Fenerbahçe Üniversitesi

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Citation Count: 0
Apocynin Exhibits an Ameliorative Effect on Endothelial Dysfunction/ Atherosclerosis-Related Factors in High-Fat Diet-Induced Obesity in Rats
(Marmara Univ, Fac Medicine, 2024) Şener, Göksel; Ertas, Busra; Kaya, Rumeysa Keles; Sevinc, Sevgi Kocyigit; Amuran, Gokce Gullu; Ercan, Feriha; Cetinel, Sule; Eczacılık Meslek Bilimleri Bölümü
Objective: The aim of this study was to reveal the effect of apocynin (APO) on the factors involved in obesity-related endothelial dysfunction (ED) and atherosclerosis (AS). Materials and Methods: Male Wistar albino rats were divided into control (CNT), high-fat diet (HFD) and HFD+APO groups. HFD and HFD+APO groups were fed HFD for sixteen weeks. APO (25 mg/kg) was administered to the HFD+APO group for the last four weeks. The effects of APO on: AS-related metabolic parameters (triglyceride, total cholesterol, high-density lipoprotein-cholesterol, insulin and leptin), oxidative stress (OS), [ malondialdehyde, glutathione, nicotinamide adenine dinucleotide phosphate (NADPH)oxidase-2, oxidised-low-density lipoprotein (ox-LDL) and 8-hydroxy-2-deoxyguanosine], low-density lipoprotein and ox-LDL uptake potential (activin receptor-like kinase-1 and lectin-like oxidized low-density lipoprotein receptor-1, respectively), tissue inflammation inducible-nitric oxide synthase, nitric oxide), programmed cell death (terminal deoxynucleotidyl-transferase-dUTP-nick-end (alpha-smooth muscle actin), histology and ultrastructure of thoracic aorta were evaluated. Results: In obesity, APO had an ameliorative effect on metabolic parameters, OS, inflammation, ED, programmed cell death and oxLDL uptake potential, but not on foam cell formation and LDL uptake potential. Conclusion: Apocynin may improve ED and AS in obesity by suppressing OS-linked factors involved in the early stage of AS.
Citation Count: 0
Assessments of Energy, Macro and Micronutrient Intakes in Children and Adolescents With Type 1 Diabetes Mellitus
(Marmara Univ, Fac Medicine, 2023) Özkaya, Şebnem Özgen; Ozkaya, Sebnem Ozgen; Beslenme ve Diyetetik Bölümü
Objective: This study aims at examining dietary intake in children and adolescents with type 1 diabetes mellitus (DM) and comparing the results with national dietary intake recommendations. Patients and Methods: One hundred fifty children and adolescents (52.7% female) with an average age of 12.2 +/- 3.1 years and with type 1 DM who were followed by the Pediatric Endocrinology Polyclinic participated in the study. Three-day food intake records and clinical information regarding the type 1 DM condition of the participants were obtained. Results: No gender-related significant difference was found among the participants regarding food intake. The percentage of energy derived from fat (average 39.6%) and saturated fat (16.1%) were higher than the recommended levels in both gender groups. The percentage of energy derived from carbohydrates (female 44.1 +/- 5.7%, male 43.0 +/- 6.8%) was below the recommended levels. The dietary fiber intake in children aged 6-10 years with type 1 DM met recommendations, whereas, it was below the recommended levels in other age groups. Micronutrient inadequacy was common in children and adolescents with type 1 DM. Conclusions: The authors believe that guidelines and programs are needed for children and adolescents with type 1 DM to reduce total fat and saturated fat intake, increase carbohydrate and dietary fiber intake up to the recommended levels, and prevent multiple micronutrient inadequacies.
