Fenerbahçe Üniversitesi

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Citation - WoS: 11
Citation - Scopus: 9
Antibiotic Use and Influencing Factors Among Hospitalized Patients With Covid-19: a Multicenter Point-Prevalence Study From Turkey
(Galenos Publ House, 2022) Sencan, Irfan; Cag, Yasemin; Karabay, Oguz; Kurtaran, Behice; Guclu, Ertugrul; Ogutlu, Aziz; Agalar, Canan
Background: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.
Citation - WoS: 3
Citation - Scopus: 3
Antioxidants, Enzyme Inhibitory Activities, and Phytochemical Profiles of Seven Medicinal Plants Grown With Organic Farming Techniques
(Tubitak Scientific & Technological Research Council Turkey, 2023) Zor, Murat; Ozupek, Burcin; Pekacar, Sultan; Deliorman Orhan, Didem
In this study, the potential antihyperlipidemic, antidiabetic, and antiobesity effects of extracts obtained via infusion techniques from Artemisia absinthium L., Achillea millefolium L., Calendula officinalis L., Fumaria officinalis L., Mentha piperita L., Origanum onites L., and Urtica dioica L. grown with organic farming techniques were investigated using enzyme inhibition methods (alpha-glucosidase, pan-creatic cholesterol esterase, pancreatic lipase, and alpha-amylase). It is important that natural compounds or extracts to be used in the treat-ment of metabolic problems have antioxidant effects. The antioxidant effects of these species were tested in terms of ABTS and DPPH radical scavenging activity, ferric reducing power, and metal chelating capacity. Extracts (2 mg/mL) of M. piperita (91.43 +/- 0.90%) and O. onites (70.18 +/- 2.02%) showed potent inhibitory effects on the alpha-glucosidase enzyme. Among all species, only O. onites extract ex-erted an inhibitory effect on the cholesterol esterase enzyme close to that of reference compound simvastatin. While all extracts were effective in the tested antioxidant activity methods, it was determined that the M. piperita and O. onites extracts displayed particularly significantly strong activities in terms of ferric reducing power, ABTS radical scavenging effect, and metal chelating capacity. The total flavonoid and phenolic contents of all extracts were determined. The compositions of the most active extracts were analyzed for pheno-lic acids and flavonoids using RP-HPLC. The results of RP-HPLC analysis showed that the levels of ellagic acid (0.923 +/- 0.000 g/100 g extract) in the M. piperita extract and rosmarinic acid (0.813 +/- 0.003 g/100 g extract) in the O. onites extract were high. As a result, all species grown with organic farming techniques except U. dioica were found to have high antioxidant effects. In light of these findings, it was concluded that M. piperita and O. onites grown with organic farming techniques showed strong inhibitory effects in terms of the tested activities, especially for alpha-glucosidase and pancreatic cholesterol esterase, and that in vivo studies and activity-guided isolation studies should be conducted on these species in the future.
Citation - WoS: 1
Citation - Scopus: 1
Are Child and Parent Health Behaviors Associated With Childhood Obesity? a Descriptive and Methodological Study
(Elsevier Science inc, 2023) Ozturk, Gizem; Kolcu, Merve
Purpose: This study was conducted to determine the relationship between child and parents' health behaviors and childhood obesity. In addition, an adaptation of the Turkish version of the Family Health Behavior Scale (FHBS) was performed in this study.Design and methods: This is a descriptive and methodological study. The research sample consisted of 358 parents who have a child between the ages of 5 and 12 studying in one of the seven state schools at the kindergarten, primary, and secondary school levels in Istanbul. Data were collected between February 2022 to May 2022 using the Parent and Child Descriptive Information Form, the Family Nutrition and Physical Activity (FNPA) Screening Tool, and the FHBS. IBM SPSS 25.0 (IBM, Armonk, NY, USA) and SPSS AMOS 21.0 software were used to analyze the data.Results: It was found that the confirmatory factor analysis result of FHBS confirmed the original structure of the scale, and Cronbach's Alpha coefficient was calculated as 0.80. A positive correlation was found between the parents' total scores of FNPA and FHBS (r:0.511, p < 0.001).Conclusions: It is recommended to evaluate the child and their parents holistically in preventing and managing childhood obesity. School health nurses should plan family-centered interventions to improve health behaviors and carry out these interventions with a multidisciplinary team. Moreover, it has been determined that FHBS is a valid and reliable measurement tool for the Turkish population.
