WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Gold Nanoparticle/Silk Fibroin-Based Nanofiber Enhances Skin Regeneration
    (Oxford University Press, 2025) Özcan, Ozan; Tufan, Elif; Muhan, Aleyna Tanrıverdi; Çalişkan-Ak, Esin; Şener, Göksel; Tunalı-Akbay, Tuǧba; Ak, Esin
    Objectives The aim of this study was to determine the wound-healing potential of gold nanoparticles and silk fibroin-based nanofiber produced by green chemistry. Methods The electrospinning method was used to prepare the nanofiber. Twenty rats were exposed to a 7-day treatment period and another 20 rats were exposed to a 21-day treatment period. Rat groups were control, silver, silk fibroin, and silk + gold nanoparticle groups for each period. The effect of the gold nanoparticle/silk fibroin-based nanofiber was examined in skin samples by using biochemical and histological analysis. In biochemical analysis, skin oxidant and antioxidant parameters were determined. Key findings Parameters indicating skin damage returned to their previous levels 7 and 21 days after the wound formation using gold nanoparticle/silk fibroin-based nanofiber. Gold nanoparticle/silk fibroin-based nanofiber initiated hair follicle formation at the wound site and accelerated the re-epithelialization process. Conclusions It was found that the nanofiber prepared by adding gold nanoparticles to silk fibroin had better wound-healing properties than silk fibroin nanofibers without gold nanoparticles. © 2025 Elsevier B.V., All rights reserved.
  • Article
    The Protective Effects of Myrtus Communis Subsp. on Ovariectomized Diabetic Rats’ Renal and Intestinal Tissues: in Vivo and in Silico Approaches
    (Taylor and Francis Ltd., 2025) Ertik, O.; Kadıoğlu-Yaman, Beril; Şen, Ali; Şener, Göksel; Yanardag, Refiye
    Introduction: Postmenopausal diabetes is a condition that affects millions of women and their quality of life. Also, kidney and small intestine tissues are damaged due to diabetes. The present study aimed to examine the protective effects of an extract prepared from Myrtus communis leaves on kidney and small intestine tissues against experimentally created postmenopausal diabetes. Methods: For this purpose, experimental rats were randomly divided into six groups (Control; ovariectomy:OVX, diabetic:D, ovariectomy + diabetic:OVX + D, ovariectomy + diabetic + oestrogen:OVX + D+E2, ovariectomy + diabetic + MC: OVX + D+MC) and kidney and small intestine tissues were taken after the experimental procedure. Results: Evaluations of biochemical parameters (glutathione and glutathione-related enzymes, antioxidant enzymes, etc.) showed that MC had a protective effect on kidney and small intestine tissues in diabetes and ovariectomy groups. Conclusion: It can be suggested that MC extract has a protective effect on small intestine and kidney tissues in postmenopausal diabetes and may be a good herbal source for this purpose. © 2024 Informa UK Limited, trading as Taylor & Francis Group.