfan; Bulut, Dilek; Agalar, Canan; Sencan, Ismail Hakki
Abstract: In this review, we evaluated health care problems, which were not common before pandemic outbreak but have been common issues after its appereance and approaches to control pandemic considering its influences on people. We revised current health care developing approaches under the light of experience obtained throughout the pandemic so far. The aim is to be prepared in advance for possible upcoming pandemics. As in Covid 19 pandemics, such long lasting and widely affecting situations, durability is also very important together with flexibility and quickness. To provide durability, we need global policies taking the health to its center as well as health system policies.Key words: Covid-19, health system, emergency, crisis, vulnerability, durability
Citation - WoS: 2
Citation - Scopus: 1
Multidrug Resistance in Pathogens of Community-Acquired Urinary Tract Infections in Turkey: a Multicentre Prospective Observational Study
(Tubitak Scientific & Technological Research Council Turkey, 2023) Sencan, Irfan; Karabay, Oguz; Altay, Fatma Aybala; Suzuk Yildiz, Serap; Simsek, Husniye; Gozukara, Melih Gaffar; Surme, Serkan
Background/aim: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options.Materials and methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed. Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advanced age, and having two or more risk factors showed a statistically significant relation with MDR existence (p < 0.001, p: 0.014, p < 0.001, respectively) that increasing number of risk factors or degree of advancing in age directly affects the number of antibiotic groups detected to have resistance by pathogens. In total, MDR isolates corresponded to 36.1% of our CAUTI samples; MDR existence was 35.7% in E. coli isolates and 57.2% in Klebsiella spp. isolates. Our results did not show an association between resistance or MDR occurrence rates and NUTS regions.Conclusion: The necessity of urine culture in outpatient clinics should be taken into consideration, at least after evaluating risk factors for antibacterial resistance individually. Community-acquired UTIs should be followed up time-and region-dependently. Antibiotic stewardship programmes should be more widely and effectively administrated.
Citation - Scopus: 1
In Silico Evaluation of H1-Antihistamine as Potential Inhibitors of SARS-CoV RNA-Dependent RNA Polymerase: Repurposing Study of COVID-19 Therapy
(Turkish Pharmacists Association, 2024) Küçükgüzel, İlkay; Kulabaş, Necla; Hamdan, Mazın
Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), from the family Coronaviridae, is the seventh known coronavirus to infect humans and cause acute respiratory syndrome. Although vaccination efforts have been conducted against this virus, which emerged in Wuhan, China, in December 2019 and has spread rapidly around the world, the lack of an Food and Drug Administration-approved antiviral agent has made drug repurposing an important approach for emergency response during the COVID-19 pandemic. The aim of this study was to investigate the potential of H1-antihistamines as antiviral agents against SARS-CoV-2 RNA-dependent RNA polymerase enzyme. Materials and Methods: Using molecular docking techniques, we explored the interactions between H1-antihistamines and RNA-dependent RNA polymerase (RdRp), a key enzyme involved in viral replication. The three-dimensional structure of 37 H1-antihistamine molecules was drawn and their energies were minimized using Spartan 0.4. Subsequently, we conducted a docking study with Autodock Vina to assess the binding affinity of these molecules to the target site. The docking scores and conformations were then visualized using Discovery Studio. Results: The results examined showed that the docking scores of the H1-antihistamines were between 5.0 and 8.3 kcal/mol. These findings suggested that among all the analyzed drugs, bilastine, fexofenadine, montelukast, zafirlukast, mizolastine, and rupatadine might bind with the best binding energy (< -7.0 kcal/mol) and inhibit RdRp, potentially halting the replication of the virus. Conclusion: This study highlights the potential of H1-antihistamines in combating COVID-19 and underscores the value of computational approaches in rapid drug discovery and repurposing efforts. Finally, experimental studies are required to measure the potency of H1-antihistamines before their clinical use against COVID-19 as RdRp inhibitors.