Citation - WoS: 6
Citation - Scopus: 6
Artificial Intelligence in Nursing Practice: A Qualitative Study of Nurses' Perspectives on Opportunities, Challenges, and Ethical Implications
(BMC, 2025) Bodur, Gonul; Cakir, Hanife; Turan, Suzan; Seren, Arzu Kader Harmanci; Goktas, Polat
BackgroundThe study aims to explore nurses' views on the effects of artificial intelligence (AI) in nursing, focusing on their understanding, practical applications, ethical considerations, and perceived opportunities and threats.MethodsThis qualitative study used semi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\:-$$\end{document}structured interviews to gain comprehensive insights from clinical nurses, adhering to the Standards for Reporting Qualitative Research for methodological rigor. After obtaining ethical approval, researchers conducted semi\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\:-$$\end{document}structured interviews with 25 clinical nurses. The interviews explored nurses' perceptions of AI, including its basic concepts, applications in nursing practice, ethical and social implications, and potential benefits and drawbacks.ResultsThe analysis identified four overarching themes: (1) Nurses' Conceptualizations of Artificial Intelligence, (2) Opportunities of AI in Nursing Practice, (3) Threats of AI in Nursing Practice, and (4) Ethical and Psychological Concerns in AI-Based Nursing Practice. The findings revealed that nurses had a foundational understanding of AI and its definitions. They acknowledged both the positive and negative impacts of AI technologies on their practice. Nurses expressed that AI could reduce workload, enhance patient care, and improve efficiency. However, they also articulated significant threats, including concerns over professional redundancy, emotional disconnection in caregiving, de-skilling, and the risk of dehumanizing the healthcare environment. Additionally, ethical and psychological concerns emerged, such as ambiguity in accountability, threats to data security and patient safety, unsuitability in psychiatric care contexts, staff surveillance anxiety, and risks of misuse or systemic bias.ConclusionThe study concluded that while nurses possess a basic understanding of AI, the effective and ethical integration of AI technologies in nursing requires targeted training, institutional preparedness, and robust interdisciplinary collaboration. To ensure AI complements rather than compromises nursing values, it is imperative to equip nurses with skills in digital literacy, ethical reasoning, and critical engagement with AI tools. The findings highlight the necessity of structured education programs and policy development that address both the technological and humanistic dimensions of AI use in healthcare. Future research should actively incorporate patient and public voices to ensure that AI-driven transformations in care remain aligned with the principles of patient-centeredness and human dignity.