Citation Count: 0
Association Between Carbohydrate Quality Index and Dietary Patterns, Sleep Quality, Anxiety Level, and Depression Symptoms: a Cross-Sectional Study
(Soc Chilena Nutricion, Bromatologia & Toxicologia, 2022) Yalçın, Bahar; Yilmaz-Onal, Hulya; Basturk, Berrak; Yalcin, Bahar; Beslenme ve Diyetetik Bölümü
Aim: This study was conducted to determine the relationship between carbohydrate quality and sleep quality, depression, anxiety, stress and anthropometric measurements. Methods: The carbohydrate quality was calculated using the total fiber intake, ratio of whole grains to total grains, the ratio of solid carbohydrates to total carbohydrates, and the glycemic index. Sleep status was determined using the Pittsburgh Sleep Quality Index (PSQI) and nutritional status was determined by taking a 1-day food consumption record and food consumption frequency. Results: It was found that 20% of the participants with the highest carbohydrate quality had the highest sleep quality and the lowest body mass index. Conclusion: Adults should be informed that the quality of carbohydrates that they consume, was associated with better sleep quality and some micronutrients (potassium, magnesium, vitamin A-D-K-C-81-86, Folate) but no significant correlation was found between anxiety, depression, and stress scores
Citation Count: 0
Bangladesh Journal of Pharmacology
(Bangladesh Pharmacological Soc, 2024) Küçükgüzel, İlkay; Guven, Cansu Tamniku; Duracik, Merve; Ozakpinar, Ozlem Bingol; Kucukguzel, Ilkay; Eczacılık Meslek Bilimleri Bölümü
[No Abstract Available]
Citation Count: 0
Bibliometric Analysis of Publications on Stigmatization in Psychiatric Nursing Literature
(Kare Publ, 2024) Dikeç, Gül; Saritas, Merve; Oban, Volkan; Hemşirelik Bölümü
Objectives: In the past two decades, the number of publications on stigma has increased in the literature. This study aimed to conduct a bibliometric analysis of publications related to stigmatization in the psychiatric nursing literature. Methods: In this study, a search was performed on the PubMed database on September 11, 2022, with the Medical Searching Terms "(Stigmatization [Title OR Abstract] OR Social Stigma [Title OR Abstract]) OR (Stigma [Title OR Abstract] OR Stereotyping [Title OR Abstract] OR Discrimination [Title OR Abstract]) AND (Psychiatric Nursing [Title OR Abstract] OR Nursing [Title OR Abstract])." Between 1990 and 2022, 10,571 studies published in English, available in full text, and published in journals indexed with SCI, SSCI, and ESCI were found. Results: The number of published articles reached the highest number in 2020, with an increase of 4.05 times in 30 years; it was determined that 92.8% of the publications were of the descriptive study, and Happell was the most productive author in this field. Frequently, articles were published in the Journal of Psychiatric and Mental Health Nursing (n=762), Journal of Psychosocial Nursing and Mental Health Services (n=550), International Journal of Mental Health Nursing (n=480), Issues in Mental Health Nursing (n=445), and Journal of Advanced Nursing (n=429). It was determined that the top five most frequently repeated keywords were humans, female, psychiatric nursing, male, and adult, respectively. Conclusion: The findings obtained from this study can provide information about the number of publications, research types, researchers, and institutions, as well as give ideas for new research strategies in psychiatric nursing literature. Establishing cooperation between institutions and authors can guide psychiatric nurses in creating projects to reduce stigma.
Citation Count: 0
Bibliometric Analysis of Publications on Stigmatization in Psychiatric Nursing Literature
(Kare Publishing, 2024) Dikeç, G.; Sarıtaş, M.; Oban, V.
Objectives: In the past two decades, the number of publications on stigma has increased in the literature. This study aimed to conduct a bibliometric analysis of publications related to stigmatization in the psychiatric nursing literature. Methods: In this study, a search was performed on the PubMed database on September 11, 2022, with the Medical Searching Terms “(Stigmatization [Title OR Abstract] OR Social Stigma [Title OR Abstract]) OR (Stigma [Title OR Abstract] OR Stereotyping [Title OR Abstract] OR Discrimination [Title OR Abstract]) AND (Psychiatric Nursing [Title OR Abstract] OR Nursing [Title OR Abstract]).” Between 1990 and 2022, 10,571 studies published in English, available in full text, and published in journals indexed with SCI, SSCI, and ESCI were found. Results: The number of published articles reached the highest number in 2020, with an increase of 4.05 times in 30 years; it was determined that 92.8% of the publications were of the descriptive study, and Happell was the most productive author in this field. Frequently, articles were published in the Journal of Psychiatric and Mental Health Nursing (n=762), Journal of Psychosocial Nursing and Mental Health Services (n=550), International Journal of Mental Health Nursing (n=480), Issues in Mental Health Nursing (n=445), and Journal of Advanced Nursing (n=429). It was determined that the top five most frequently repeated keywords were humans, female, psychiatric nursing, male, and adult, respectively. Conclusion: The findings obtained from this study can provide information about the number of publications, research types, researchers, and institutions, as well as give ideas for new research strategies in psychiatric nursing literature. Establishing cooperation between institutions and authors can guide psychiatric nurses in creating projects to reduce stigma. © 2024 by Journal of Psychiatric Nursing-Available.