The Effect of 3d Modeling on Family Quality of Life, Surgical Success, and Patient Outcomes in Congenital Heart Diseases: Objectives and Design of a Randomized Controlled Trial
(Turkish J Pediatrics, 2024) Sumengen, Aylin Akca; Ismailoglu, Abdul Veli; Ismailoglu, Pelin; Gumus, Terman; Celiker, Alpay; Namlisesli, Deniz; Cakir, Gokce Naz
Background. Understanding the severity of the disease from the parents' perspective can lead to better patient outcomes, improving both the child's health -related quality of life and the family's quality of life. The implementation of 3 -dimensional (3D) modeling technology in care is critical from a translational science perspective. Aim. The purpose of this study is to determine the effect of 3D modeling on family quality of life, surgical success, and patient outcomes in congenital heart diseases. Additionally, we aim to identify challenges and potential solutions related to this innovative technology. Methods. The study is a two -group pretest -posttest randomized controlled trial protocol. The sample size is 15 in the experimental group and 15 in the control group. The experimental group's heart models will be made from their own computed tomography (CT) images and printed using a 3D printer. The experimental group will receive surgical simulation and preoperative parent education with their 3D heart model. The control group will receive the same parent education using the standard anatomical model. Both groups will complete the Sociodemographic Information Form, the Surgical Simulation Evaluation Form - Part I -II, and the Pediatric Quality of Life Inventory (PedsQL) Family Impacts Module. The primary outcome of the research is the average PedsQL Family Impacts Module score. Secondary outcome measurement includes surgical success and patient outcomes. Separate analyses will be conducted for each outcome and compared between the intervention and control groups. Conclusions. Anomalies that can be clearly understood by parents according to the actual size and dimensions of the child's heart will affect the preoperative preparation of the surgical procedure and the recovery rate in the postoperative period.
Citation - WoS: 2
Citation - Scopus: 2
Preparation and Application of Caffeic Acid Imprinted Polymer
(Tubitak Scientific & Technological Research Council Turkey, 2023) Ersoy, Seyda K. A. R. A. M. A. N.; Tutem, Esma; Baskan, Kevser SoeZGEN; Apak, Resat
In the present study, molecularly imprinted polymers were synthesized using caffeic acid (CA) as a template molecule and then used for the extraction of CA and chlorogenic acid (CLA) from complex matrices. Syntheses were carried out in tetrahydrofuran as porogenic solvent using 4-vinyl pyridine, methacrylic acid, acrylamide, and 1-vinyl imidazole as monomers, ethylene glycol dimethacrylate as crosslinker and 2,2'-azobisisobutyronitrile as initiator. In polymerization processes, different ratios of the template:monomer:crosslinker (T:M:CrL) were used to obtain the most suitable polymer. Caffeic acid:4-vinylpiridine:ethylene glycol dimethacrylate's 1:4:16 mole ratio of MIP was determined as the most convenient polymer for CA recognition. In addition, nonimprinted polymers (NIPs) without templates were prepared. Dynamic and static adsorption tests were applied to determine the absorption features of the NIPs and CA-MIPs. Separation and purification studies of CA and CLA were performed with molecular imprinted solid phase extraction (MISPE) application. All steps of MISPE (loading, washing, elution) were optimized by HPLC analysis.
Aqueous Parsley (Petroselinum crispum) Extract Ameliorated Methotrexate-Induced Brain and Small Intestine Damage in Rats
(Ankara Univ, 2025) Saçan, Ozlem; Şener, Göksel; Yanardag, Refıye; Tunali-Akbay, Tugba; Sivas, Guzin Goksun; Karaoğlu, Sümeyye Yılmaz; Dursun, Ercan
Methotrexate (MTX) is a widely used antiarthritic and chemotherapeutic agent known to cause damage to various tissues. This study investigated the potential protective effects of parsley extract against MTX-induced brain and intestinal tissue damage. Sprague-Dawley rats were divided into control, control + parsley, MTX, and MTX + parsley. MTX (20 mg/kg, i.p.) was administered to the MTX and MTX + parsley groups. The control + parsley, and MTX + parsley groups were administered 2 g/kg parsley extract by oral gavage for five consecutive days. After the fifth day, brain and small intestinal tissues were taken. Total protein, nitric oxide, lipid peroxidation, glutathione levels, tissue factor, superoxide dismutase, and glutathione S-transferase activities were determined in these tissues. The protein profiles of the tissues were evaluated using SDS polyacrylamide gel electrophoresis. Parsley administration caused a decrease in lipid peroxidation levels in both tissues of the MTX group. On the other hand, glutathione level, glutathione-S-transferase, and superoxide dismutase activities were found to be increased. On the other hand, parsley decreased the nitric oxide level which was increased in the intestinal tissues of the MTX group. There was no significant change in brain nitric oxide level and tissue factor activity between groups. MTX and parsley administration altered protein expression, leading to the appearance or disappearance of specific bands in intestinal and brain tissues. In conclusion, parsley alleviated MTX-induced damage in brain and intestinal tissues by reducing lipid peroxidation and modulating antioxidant defenses.