Citation - WoS: 21
Citation - Scopus: 22
Assessment of the Quality and Reliability of Information on Nutrition After Bariatric Surgery on Youtube
(Springer, 2020) Batar, Nazli; Kermen, Seda; Sevdin, Sezen; Yildiz, Nida; Guclu, Duygu
Background YouTube (TM) is a platform that many people, including patients, use to access health information. Recent studies have revealed that videos on YouTube (TM) are misleading or that medical videos may not contain appropriate information. This study aimed to assess the quality and reliability of videos on nutrition after bariatric surgery. Materials and Methods The keywords "after bariatric surgery diet" and "weight loss surgery postop diet" were used, and the first 100 videos for each keyword on YouTube (TM) were analyzed by considering the source, duration, content, and the number of likes of the video. The popularity of the video was calculated using the video power index (VPI) and view rate. The educational quality of the videos was evaluated using the DISCERN score, the Journal of the American Medical Association (JAMA) score, the Global Quality Score (GQS), the usefulness score, and a novel postoperation nutrition score (PONS). Results One hundred fourteen patients were included in the study. The mean duration and number of views were 12.51 min and 87,558.46, respectively. The DISCERN score, JAMA score, GQS, and usefulness score of the physicians or dietician-based videos were significantly higher than those of the patient-based videos (p < 0.001). Positive correlations were found between the VPI and view ratio, as well as between the duration and number of likes. Additionally, the DISCERN score was significant correlated with the duration and number of likes. Significantly positive correlations were found between the usefulness score and duration, usefulness score and number of likes, and PONS and duration (p < 0.01). Conclusions Informational videos on nutrition after bariatric surgery on YouTube (TM) are of low quality. Although the videos uploaded by physicians and dieticians have higher quality, only a few are available. Additionally, patients prefer to watch low-quality videos.
The Association of Exhaled Nitric Oxide Level With Respiratory Muscle Strength, Pulmonary Function, Exercise Capacity, Sleep Quality, Functional Status, and Health-Related Quality of Life in Patients With Pulmonary Arterial Hypertension
(Amer Thoracic Soc, 2025) Naci, B.; Demir, R.; Onder, O. O.; Sinan, U.; Kucukoglu, M.
Citation - WoS: 1
A Bibliometric Analysis of Refugee Health Publications in the Nursing Field by Visual Mapping Method
(Cambridge Univ Press, 2024) Ozturk, G.; Dikec, G.; Seren, A. K. H.
[No Abstract Available]
Burn Rehabilitation: Evaluation of Physiotherapists' Knowledge and Awareness Levels
(Elsevier Sci Ltd, 2025) Seyyah, Mine; Akkurt, Mustafa Ferit; Yilmaz, Nergis
Objective: The aim of this study was to evaluate the level of knowledge and awareness of physiotherapists working in Turkey about burn rehabilitation. Method: This was a cross-sectional study conducted between March and June 2025 and data were collected using Google Form. A total of 324 people were included in the study. The level of knowledge and awareness of the participants about burn rehabilitation was evaluated with 28 questions created by taking expert opinion. Results: While 25.6 % of participants had experience in burn rehabilitation, only 1.2 % frequently encountered burn patients. Although 60.5 % had taken courses on burn rehabilitation, only 15.1 % considered their knowledge sufficient. Correct response rates to key knowledge questions were 78.7 % for exercise applicability, 79.6 % for timing, 54.6 % for the most common burn type in Turkey, 35.8 % for edema management, and 13 % for pressure garment duration, revealing gaps in clinical knowledge. Additionally, 92.9 % believed early physiotherapy improves recovery, and 98.4 % reported positive effects on quality of life. Discussion: Our results indicate that although most physiotherapists had taken courses on burn rehabilitation, their knowledge remains insufficient, whereas their awareness is high, underscoring the need for targeted training and certification programs.