Citation Count: 4
Bitter Melon (momordica Charantia) Fruit Extract Ameliorates Methotrexate-Induced Reproductive Toxicity in Male Rats
(Marmara Univ, Fac Medicine, 2021) Şener, Göksel; Ozbeyli, Dilek; Sen, Ali; Cevik, Ozge; Sener, Goksel; Ercan, Feriha; Eczacılık Meslek Bilimleri Bölümü
Objective: Methotrexate (MTX) is a drug commonly used for the treatment of malign neoplastic and inflammatory diseases. Anti-oxidant and anti-inflammatory effects of bitter melon (BM) were reported. The aim of this study was to examine the effects of BM fruit extract on MTX-induced testicular and epididymal damage. Materials and Methods: Sprague Dawley male rats were divided into three groups (n=8) as control, MTX and MTX+BM. A single dose of MTX (20 mg/kg) was injected intraperitoneally to the MTX and MTX+BM groups. BM fruit extract (600 mg/kg) was applied to the MTX+BM group orally for 5 days. Testes were examined for general histopathology, proliferating and apoptotic cells. The epididymis samples were used for the evaluation of sperm morphology. Oxidative and inflammatory markers were analysed biochemically. Results: Increased abnormal spermatozoa, degenerated seminiferous tubules with increased apoptotic cells and decreased proliferative cells were observed in the MTX group. TNF-alpha, IL-1 beta, 8-hydroxy-2-deoxyguanosine and caspase-3 levels increased, superoxide dismutase and catalase levels decreased in both testis and epididymis samples. All these histological and biochemical parameters were ameliorated in the MTX+BM group. Conclusion: Methotrexate causes testis damage by decreasing spermatogenic cells and increasing apoptosis through oxidative stress and inflammation. BM extract improves testis and epididymis damage with its possible anti-oxidant and anti-inflammatory effects.
Citation Count: 0
Brain in Metabolic Syndrome Model: the Effect of Exercises and Caloric Restriction
(Marmara Univ, 2022) Şener, Göksel; Genc-Kahraman, Nevin; Ipekci, Hazal; Ustundag, Unsal Veli; Tunali-Akbay, Tugba; Emekli-Alturfan, Ebru; Yarat, Aysen; Eczacılık Meslek Bilimleri Bölümü
Caloric restriction (CR) and exercise (EX) have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX and/or CR in metabolic syndrome (MeS) induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10% fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX and/or CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control (C) group. These parameters reduced significantly in the metabolic syndrome with caloric restriction (MeS+CR) group, and more significantly in the metabolic syndrome with exercise and caloric restriction group (MeS+EXCR), compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeS+CR group, and MeS+EXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeS+EXCR group.
Citation Count: 0
The Challenges Experienced by International Nursing Students in Nursing Education: a Qualitative Study
(Ataturk Univ, 2024) Elmali Simsek, Hulya; Karali, Ece; Arslan, Gunay
Objective: The study aimed to determine the challenges experienced by international nursing undergraduate students during their education period. Methods: A phenomenological research design was used. The study was conducted with 20 international nursing students enrolled in a foundation university in T & uuml;rkiye. Colaizzi's phenomenological data analysis method was employed in the study. Results: Based on the study's results, three main themes, 'Learning in a different environment', 'Challenges', 'Solution-Non Solution' and 'System difference, Language problems in clinical practice, Broad nursing curriculum, Facilitators, Language barrier, Feeling homesick, Racism and discrimination, Housing difficulties, Lack of funding, Instant solution, Failing to find a solution sub-themes themes were created. Conclusion: It has been observed that students experience different environments, uncertainties, and various challenges, and that these situations directly affect their education and success. To that end, both the institutions they receive education and the academicians must support the students in various ways.