Citation - WoS: 5
Citation - Scopus: 6
An Integrated Methodology Proposal for Sustainable Fashion: Understanding and Examining Criteria Affecting the Second-Hand Clothes Shopping
(Gazi Univ, Fac Engineering Architecture, 2022) Usta, Saliha Karadayi; Kadaifci, Cigdem
Sustainable fashion is an important movement that offers numerous benefits in the long run by questioning the actual needs of the consumer, selecting the natural fabrics, preferring the brands providing ethical working conditions for the employees, using the acquired clothes as long as possible, repairing when necessary, and recycling into yarn when the lifetime is over, or transforming into a new product by changing the function of the items. In this context, the most active role of consumers is to prefer quality products that can last for many years and to extend the time of the products remaining in use, especially through the purchase and sale of second-hand clothes. While current papers provide roadmaps based on conceptual details, and consumer perception and attitude, there is no comprehensive study in second-hand shopping practices specific to clothing. Hence, the aim of this study is proposing an integrated methodology to understand the criteria that consumers pay attention in second-hand clothes shopping platforms as a tool that makes sustainable fashion possible via literature review, individual interviews and text mining, to determine the weights of these criteria according to their importance via Step-Wise Weight Assessment Ratio Analysis (SWARA) methodology, and to compare the prominent platform alternatives via Weighted Aggregated Sum Product Assessment (WASPAS) technique. The criteria weights vary depending on the sustainability awareness of consumers, and on the generation gap.
Citation - WoS: 1
Citation - Scopus: 1
Functional Features and Benefits of Residential Gardens: the Case of Istanbul (european Side)
(Aves, 2022) Bozkurt, Selvinaz Gulcin; Yener, Serife Doganay; Akdeniz, Nilufer Seyidoglu
This article investigates the extent to which residential gardens affect human welfare in Istanbul (the European side). The developing technology, population growth, and immigration are factors which expose the city of Istanbul to intense construction. Consequently, the gardens in the houses located at the center of Istanbul are decreasing day by day, limiting outdoor activities for the residents, and affecting them physically and mentally. In this study, a questionnaire was applied to 400 people in Istanbul's European side to investigate the extent to which residential gardens affect human well-being. These questionnaires were applied according to five-point Likert scales and the results were analyzed in the SPSS program by applying correlation analysis. The data obtained from the applied questionnaires were analyzed in the SPSS program. As a result of the analysis, it was concluded that residential gardens have a positive influence on the physical and psychological development of people, and also contribute to the protection of nature and biological diversity. Statistically, it has been determined that people mostly use their gardens in the summer months (49.30%) and on the weekends, and spend an average of 0-2 hours (57.50%) in their gardens. In addition, these analyses were associated with participant characteristics such as age (18-25, 26-30, 31-40, 41-50, 51-60, 60 and older), gender (female/male), socioeconomic status (occupation and income) and social demography (change in population). As a result, this study showed that residential gardens in urban areas contribute significantly to people and nature, that more garden areas should be added to the residences to be built in urban areas, and that these areas should be designed in a functional and sustainable way for people to benefit from nature in the best way.