Citation - WoS: 1
Citation - Scopus: 1
Can Manual Therapy Alter Muscle Stiffness in Patients With Spinal Accessory Nerve Injury
(Wiley, 2025) Simsek, Ferhat; Naci, Baha; Kilicoglu, Meltem Bozaci; Alkan, Zeynep; Topcuoglu, Osman Melih; Gormez, Aysegul; Okyar, Ali Fethi
Objective. Shoulder and neck dysfunctions resulting from spinal accessory nerve injury impair quality of life. This study aims to investigate the effects of manual therapy in combination with standard physiotherapy on the mechanical properties of muscle, neck and shoulder function, pain, and quality of life in head and neck cancer patients. Study Design. Prospective, randomized, controlled, double-blind clinical trial. Setting. Department of Otorhinolaryngology Head and Neck Surgery of a university hospital. Methods. A total of 26 participants were randomized into two groups. The control group (n = 11) received standard physiotherapy including therapeutic exercises, scar tissue massage, and education. The intervention group (n = 10) received manual therapy consisting of soft tissue, myofascial release, and mobilization techniques in combination with standard physiotherapy. Outcome measures were mechanical properties of muscle, neck and shoulder active range of motion, shoulder pain and disability, and quality of life. Results. Upper trapezius and sternocleidomastoid muscle stiffness increased significantly in the control group (P < .01), whereas a significant reduction was observed in the intervention group compared to the control group (P = .001). A reduction in muscle thickness was observed bilaterally in both groups (P < .01). Moreover, all participants showed improvements in neck and shoulder active range of motion, shoulder pain, and quality of life (P < .01). Conclusion. Manual therapy in addition to standard physiotherapy was more effective in improving neck and shoulder function, quality of life, and reducing muscle stiffness compared to standard physiotherapy alone. Therefore, clinicians should consider incorporating manual therapy into their treatment protocols to optimize patient outcomes.
Cervical Stabilization Exercise Training via Telerehabilitation in Individuals with Migraine - A Randomized Controlled Trial
(BMC, 2025) Dusgun, E. S.; Karahan, N.; Celenay, S. Toprak
Citation - WoS: 3
Citation - Scopus: 3
Coach Candidates' and Coaches' Nutrition Knowledge Affects Dietary Recommendations Indirectly: Mediator Effects of Self-Efficacy
(Mdpi, 2025) Altinok, Oyku; Bas, Murat
Background/Objectives: The nutritional knowledge and behavior of athletes are considerably influenced by the dietary recommendations of their coaches, which, in turn, affect their health and performance. In the context of social cognitive theory, this study examines the impact of general and sports nutrition knowledge (GeSNK), nutrition self-efficacy (NSE), and nutrition counseling self-efficacy (NCSE) on the dietary recommendations (DRs) provided by coach candidates and coaches (CC&Cs). Additionally, it explores variations in GeSNK, NSE, and NCSE among CC&Cs based on their sports positions, genders, and types of sports. Methods: This study included 70 coach candidates and 102 coaches, with data collected via validated scales for GeSNK, NSE, and NCSE. Using the PROCESS macro, the serial multiple mediator model was applied, and group comparisons were conducted via the Mann-Whitney U test. Results: The results revealed that 36% of participants achieved adequate GeSNK scores, but only 6.4% abstained from providing DRs. Participants engaged in individual sports exhibited higher NSE and NCSE scores than those involved in team sports. Additionally, 22.7% of CC&Cs identified their former coaches as a primary source of nutrition information. The study findings revealed that GeSNK, NSE, and NCSE significantly influenced DRs, collectively accounting for 23% of the variance in DRs. The direct effect of NCSE on DRs was statistically significant, whereas the direct effects of GeSNK and NSE were not significant. GeSNK and NSE jointly explained only 41% of the variance in NCSE, suggesting that additional factors influencing NCSE and DRs remain unexplored. Conclusions: To address the issue of inadequate dietary recommendations stemming from insufficient information, it is crucial to identify and understand these additional factors affecting NCSE and DRs. Diversifying nutrition education programs to enhance the nutrition knowledge of CC&Cs is essential. Furthermore, fostering collaboration between CC&Cs and nutritionists can ensure that athletes receive accurate and comprehensive nutritional guidance.
Citation - WoS: 2
Citation - Scopus: 1
Comprehensive Bibliometric Analysis of Characteristics, Patterns, and Causes of Retractions in Pediatric Literature
(Springer, 2025) Abo-Elnour, Dina Essam; Helal, Mohamed Mohsen; Albalasy, Abdulrahman Ahmed; Abdul-Hafez, Hamza A.; Abdelkader, Ahmed; El-Sherbini, Eman Raafat; Amer, Samar A.