Citation Count: 0
Child And Adolescent Mindfulness Measure Turkish Validity And Reliability Study;
(Galenos Publishing House, 2024) Bilaç, Ö.; Dikeç, G.; Akyol, C.K.; Kale, M.K.; Sapmaz, Ş.Y.; Kandemir, H.; Aydemir, Ö.
Objectives: The number of studies on mindfulness in children and adolescents has rised in recent years, and it is crucial to evaluate the mindfulness-based interventions applied with standardized measurement tools. This aim of this study was to make the Turkish language validity and reliability of the Child and Adolescent Mindfulness Measure (CAMM), which can be used in children and adolescents about mindfulness, which has been very well-liked in recent years, and which has validity and reliability in many languages, and to bring it into our language for the ages of 9-18. Materials and Methods: The total sample of the current study consisted of 156 children and adolescents, 48 of whom were children and adolescents with any mental disorderdiagnosis according to Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5). One hundred eight of them did not have any mental disorders diagnosis according to DSM-5, who had only periodic problems or were brought for counseling. Results: In the reliability analysis of the scale, the Cronbach’s alpha coefficient was found to be 0.76 for the whole scale. In test-retest reliability two weeks apart, the two measurements have a strong correlation between the measurements (r=0.634 p<0.0001). Conclusion: In conclusion, our findings show that the Turkish version of the CAMM is a valid and reliable measurement tool for the 9-18 age group. © 2024, Galenos Publishing House. All rights reserved.
Citation Count: 0
Clinical Outcomes of Conservative Versus Surgical Treatment for Patients With Proximal Humeral Fracture Before Physiotherapy
(Acta Medica Belgica, 2024) Özdinçler, Arzu; Alpozgen, A. Zengin; Gungor, F.; Ozdincler, A. Razak; Altun, S.; Fizyoterapi Ve Rehabilitasyon Bölümü
Fear of movement, pain, and loss of shoulder function are the most common problems irrespective of their approach to management after proximal humeral fracture (PHF). However, it has been unclear whether there could be differences between both treatments in early clinical outcomes. It can help physiotherapists to guide in choosing treatment approaches. This study aimed to compare kinesiophobia, pain, range of motion (ROM), shoulder function, and Quality of life (QoL) in patients treated with either conservative (CT) versus surgical (ST) after PHF. In addition, it aimed to determine correlations between fear of movement and seconder outcome measures. This cross-sectional study enrolled the patients having 5-6 weeks (being permitted active movement) after being treated either CT or ST and receiving no physical therapy. Pain, passive and active ROMs, shoulder function, fear of movement, and QoL were evaluated. 42 patients were recruited. Kinesiophobia scores were similar (p=0.55) and moderate in both groups. There was a significant difference in degrees of shoulder active flexion, active and passive abduction in favor of the CT group (p=0.05, p=0.02, p=0.04, respectively). However, there was no difference between groups regarding the remaining clinical outcomes. Furthermore, kinesiophobia showed a moderate negative correlation with energy/fatigue, social functioning, and general health. These findings showed that patients treated surgically did not have more kinesiophobia, less function, and QoL before starting physiotherapy, despite having soft tissue damage and different types of fractures. However, surgically treated patients had significantly less range of motion.
Citation Count: 1
Cold Chain Logistics Firm Selection by Using Ahp-Vikor Integrated Method and a Case Study in Food Industry
(Springer Science and Business Media Deutschland GmbH, 2020) Çaloğlu Büyükselçuk, Elif; Endüstri Mühendisliği Bölümü
With the Industry 4.0, a new trend has started for all sectors and enterprises have entered into a period of intense working and investment to turn into intelligent systems. Cold chain logistics also has the same trend, and companies have pushed the button to be involved in this process. Due to changing lifestyles and generally decreasing prices, the world market for perishable products such as processed foods and cooled products is growing. Cold chain transportation is an important issue in basic food and health product logistics to prevent the growth of harmful microorganisms and to ensure that the products remain intact. In this study, it is aimed to determine the right cold chain logistics firm for company EDB that is a small and medium-sized enterprise (SME) operating in the food industry. Firstly, the selection criteria are defined according to the literature survey and expert views. AHP approach has been used to calculate the weight of them. After the determination of weight of criteria, VIKOR approach has been used to identify the best cold chain logistics firm for company EDB. The results were obtained by using Expert Choice 11.0 and Excel calculator finally the best one has been determined. © 2020, Springer Nature Switzerland AG.
