TR-Dizin İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9
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Article Citation - WoS: 1Citation - Scopus: 1A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts(Marmara University, 2025) Sen, Ali; Servı, Hüseyın; Barak, Timur Hakan; Tekin, Fethullah; Şener, Azize; Marzi, Mahdi; Gülmez, GizemPlants are the significant global interest as alternative treatment sources with their biologically activecompounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobialproperties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemicalcompositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC)contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showedthe highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. TheMIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714;2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies haveshown that TPC was 100.60±5.06, 127.90±0.30, 69.01±0.30 mg GAE /g extract; TFC was 80.07±0.15, 25.35±0.0, 16.58±0.31mg KE/g and TTC was 217.30±6.05,172.40±2.17, 126.30±4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 inparticular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategiesand potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also apreliminary study for future studies.Article Relationship Between Resilience, Secondary Traumatic Stress and Work-Related Factors Among Mental Health Professionals(Kare Publ, 2025) Dikec, Gul; Tokatlıoglu, Tugba Sahın; Çetinkaya, Saadet; Yasar, SaadetObjectives: Resilience is the ability to maintain or rapidly recover mental health under stress. Mental health profes- sionals are often exposed to workplace stress through violence, emotional labor, restrictions, and traumatic stories. Secondary traumatic stress results from being affected by others’ traumatic experiences. Examining the relationship between resilience and secondary traumatic stress among mental health professionals is therefore essential. Methods: This descriptive study was conducted between February and April 2022. Data were collected using the Per- sonal Information Form, the Resilience Scale for Adults, and the Secondary Traumatic Stress Scale. Participants included 212 psychiatric and mental health nurses, 28 psychiatrists, 14 psychologists, and six social workers. Results: A significant positive relationship was found between resilience and secondary traumatic stress. The regres- sion model, including secondary traumatic stress, gender, educational status, willingness to work in mental health, job satisfaction, and unit of work, significantly predicted resilience. Conclusion: Secondary traumatic stress and work-related factors, such as willingness and satisfaction with working in mental health and the unit of work, were found to play an essential role in resilience. Institutional support and supervision may strengthen resilience, while reducing secondary traumatic stress can enhance motivation and well- being. Institutions are recommended to implement strategies that address these factors to improve both resilience and professional effectiveness.Article Evaluation of Dietary Habits and Related Parameters in a Group of Inpatients With Mental Disorders(Kare Publ, 2025) Dikec, Gul; Ata, Elvan Emıne; Özer, Duygu; Çalışkan, Mahinur Betül; Taliskan, Mahinur BetulObjectives: This study aimed to examine the dietary habits and related parameters of individuals with mental disorders. Methods: This study was descriptive and cross-sectional. The sample consisted of 94 individuals hospitalized in the psychiatric clinic of a hospital between June and December 2021. Data were collected using an information form cre- ated by the researchers. Results: Of the participants, 83% were male, and 25.5% had a chronic physical illness. The patients had a diagnosis of mental disorder for an average of 6.07 years. The most common side effect was an increase in appetite (36.4%). Additionally, 76.6% ate within 15 minutes, 93.6% consumed fish once a week or never, and 56.4% never exercised. In- dividuals who consumed home-cooked