PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/8

Browse

Filters

20263

Settings

Author: search.filters.author.Marzi, MahdiDepartment: search.filters.department.Fenerbahçe University

Search Results

Now showing 1 - 3 of 3
  • Article
    The Gut-Kidney Axis in Calcium Oxalate Nephrolithiasis: Nutritional and Microbial Insights
    (Kare Publ, 2026) Sener, Goksel; Marzi, Mahdi; Sener, Tarik Emre
    Calcium oxalate (CaOx) nephrolithiasis is the most common type of kidney stone disease worldwide. Recent studies show that its development cannot be explained solely by renal solute handling; instead, it reflects a broader interaction between dietary habits, the intestinal microbiota, and host metabolic responses. Intestinal absorption of calcium and oxalate-two central drivers of lithogenesis-is shaped by both microbial composition and dietary patterns. Although Oxalobacter formigenes was initially regarded as the main oxalate-degrading organism, newer studies indicate that a wider disturbance of the gut microbiota, especially the loss of short-chain fatty acid (SCFA)-producing species, may increase susceptibility to stone formation. In this review, nutritional, microbial, and mechanistic evidence is brought together to examine how diet-particularly salt, animal protein, calcium, oxalate, fruits, vegetables, and water intake-modulates the gut-kidney axis. Diets high in salt or animal protein tend to shift the microbiota toward more pro-inflammatory and acidogenic profiles, while fiber-rich, plant-based diets and adequate hydration appear to support microbial diversity, SCFA production, and epithelial barrier integrity. Probiotic and synbiotic interventions have also gained attention as potential strategies to reduce stone recurrence by targeting gut microbial function. Taken together, current findings suggest that the gut-kidney axis is a dynamic metabolic link between diet, microbial ecology, and renal physiology. Future studies combining multi-omics methods with personalized nutritional approaches may help develop more effective microbiota-based prevention and treatment strategies for CaOx nephrolithiasis.
  • Article
    Protective Effects of L-Theanine against Bisphenol A-Induced Oxidative Stress and Gut Microbiota Disruption in Wistar Rats
    (Springer, 2026) Sener, Azize; Marzi, Mahdi; Sener, Goksel; Donmez, Muhammet Oguzhan
    Background Gut microbiota homeostasis plays a central role in maintaining intestinal redox balance and immune regulation. Bisphenol A (BPA), a widely distributed environmental contaminant, has been associated with oxidative stress, inflammatory responses, and disturbances in intestinal microbial communities. L-theanine (LTN), a bioactive amino acid naturally present in green tea, possesses well-documented antioxidant and anti-inflammatory properties; however, its potential protective role against BPA-induced intestinal injury has not been fully clarified. Methods and Results In the present study, female Wistar albino rats were randomly allocated into three groups: control, BPA (50 mg/kg/day), and BPA + LTN (100 mg/kg/day) and treated for 30 days. Oxidative stress and inflammatory responses in intestinal and colonic tissues were assessed by measuring malondialdehyde (MDA), reduced glutathione (GSH) levels and myeloperoxidase (MPO), catalase (CAT) activities. BPA exposure significantly increased MDA (p < 0.001) level and MPO (p < 0.001) activity while reducing GSH content (p < 0.001) and CAT activity (p < 0.001) compared with the control group. Compared to the BPA group, LTN treatment led to significant changes in MDA, MPO, and GSH levels in both tissues. MDA and MPO levels were significantly reduced in the intestine and colon tissues of the BPA + LTN group (p < 0.001). GSH and CAT levels were significantly increased in both the intestine and colon compared to the BPA group (p < 0.001). In addition, fecal microbiota composition was analyzed using 16 S rRNA gene sequencing, with taxonomic profiling performed at the phylum, genus and species levels. BPA exposure was associated with reduced microbial stability and compositional shifts within the gut microbiota, whereas LTN treatment partially restored microbial richness and community structure. Conclusions Collectively, these findings indicate that LTN alleviates BPA-induced intestinal oxidative stress and microbiota dysbiosis, suggesting its potential as a protective dietary compound against environmental toxicant-related intestinal injury.
  • Article
    Advances and Strategies in Biosensor-Based Diagnostics for Parasitic Infections: A Comprehensive Scoping Review
    (Springer, 2026) Aminizadeh, Selva; Alizadeh, Gita; Alizadeh, Zahra; Khalilzadeh, Balal; Abidin, Zurina Zainal; Marzi, Mahdi; Rafiei-Sefiddashti, Raheleh
    Parasitic diseases are among the most widespread infections worldwide, causing millions of deaths and illnesses each year. So rapid and accurate diagnosis is essential, requiring highly sensitive and specific tests. Biosensors can provide significant advantages over traditional diagnostic methods because of their specificity, sensitivity, speed, simplicity, ease of use, repeatability, and capacity for early-stage disease detection. Recent advances in modern diagnostic tools for detecting parasitic infections use nanomaterials such as gold nanoparticles, carbon nanofibers, and carbon nanotubes. These developments have significantly lowered detection limits to the picogram and femtogram levels. This review will cover recent advancements in biosensor-based diagnostic techniques in parasitology.