Citation Count: 3
Comparison of Motorcyclists’ Hand Grip Strength and Reaction Time
(Didactic Asociation Andalucia, 2022) Tekin, D.; Tekin, Demet; Agopyan, A.; Terapi ve Rehabilitasyon Bölümü
The purpose of this study was to compare hand grip strength and reaction times in male motorcycle racers grouped according to different ages and the classes of motorcycle used and determine the relation between these characteristics. Sixty-five healthy male motorcycle racers were divided into four groups according to their age and the power of the motorcycles’ engine: (Group-1 [G1] = 600-CC/23-34 years; Group-2 [G2] = 600-CC/35-48 years; Group-3 [G3] = 1000-CC/23-34 years; Group-4 [G4] = 1000-CC/35-48 years). Then, Nelson’s reaction time and maximal hand grip strength were measured for both hands. There were no significant differences between the groups’ grip strength (p>0.05). It was found that G1’s right-and left-hand reaction time was faster than that of G2, and G1’s left-hand reaction time was faster than that of G3 (p<0.05). The right-hand visual reaction time was found to have a negative weak correlation with the left-hand absolute grip strength (r=-0.247, p=0.047), and there was a weak positive correlation between the left-hand visual reaction time and height (r=0.315, p=0.011). G1’s right-hand visual reaction time was better than that of G2 (p< 0.001), and G1’s visual left-hand reaction time was better than those of G2 (p< 0.034) and G3 (p< 0.011). Although the absolute and relative hand grip strength values did not differ according to the ages and the engine power of the motorcycle used, it was found that the simple reaction time increased with increasing age. © 2022 Didactic Asociation Andalucia. All rights reserved.
The Correlation Between Vitamin D Levels and Thyroid Functions in Early Pregnancy
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Dülger, Ö.; Oğul, Z.; Dinmez, S.
Vitamin D deficiency (serum vitamin D <10 ng/ml) and thyroid dysfunctions are prevalent issues globally, particularly during pregnancy. Evidence suggests a potential link between thyroid function and vitamin D levels. This study aims to investigate the correlation between serum vitamin D levels and thyroid functions in wome n during the first trimester of pregnancy. The study was conducted retrospectively at a University Education and Research Hospital’s pregnancy clinic, covering data from August 2023 to March 2024. The sample group consisted of first-trimester pregnant women who attended routine pregnancy check-ups and had complete vitamin D levels and thyroid function tests (n=185). The sociodemographic data form and blood serum level assessment forms were used as data collection tools. The data were analyzed using descriptive statistics and correlation analysis. The average age of the pregnant women participating i n our study was 27.6±4.9 years, and the Body Mass Index (BMI) was 25.4±4.8 (overweight). The mean number of pregnancies was 1.13±0.3, and the gestational week was 8.19±1.8. Of the participants, 35 had subclinical hypothyroidism, 37 had thyroiditis, and 113 had normal thyroid functions. The study identified 36 women with normal/adequate vitamin D levels (≥20 ng/ml), 113 with vitamin D insufficiency (10–20 ng/ml), and 36 with vitamin D deficiency (<10 ng/ml). The correlation analysis revealed no significant relationship between the thyroid function tests and vitamin D levels of the pregnant women. It was determined that vitamin D levels do not affect thyroid gland function in the first trimester. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
The Correlational Study of the Vertical Jump Test and Wingate Cycle Test as a Method To Assess Anaerobic Power in Road Cyclists
(Nevzat Demirci, 2023) Ulusoy, Y.; Koçak, F.