meals had lower BMI averages than those who consumed fast food. A weakly significant positive correlation was found between BMI and waist circumference averages and the duration of medica- tion use. Individuals with anxiety disorders had lower waist circumference, glucose, and LDL values compared to those with mood disorders. In contrast, individuals with psychotic disorders had significantly lower LDL levels than those diagnosed with mood disorders. Conclusion: Individuals with mental disorders were found to have inadequate and unbalanced nutrition, consuming diets rich in carbohydrates and low in protein, which negatively affected their parameters. Psychiatric nurses should evaluate the dietary habits of patients and provide counseling about healthy nutrition.Article Determination of Post-Earthquake Trauma Level and Investigation of the Relationship with Physical Activity Status(Turkish Physiotherapy Association, 2025) Tosun, Anil; Yılmaz, Nergis; Luque, Demet Tekın De Las Penas; Tekin De Las Penas Luque, DemetAmaç: Çalışmanın amacı; 06 Şubat 2023’te meydana gelen Pazarcık-Elbistan merkezli depremler sebebiyle kişilerde oluşan travma düzeyinin, kişinin fiziksel aktivite durumu ile ilişkisini incelemektir. Aynı zamanda, kişilerde deprem sonrası ağrı varlığının sorgulanması ve bu durumun travma düzeyi ile ilişkisini ortaya koymaktır. Yöntem: Veriler çevrimiçi olarak Google formları aracılığıyla toplandı, 18-65 yaş arası 388 gönüllü katılımcı (299 kadın, 89 erkek) çalışmaya dahil edildi. Katılımcıların genel özelliklerini belirlemek için “Sosyodemografik Bilgi Formu”, travma düzeyini değerlendirmek için “Deprem Sonrası Travma Düzeyini Belirleme Ölçeği” (DSTDBÖ) ve fiziksel aktivite durumlarını belirlemek için “Uluslararası Fiziksel Aktivite Anketi Kısa Formu” (IPAQ-KF) kullanıldı. Bulgular: Deprem bölgesinde bulunma durumuna göre DSTDBÖ genel puan ortalamaları arasında anlamlı fark saptandı (p<0,001). Deprem bölgesinde bulunan 126 kişinin DSTDBÖ genel puan ortalaması 57,66±19,87 iken, bölgede bulunmayan 262 kişinin ortalaması 49,00±18,49 olarak bulundu. Spearman korelasyon analiziyle deprem bölgesinde olan ve olmayan bireylerin IPAQ-KF toplam puanları, DSTDBÖ alt faktör ve toplam puanları arasındaki ilişki incelenmiş olup sadece “Bilişsel Yapılandırma” alt faktörü ile IPAQ-KF toplam puanları arasında anlamlı bir ilişkiyi yansıtmayan negatif zayıf ilişki bulundu (deprem bölgesinde olanlar için Spearman korelasyon katsayı değeri =-0,18, p=0,042). Ve deprem sonrası ağrı yaşayan bireylerin DSTDBÖ puanları, ağrı yaşamayanlardan daha yüksek olarak saptandı (p=0,000). Sonuç: Bu çalışma ile deprem sonrası travma düzeyinin, fiziksel aktivite ile negatif ilişki gösterdiği belirlendi. İnaktif bireyler daha yüksek travma düzeylerine sahipken, minimal aktif bireylerde travma düzeyleri daha düşük bulundu. Bu bulgular, deprem sonrası fiziksel aktivitenin artırılmasının travma düzeylerini azaltmada etkili bir strateji olabileceğini göstermektedir. Bu alanda daha fazla araştırma, eğitim ve proje çalışmalarının yapılması gerekmektedir.Article In Vitro Efficacy of Sumac (Rhus coriaria) Extracts Against Leishmania Tropicana and Leishmania Mexicana: A Preliminary Study from Turkiye(Istanbul Univ, 2025) Mete, Ergun; Ozel, Yener; Bardakci, Hilal; Durmuskahya, Cenk; Koseler, Aylin; Kurt, OzgurObjective: Cutaneous leishmaniasis (CL) is a common clinical manifestation of leishmaniasis. Here, the in vitro anti-leishmanial efficacy of sumac extracts was tested for the first time on both Leishmania (L.) tropica and L. mexicana isolates using Rhus (R.) coriaria plant, which was collected in western Anatolia. Materials and Methods: The dried and powdered fruits of R. coriaria were macerated in acetone, ethyl alcohol, and ethyl alcohol-water mixture at room temperature for two days. The pooled extracts were evaporated under reduced pressure and lyophilized form for the study. Isolates of L. tropica and L. mexicana in Acibadem University R&D Laboratory were initially thawed and cultivated in NNN medium. Assessments were made using the