PubMed İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8
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Article The Gut-Kidney Axis in Calcium Oxalate Nephrolithiasis: Nutritional and Microbial Insights(Kare Publ, 2026) Sener, Goksel; Marzi, Mahdi; Sener, Tarik EmreCalcium oxalate (CaOx) nephrolithiasis is the most common type of kidney stone disease worldwide. Recent studies show that its development cannot be explained solely by renal solute handling; instead, it reflects a broader interaction between dietary habits, the intestinal microbiota, and host metabolic responses. Intestinal absorption of calcium and oxalate-two central drivers of lithogenesis-is shaped by both microbial composition and dietary patterns. Although Oxalobacter formigenes was initially regarded as the main oxalate-degrading organism, newer studies indicate that a wider disturbance of the gut microbiota, especially the loss of short-chain fatty acid (SCFA)-producing species, may increase susceptibility to stone formation. In this review, nutritional, microbial, and mechanistic evidence is brought together to examine how diet-particularly salt, animal protein, calcium, oxalate, fruits, vegetables, and water intake-modulates the gut-kidney axis. Diets high in salt or animal protein tend to shift the microbiota toward more pro-inflammatory and acidogenic profiles, while fiber-rich, plant-based diets and adequate hydration appear to support microbial diversity, SCFA production, and epithelial barrier integrity. Probiotic and synbiotic interventions have also gained attention as potential strategies to reduce stone recurrence by targeting gut microbial function. Taken together, current findings suggest that the gut-kidney axis is a dynamic metabolic link between diet, microbial ecology, and renal physiology. Future studies combining multi-omics methods with personalized nutritional approaches may help develop more effective microbiota-based prevention and treatment strategies for CaOx nephrolithiasis.Article The Impact of Home-Based Telerehabilitation Pranayama on Sleep Quality and Wellbeing in Mild to Moderate Obstructive Sleep Apnea Syndrome. A Randomized Controlled Trial(BMC, 2026) Mustafaoğlu, Rüstem; Naci, Baha; Demir, Rengin; Önder, Ömer Önder; Atahan, Ersan; Kaçar Akkoç, ZeynepBackground Obstructive sleep apnea syndrome (OSAS) is a common disorder that causes repeated airway obstruction, disrupted breathing, and fragmented sleep. This study aimed to investigate the effects of Pranayama on sleep quality, daytime sleepiness, quality of life, fatigue, depression, and anxiety in patients with OSAS. Methods This study was designed as an open-label, prospective, randomized controlled trial. OSAS patients meeting the inclusion criteria were randomly assigned to either an Intervention group or a Control group. Pranayama training was applied to the Intervention group for 8 weeks, 7 days a week, and 3 times a day for 15 min. In addition, a single 15-minute session, 3 days a week, was conducted online under the supervision of a physiotherapist. The control group did not receive any intervention. Primary outcome was sleep quality (Pittsburgh Sleep Quality Index, PSQ). Secondary outcomes included daytime sleepiness (Epworth Sleepiness Scale, ESS), Fatigue Severity Scale (FSS), Functional Outcomes of Sleep Questionnaire (FOSQ), Nottingham Health Profile (NHP), and Hospital Anxiety and Depression Scale (HADS). All outcome measures were assessed at baseline and reassessed after the 8-week intervention period. Results Thirty-eight OSAS patients meeting the inclusion criteria were randomly assigned to either an Intervention group 6n = 19 ) or a Control group (n = 19) Four participants (two in each group) were lost to follow-up, leaving the data of participants (17 per group) available for inclusion in the final analysis. In the intervention group, PSQI scores decreased from 9.12 +4.71 to 6.88 +/- 4.45 (p < 0.001) whereas no improvement was observed in the control group. Regarding the primary outcome, the reduction in PSQI scores was significantly greater in the intervention group than in the control group (p < 0.001) The ESS scores also decreased significantly in the intervention group, from 9.41 +/- 6.15 to 7.41 +/- 6.18 6p = 0.006 with a significant between-group difference (p < 0.001) Fatigue severity decreased in the intervention group (FSS change: 0.53 +/- 0.70; p = 0.006 ), with a significant between-group difference 6p = 0.037 The FOSQ score improved markedly, with significant gains in FOSQ total score (-0.38 +/- 0.25 vs. 0.14 +/- 0.22 in controls; p < 0.001) and in activity level and vigilance subdomains (both p < 0.001). The HADS-anxiety scores decreased by 1.94 +/- 3.94 (p = 0.059) and depression scores by 3.06 +/- 2.05 (p < 0.001) in the intervention group, with significant between-group differences for both anxiety (p = 0.008) and depression (p < 0.001). Conclusion Pranayama was an effective adjunct therapy for these OSAS patients, and incorporating it into treatment strategies may enhance patient outcomes. Clinical trial registration number/date NCT04632147/22.10.2020.Article Short-Term Effects of Targeted Movement Training on Gait Kinematics in Children with Juvenile Idiopathic Arthritis: A Motion Analysis Study(MDPI, 2026) Argunsah, Hande; Dönmez, İrem; Ayaz, Nuray Aktay; Yekdaneh, Asena; Albayrak, Asya; Arman, Nilay; Aktay Ayaz, Nuray; Özbal, SibelBackground: Children with juvenile idiopathic arthritis (JIA) exhibit gait abnormalities, postural