Road Cycling is an important sport that uses anaerobic and aerobic metabolism and especially sprinter cyclists have higher anaerobic capacity. The assessment of anaerobic power in cyclists often involves the use of the vertical jump and Wingate cycle tests. The lack of research in the field of cycling-specific tests to assess anaerobic performance has led to the improvement of existing research. The objective of this research was to investigate the correlation between the vertical jump test and the Wingate anaerobic cycling tests, both of which are often used to assess anaerobic power in road cyclists. A correlation study was conducted on 15 athletes of the Turkish national road cycling team in the 14-16 age group (15.107 ± 0.717 (SD)). The sample of the study was determined by using the convenient sampling method. On the first day, anthropometric measurements and the vertical jump test were conducted. The Wingate cycle ergometer test, lasting for a duration of 30 seconds, was administered to the participants on the second day. The computer application was used to determine the 30-second peak and average anaerobic power during the test. The results acquired from the study revealed a statistically significant positive relationship between the vertical jump performance and the peak power production measured during the Wingate cycle test (r=0.321, p<0.05). The findings indicate that vertical jump tests may serve as suitable field measurements of anaerobic power for road cyclists, as an alternative to the laboratory-based Wingate anaerobic test. © The Author(s) 2023.
Decentralisation as Resistance: Web3’s Potential in Countering Digital Censorship and Redefining Cyber Sovereignty
(Eotvos Lorand Tudomanyegyetem, 2024) Eldem, T.
The Internet, initially celebrated as a bastion of freedom and openness, is increasingly becoming a domain of control, surveillance, and regulation by both states and private entities. The rise of state control and regulation of the Internet, along with the private sector’s expanding control over information, poses significant challenges to the ideals of freedom and openness that once defined the Internet. This article examines the transformation in Internet governance from a state of minimal regulation to a heavily controlled environment by both governments and corporations and explores how the blockchain technology and decentralised architecture underlying Web3 promise to redefine Internet governance and resist censorship. Through a mixed-method approach that synthesises insights from computer science, political science, and legal studies, the paper argues that public blockchains challenge Internet Corporation for Assigned Names and Numbers’ (ICANN) traditional control over DNS and significantly reduce the ability of centralised entities to exert control over content and communication, thereby enhancing freedom of expression and resisting censorship. The ability of Web3 to fully realise this potential is, however, dependent on overcoming complex technical and regulatory challenges. © 2024, Eotvos Lorand Tudomanyegyetem. All rights reserved.
Citation Count: 0
Decreased Stuttering While Walking: Speech and Fmri Findings
(Galenos Publ House, 2023) Oge-Dasdogen, Ozlem; Ulasoglu-Yildiz, Cigdem; Kurt, Elif; Demiralp, Tamer
[No Abstract Available]
Citation Count: 0
Dodder (cuscuta Sp.) Extract Prevents Cognitive Deficits in a Rat Model of Hepatic Encephalopathy
(Kare Publishing, 2024) Albayrak, O.; Hatipoglu, B.N.; Ozbeyli, D.; Sen, A.; Koyuncuoglu, T.; Cevik, O.; Sener, G.
OBJECTIVE: In our study, the protective effect of dodder plant extract against encephalopathy induced by cholestatic liver disease model was investigated. METHODS: Spraque Dawley rats were used in the study. For the cholestatic liver disease model, the bile duct ligation (BDL) was applied. The groups were determined as control, Cuscuta sp. (CUS), BDL and BDL + CUS. Double ligation was performed in the bile duct in the BDL groups. For the applications, saline (SF) was administered to the control and BDL groups for 28 days while 250 mg/ kg of Cuscuta sp. extract was given by oral gavage to the CUS and BDL + CUS groups. At the end of the experiment, cognitive evaluations were made by applying new object recognition and Morris water maze tests. After these tests, blood-brain barrier (BBB) measurements were made in half of the groups. In the other half of the groups, brain tissue samples were taken by decapitation and transforming growth factor-beta (TGF-β), 8-hydroxydeoxyguanosine (8-OHdG) and sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) measurements were made in the tissues. Histological examinations of the tissues were also performed. RESULTS: Cognitive performance was low, and BBB permeability was found to be increased in the group with bile duct ligation. In addition, TGF-β and 8-OHdG levels were increased in tissues, while Na+/K+-ATPase enzyme activity was suppressed. Treatment with Cuscuta sp. increased cognitive performance and decreased BBB permeability. Other biochemical parameters examined were significantly (p<0.05–0.001) reversed and supported by histological findings. CONCLUSION: Our findings in the study suggest that dodder plant may be beneficial for the protection of cognitive performance and brain tissue in encephalopathy caused by cholestasis. © 2024, Kare Publishing. All rights reserved.
