TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9

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2000’lı Yıllarda Türkiye Ekonomisi: İmalat Sanayinde Verimlilik Değişimleri
(2021) Özşahin, Gülşah; Das, Zuhal Ozbay
Bu çalışmanın amacı, 2000’li yıllarda Türkiye'nin imalat ve hizmet sektörlerinin verimlilik performanslarını tartışmaktır. 2000'li yıllarda Türkiye imalatının yapısal değişiminin yönü konusunda fikir edinmek için bir ayrıştırma analizi uygulanmıştır. Sonuçlar, 2003–2007 döneminde tüm imalat kategorilerinde, emek verimliliğinin düştüğünü, buna karşın 2010–2015 döneminde tüm imalat kategorilerinde emek verimliliğinin arttığını göstermektedir. 2016-2018 döneminde tüm gruplarda emek verimliliği daha da artmıştır, ancak, orta-düşük-teknoloji kategorisinde artış hızı daha yavaş, yüksek-teknoloji endüstrileri durağan bir görünüm sergilemiştir. Hizmet sektöründe emek verimliliği, dönemler itibarıyla imalatta görülenden biraz farklı bir yapı sergilemektedir. Özellikle yüksek teknolojili hizmet grubunda neredeyse tüm dönemlerde nispeten düşük verimli sektörlere doğru bir statik kayma gözlenmiştir. Daha az bilgi yoğun hizmetlerde, emek verimliliği ilk dönemde azalmış, ancak 2010-2015 döneminde belirgin biçimde artmıştır. Sonuçlar, özellikle 2010 sonrası dönemde sanayi politikalarının rolünü tartışmanın anlamlı olduğunu göstermektedir. Bununla birlikte, 2016 sonrasında siyasi ve ekonomik ortamdaki değişiklikler imalat sektöründeki verimlilik değişimlerinin anlaşılmasında ipuçları vermektedir.
Acute Serious Hepatitis of Unknown Cause in Children
(Galenos Publishing House, 2022) Kılbaş, E.P.K.; Altındiş, M.
On April 5, 2022, an increase in cases of acute hepatitis of unknown etiology was reported in previously healthy children under the age of 10 in the United Kingdom. Since there is no link between these patients, called acute non-HepA-E hepatitis, and viral hepatitis agents (hepatitis A, B, C, D, and E), the possible etiology, and pathogenesis of this emergency is being investigated. One of the alarming features of this epidemic is the high requirement for liver transplantation in a fraction of the cases. In cases other than hepatitis A, B, C, D, and E, a case definition is made by looking at a series of clinical pictures, including serum transaminase levels and age. As of August 26, 2022, 513 cases of acute hepatitis have been reported in Europe and 1,010 globally. Adenovirus was detected in 75% of cases tested in the UK, but data for other countries are still lacking. The role of other etiologic agents is still under investigation. The exact disease pathogenesis has not yet clear. Evidence of human-to-human transmission of the disease remains unclear. Epidemiological studies are critical in clarifying the uncertainties regarding the existence of links between the cases reported to date. Continuing the national and international surveillance activities of the countries in an organized manner is the most basic issue required for the elimination of the epidemic. Copyright © 2022 Tehran University of Medical Sciences.
Citation - WoS: 0
Adaptation of Caregivers' Task Scale for Multiple Sclerosis To Turkish Society: Validity and Reliability Study
(Dokuz Eylul Univ inst Health Sciences, 2022) Eroğlu, Nermin; Tosun, Anil Tekeoglu; Hemşirelik Bölümü
Objectives: This study was planned and carried out methodologically to adapt the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS) to Turkish society. Methods: A methodological research. The study was conducted with caregivers of individuals with multiple sclerosis who presented to the neurology clinic of a university hospital between June 2019 and September 2020. The validity and reliability study of the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS) was performed with a total of 142 individuals, which is more than 5 times the number of items on the scale (24 items). Results: The validity of the CTiMSS was evaluated with language validity, construct validity (CFA), and content validity. The reliability coefficient of the internal consistency analysis (Cronbach's Alpha) was found to be extremely high (0.97). Item-total correlation of the scale was examined, and accordingly, no items were removed from the scale. The scale was administered to 30 patients at a two-week interval to analyze test-retest reliability and time-dependent invariance. Conclusion: The CTiMSS, which was adapted to Turkish society to evaluate the tasks of individuals providing care for individuals with multiple sclerosis, is a valid and reliable tool. We recommend that it should be administered to different groups and cultures to increase its evidence value. CTiMSS is an appropriate measurement tool to determine the duties of caregivers of individuals with multiple sclerosis.
