PubMed İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8
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Article The Gut-Kidney Axis in Calcium Oxalate Nephrolithiasis: Nutritional and Microbial Insights(Kare Publ, 2026) Sener, Goksel; Marzi, Mahdi; Sener, Tarik EmreCalcium oxalate (CaOx) nephrolithiasis is the most common type of kidney stone disease worldwide. Recent studies show that its development cannot be explained solely by renal solute handling; instead, it reflects a broader interaction between dietary habits, the intestinal microbiota, and host metabolic responses. Intestinal absorption of calcium and oxalate-two central drivers of lithogenesis-is shaped by both microbial composition and dietary patterns. Although Oxalobacter formigenes was initially regarded as the main oxalate-degrading organism, newer studies indicate that a wider disturbance of the gut microbiota, especially the loss of short-chain fatty acid (SCFA)-producing species, may increase susceptibility to stone formation. In this review, nutritional, microbial, and mechanistic evidence is brought together to examine how diet-particularly salt, animal protein, calcium, oxalate, fruits, vegetables, and water intake-modulates the gut-kidney axis. Diets high in salt or animal protein tend to shift the microbiota toward more pro-inflammatory and acidogenic profiles, while fiber-rich, plant-based diets and adequate hydration appear to support microbial diversity, SCFA production, and epithelial barrier integrity. Probiotic and synbiotic interventions have also gained attention as potential strategies to reduce stone recurrence by targeting gut microbial function. Taken together, current findings suggest that the gut-kidney axis is a dynamic metabolic link between diet, microbial ecology, and renal physiology. Future studies combining multi-omics methods with personalized nutritional approaches may help develop more effective microbiota-based prevention and treatment strategies for CaOx nephrolithiasis.Article Nutritional, Sleep, Physical Activity, and Quality-of-Life Changes during Ramadan Fasting: A Prospective Comparative Study(Frontiers Media SA, 2026) Bayraktaroglu, Emre; Erdem, Nihal Zekiye; Mizrak, Elif; Oner Sayar, Canel; Karaagac, Rabia Melda; Gecgil Demir, Eftal; Tarakci Filiz, Nadide GizemBackground: Ramadan is the holiest month in the Islamic calendar. Ramadan fasting, which lasts from sunrise to sunset, significantly affects eating habits, physical activity, daytime sleepiness, and quality of life. In this study, body weight, daytime sleepiness (Epworth Sleepiness Scale), physical activity level, dietary intake, and quality of life (SF-36) were assessed in fasting and non-fasting individuals before, during, and after Ramadan. Methods: In this prospective longitudinal comparative study of 282 healthy adults, individuals were divided into fasting and non-fasting groups. Data were collected in four phases: 1 week before, in the middle, at the end, and 2 weeks after Ramadan. Results: Total energy intake, macronutrient consumption, and body weight decreased during Ramadan and increased again after Ramadan, with these changes being more pronounced in the fasting group. Daytime sleepiness increased and physical activity level decreased in fasting individuals during Ramadan, but both returned toward baseline levels after Ramadan. In terms of quality of life, significant differences between fasting and non-fasting individuals were observed, particularly in physical and emotional role functioning domains (p < 0.05). Conclusion: This study demonstrated that Ramadan fasting is associated with changes in dietary intake, daytime sleepiness, physical activity, and quality of life. Moreover, similar patterns observed in non-fasting individuals suggest that environmental and lifestyle factors during Ramadan may also play a role.Article Evaluation of the Relationship Between Job Stress Level, Adherence to the Mediterranean Diet, and Phytochemical Index(MDPI, 2025) Cetiner Bingul, Bengi; Bas, MuratBackground/Objectives: Job stress negatively affects physical and psychological health and can lead to behavioral changes such as unhealthy eating. This study aimed to evaluate the relationship between job stress levels, adherence to the Mediterranean diet, and the phytochemical index (PI). Methods: The study included 200 healthy individuals aged 18-50 working at the Tuzla Gum Factory. Data were collected through demographic and dietary questionnaires, two-day 24-h food records, PI values, and anthropometric measurements. Job stress was assessed using the Job Stress Scale, and Mediterranean diet adherence was assessed with the Mediterranean Diet Adherence Questionnaire. Results: Waist and hip circumference, waist/hip ratio, and BMI were significantly higher in individuals with high levels of job stress (p < 0.01). Unskilled workers reported higher stress than professionals (p < 0.01). Significant differences were found in carbohydrate and fiber intake among males and in energy, protein, carbohydrate, and vitamin A intake among females with varying stress levels (p < 0.01). No significant difference in Mediterranean diet adherence was observed between medium and high stress groups. However, women had higher adherence and PI scores than men (p < 0.01). Diet adherence was better among managers than service-sales and technical staff (p < 0.01). PI scores were higher in medium stress than high stress individuals (p < 0.05) and in those with a higher BMI compared to a normal BMI (p < 0.01). Conclusions: Job stress influences both anthropometric parameters and dietary habits. Effective stress management may improve adherence to the Mediterranean diet and phytochemical intake. Workplace strategies supporting healthy eating behaviors are recommended.Article Citation - WoS: 2Citation - Scopus: 4The Effects of Dietary Changes on Bone Markers in Postmenopausal Vertebral Osteopenia(Churchill Livingstone, 2020) Islamoglu, A. Humeyra; Garipagaoglu, Muazzez; Bicer, H. Selcen; Kurtulus, Duygu; Ozturk, Mustafa; Gunes, F. EsraBackground & aims: Nutrition is one of the most important environmental factors affecting the formation of osteopenia. The purpose of this study was to investigate the effects of dietary changes on bone formation and bone resorption markers of postmenopausal women with vertebral osteopenia. Methods: In this study, 108 women with postmenopausal vertebral osteopenia were included. Patients were observed for a month to identify their regular nutritional status. Before intervention, blood and urine samples were taken from all patients. Then, 2-day food consumption records were taken and the patients were divided into 4 groups. Different types of diets (opposite of their regular diets) were prepared for these groups (1: control, 2: reduced-carbohydrate, 3: reduced-protein, 4: reduced-sodium) and followed for 3 months. At the end of follow-ups, blood and urine samples were taken again and changes in osteocalcin (OC) and N-terminal telopeptide (NTX) levels were examined. Results: According to biochemical analysis, there was a significant decrease (p < 0,001) in OC levels in reduced protein group and an increase (p > 0,05) in reduced carbohydrate group. When NTX levels were assessed, a significant decrease (p < 0.001) in the reduced carbohydrate group and a significant increase in the reduced protein group (p < 0.05) were found. Conclusion: Our findings show that reduced carbohydrate diet protected whereas, reduced protein diet negatively affected bone health. Osteopenic individuals were thought to be able to improve bone health and their quality of life by early dietary intervention. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.