Dodder (Cuscuta sp.) Extract Prevents Cognitive Deficits in a Rat Model of Hepatic Encephalopathy
(Kare Publ, 2024) Cevik, Ozge; Sen, Ali; Şener, Göksel; Ercan, Feriha; Doğan, Ahmet; Özbeyli, Dilek; Hatipoğlu, Bilge Nur
OBJECTIVE: In our study, the protective effect of dodder plant extract against encephalopathy induced by cholestatic liver disease model was investigated. METHODS: Spraque Dawley rats were used in the study. For the cholestatic liver disease model, the bile duct ligation (BDL) was applied. The groups were determined as control, Cuscuta sp. (CUS), BDL and BDL + CUS. Double ligation was performed in the bile duct in the BDL groups. For the applications, saline (SF) was administered to the control and BDL groups for 28 days while 250 mg/ kg of Cuscuta sp. extract was given by oral gavage to the CUS and BDL + CUS groups. At the end of the experiment, cognitive eval- uations were made by applying new object recognition and Morris water maze tests. After these tests, blood-brain barrier (BBB) measurements were made in half of the groups. In the other half of the groups, brain tissue samples were taken by decapitation and transforming growth factor-beta (TGF-β), 8-hydroxydeoxyguanosine (8-OHdG) and sodium-potassium adenosine triphospha- tase (Na+/K+-ATPase) measurements were made in the tissues. Histological examinations of the tissues were also performed. RESULTS: Cognitive performance was low, and BBB permeability was found to be increased in the group with bile duct liga- tion. In addition, TGF-β and 8-OHdG levels were increased in tissues, while Na+/K+-ATPase enzyme activity was suppressed. Treatment with Cuscuta sp. increased cognitive performance and decreased BBB permeability. Other biochemical parameters examined were significantly (p<0.05–0.001) reversed and supported by histological findings. CONCLUSION: Our findings in the study suggest that dodder plant may be beneficial for the protection of cognitive perfor- mance and brain tissue in encephalopathy caused by cholestasis. Keywords: Cuscuta sp.; cholestasis; encephalopathy; fibrosis.
Citation - Scopus: 1
Ethanolic Extract of Cotinus Coggygria Leaves Attenuates Crystalluria and Kidney Damage in Ethylene Glycol-Induced Urolithiasis in Rats
(Kare Publishing, 2023) Gumru, S.; Ozgur, G.; Ertas, B.; Sen, A.; Eker, P.; Sener, T.E.; Sener, G.
OBJECTIVE: Nephrolithiasis is a common cause of kidney insufficiency. Nephrolithiasis is proven to be the result of various biochemical and inflammatory processes that result in crystal formation and subsequent aggregation. Cotinus coggygria L. (CCog) is a plant extract which has been used as a Turkish remedy for kidney stones. With this study, we planned to evaluate the effects of CCog extract in ethylene glycol (EG)-induced nephrolithiasis model in rats. METHODS: The study group comprised 32 Wistar albino rats which were divided into Control (C), EG, CCog Prophylaxis (CC+EG+CC), and CCog Treatment (EG+CC) groups. Stone formation was induced by adding EG (0.75%) into rat’s drinking water. Normal drinking water was given to Control group for 8 weeks. Throughout the study period of 8 weeks, EG group was given only EG (0.75%) and CC+EG+CC group was given both EG and CCog. In EG+CC group, EG (0.75%) was given for 8 weeks whereas CCog was given for the past 4 weeks. After the 8th week, 24-h urine samples were collected. Rats were then sacrificed and kidney tissue samples were harvested. RESULTS: Metabolites (calcium, citrate) and creatinine in 24 h urine samples were decreased in CC+EG+CC and EG+CC groups. While hyperoxaluria was observed in the EG group, oxalate levels were similar to control levels in the P-CCog and C-CCog groups. The N-acetyl-β-glucosaminidase and myeloperoxidase activities were both increased in EG group and these parameters were significantly decreased on CCog treatment. CONCLUSION: We can conclude that C. coggygria extract can have beneficial effect on lowering concentration of stone-forming metabolites in urine and consequently protect renal tissues from damage due to nephrolithiasis. C. coggygria extract can be considered as a potential prophylactic and therapeutic option in high-risk stone formers. Furthermore, our data confirm ethnobotanical use of CC against nephrolithiasis. © 2023 by Istanbul Provincial Directorate of Health.