Citation - WoS: 1
Analysis of Selected Steroid Hormones in Sea of Marmara Sediment Samples by Lc-esi/Ms-ms
(Istanbul Univ, Fac Pharmacy, 2023) Yurdun, Türkan; Yurdun, Turkan; Eczacılık Meslek Bilimleri Bölümü
Background and Aims: Sediment is the general name given to the muddy structure located at the bottom of aquatic environments such as the sea. In our study, the amounts of steroid hormones were investigated in the sediment samples taken from the Marmara Sea. According to other studies, it has been determined that the excess of the hormone load in the sediments may be an indicator of human/animal sourced pollution, as well as the negative effects of the hormones mixed in the seas with the ecological cycle on the health of humans and animals.Methods: In our study, 31 selected human/animal, plant, natural and synthetic hormone-steroids were studied using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI/MS-MS). Methanol and QuEChERS were used as extraction methods. Sediment samples were taken from a total of 27 points selected for sampling at the Marmara Sea.Results: According to the results we found, the androgens: androsterone (24.50-1718.18 ng g-1), testosterone (86.30-1600.32 ng g-1); the estrogens: mestranol (33.73-228.32 ng g-1), equilin (53.44-1232.53 ng g-1); the progestagens; pregnenolone (37.50374.76 ng g-1), progesterone (39.96-405.60 ng g-1); levonorgestrel (325.25 and 937.93 ng g-1); the fecal sterols: cholestanone (57.57-1726.32 ng g-1), coprostanol + epicoprostanol (51.43-1370.33 ng g-1); and the plant sterol; campesterol (35.30-1859.90 ng g-1) were the compounds detected.Conclusion: Estrogens and progestogens are active components of birth control pills, and cholestanone and coprostanol + epicoprostanol are steroids that are indicative of human/animal pollution. Coprostanol + epicoprostanol and cholestanone, which are indicators of fecal pollution, were detected in all sediment samples. In our study, steroid hormones were detected for the first time in Sea of Marmara sediments and possible environmental risks were evaluated.
Citation - WoS: 8
Citation - Scopus: 7
Antibiotic Use and Influencing Factors Among Hospitalized Patients With Covid-19: a Multicenter Point-Prevalence Study From Turkey
(Galenos Publ House, 2022) Ağalar, Canan; Cag, Yasemin; Karabay, Oguz; Kurtaran, Behice; Guclu, Ertugrul; Ogutlu, Aziz; Agalar, Canan; Tıbbi Hizmetler ve Teknikler Bölümü
Background: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.
Antimicrobial Effect of Drinkable Lugol Solution
(2024) Tunç, Ayşe Karacalı; Sarıtaş, Büşra Merve; Marzi, Mahdi; Dursun, Feray; Kaya, Şevin
The death rates due to infection in patients receiving long-term antibiotic treatment and hospitalized patients are quite alarming. Treatment of multidrug-resistant strains of Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, which cause widespread nosocomial infection, has become a global problem. Alternative treatment methods are needed for these species, which use all their resistance mechanisms day by day. Recently, it has been seen that iodine (lugol) solution has been used in the treatment of many infections. Significant results are observed, especially for nosocomial and wound infections. The literature on the antimicrobial effect of Lugol solution is very limited. In order to scientifically support such treatments, we aimed to investigate the antimicrobial effect of lugol on resistant bacteria in a laboratory environment. In our laboratory, we have previously isolated Acinetobacter baumannii, Shigella sonneii, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus strains with known antibiotic resistance. For these isolates, the agar dilution method prepared with different concentrations of lugol and the Broth Microdilution Method were used. As a result of our study, it was observed that drinkable Lugol solution affects multidrug-resistant microorganisms at very low concentrations. Thus, Lugol's success in infection treatments will be scientifically supported.