This study aimed to systematically identify the key characteristics of retracted articles in pediatric literature and explore the patterns and reasons of pediatric retraction from 1995 to 2024. We searched PubMed and Retraction Watch databases to identify all retracted publications in the field of pediatrics. After the screening process, data were extracted into Excel. Statistical analysis was conducted using Jamovi and Excel. A correlation matrix was used for the important retraction-related factors. After screening, 590 unique retracted pediatric articles were included, with most of them, 572 (96.9%), having retraction notices available; 516 (87.5%) published as open access; 433 (73.4%) from Asia-mostly China; 348 (59%) retracted by the publisher; 301 (51.0%) published by Hindawi; 275 (46.6%) observational studies; and 221 (37.5%) retracted due to misconduct. Articles with four authors showed the highest retraction rate, and the retraction rate generally decreased as the number of authors increased. Most retractions occurred in 2023. The most common pediatric age group included in the retracted papers was children. The median H-index of authors of retracted papers was 8 for first authors and 10 for senior authors. The median time from submission to acceptance of retracted papers was 50 days and that from publication to retraction was 15 months. Additionally, time to retraction was positively correlated with the journal's impact factor (r = 0.106, p = 0.015) and the citation count (r = 0.213, p < 0.001) but showed no significant correlation with time to acceptance (r = - 0.019, p = 0.675). Conclusion: The increasing number of retracted pediatric papers reflects a growing concern with a complex pattern and various determinants. Researchers and publishers should adopt strong regulations and guidelines to improve the integrity of scientific research, especially pediatric research.
Citation - WoS: 1
Consumption and Preferences of Fruits and Vegetables in Turkish Adults
(Cambridge Univ Press, 2020) Guldemir, Hilal Hizli; Yousefirad, Neda; Akman, Cansu; Sezer, Fatma Elif; Ilktac, Havvanur Yoldas; Garipagaoglu, Muazzez; Ersoy, Gulgun
[No Abstract Available]
Corrigendum to “on Clinical Nurses’ Views About Diversities- A Qualitative Study”
(Elsevier Ltd, 2025) Cakir, H.; Harmanci Seren, A.K.
In the original published version of this article, there were unwanted reference links in 2.3. Sample and setting and new references [1], [2] and [3] has been added in the revised version removing the older reference [1]. The original manuscript showed the Introduction, 2.3. Sample and setting and reference [1] as below: Until the beginning of the 20. century, nearly all civilized societies were controlled by upper-class white men. As a result, diverse people from the leading culture were marginalized based on ethnicity, race, religion, language, sex, or sexual orientation. The “Diversity management" concept first emerged in the United States of America (USA) to manage personal and cultural differences among employees. Later, globalization became a worldwide concept parallel with the internationalization of businesses, employees, and clients [1]. Snowball sampling was applied. Inclusion criteria were working in a hospital in Istanbul for at least one year [1], three years or more of professional experience [2], bachelor's or upper degrees in nursing education [3] and working as a staff or a manager nurse [4]. [1] J.L. Bronstein, D.I. Bolnick, “Her joyous enthusiasm for her life-work …”: early women authors in the American naturalist, Am. Nat. 192 (6) (2018) 655–663. The corrected version of Introduction with relevant references and 2.3. Sample and setting are as below: Until the beginning of the 20. century, nearly all civilized societies were controlled by upper-class white men [1]. As a result, diverse people from the leading culture were marginalized based on ethnicity, race, religion, language, sex, or sexual orientation [2]. The “Diversity management” concept first emerged in the United States of America (USA) to manage personal and cultural differences among employees. Later, globalization became a worldwide concept parallel with the internationalization of businesses, employees, and clients [3]. Snowball sampling was applied. Inclusion criteria were: 1. working in a hospital in Istanbul for at least one year, 2. three years or more of professional experience, 3. bachelor's or upper degrees in nursing education 4. and working as a staff or a manager nurse. [1] Judy, R. W., & d'Amico, C. (1997). Workforce 2020: Work and workers in the 21st century. Hudson Institute, Herman Kahn Center, PO Box 26–919, Indianapolis, IN 46226; tele. [2] Penaluna, B. E., Arismendi, I., Moffitt, C. M., & Penney, Z. L. (2017). Nine proposed action areas to enhance diversity and inclusion in the American Fisheries Society. Fisheries, 42(8), 399–402. [3] Hiranandani, V. (2012). Diversity management in the Canadian workplace: Towards an antiracism approach. Urban Studies Research, 2012(1), 385806. The authors apologize for the errors. © 2025 The Author(s)
