Protective Effect Of Chard Extract On Glycoprotein Compounds And Advanced Oxidation Protein Product Levels İn Diabetic Rat Livers;

Abstract

Objective: Diabetes mellitus is a metabolic disease of global importance. It affects many people by reducing their quality of life and even causing death. Therefore, research on diabetes mellitus maintains its popularity and continues to develop. Chard (Beta vulgaris L. var. cicla) is commonly used in diets and is known to have alternative hypoglycemic effects in diabetic individuals. This study investigated the protective effects of chard on glycoproteins (hexose, hexosamine, fucose and sialic acid) and the advanced oxidation protein product levels in diabetic rats’ livers. Materials and Methods: For this experiment, male Sprague–Daw-ley rats were separated into three groups: the control; Streptozotocin (STZ)-induced diabetic rats; and STZ-induced diabetic + chard extract. Fourteen days after diabetes induction, chard extract (2 g/kg/day, gavage) was administered for 45 days. On day 60, liver samples were collected, and 10% (w/v) homogenate was prepared for the analysis of glycoprotein components and advanced oxidation protein products. Results: Levels of glycoprotein parameters that include hexose, hexosamine, fucose, and sialic acid, as well as advanced oxidation protein product levels, increased in the diabetic group. Chard extract administration curatively reverted the altered biochemical parameters. Conclusion: From the results obtained, it can be suggested that chard extract has a protective effect on the diabetic livers of rats. © 2021, Istanbul University Press. All rights reserved.