Citation - WoS: 0
Citation - Scopus: 0
Antioxidants, Enzyme Inhibitory Activities, and Phytochemical Profiles of Seven Medicinal Plants Grown With Organic Farming Techniques
(Tubitak Scientific & Technological Research Council Turkey, 2023) Zor, Murat; Ozupek, Burcin; Pekacar, Sultan; Deliorman Orhan, Didem; Eczacılık Meslek Bilimleri Bölümü
In this study, the potential antihyperlipidemic, antidiabetic, and antiobesity effects of extracts obtained via infusion techniques from Artemisia absinthium L., Achillea millefolium L., Calendula officinalis L., Fumaria officinalis L., Mentha piperita L., Origanum onites L., and Urtica dioica L. grown with organic farming techniques were investigated using enzyme inhibition methods (alpha-glucosidase, pan-creatic cholesterol esterase, pancreatic lipase, and alpha-amylase). It is important that natural compounds or extracts to be used in the treat-ment of metabolic problems have antioxidant effects. The antioxidant effects of these species were tested in terms of ABTS and DPPH radical scavenging activity, ferric reducing power, and metal chelating capacity. Extracts (2 mg/mL) of M. piperita (91.43 +/- 0.90%) and O. onites (70.18 +/- 2.02%) showed potent inhibitory effects on the alpha-glucosidase enzyme. Among all species, only O. onites extract ex-erted an inhibitory effect on the cholesterol esterase enzyme close to that of reference compound simvastatin. While all extracts were effective in the tested antioxidant activity methods, it was determined that the M. piperita and O. onites extracts displayed particularly significantly strong activities in terms of ferric reducing power, ABTS radical scavenging effect, and metal chelating capacity. The total flavonoid and phenolic contents of all extracts were determined. The compositions of the most active extracts were analyzed for pheno-lic acids and flavonoids using RP-HPLC. The results of RP-HPLC analysis showed that the levels of ellagic acid (0.923 +/- 0.000 g/100 g extract) in the M. piperita extract and rosmarinic acid (0.813 +/- 0.003 g/100 g extract) in the O. onites extract were high. As a result, all species grown with organic farming techniques except U. dioica were found to have high antioxidant effects. In light of these findings, it was concluded that M. piperita and O. onites grown with organic farming techniques showed strong inhibitory effects in terms of the tested activities, especially for alpha-glucosidase and pancreatic cholesterol esterase, and that in vivo studies and activity-guided isolation studies should be conducted on these species in the future.
Citation - WoS: 4
Apocynin Ameliorates Testicular Toxicity in High-Fat Diet-Fed Rats by Regulating Oxidative Stress
(Marmara Univ, inst Health Sciences, 2023) Şener, Göksel; Koroglu, M. Kutay; Coskunlu, Busra; Ertas, Busra; Sener, Goksel; Ercan, Feriha; Eczacılık Meslek Bilimleri Bölümü
Objective: The purpose of this study was to examine the effects of apocynin (APC), an inhibitor of NADPH oxidase (NOX), on high-fat diet (HF)induced testis cytotoxicity.Methods: Wistar albino rats were divided into three groups as control, HF and HF+APC groups. Rats in HF and HF+APC groups were fed using HF for 16 weeks and in the last four weeks of this period vehicle solution or APC (25 mg/kg) was administered orally five days a week, respectively. Control group was fed with standart lab chow for 16 weeks. Cholesterol, triglyceride, high-density lipoproteins, leptin, estrogen, testosterone, LH and FSH were estimated in blood serum. Sperm parameters were analysed from the epididymis. Testicular malondialdehyde, 8-hydroxy-2deoxyguanosine, glutathione, superoxide dismutase and myeloperoxidase levels were estimated biochemically. Testicular morphology, proliferative, apoptotic and NOX2-positive cells were analysed histologically.Results: HF-induced obesity caused significant alterations in serum lipid and hormone profiles. Testicular malondialdehyde, 8-hydroxy-2deoxyguanosine, and myeloperoxidase levels increased, glutathione and superoxide dismutase levels decreased in this group. Moreover, altered sperm parameters, increased degenerated seminiferous tubules, apoptotic and NOX2 - positive cells and decreased proliferative cells were observed in the HF group. All these biochemical and histological alterations improved in the HF+APC group.Conclusion: HF-induced obesity causes altreations in lipid values, sperm parameters and testicular morphology by increasing oxidative stress through NOX2 activity. Apocynin might prevent testis damage via regulating oxidant/antioxidant balance.