haemocytometer and MTT methods at 24 and 48 h, compared with meglumine antimoniate as the control group. Results: For L. tropica, the effective concentration ranges of the extracts and the infusion were found to be 578.13-289.06 pg/mL and 289.06-144.53 pg/mL, respectively. For L. mexicana, the ranges were found to be 289.06-144.53 pg/mL and 144.53-72.27 pg/mL, respectively. It was shown that all extracts of R. coriaria were effective against both L. tropica and L. mexicana in higher doses, compared to meglumine antimoniate. Conclusion: An interesting finding was that higher sumac doses were required to eliminate L. tropica of the Old World, compared to L. mexicana of the New World. In addition, the aqueous alcohol extract showed efficacy that lasted for 48 h in half doses compared to others in L. tropica. Further assessments for both the identification of the active compounds within R. coriaria and their efficacy in vivo are planned.Article Lactobacillus Rhamnosus GG Alleviates Bisphenol-A Induced Oxidative Stress in Serum(Marmara University, Faculty of Pharmacy, 2025) Şener, Göksel; Tunali-Akbay, Tugba; Dorucu, Dogancan; Ede-Pazarbasi, Seren; Dede, Pınar; Ede-Pazarbas, SerenThe objective of this investigation was to identify changes in the serum oxidant-antioxidant balance of rats exposed to bisphenol A (BPA) and to investigate the impact of Lactobacillus rhamnosus GG (LGG) administration on those changes. Twenty-four rats (Wistar Albino, 250-300 grams, male) were divided into control, BPA, and BPA+LGG groups with an equal number of rats. BPA and LGG were applied to the rats in the relevant groups for six weeks, five days each week. Six weeks later, the blood samples were withdrawn and serum samples were prepared. Total oxidant and antioxidant status (TAS), glutathione, and lipid peroxidation determinations were determined in serum samples, and the oxidative stress index was calculated. BPA exposure decreased serum total antioxidant status and increased serum total oxidative status, oxidative stress index, and lipid peroxidation level compared to the control group. LGG administration improved the increased serum oxidative stress caused by BPA. Administration of LGG to BPA-treated rats reversed oxidative stress-induced changes. In conclusion, administration of Lactobacillus rhamnosus GG to rats for 30 consecutive days prevented oxidative stress in serum caused by bisphenol A.Article The Effect of Vitamin D and Paricalcitol on Protein Disulfide Isomerase(Marmara University, 2025) Koksal, Murat; Şekerler, Turgut; Şener, Azize; Koksal, Muhammed MuratProtein disulfide isomerase (PDI), a multifunctional protein plays an important role as oxidoreductase, isomerase and chaperone in the cell. Prior studies have identified PDI is highly expressed in many different cancer types and presented as a new potential target for cancer treatment. Here, we investigated vitamin D and its analogue paricalcitol in silico interaction of the human PDI and inhibition of PDI reductase activity in vitro. We observed a non-covalent mechanism where the main skeleton of the vitamin D3 ans paricalcitol sturcture is located at the hydrophobic site in the b' domain of PDI and forms a hydrogen bond with a residue (His138) in tihs domain. They also form multiple weak hydrophobic interactions with various chemical groups of the b' subunit. For the first time, we demonstrate that 1,25-dihydroxyvitamin D3 (1a,25(OH)2 vitamin D3) and paricalcitol inhibit the PDI reductase activity in vitro and their IC50 values are 20.79±1.43 nmol/L and 32.83±3.15 nmol/L respectively. The two compounds can also block the denistrosation activity of PDI.Article Seçici Enternasyonalizmden Askeri İzolasyona ABD Dış Politikasında Türkiye (1918-1923)(Istanbul University, 2025) Papuççular, HazalBu makale Millî Mücadele döneminde Amerika Birleşik Devletleri’nin Türkiye’ye yaklaşımını ve bu yaklaşımın zaman içindeki değişimini incelemektedir. Çalışma, Amerika’nın Millî Mücadele ile olan ilişkisine dair dört bulgu ortaya koymak- tadır. Birincisi, 1918 sonrasında Başkan Wilson’ın