Citation - WoS: 1
Citation - Scopus: 2
Determining the Effect of Urbanization on the Vegetation of Gurun District (sivas) Based on Biotope Mapping and Vegetation Analysis
(Istanbul Univ-cerrahapasa, 2020) Bozkurt, Selvinaz Gulcin; Akkemik, Unal; Kose, Nesibe
Urbanization is one of the strongest negative effects on vegetational change within and around a city. In this study, it is aimed to determine the flora and vegetational changes within and around the city based on the identification and mapping of the biotopes which show differences in terms of ecologic factors met in Gurun district center and its vicinity and which are suitable for Corine biotope classification. First, 13 main biotope types are classified. In the biotopes, total 666 plant taxa were identified, 84 of which were endemic. Vegetation of the biotopes was determined, and then similarity levels of main biotopes are calculated according to the similarity coefficient method of Sorensen. Accordingly, while the similar areas are health facilities and agricultural areas the most different ones are parks and sports areas and drainage areas. The results emphasize the similarity levels of vegetation in biotopes and the negative effect of human intervention in the study area. As a result, with its rich natural structure, vegetation covers and endemism rate, the district of Gurun has significant natural biotopes and it is suggested that biotope classification should be considered in determining vegetation change and urban planning.
Citation - WoS: 4
Citation - Scopus: 4
Evaluation of Psychosocial Outcomes of Living Liver Donors in Liver Transplantation
(Aves, 2022) Ordin, Yaprak Sarigol; Seren, Arzu Kader Harmanci; Karayurt, Ozgul; Kul, Gulay Aksu; Kilic, Murat; Bozoklar, Cemal Ata; Tokat, Yaman
Background: The purpose of this study was to evaluate the risk factors affecting psychosocial outcomes of living liver donors after liver transplantations. Methods: This was a descriptive, cross-sectional study. The sample consisted of living liver donors followed by 2 liver transplantation centers in 2 private hospitals in 2 different provinces, between August 2017 and October 2019. All the living liver donors were contacted without a time frame after donation and all the participants were evaluated once. The Beck Depression Scale, SF-36, General Self-Efficacy Scale, and Perceived Available Support Scale were used to collect data. The t-test, Kruskal-Wallis test, Mann-Whitney U-test, and Pearson correlation analysis were used for data analysis. Results: The mean age of the patients was 34.31 +/- 8.22 years. There was a positive, weak correlation between age and physical function. Gender, marital status, financial status, and education levels significantly affected physical components, social function, vitality, depression, and self-efficacy scores. High depression levels negatively affected the physical component, self-efficacy, and social support scores of the living liver donors. High self-efficacy positively affected social support. Conclusion: The study revealed that gender, marital status, employment status, and education levels were associated with psychosocial outcomes. The financial status was the main factor affecting each psychosocial variable. Financial status needs to be assessed in detail before and after the operation.
Citation - WoS: 6
Citation - Scopus: 7
Molecular Epidemiology of Carbapenem-Resistant Acinetobacter Baumannii Isolates in Turkiye: Systematic Review
(Kare Publ, 2023) Kilbas, Elmas Pinar Kahraman; Kilbas, Imdat; Ciftci, Ihsan Hakki
The World Health Organization has designated carbapenem-resistant Acinetobacter baumannii (CRAB) as a "critical" pathogen on the global priority list of antibiotic-resistant bacteria. This study aims to discuss the molecular epidemiology of CRAB isolates in Turkiye in the last 12 years and the prevalence of gene regions associated with resistance or pathogenesis using a systematic review method. Our study consists of a literature search, determination of eligibility and exclusion criteria, qualitative analysis of studies, data extraction, and statistical analysis. All studies were analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Guidelines. The incidence rates of blaOXA-23, blaOXA-23-like, blaOXA-24/40, blaOXA-24/40-like, blaOXA-51, blaOXA-51-like, blaOXA-58, and blaOXA-58-like genes in CRAB strains were 76.4%, 68.6%, 1.2%, 3.4%, 97.0%, 98.6%, 8.4%, and 17.1%, respectively. It was determined that the prevalence of the blaOXA-23 and blaOXA-58 gene regions showed a statistically significant change over the years. Due to the high prevalence of A. baumannii strains carrying the blaOXA-23 variant, it is necessary to follow its geographical distribution and transposon and plasmid movements. Based on available data, molecular surveillance of CRAB strains should be standardized. In addition, sterilization and disinfection processes applied within the scope of an effective struggle against CRAB strains that can remain live on surfaces for a long time should be reviewed frequently.