Citation - WoS: 0
Bibliometric Analysis of Publications on Stigmatization in Psychiatric Nursing Literature
(Kare Publ, 2024) Dikeç, Gül; Saritas, Merve; Oban, Volkan; Hemşirelik Bölümü
Objectives: In the past two decades, the number of publications on stigma has increased in the literature. This study aimed to conduct a bibliometric analysis of publications related to stigmatization in the psychiatric nursing literature. Methods: In this study, a search was performed on the PubMed database on September 11, 2022, with the Medical Searching Terms "(Stigmatization [Title OR Abstract] OR Social Stigma [Title OR Abstract]) OR (Stigma [Title OR Abstract] OR Stereotyping [Title OR Abstract] OR Discrimination [Title OR Abstract]) AND (Psychiatric Nursing [Title OR Abstract] OR Nursing [Title OR Abstract])." Between 1990 and 2022, 10,571 studies published in English, available in full text, and published in journals indexed with SCI, SSCI, and ESCI were found. Results: The number of published articles reached the highest number in 2020, with an increase of 4.05 times in 30 years; it was determined that 92.8% of the publications were of the descriptive study, and Happell was the most productive author in this field. Frequently, articles were published in the Journal of Psychiatric and Mental Health Nursing (n=762), Journal of Psychosocial Nursing and Mental Health Services (n=550), International Journal of Mental Health Nursing (n=480), Issues in Mental Health Nursing (n=445), and Journal of Advanced Nursing (n=429). It was determined that the top five most frequently repeated keywords were humans, female, psychiatric nursing, male, and adult, respectively. Conclusion: The findings obtained from this study can provide information about the number of publications, research types, researchers, and institutions, as well as give ideas for new research strategies in psychiatric nursing literature. Establishing cooperation between institutions and authors can guide psychiatric nurses in creating projects to reduce stigma.
Bir Tiyoeter-triazol Hibriti: Güçlü Metap2 Inhibitörü ve Prostat Kanseri için In Vivo Tümör Baskılayıcı Bileşiğin In Silico Çalışmaları ve In Vitro Mikrozomal Metabolizması
(2023) Coşkun, Göknil Pelin; Ulgen, Mert; Birgül, Kaan; Evren, Asaf Evrim; Küçükgüzel, Ş.güniz
Arka plan/amaç: Antikanser bir ilaç adayı bileşik olan ( S)-3-((2,4,6-trimetilfenil)tiyo)-4-(4-florofenil)-5-(1-(6-metoksinaftalen-2-)il) etil)-4H-1,2,4-triazol (SGK636), bileşiğinin in vitro mikrozomal metabolizması çalışılmış ve potansiyel S-oksidasyon ve S-dealkilasyon metabolitlerini belirlemek için NADPH ile güçlendirilmiş domuz mikrozomal preparatları kullanılarak incelenmiştir. Gereç ve Yöntemler: Bu çalışmada, sülfoksit metaboliti kromatografik ve spektroskopik yöntemlerle sentezlenmiş, saflaştırılmış ve karakterize edilmiştir. SGK636, S-oksidasyon ve S-dealkilasyon metabolitleri daha sonra ters fazlı bir LC-MS, UV spektroskopisi ve bir HP-TLC sistemi ile ayrılmıştır. In vitro mikrozomal metabolik deneylerin sonuçları, SGK636’nın, aynı Rt ve Rfx100 değerleri ve UV/ ile LC-MS, LC-MS/MS ve HP-TLC tarafından gözlemlenen karşılık gelen S-oksidasyon metabolitini (sülfoksit) ürettiğini göstermiştir. Otantik bileşiklerle karşılaştırıldığında MS spektrumlarında, herhangi bir S-dealkilasyon metaboliti tespit edilmemiştir. Bulgular: Mevcut sonuçlar moleküler doking ve moleküler dinamik çalışmalarla kanıtlanmıştır. Sülfoksidasyon işlemi tersine çevrilebilir olduğundan ve deneyimizdeki düşük miktarda sülfoksit metabolitini kısmen açıklayabildiğinden, sülfoksit bileşiği de inkübe edilmiştir. Substrata (SGK636) geri dönüşüm gözlenmemiş olup, karşılık gelen sülfon metabolitinin oluştuğu gözlenmiştir. SGK636’nın otooksidize olup olmadığını belirlemek için substrat ayrıca standart inkübasyon koşulları altında tampon içinde inkübe edilmiştir, ancak karşılık gelen sülfoksitte herhangi bir oto-oksidasyon gözlenmemiştir. Sülfona herhangi bir olası otooksidasyonu veya tekrar SGK636’ya indirgemeyi görmek için tampondaki SGK636-SO (sülfoksit) için bir stabilite çalışması da yapılmıştır. Her iki şekilde de dönüşüm gözlemlenmemiştir. Substrat, farmakolojik aktivitesi açısından bir avantaj olabilecek metabolik reaksiyonlara ve otooksidasyona karşı kararlı görünmektedir. Sonuç: Mevcut metabolik çalışma, SGK 636’nın S-oksidasyonuna uğradığını göstermektedir. Sorumlu oksidatif enzimi belirlemek için moleküler yerleştirme ve moleküler dinamik çalışmalar yapılmıştır. CYP3A4’ün S-oksidasyonundan sorumlu enzim olduğu bulunmuştur.