Citation - WoS: 12
Citation - Scopus: 13
Critical Thinking Among Clinical Nurses and Related Factors: a Survey Study in Public Hospitals
(Wiley, 2022) Urhan, Eylul; Zuriguel-Perez, Esperanza; Seren, Arzu Kader Harmanci
Aims and objectives The study investigated clinical nurses' critical thinking levels in public hospitals and related factors. Background Since health care environments have become more complex, the critical thinking skills of clinical nurses are more important in daily problem-solving and decision-making processes. However, little research was conducted on this topic among clinical nurses. Methods It was a cross-sectional study at five public hospitals between December 2018 and January 2019. The study followed the STROBE guideline. Data were collected from 559 nurses by a survey consisted of a data form and the Turkish version of the Nursing Critical Thinking in Clinical Practice Questionnaire. Results Nurses' mean critical thinking scores were moderate level. Total critical thinking scores of the clinical nurses significantly differed according to education, hospital type, shift work, professional category and role. There was a significant effect on the total critical thinking scores of the clinical nurses according to variables. Conclusion This study found that critical thinking levels of nurses' working in clinical settings in public hospitals were moderate level. Hospital type, shift work, professional and educational level and role were significantly associated with clinical nurses' critical thinking levels. Relevance to clinical practice This study provides evidence related to the levels of critical thinking of clinical nurses working in public hospitals. Since the critical thinking scores of the manager nurses, daytime working nurses' and nurses with bachelor's and master's degree education are higher, hospital managers may benefit from the study to implement effective strategies to improve the competence of critical thinking levels of nurses.
Citation - WoS: 7
Citation - Scopus: 6
A Cross-Sectional Survey Study on Homophobia Among Medical, Nursing, Pharmacy, and Other Health Sciences Students
(Routledge Journals, Taylor & Francis Ltd, 2023) Seren, Arzu Kader Harmanci; Bacaksiz, Feride Eskin; Cakir, Hanife; Yilmaz, Sevil; Sukut, Ozge; Turan, Suzan; Maghsoudi, Nurten
Since the lesbian, gay, bisexual, transgender, and intersex (LGBTI) community may be exposed to violence, discrimination, stigma, exclusion, and maltreatment due to their sexual orientation while accessing healthcare services, understanding, and improving the attitudes of future's health care professionals toward LGBTI individuals seem essential. This descriptive and cross-sectional study aimed to investigate the homophobia among medical, nursing, pharmacy, and healthcare sciences students and examine the related factors. The study included 2,531 students from medicine, nursing, pharmacy, and other health sciences (midwifery, nutrition and dietetics, physiotherapy, management of healthcare facilities) disciplines. Homophobia was measured with the Hudson and Ricketts Homophobia Scale. After getting ethical and institutional approvals, data were collected and analyzed using descriptive and inferential statistical tests. Medical students had the lowest homophobia score, and their mean score was significantly lower than other students. There was a significant difference between students' scores according to years of study, age, sex, acquaintance with LGBTI individuals, providing healthcare services to an LGBTI person, and opinions on providing care. Although homophobia scores of nursing, pharmacy, and other health sciences students were lower than the medical students', policies and expansive content regarding LGBTI should be in place in all health science educational institutes, including medical schools, to prevent students from holding homophobic and prejudicial attitudes against LGBTI individuals.