Citation - WoS: 3
Citation - Scopus: 4
Qualitative and Artificial Intelligence-Based Sentiment Analysis of Turkish Tweets Related To Schizophrenia
(Turkiye Sinir ve Ruh Sagligi dernegi, 2023) Dikec, Gul; Oban, Volkan; Usta, Mirac Baris
Objective: The aim of this study was to qualitatively examine Turkish tweets about schizophrenia in respect of stigmatization and discrimination within a one-month period and to conduct emotional analysis using artificial intelligence applications. Method: Using the keyword 'schizophrenia,' Turkish tweets were gathered from the Python Tweepy application between December 19, 2020 and January 18, 2021. Features were extracted using the Bidirectional Encoder Representations from Transformers (BERT) method and artificial neural networks and tweets were classified as positive, neutral, or negative. Approximately 5% of the tweets were qualitatively analyzed, constituting those most frequently liked and retweeted. Results: The study found that, of the total of 3406 schizophrenia-related messages shared in Turkey over a period of one-month, 2996 were original, and were then retweeted a total of 1823 times, and liked by 25,413 people. It was determined that 63.4% of the tweets shared about schizophrenia contained negative emotions, 28.7% were neutral, and 7.71% expressed positive emotions. Within the scope of the qualitative analysis, 145 tweets were examined and classified under four main themes and two sub-themes; namely, news about violent patients, insult (insulting people in interpersonal relationships, insulting people in the news), mockery, and information. Conclusion: The results of this study showed that the Turkish tweets about schizophrenia, which were emotionally analyzed using artificial intelligence were found often to contain negative emotions. It was also seen that Twitter users used the term schizophrenia, not in a medical sense but to insult and make fun of individuals, frequently shared the news that patients were victims or perpetrators of violence, and the messages shared by professional branch organizations or mental health professionals were primarily for conveying information to the public.
Citation - WoS: 2
Citation - Scopus: 2
Rapid Synthesis of Silver Nanoparticles With Rheum Ribes L Fruit Peels: Anticancer and Antimicrobial Effects With Biocompatible Structures
(Ankara Univ, Fac Agriculture, 2024) Zor, Murat; Baran, Mehmet Firat; Ipek, Duygu Neval S. A. Y. I. N.
Silver nanoparticles (AgNPs) are substances with a wide range of uses. Utilizing extracts obtained from the peels of Rheum ribes L. (Rr) fruit growing in Erzurum region, silver nanoparticles were rapidly created in this study with a quick, easy, and environmentally friendly technique without harmful processes. In order to evaluate the attributes of the synthesized Rr-AgNPs, FE-SEM or TEM micrographs were utilized to characterize their morphology. A UV -visible spectrophotometer was used to assess the highest absorbance bands of RR-AgNPs. These data were used to define RR-AgNPs, which were characterized as having exclusively negative surface charges of -25 mV, spherical shape, maximum absorbance at 428 nm wavelength, and 96 nm size distribution. The effectiveness of the produced AgNPs for use in medical applications was assessed using the MTT technique with microdilution. Minimum inhibition concentrations of Rr-AgNPs for pathogen strains ranged from 0.03 to 0.50 mg/L. Additionally, it was discovered that AgNPs effectively suppressed malignant cells, with rates of 86.27%, 74.67%, and 73.49%, in the investigation of the anticancer effects of AgNPs. Healthy cells were not subject to any inhibitory effects at the same concentrations.