Biyofilik Tasarım Parametrelerinin Ağırlıklarının Swara Yöntemi ile Belirlenmesi
(2021) Eriş, Evin; Büyükselçuk, Elif Çaloğlu
Bu çalışma son dönemde tüm dünyanın maruz kaldığı COVID-19 pandemisi ile birlikte insan-mekan-doğa ilişkisinin insan psikolojisindeki yeri ve etkileri üzerine literatürde yer alan ampirik deneylerle oluşturulmuş biyofilik tasarım parametrelerinin ağırlık katsayılarının ölçülmesi üzerine kurgulanmıştır. Karar verme ve performans değerlendirme süreçlerinde kriter ağırlıklarının belirlenmesi için kullanılan SWARA yöntemi ile, literatürde 3 ana başlık ve 14 temel parametre altında ele alınan biyofilik tasarım parametrelerinin ağırlıklarının hesaplanması amaçlanmıştır. Bu maksatla, 40 kişilik ulusal ve uluslarası düzeyde akademik ve uygulama yapan mimara bir anket çalışması yapılmıştır. Elde edilen anket sonuçları SWARA yönteminde kullanılmış ve biyofilik tasarım parametrelerinin ağırlıkları belirlenmiştir. Elde edilen sonuçlara göre literatürde yer alan parametrelerden manzara (geniş görüş alanı), doğa ile görsel bağlantı ve doğal sistem ve süreçlerle bağlantı parametreleri en önemli tasarım parametreleri olarak belirlenmiştir. Ayrıca elde edilen bu sonuçların ilerleyen çalışmalarda kullanılması ve “Biyofilik Ayaz İzi” veya “Biyofilik Yeterlilik Katsayısı” gibi kavramların literatüre kazandırılması amaçlanmaktadır.
Biyolojik ve Biyolojik Olmayan Ağlar Üzerine
(2021) Demıral, Dılek Gonçer; Uğurlu, Erginbay; Gürsakal, Necmi
Genel bir sınıflandırmayla, dünyada iki tür ağ vardır: Biyolojik ve biyolojik olmayan ağlar. Biyolojik ağlarınyapısı değiştirilememektedir. Ancak sosyal ağlar, teknolojik ağlar ve ulaşım ağları gibi biyolojik olmayan ağlarınmimarileri tasarlanabilir ve bu ağlar insanlar tarafından değiştirilebilir. Ağlar; rassal ağlar, küçük dünya ağları veölçekten bağımsız ağlar olarak sınıflandırılabilir. Ancak küçük dünya ağları ve ölçekten bağımsız ağlar ile ilgilisorunlarımız vardır. Bazı yazarların sorduğu gibi, “Küçük dünya ağları ne kadar küçüktür ve diğer modeller ilekarşılaştırıldığında nasıldır?”. Ölçekten bağımsız ağların yaygın mı yoksa nadir mi olduğu konusu halentartışılmaktadır. Bu çalışmadaki temel amaç biyolojik ve biyolojik olmayan ağların temel tanımlayıcı özellikleresahip olup olmadığının araştırılmasıdır. Özellikle biyolojik ağların özelliklerini detaylı bir şekilde belirleyebilirsek,daha sağlam ve etkili biyolojik olmayan ağları tasarlama şansımız olabilir. Ancak bu araştırma sonuçları, biyolojikağların özelliklerine ilişkin tartışmaların henüz tamamlanmadığını göstermektedir.
