A Rare Presentation of Bilateral Periventricular Nodular Heterotopia With Intra-Axial Pontine Lesion: A Case Report and Treatment Approach

dc.authorid Ibrahim, Ismail/0000-0002-0805-8181
dc.authorid Al-Qiami, Almonzer/0000-0003-3147-5060
dc.authorid Shenno, Milad/0009-0003-5489-6930
dc.authorid Nashwan, Abdulqadir/0000-0003-4845-4119
dc.authorscopusid 58732730100
dc.authorscopusid 58732317000
dc.authorscopusid 58731515200
dc.authorscopusid 58730695100
dc.authorscopusid 22985634100
dc.authorwosid Ibrahim, Ismail/KLC-4059-2024
dc.authorwosid Al-Qiami, Almonzer/KSL-5573-2024
dc.authorwosid Nashwan, Abdulqadir/J-6241-2019
dc.contributor.author Shenno, Milad
dc.contributor.author Al-Qiami, Almonzer
dc.contributor.author Ibrahim, Ismail A.
dc.contributor.author Elhaw, Lojin
dc.contributor.author Nashwan, Abdulqadir J.
dc.date.accessioned 2025-01-11T13:04:22Z
dc.date.available 2025-01-11T13:04:22Z
dc.date.issued 2024
dc.department Fenerbahçe University en_US
dc.department-temp [Shenno, Milad] Ain Shams Univ, Fac Med, Dept Neurosurg, Cairo, Egypt; [Al-Qiami, Almonzer] Kassala Univ, Fac Med & Hlth Sci, Kassala, South Sudan; [Ibrahim, Ismail A.] Fenerbahce Univ, Fac Hlth Sci, Istanbul, Turkiye; [Elhaw, Lojin] Delta Univ Sci & Technol, Fac Med, New Mansoura, Egypt; [Nashwan, Abdulqadir J.] Hamad Med Corp, Doha, Qatar en_US
dc.description Ibrahim, Ismail/0000-0002-0805-8181; Al-Qiami, Almonzer/0000-0003-3147-5060; Shenno, Milad/0009-0003-5489-6930; Nashwan, Abdulqadir/0000-0003-4845-4119 en_US
dc.description.abstract This report presents a rare case of a 19-year-old male with bilateral periventricular nodular heterotopia (PVNH), a congenital brain abnormality resulting from failed neural cell migration, along with an intra-axial pontine lesion of unknown pathology. The differential diagnosis of childhood brainstem tumors in such cases commonly includes diffuse midline glioma (DMG), which is associated with a dismal prognosis due to H3 K27 gene mutation. However, this case exhibits a unique focal dorsal exophytic brainstem glioma variant, accounting for only a small percentage (approximately 10 %) of pontine tumors and carrying a more favorable prognosis. The lesion is suspected to be a pilocytic astrocytoma, presenting distinct neurological symptoms. In this case, the patient presented with symptoms include mainly occasional tonic-clonic seizures, right side mild spasticity with ataxic gait and right eye blurring of vision along with right side facial palsy. The patient's clinical evaluation, in conjunction with various medical diagnostic tests and MRI with and without contrast, led to the final diagnosis. Management began with anti-epileptic medication, with a plan for further treatment and follow-up. en_US
dc.description.sponsorship Qatar National Library en_US
dc.description.sponsorship <B>Acknowledgment</B> Open Access funding provided by the Qatar National Library. Statement of Ethics. Verbal informed consent was obtained from the patient for publi-cation of this case report and any accompanying images. en_US
dc.description.woscitationindex Emerging Sources Citation Index
dc.identifier.citation 0
dc.identifier.doi 10.1016/j.inat.2023.101894
dc.identifier.issn 2214-7519
dc.identifier.scopus 2-s2.0-85178210401
dc.identifier.scopusquality Q4
dc.identifier.uri https://doi.org/10.1016/j.inat.2023.101894
dc.identifier.uri https://hdl.handle.net/20.500.14627/357
dc.identifier.volume 36 en_US
dc.identifier.wos WOS:001125521100001
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 0
dc.subject Epilepsy en_US
dc.subject Pvnh en_US
dc.subject Congenital Anomaly en_US
dc.title A Rare Presentation of Bilateral Periventricular Nodular Heterotopia With Intra-Axial Pontine Lesion: A Case Report and Treatment Approach en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication

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