The Use of Probiotics in the Treatment and Prophylaxis of Various Diseases in Turkiye: a Systematic Review

dc.authorid Kahraman Kilbas, Elmas Pinar/0000-0003-1348-625X
dc.authorid Altindis, Mustafa/0000-0003-0411-9669
dc.authorwosid Altindis, Mustafa/O-8413-2019
dc.authorwosid Kılbaş, Elmas/HRC-3339-2023
dc.contributor.author Kahraman Kılbaş, Elmas Pınar
dc.contributor.author Altindis, Mustafa
dc.contributor.other Tıbbi Hizmetler ve Teknikler Bölümü
dc.date.accessioned 2025-01-11T13:01:16Z
dc.date.available 2025-01-11T13:01:16Z
dc.date.issued 2023
dc.department Fenerbahçe University en_US
dc.department-temp [Kilbas, Elmas Pinar Kahraman] Fenerbahce Univ, Program Med Lab Tech, Vocatinal Sch Hlth Serv, Istanbul, Turkiye; [Altindis, Mustafa] Sakarya Univ, Dept Med Microbiol, Div Med Virol, Fac Med, Sakarya, Turkiye en_US
dc.description Kahraman Kilbas, Elmas Pinar/0000-0003-1348-625X; Altindis, Mustafa/0000-0003-0411-9669 en_US
dc.description.abstract The aim of this study is to analyze the available information on the use of probiotics containing different microorganisms, singly or in combination, in order to investigate the effect of probiotics on the treatment, prophylaxis and microbiota of various diseases. In addition to Pubmed, Google Scholar, SCOPUS, EMBASE, Cochrane Library of Systematic Reviews, CINAHL, AMED, Turkish Medline electronic da- tabases, the gray literature was searched to cover the years 2004-2021. Randomized controlled studies (RCTs) included in the specified selection criteria were brought together. RCTs were evaluated using the Cochrane risk of bias tool. Of the 32 RCTs included in total, only yeast (Saccharomyces spp.) was administered in fourteen, only Lactobacillus spp. in six, Bifidobacterium spp. only in four, and probiotic supplementation containing more than one bacterial strain in six. Only 10/32 of the included studies fully reported the probiotic strain, and 22/32 reported only at the species level. In all nine studies using probiotics for the treatment of diarrhea, probiotics were reported to shorten the duration of diarrhea and length of hospital stay. Four of the five studies reporting the use of probiotics in the treatment of necrotizing enterocolitis reported that probiotics were not effective in reducing the incidence of necrotizing enterocolitis, but could improve nutritional tolerance. In two of the four RCTs investigating the use of probiotics in the treatment of Helicobacter pylori infec- tion, it was stated that the side effects associated with eradication therapy decreased. In both studies conducted for prophylaxis, it was reported that probiotics prevent antibiotic-associated diarrhea. This study shows that probiotics have positive results for the treatment indications and prophylaxis of various diseases. For the sustainability of these health benefits and the safe administration of probiotics, more research is needed that includes strain information and side effect reports. en_US
dc.description.woscitationindex Emerging Sources Citation Index
dc.identifier.citation 0
dc.identifier.doi 10.5578/flora.20239902
dc.identifier.endpage 36 en_US
dc.identifier.issn 1300-932X
dc.identifier.issn 2602-2842
dc.identifier.issue 1 en_US
dc.identifier.scopusquality N/A
dc.identifier.startpage 19 en_US
dc.identifier.trdizinid 1165122
dc.identifier.uri https://doi.org/10.5578/flora.20239902
dc.identifier.uri https://hdl.handle.net/20.500.14627/112
dc.identifier.volume 28 en_US
dc.identifier.wos WOS:000972603100003
dc.language.iso en en_US
dc.publisher Bilimsel Tip Yayinevi en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Probiotic en_US
dc.subject Microbiota en_US
dc.subject Saccharomyces Spp en_US
dc.subject Lactobacillus Spp en_US
dc.subject Bifidobacterium Spp en_US
dc.title The Use of Probiotics in the Treatment and Prophylaxis of Various Diseases in Turkiye: a Systematic Review en_US
dc.type Review en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
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relation.isAuthorOfPublication.latestForDiscovery cc28c727-07ae-40d8-9418-75b409b22d85
relation.isOrgUnitOfPublication 71e25e1a-470b-4aba-b574-5311c2551e2d
relation.isOrgUnitOfPublication.latestForDiscovery 71e25e1a-470b-4aba-b574-5311c2551e2d

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