Citation - WoS: 0
Citation - Scopus: 0
Brain in Metabolic Syndrome Model: the Effect of Exercises and Caloric Restriction
(Marmara Univ, 2022) Şener, Göksel; Genc-Kahraman, Nevin; Ipekci, Hazal; Ustundag, Unsal Veli; Tunali-Akbay, Tugba; Emekli-Alturfan, Ebru; Yarat, Aysen; Eczacılık Meslek Bilimleri Bölümü
Caloric restriction (CR) and exercise (EX) have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX and/or CR in metabolic syndrome (MeS) induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10% fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX and/or CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control (C) group. These parameters reduced significantly in the metabolic syndrome with caloric restriction (MeS+CR) group, and more significantly in the metabolic syndrome with exercise and caloric restriction group (MeS+EXCR), compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeS+CR group, and MeS+EXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeS+EXCR group.
Büyük Veri Şirketleri ve Açık Kaynak Hareketi Öz
(2021) Gürsakal, Necmi; Çelik, Sadullah; Gürsakal, Sevda
Bu çalışmanın amacı, açık kaynak kodlu yazılımların büyük veri şirketleri tarafından amaçları dışında kötüye kullanılabileceğini tartışmaktır. Son yıllarda bilişim ve iletişim teknolojilerinde yaşanan gelişmeler Büyük Veri ve açık kaynak kodlu yazılımların kullanımını artırmıştır. R, Python, Hadoop, Spark, MapReduce gibi açık kaynak kodlu yazılımlar çok sayıda kişi tarafından geliştirilmekte ve bunlar Büyük Veri, Veri Bilimi, Yapay Zeka, Nesnelerin İnterneti ve Blok Zincir gibi birçok teknolojide kullanılmaktadır. Makine öğrenmesi ve derin öğrenme gibi Büyük Veri’ye değer katan yaklaşımlar açısından da, açık kaynak kodlu yazılımların önemi büyüktür. Bu yazılımların kaynak kodları herkese açıktır ve bunlara herkes katkıda bulunup istediği amaç doğrultusunda ücretsiz kullanabilir. Bugün Apple, Amazon, Google, Facebook, Microsoft, Samsung, Yahoo ve Qualcomm gibi birçok büyük veri şirketi, makine öğrenmesini hızlandırmak ve yazılıma uygun donanım geliştirmek için yoğun çalışmalar yapmaktadır. Ayrıca büyük veri şirketleri, TODO Group’u kurarak açık kaynak kodlu yazılım bilgilerini birbirleriyle paylaşmaya başlamışlardır. Ne yazık
Canlı Karaciğer Donör Adaylarında Hepatosteatozun Saptanmasında Biyopsi, Bilgisayarlı Tomografi ve Manyetik Rezonans Görüntülemenin Karşılaştırılması
(2021) Sokmen, Bedriye Koyuncu; Şahin, Tolga; Koçak, Erdem; Oral, Alihan
Amaç: Karaciğer donöründe hepatosteatoz (HS) varlığı, karaciğer transplantasyonu sonuçları üzerinde olumsuz etkilere sahiptir. Bu nedenle, donörde HS’nin tespiti, nakil öncesi dönemde hayati önem taşımaktadır. Bu çalışmanın amacı, canlı karaciğer donör adaylarında HS’nin saptanmasında karaciğer biyopsisi ve radyolojik yöntemlerin etkinliğini karşılaştırmaktır. Gereç ve Yöntem: Demiroğlu Bilim Üniversitesi’ne karaciğer transplantasyonu için donör adayı olarak kabul edilen 226 sağlıklı birey çalışmaya dahil edildi. Donörlerin demografik, histopatolojik, laboratuvar ve görüntüleme bulguları retrospektif olarak incelendi. Donörlerin bilgisayarlı tomografi (BT) ve manyetik rezonans görüntüleme (MRG) taramaları geriye dönük olarak yeniden değerlendirildi ve karaciğer yağ ölçümleri kaydedildi. Bulgular: Hastaların %39’u (88) kadın, %61’i (138) erkekti. Çalışma popülasyonunda ortalama yaş 34,3±8,7 yıl, ortalama ağırlık 78,0±12,6 kg, ortalama boy 169,1±9,6 cm ve ortalama vücut kitle indeksi 27,2±4,0 idi. Karaciğer biyopsisinde donörlerin %42’sinde <%5 HS vardı ve donörlerin %58’inde >%5 HS vardı. Hem BT hem de MRG, HS saptamada biyopsi ile anlamlı korelasyon gösterdi (p<0,05). Sonuç: Çalışmamızda MRG’nin BT kadar biyopsi ile ilişkili olduğu ve HS’nin saptanmasında rahatlıkla kullanılabileceği bulunmuştur. Karaciğer donörlerinde MRG kullanımı, iyonizan radyasyon içermemesinden dolayı nakil öncesi donör için daha uygun bir yöntem olabilir.