bölgeye bakışının çoğunlukla Ermenistan mandası üzerinden şekillenip sekteryan bir tercihi yansıttığıdır. Bu durum, başkanın enternasyonalist düşüncelerinde seçici olduğunu göstermektedir. İkincisi, Anadolu’daki gayrimüslimlerin durumunun Wilson’ın başkanlığından sonra da ABD’nin bölgeye bakışındaki önemli unsurlardan biri olmaya devam ettiğidir. Ancak Wilson döneminin aksine, ABD bu meseleleri takiple yetinmiş ve çoğu zaman konuya müdahil olmamıştır. Bu durum, ABD dış politikasında yaşanan askeri-siyasi izolasyon süreci ve bu zaman zarfında dış ilişkilerde ticari çıkarların ön planda olmasıyla yakından ilişkilidir. Üçüncüsü, Türklerin Millî Mücadele’de zamanla artan başarısının da ABD’yi iktisadi ve ticari çıkarları sebebiyle Ankara’ya karşı daha farklı bir politika izlemeye itmesidir. Sonuncusu ise hem gayrimüslimler hem de iktisadi çıkarlar çerçevesinde, yardım misyonları, iş çevreleri, lobi grupları gibi birbiriyle çatışan hedefleri olan çeşitli aktörlerin bu süreçte Amerikan siyasetini etkilemek için yoğun çaba sarf ettiğidir. Makale, Ankara’nın ABD’ye temel bakışının ise İngiltere ve Fransa’ya karşı bir denge oluşturma politikası olarak analiz etmektedir. Bu bağlamda, Türkiye’nin ABD ile olan ilişkileri kuruluş dönemi diplomasisini de iyi bir biçimde yansıtmaktadır.Article Life and Stigma Experiences of Individuals with Substance Use Disorder: A Qualitative Study(Turkish Green Crescent Soc, 2025) Dikec, Gul; Umut, Gokhan; Albal, EsraThis study aimed to determine the life and stigma experiences of individuals with substance use disorder who received inpatient treatment in an adult detoxification center. Data for this qualitative phenomenological study were collected in Istanbul between April and December 2023. The data were analyzed using Colazzi steps. A total of 26 individuals with substance use disorder were interviewed. The content analysis identified three main themes. The initial topic discussed was the effect of substance use on individuals’ lives. The sec- ond theme discussed was stigmatization. The final theme addressed coping with stigmatization. The study revealed that participants experienced negative emotions, including regret, guilt, and shame, due to stigma- tization, exclusion, and discrimination. Substance use treatment should not only focus on pharmacotherapy but also the psychological and social needs of the individual. Furthermore, to address negative attitudes in society, mental health professionals could inform families and disseminate anti-stigma programs.Article Acute Serious Hepatitis of Unknown Cause in Children(Galenos Publishing House, 2022) Kılbaş, E.P.K.; Altındiş, M.On April 5, 2022, an increase in cases of acute hepatitis of unknown etiology was reported in previously healthy children under the age of 10 in the United Kingdom. Since there is no link between these patients, called acute non-HepA-E hepatitis, and viral hepatitis agents (hepatitis A, B, C, D, and E), the possible etiology, and pathogenesis of this emergency is being investigated. One of the alarming features of this epidemic is the high requirement for liver transplantation in a fraction of the cases. In cases other than hepatitis A, B, C, D, and E, a case definition is made by looking at a series of clinical pictures, including serum transaminase levels and age. As of August 26, 2022, 513 cases of acute hepatitis have been reported in Europe and 1,010 globally. Adenovirus was detected in 75% of cases tested in the UK, but data for other countries are still lacking. The role of other etiologic agents is still under investigation. The exact disease pathogenesis has not yet clear. Evidence of human-to-human transmission of the disease remains unclear. Epidemiological studies are critical in clarifying the uncertainties regarding the existence of links between the cases reported to date. Continuing the national and international surveillance activities of the countries in an organized manner is the most basic issue required for the elimination of the epidemic. 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