Comparison of Intraoperative Biliary Anastomosis Stenting Technique in Living-Donor Liver Transplantation: Review of 41 Patients
(Turkiye Klinikleri, 2022) Dönmez, R.; Balas, Ş.; Göktuğ, U.U.; Emek, E.; Tokat, Y.
Background/aim: Biliary fistula is one of the most important complications in liver transplantation. Complications can vary from simple local peritonitis to death, and various techniques have been described to prevent them. In this study, we compared two different stenting methods used in biliary tract anastomosis in living-donor liver transplantation. Material and methods: We retrospectively analyzed data from 41 living-donor liver transplantations that were performed due to end-stage liver failure between August 2019 and November 2020. Patients were grouped according to the stenting technique used in biliary anastomosis. Postoperative biliary tract complications were investigated. Results: Biliary fistulas were observed in 2 (7.4%) patients in the internal stent group, while 4 (28.5) fistulas were observed in the external stent group. Biliary tract stricture was observed in 2 (7.4%) patients in the internal stent group, but there was no statistical difference in complications. The preoperative MELD score (p = 0.038*) was found to be statistically significant in regard to developing complications. Conclusion: Our study did not show the effect of stenting methods used during biliary anastomosis on the development of complications. However, larger randomized controlled studies are needed. © TÜBİTAK.
Design and Implementation of a Low Cost and Portable Tactile Stimulator Br
(Tubitak Scientific & Technological Research Council Turkey, 2022) Kazma, Coskun; Levent, Vecdi Emre; Cardak, Merve; Aydin, Nizamettin
When central nervous system has a problem, somatic area I and II respond to stimulation differently. Therefore, it is possible to identify some of the central nervous diseases when somatosensory on the fingertip is stimulated and responses are recorded and analyzed. We designed a system to stimulate the mechanoreceptors on fingertips. It is composed of a mechanical system for fingertip stimulation, an embedded controller, a control computer, and a software to control overall operation. During test, mechanoreceptors are stimulated according to the test protocols. Individuals' answers are recorded to be evaluated by the developed software. In this study, several design approaches for embedded controller were also examined and an FPGA based controller with the same functionality but higher performance was implemented. A test procedure was performed on 51 individuals at the department of pediatric psychiatry in a hospital, to investigate whether the sex has an effect on attention deficit and hyperactivity disorder.
Mekanik Boyun Ağrılı Bireylerde Alt Ekstremite Posterior Plan Kaslarına Foam Roller İle Uygulanan Miyofasyal Gevşetme Tekniğinin Akut Etkisi
(2021) Alkan, Mirsad; Besen, Kardelen; Coşkunsu, Dilber Karagözoğlu; Güler, Dilara
Amaç: Myers tarafından tanımlanan fasyal\rzincirlerden biri olan Süperfisyal arka zincir\r(SAZ) ayak parmaklarından başlayıp supraorbital\rçıkıntıya kadar uzanan fasyal bir\rbanttır. SAZ öne eğilme (fleksiyon) hareketini\rlimitleyen ya da işlev bozukluğunda aşırı\rarkaya eğilme hareketine (ekstansiyon) sebep\rolan, primer olarak sagital planda postürü ve\rhareketi sağlayan başlıca zincirdir. Sağ ve\rsol tarafta olmak üzere iki SAZ vardır ve iki\rtaraf arasında etkileşim olduğundan dolayı\rdengesizliklerin gözlemlenip düzeltilmesi\rgerekir. Bu çalışmada aktif komponentler\rarası etkileşimi değerlendirmek için; Mekanik\rBoyun Ağrılı bireylerde Hamstring ve\rGastroknemius kaslarına uygulayarak Foam\rRoller (FR) Self Miyofasyal Gevşetme (SMG)\rtekniğinin servikal bölge Eklem Hareket\rAçıklığı’na (EHA), ağrıya ve kas kuvvetine\rolan akut etkisi araştırılmıştır.