instability, and compensatory movement strategies due to joint pain, inflammation, and reduced neuromuscular control. These alterations negatively affect functional mobility and movement efficiency. Although gait retraining is commonly recommended in rehabilitation, objective evidence on its short-term biomechanical effects remains limited. This study aimed to evaluate the immediate impact of a single-session standardized movement training intervention on gait biomechanics in children with JIA. Methods: Seventeen children with JIA underwent pre-post gait assessments using the Xsens MVN Awinda wearable motion capture system. The intervention focused on step symmetry, stride length, heel-toe progression, and upright trunk posture, delivered by an experienced physiotherapist following a standardized protocol. Scalar kinematic outcomes were analyzed using paired statistical tests, and time-normalized kinematic waveforms were compared with healthy reference data from 25 age-matched participants derived from the COMPWALK-ACL dataset. Results: Significant improvements were observed in multiple gait parameters following the intervention. Trunk lateral lean decreased significantly (p = 0.0002; d = -1.35), indicating enhanced postural stability. Significant changes were also found in ankle dorsiflexion-plantarflexion (p = 0.0081; d = 0.83) and knee flexion-extension (p = 0.0252; d = 0.68). Waveform analyses showed increased similarity to healthy patterns, particularly in trunk and knee kinematics. Spatiotemporal parameters reflected a slower, more controlled gait pattern, with increased stride time and stance duration. Conclusions: A single session of standardized movement training can produce immediate improvements in gait biomechanics in children with JIA, especially in trunk control and lower-limb kinematics. Wearable motion analysis provides a sensitive tool for detecting these short-term adaptations and supports the inclusion of structured movement training in pediatric JIA rehabilitation.Article Article The Effect of Preoperative Melatonin Patches on Sleep Quality in Patients Undergoing Urological Surgery(Assoc Medica Brasileira, 2026) Akok, Selin Ayten; Akinci, Naile; Toprak, ÇağlaOBJECTIVE: The aim of this study was to determine the effects of transdermal melatonin patches on sleep quality in patients undergoing urological surgery. METHODS: This study is a randomized controlled trial. Fifty-seven patients hospitalized in the urology department of a university hospital in Istanbul were included. Patients were randomly assigned to two groups (melatonin and control). Patients in the melatonin group received transdermal melatonin containing 7 mg of melatonin at 11:00 PM in a quiet, darkened room the night before surgery. RESULTS: According to the results of this study, Richards-Campbell Sleep Scale sleep-quality scores increased significantly in the melatonin group (p<0.001). The control group showed lower sleep-quality scores. In addition, a statistically significant decrease was observed between the visual analog scale well-being scores before and after the application in the melatonin group (p<0.001). CONCLUSION: In this study, our results showed that melatonin patches improved sleep quality and psychological well-being in patients undergoing urological surgery.Article Protective Effects of Lactobacillus Rhamnosus GG Against Methotrexate-Induced Oxidative Renal Toxicity(Springer, 2026) Yanardag, Refiye; Bayrak, Bertan Boran; Sener, Goksel; Almurad, Bade; Donmez, Muhammet OguzhanMethotrexate (MTX) is commonly prescribed for various malignant and autoimmune conditions, but it can cause significant oxidative and functional impairment in renal tissue. Lactobacillus rhamnosus GG. (LGG) is a well-known probiotic with biological activities that support antioxidant balance. This study investigated the impact of LGG on MTX-induced kidney damage. Male Sprague-Dawley rats were divided into four groups: physiological saline-treated control group; a group receiving MTX alone; a group receiving MTX alongside a low dose of LGG; and a group receiving MTX alongside a high dose of LGG. MTX was administered as single dose (20 mg/kg/bw) intraperitoneally and LGG (low dose 1 x 10(9) CFU/day and high dose 5 & times; 10(9) CFU/day, respectively) orally for five days. On day six, blood and kidney samples were collected and examined for oxidative indicators, enzymatic antioxidant responses, and renal functional markers. MTX significantly increased in glomerular filtration markers in serum and elevated key indicators of oxidative stress in renal tissues. More so, MTX demonstrated to disrupt renal ionic homeostasis, such as declined sodium/potassium-ATPase, paraoxonase, and increased lactate dehydrogenase, carbonic anhydrase, xanthine oxidase, myeloperoxidase, and arginase activities. In contrast, LGG supplementation has been shown to effectively reverse all MTX-induced biochemical alterations in both serum and renal tissue. We can suggest that LGG can provide significant protection against oxidative renal toxicity induced by MTX in rats.Article Nutritional, Sleep, Physical Activity, and Quality-of-Life Changes during Ramadan Fasting: A Prospective Comparative Study(Frontiers Media SA, 2026) Bayraktaroglu, Emre; Erdem, Nihal Zekiye; Mizrak, Elif; Oner Sayar, Canel; Karaagac, Rabia Melda; Gecgil Demir, Eftal; Tarakci Filiz, Nadide GizemBackground: Ramadan is the holiest month in the Islamic calendar. Ramadan fasting, which lasts from sunrise to sunset, significantly