Design and Synthesis of Thiosemicarbazides and 1,2,4-Triazoles Derived From Ibuprofen as Potential Metap (Type II) Inhibitors
(Elsevier Ireland Ltd, 2025) Yilmaz, Ozgur; Biliz, Yagmur; Ayan, Sumeyra; Cevik, Ozge; Karahasanoglu, Mufide; Cotuker, Reyhan; Kucukguzel, S. Guniz
In the present study, a range of novel thiosemicarbazides 4a-i and 1,2,4-triazoles 5a-i derived from ibuprofen, were synthesized. Structural elucidation of these synthesized compounds was performed utilizing a variety of spectroscopic methods, including FTIR, 1H NMR, 13C NMR and HR-MS. The synthesized compounds were tested for cytotoxicity in five different cancer cell lines (cervical cancer (HeLa), human breast cancer (MCF-7), human gastric adenocarcinoma (MKN-45), human metastatic prostate cancer (PC3) and human glioblastoma (U87)). The compounds were compared with healthy cells (NIH-3T3) and the most effective compounds were determined by means of the selectivity index. Thiosemicarbazides derived form ibuprofen 4i and 4d showed anticancer activity, while 1,2,4-triazoles derived form ibuprofen 5b, 5c, 5d, 5e, 5h, 5g showed anticancer activity in HeLa, MCF-7, MKN-45, PC3 and U87 cells. To test the stability of the protein-drug complexes all 18 compounds 4a-i and 5a-i were docked into the active site of the MetAP2 enzyme In general, computational inhibition constants values were correlated with the experimental values. The dynamic behavior of MetAP2-inhibitor complexes was analyzed using all atoms Molecular Dynamic (MD) simulations for 200 ns duration. MD revealed that the drugs bind in the active center of MetAP2 with stable RMSD and RMSF. In conclusion, in-silico results and in-vitro studies suggests that thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen may be novel anticancer drug candidates for treating cervical, breast, prostate, gastric and glioblastoma. Compounds provided induction of apoptotic proteins in the cell by inhibiting MetAP2 enzyme. Furthermore, the potential antioxidant activities of the compounds were evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Among the compounds tested, 4a, 4b, 4e, 4f, 4h, and 4i exhibited values closely resembling the DPPH activity of the standards.
Citation - WoS: 11
Citation - Scopus: 11
The Deterioration in Credibility, Destabilization of Exchange Rate and the Rise in Exchange Rate Pass-Through in Turkey
(Elsevier, 2021) Gayaker, Savas; Agaslan, Erkan; Alkan, Buket; Cicek, Serkan
The early literature on inflation targeting (IT) regime argues that adopting an IT regime in itself reduces the exchange rate pass-through (ERPT). The basic logic behind this argument is that pursuing a credible and independent monetary policy will help to anchor the inflation expecta-tions and stabilize the exchange rate volatility. In this study, we investigate whether the ERPT has increased in the last decade in Turkey where the credibility of the Central Bank of the Republic of Turkey (CBRT) has deteriorated and the exchange rate uncertainty has increased due to the weakening of commitment to inflation after political pressures although the IT regime has been implementing. Employing the Phillips curve model and then applying a narrowing window analysis, we have found that the ERPT coefficient increased as the beginning of the sample ap-proaches towards the last observation, especially since 2011. To search for the reason behind this increase, we additionally employed a threshold regression method following the work of Murase (2013) which allows both possibility of non-linearity in the ERPT relationship and exogenously adding the threshold variable to the model. When the gap between inflation expectations and the inflation forecasts grows, then the credibility is considered to decrease and we found that the ERPT gets higher if the gap exceeds a certain threshold. Similarly, we have found evidence supporting that the ERPT coefficient was higher when the exchange rate uncertainty exceeded a certain threshold.