Canlı Vericili Karaciğer Naklinde Retrospektif Donör Hepatektomi Sonuçları- Tek Merkezdeneyimi
(2021) Andaçoğlu, Oya M.; Dönmez, Ramazan
Amaç: Donör hepatektomi tekniğimizi ve donör seçimimizi tanımlamayı, vaka serimizi gözden geçirmeyi, \rkomplikasyon oranlarımızı ve sonuçlarımızı bildirmeyi amaçladık. \rGereç ve Yöntemler: Yeditepe Üniversite Hastanesi'nde Ekim 2019- Kasım 2020 tarihleri arasında 41 ardışık \rdonör hepatektomi olgusunu retrospektif olarak inceledik. Komplikasyonlar Clavien-Dindo sınıflamasına göre \rderecelendirildi. Tüm olgular laparotomi ile yapıldı. \rBulgular: 41 donör olgusunun 38'i (%92,6) sağ lob, 2'si (%4,8) sol lob ve 1'i (%2,4) sol lateral segment donör \rhepatektomisi idi. Takip süresi 9 ± 2,2 aydı (4-16 ay). Sekiz (%19,5) komplikasyon vardı ve hepsi minördü \r(derece 1 veya 2). Derece 3 veya daha yüksek komplikasyon görülmedi. Üç donörde heterozigot Faktör 5 \rLeiden mutasyonu ve 4 tanesinde heterozigot protrombin mutasyonu vardı. Kalış süresi ortalama 6,4±1,4 gündü \r(aralık = 5-12). Kontrollü diyet ve egzersiz programı ile 10 donör kilo verdi. Bu hasta alt grubunda bir yara \rkomplikasyonu vardı. \rSonuç: Tek merkezli donör hepatektomi serimizi çok iyi sonuçlarla sunuyoruz. Ayrıca Vücut Kitle İndeksi > 30\rkg/m2\rolan donörler için başarılı kilo vermeyi de tanımlıyoruz. Donör güvenliği, canlı donör karaciğer naklinin \ren önemli bileşenidir. Donör sonuçları iyi oldukça, canlı vericili karaciğer nakli dünya çapında yaygınlaşmaya \rdevam edecektir.\r
Case Report of Rare Tissue Injury and Left Arm Dislocation After Incorrect Blood Pressure Measurement During Clinical Practice
(2023) Karaman, Özen Esra; Altıparmak, Yüksel Duygu
In midwifery education based on theoretical and practical foundations, students encounter midwifery profession education which based on for the first time in the Basic Clinical Skills in Midwifery Course. The aim of the Basic Clinical Skills in Midwifery Course is to help students understand the basic philosophy of midwifery and the role of the midwife in the health system, and to provide the student with knowledge, skills and attitudes about the basic concepts, principles and methods in midwifery care. In the Basic Clinical Skills in Midwifery Course, students are offered learning methods that will enable them to develop behaviors in the cognitive, affective and psychomotor domains. In this context, the course is carried out in skill development laboratories and clinical environments, after the lecturer in the classroom explains the basic concepts, the health system and midwifery, the protection and development of health, the fulfillment of physiological care needs, and the demonstration of the skills related to the psychomotor domain. Clinical practices are an indispensable element of midwifery education. The Midwifery Basic Clinical Skills Course has a very important place in clinical skills training, as students experience the hospital environment for the first time in their education life and experience midwifery practices for the first time on real patients. The aim here is to discuss a case that can be experienced after the correct application of vital sign measurement techniques and erroneous measurement.