affects eating habits, physical activity, daytime sleepiness, and quality of life. In this study, body weight, daytime sleepiness (Epworth Sleepiness Scale), physical activity level, dietary intake, and quality of life (SF-36) were assessed in fasting and non-fasting individuals before, during, and after Ramadan. Methods: In this prospective longitudinal comparative study of 282 healthy adults, individuals were divided into fasting and non-fasting groups. Data were collected in four phases: 1 week before, in the middle, at the end, and 2 weeks after Ramadan. Results: Total energy intake, macronutrient consumption, and body weight decreased during Ramadan and increased again after Ramadan, with these changes being more pronounced in the fasting group. Daytime sleepiness increased and physical activity level decreased in fasting individuals during Ramadan, but both returned toward baseline levels after Ramadan. In terms of quality of life, significant differences between fasting and non-fasting individuals were observed, particularly in physical and emotional role functioning domains (p < 0.05). Conclusion: This study demonstrated that Ramadan fasting is associated with changes in dietary intake, daytime sleepiness, physical activity, and quality of life. Moreover, similar patterns observed in non-fasting individuals suggest that environmental and lifestyle factors during Ramadan may also play a role.Article Effectiveness of Escape Room–Based Learning for Patient Safety Education in Nursing Students(BMC, 2026) Demet, Inangil; Kokkiz, Rukiye; Semiz, Demet; Turkmen, KübraBackground Ensuring patient safety is a cornerstone of nursing practice, and its foundation is established during nursing education. The study evaluates the effectiveness of escape room-based learning designed in accordance with the International Patient Safety Goals on nursing students' self-efficacy about patient safety. Methods The study was conducted with senior nursing students from February to May 2024. Data were collected using the Student Information Form, Patient Safety Self-Efficacy Questionnaire, and Satisfaction with Training Methods Scale. The escape room was structured in three phases-prebriefing, simulation, and debriefing-following INACSL standards. Clinical trial number: NCT07179367. Results The average age of the participants was 23.5, and 43.5% had previously completed an elective course on patient safety. Analyses revealed that participants spent the most time, averaging 2.59 min, in the room dedicated to information questions. The average self-efficacy score before the intervention was 61.26, which increased to 71.32 after the intervention, and participants reported a high level of satisfaction. Conclusion This study's findings indicate that patient safety-themed escape room training significantly enhances students' self-efficacy in patient safety, as well as their overall satisfaction and motivation.Correction Cleats on, Battle Real: Sustainability and Gender Equality in Women’s Football (Vol 17, 1743515, 2026)(Frontiers Media SA, 2026) Aksakal, Nalan; Ornek, Serda; Erkan, Mert; Besiktas, Murat Yalcin; Terekli, Mustafa SerdarArticle A Nurse-Led Approach to Preventing Delirium in the ICU: A Randomised Controlled Trial of NICE Guideline-Based Sensory Modulation(Wiley, 2026) Ozdemir Urkmez, Dilek; Ervatan, Zekeriya; Topcu, Serpil; Sen Yilmaz, Melis; Kiymac Sari, MerveBackground Delirium is a preventable yet pervasive complication in intensive care units (ICUs) settings, disproportionately increasing patient morbidity and healthcare costs. While environmental disruptions (e.g., light/noise) are modifiable risk factors, nurse-delivered, non-pharmacological strategies may be under-implemented in routine practice despite guideline recommendations.Aim This study aimed to evaluate the efficacy of a simple, holistic nursing intervention-eye masks and earplugs-to mitigate delirium incidence in ICU patients.Study Design A randomised controlled trial was conducted in the adult general intensive care unit of a public hospital in Istanbul, Türkiye, between May and September 2024. Patients were assigned to either an intervention group (nightly use of eye masks and earplugs together with a delirium prevention guide) or a control group (delirium prevention guide only). Delirium was assessed using the Richmond Agitation Sedation Scale (RASS) and the Nursing Delirium Screening Scale (Nu-DESC).Results In total, 190 patients were randomised. Ten participants allocated to the intervention group did not receive the intervention because 9 were unwilling to continue and 1 became intubated. Consequently, 180 patients were analysed (90 per group). The intervention group showed a 62% lower incidence of delirium than the control group (7.8% vs. 20%, p = 0.001). In addition, delirium developed later in the intervention group (2.57 +/- 0.79 vs. 1.89 +/- 0.85 days, p = 0.001), and Nu-DESC scores differed significantly between the groups (p = 0.001).Conclusions Nightly use of eye masks and earplugs was associated with lower delirium incidence and later onset in ICU patients when implemented alongside a NICE-aligned delirium prevention guide.Relevance to Clinical Practice As a scalable, non-pharmacological approach, this intervention offers a feasible, low-cost option that empowers nurses to lead delirium prevention through holistic, patient-centred care. Further studies may help clarify generalisability across different ICU settings.Trial Registration ClinicalTrials.gov ID: NCT06403410