Citation - WoS: 8
Citation - Scopus: 10
Determination of Chemical Components of the Endemic Species allium Turcicum L. Plant Extract by Lc-ms/Ms and Evaluation of Medicinal Potentials
(Cell Press, 2024) Ipek, Polat; Atalar, Mehmet Nuri; Baran, Ayse; Baran, Mehmet Firat; Ommati, Mohammad Mehdi; Karadag, Musa; Khalilov, Rovshan
The Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first time, we evaluated the bioactive profile of components (using LC-MS/MS), cytotoxicity, anticancer, antioxidant, and antibacterial prospectives of Zuzubak methanol extract. Reported results show that the extract is rich in bioactive compounds and has anticancer activity with breast cancer cells (MCF-7), human prostate cancer cells (DU -145), and Human osteosarcoma cancer Cell lines of (IC50) in dose dependent manner in the concentration range of 31.25 mu g/mL and 2000 mu g/mL for 24 and 48 h. Western blotting results determined that the extract significantly suppressed the growth of U2OS, MCF-7, and DU -145 cancer cells by down expression of Ang-1 (angiogenic protein) and Beclin-1 (autophagy protein) and overexpression of Bax (a proapoptotic protein). The oxidative stress indices showed a reduction in RPE-1 and MCF-7 cells and an upsurge in U2OS and DU -145 cells. Additionally, the antimicrobial assay showed suppression of the growth of various pathogenic microorganisms in 4.00 - 8.00 mu g/concentrations of Zuzubak extract using the microdilution method. The phytochemicals identified showed promising anticancer, antioxidant effects, and antimicrobial properties, representing a valuable herbal source for drug development studies.
Development of the Medical Adherence Scale in Adolescents Using Psychotropic Medication and Evaluation of Validity and Reliability in Turkish Population
(Elsevier Science inc, 2024) Dikec, Gul; Bilac, Oznur; Sonkaya, Hilal Isleyen; Aydemir, Omer
Purpose: Although treatment non -adherence is relatively high among adolescents, there is a need for standardized measurement tools that measure adherence to treatment in adolescents. This study aimed to develop a new measurement tool to assess the adherence to treatment of adolescents with mental disorders who use psychotropic medication. Methods: The data of this methodologically designed study were collected between 01.04.2022 and 01.07.2023 in the Department of Child and Adolescent Psychiatry of a university hospital in the Aegean Region of Turkey. The Medication Adherence Reporting Scale and Adolescent Medical Adherence Scale draft form were used for data collection. The scale items were formed from the themes, sub -themes, and statements in the qualitative study that the researchers had conducted with adolescents with mental disorders and their parents, clinicians' experiences, and systematic reviews and meta -synthesis in the literature. The study sample consisted of 95 adolescents with mental disorders. Exploratory factor analysis was performed with Varimax rotation to determine the factorial construct validity of the scale. Internal consistency analyses were performed in reliability analyses, and Cronbach's alpha coeff icient was used. Results: The mean age of the adolescents was 14.18 years (1.81); 50.5% were male, and 96.8% were attending school. When the mental disorder diagnoses were analyzed, 65.3% of the adolescents were being followed up with Attention De ficit and Hyperactivity Disorder diagnoses, and 58.8% were using stimulants. The 12 -item form of the Adolescent Medical Adherence Scale was found to have a three -factor structure with item -total correlation values ranging between 0.26 and 0.66, and these factors were named functionality, responsibility in treatment, and medication adherence. Factor loadings ranged between 0.44 and 0.86, and the items explained 62.98% of the total variance. The internal consistency coef ficients of the scale were between 0.69 and 0.83 for the subscales and 0.82 for the total scale. Conclusion: Based on the analysis and results used in this study, the Adolescent Medical Adherence Scale is a valid and reliable new measurement tool. Practice implications: This tool can be used in clinical settings to evaluate adolescents' treatment adherence and prognosis. Clinical studies conducted with adolescents can also determine adherence to treatment and affecting factors. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

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