Citation - WoS: 1
The Effect of myrtus Communis L. Extract on Nephrolithiasis Model in Rats
(Kare Publ, 2024) Ertas, Busra; Dorucu, Dogancan; Gulerturk, Oznur; Sen, Ali; Cevik, Ozge; Cetinel, Sule; Sener, Goksel
OBJECTIVE: Nephrolithiasis is a common urological disease that can lead to renal failure. Oxidative stress has been shown to be a contributing factor for nephrolithiasis and many agents have been studied to prevent and treat oxidative stress-related nephrolithiasis and renal damage. Myrtus communis (MC) extract has been shown to be an important antioxidant in different animal models. In this study, MC extract was administered preventively or therapeutically to rats with kidney stones, and its effectiveness was investigated. METHODS: Wistar albino rats were divided into four groups (n=8); control (C), ethylene glycol (EG), EG+preventive MC, and EG+curative MC groups. The nephrolithiasis model was created by adding 0.75% EG to drinking water for 8 weeks. Ultimately, 24-hour urine was collected to measure calcium, citrate, and creatinine levels. After decapitation, kidney tissues were harvested for histological analyses, measurement of osteopontin and 8-hydroxydeoxyguanosine (8-OHdG) levels, and N-acetyl-beta-glucosaminidase (NAG), myeloperoxidase (MPO) and caspase-3 activities. RESULTS: In 24-hour urine samples, calcium, citrate and creatinine levels were decreased in the EG group, while oxalate levels were increased and in treatment groups these parameters returned to control levels. MPO, 8-OHdG, caspase-3 and NAG activity were significantly increased in tissue and these changes were reversed in both MC groups. Histological findings also supported the biochemical parameters. CONCLUSION: MC can reduce oxidative stress and histopathological changes in kidney tissues in rat nephrolithiasis model when used as either a preventive or therapeutic agent. If supported with further clinical trials, MC might have clinical implications in preventing oxidative renal cell injury and ultimately kidney stone formation.
Measuring Shoulder Abduction Strength Using 2 Different Dynamometers: Comprehensive Intrarater and Interrater Reliability and Validity
(Turkish Assoc Orthopaedics Traumatology, 2025) Atli, Ecenur; Topaloglu, Mahir; Hosbay, Zeynep; Ozdincler, Arzu Razak
Objective: The purpose of this study is to investigate the intrarater and interrater reliability of handheld dynamometer (HHD) measurements in assessing isometric muscle strength of the shoulder abductors and to compare these results with those obtained using a fixed dynamometer (FD). Methods: The study involved 25 voluntary participants, all over the age of 18, asymptomatic (with no injuries in the upper extremity), and not engaged in overhead sports. The participants were evaluated twice by 2 different testers who were experienced in orthopedic rehabilitation, at 90 degrees of shoulder abduction in the scapular plane. On the first measurement day, Tester 1 performed measurements using both HHD and FD, while on the second measurement day, both testers used only the HHD. A 3-to 7-day interval separated the 2 measurement sessions. Paired-samples t-tests were used to evaluate the systematic bias between the testers. Spearman's rank correlation coefficient, intraclass correlation coefficient, standard error of measurement, and minimal detectable change were calculated. The statistical significance level was accepted as P < .05. Results: Data from 22 participants (15 women, 7 men; mean age: 23.00 +/- 3.19 years) were analyzed, as 3 individuals did not attend the final assessment. A strong correlation (r = 0.772) was found between Tester 1's HHD measurements and FD, while a similarly strong correlation (r = 0.748) was observed for Tester 2's HHD measurements. Excellent intrarater reliability (intraclass correlation coefficient [ICC]= 0.941) was found between Tester 1's measurements, and excellent interrater reliability (ICC= 0.889) was found between testers. Conclusion: Handheld dynamometer has demonstrated excellent interrater and intrarater reliability and high validity for assessing shoulder abductor muscle strength in research and clinical use. Since the muscle strength of testers using the HHD may influence the results, the FD may be a more appropriate option when the study population is stronger than the testers. Studies involving different clinical populations and testers with varying experience levels are needed to improve the relevance of the results. Level of Evidence: Level III, Diagnostic Study.