Citation Count: 7
The Effect of cotinus Coggygria L. Ethanol Extract in the Treatment of Burn Wounds
(Marmara Univ, 2022) Şener, Göksel; Okuyan, Betul; Sen, Ali; Ercan, Feriha; Onel, Huseyin; Goger, Fatih; Sener, Goksel; Eczacılık Meslek Bilimleri Bölümü
The overall aim of the present research is to evaluate for the first time the curative effect of Cotinus coggygria leaves on burn injury in an experimental burn model along with its anti-inflammatory and antioxidant activity potential. Also, phenolic compounds of C. coggygria were characterised by LC-MS/MS. Wistar albino rats weighing 200-250 g were exposed to 90 degrees C bath for 10 s to induce burn injury, involving 30% of the total body surface area. In the treatment groups, 5% C. coggygria ethanol extract was applied topically as a cream immediately after the burn. Blood and skin tissue samples were taken after decapitation at the 4th and 48th hours following the burn procedure. Interleukin 1-beta (IL-1 beta) and tumour necrosis factor (TNF-alpha) were determined in serum samples, and hydroxyproline, prostoglandin E2 (PGE2), and myeloperoxidase (MPO) activity and 8-hydroxy-2'-deoxy-guanosine (8-OHdG) levels were determined in skin tissue samples. Increased levels of serum cytokines were decreased with C. coggygria treatment in both periods. MPO activity, prostaglandine (PGE2), and 8-OhdG levels increased, while hydroxyproline levels decreased due to burn damage. On the other hand, these parameters were returned to its normal levels with C. coggygria treatment. In addition, the tissue histology of animals treated with C. coggygria showed a complete epithelialization with increased collagenation. As a result, C. coggygria may be an alternative treatment approach for burns-induced skin damage and wounds.
Citation Count: 0
The Effect of myrtus Communis L. Extract on Nephrolithiasis Model in Rats
(Kare Publ, 2024) Şener, Göksel; Dorucu, Dogancan; Gulerturk, Oznur; Sen, Ali; Cevik, Ozge; Cetinel, Sule; Sener, Goksel; Eczacılık Meslek Bilimleri Bölümü
OBJECTIVE: Nephrolithiasis is a common urological disease that can lead to renal failure. Oxidative stress has been shown to be a contributing factor for nephrolithiasis and many agents have been studied to prevent and treat oxidative stress-related nephrolithiasis and renal damage. Myrtus communis (MC) extract has been shown to be an important antioxidant in different animal models. In this study, MC extract was administered preventively or therapeutically to rats with kidney stones, and its effectiveness was investigated. METHODS: Wistar albino rats were divided into four groups (n=8); control (C), ethylene glycol (EG), EG+preventive MC, and EG+curative MC groups. The nephrolithiasis model was created by adding 0.75% EG to drinking water for 8 weeks. Ultimately, 24-hour urine was collected to measure calcium, citrate, and creatinine levels. After decapitation, kidney tissues were harvested for histological analyses, measurement of osteopontin and 8-hydroxydeoxyguanosine (8-OHdG) levels, and N-acetyl-beta-glucosaminidase (NAG), myeloperoxidase (MPO) and caspase-3 activities. RESULTS: In 24-hour urine samples, calcium, citrate and creatinine levels were decreased in the EG group, while oxalate levels were increased and in treatment groups these parameters returned to control levels. MPO, 8-OHdG, caspase-3 and NAG activity were significantly increased in tissue and these changes were reversed in both MC groups. Histological findings also supported the biochemical parameters. CONCLUSION: MC can reduce oxidative stress and histopathological changes in kidney tissues in rat nephrolithiasis model when used as either a preventive or therapeutic agent. If supported with further clinical trials, MC might have clinical implications in preventing oxidative renal cell injury and ultimately kidney stone formation.

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