Citation - WoS: 0
Citation - Scopus: 0
The Challenges Experienced by International Nursing Students in Nursing Education: a Qualitative Study
(Ataturk Univ, 2024) Elmali Simsek, Hulya; Karali, Ece; Arslan, Gunay
Objective: The study aimed to determine the challenges experienced by international nursing undergraduate students during their education period. Methods: A phenomenological research design was used. The study was conducted with 20 international nursing students enrolled in a foundation university in T & uuml;rkiye. Colaizzi's phenomenological data analysis method was employed in the study. Results: Based on the study's results, three main themes, 'Learning in a different environment', 'Challenges', 'Solution-Non Solution' and 'System difference, Language problems in clinical practice, Broad nursing curriculum, Facilitators, Language barrier, Feeling homesick, Racism and discrimination, Housing difficulties, Lack of funding, Instant solution, Failing to find a solution sub-themes themes were created. Conclusion: It has been observed that students experience different environments, uncertainties, and various challenges, and that these situations directly affect their education and success. To that end, both the institutions they receive education and the academicians must support the students in various ways.
Citation - WoS: 1
Chatgpt as a Solution To Emotional Loneliness: a New Tool for Interpersonal Communication
(Marmara Univ, Fac Communication, 2024) Sarioglu, Elif Basak; Guregen, Esra Pelin
Loneliness stands as one of the most pervasive and universal health issues in contemporary society. This study, conducted within the scope of emotional loneliness, delves into the nuances of loneliness, understanding its origin and how it manifests in individuals. In the research where students from the Faculty of Communication of a foundation university in Istanbul were chosen as the sample, the data collected through in-depth interviews, a qualitative data collection tool, were analyzed using content analysis method. This phenomenological research design aimed to assess participants' attitudes toward utilizing a chatbot (ChatGPT) as a tool to combat emotional loneliness. Despite their generally positive disposition and strong tendency to anthropomorphize, participants were found to approach the use of ChatGPT with caution. The majority harbored negative judgments about ChatGPT and technological tools meeting emotional and social needs. However, a significant portion believes that the widespread adoption of ChatGPT and similar tools for socialization is imminent in the near future. Concerns predominantly revolve around mistrust in artificial intelligence technologies' ability to meet emotional needs and the potential harms they could inflict on socio-cultural life, with ethical issues forming another major theme. Notably, when expressing their apprehensions, participants frequently referenced artificial intelligence representations in popular culture, such as films, series, and games.
Comparing the Effectiveness of Chiropractic Manipulation and Muscle Energy Technique in Sacroiliac Joint Dysfunction Treatment
(2022) Tekın, Demet; Bayram, Korhan Barış; Hatık, Sefa Haktan
Objective: The effects of chiropractic manipulation, muscle energy technique and home exercise program on pain, depression and functional level were compared in patients diagnosed with sacroiliac joint dysfunction (SIJD) in this study. Material-Method: Forty-five volunteer patients aged 20-65 years who were diagnosed with SIJD participated in this study. The patients were tested through chiropractic and orthopedic examination methods, and aspects of dysfunction were detected. Patients were randomized into 3 groups: Chiropractic Manipulation Group (CM), Muscle Energy Technique Group (MET), Control Group. All groups were assigned a home exercise program. All treatment groups were evaluated with numerical pain scale (NPS), Oswestry low back pain disability questionnaire (OLBPDQ), Beck depression inventory (BDI) and algometer before and after treatment. Descriptive statistics were used in data analysis, Kruskal-Wallis tests in intergroup comparisons, Mann-Whitney U tests in pairwise comparisons, and Friedman, post-hoc Wilcoxon Rank tests were used for intragroup comparisons. The statistical significance value was set at p<0.05 in the study. Results: Of the 45 volunteers who continued the study, 27 were female and 18 were male, and their mean age was 39.47±9.92 years. According to the results of intragroup analyses, a significant difference was found in all examination methods, and as a result of the intergroup analyses, there was a significant difference in all examination parameters except BDI. In the paired comparisons, positive results were obtained in all examinations in the CM and MET groups compared to the control group, in all parameters except for BDI in the analyses between CM and MET, and in examinations performed after the 4-week implementation in favor of CM (p<0.05). Conclusion: In patients with SIJD, CM performed in addition to exercises was found to be more effective than MET and exercise alone

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