Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts
(Marmara University, 2025) Gülmez, G.; Sen, A.; Servi, H.; Barak, T.H.; Tekin, F.; Marzi, M.; Şener, A.
Plants are the significant global interest as alternative treatment sources with their biologically active compounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobial properties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemical compositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC) contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showed the highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. The MIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714; 2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies have shown that TPC was 100.60±5.06, 127.90±0.30, 69.01±0.30 mg GAE /g extract; TFC was 80.07±0.15, 25.35±0.0, 16.58±0.31 mg KE/g and TTC was 217.30±6.05,172.40±2.17, 126.30±4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 in particular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategies and potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also a preliminary study for future studies. © 2025 Marmara University Press.
Citation - WoS: 3
Citation - Scopus: 4
Analysis for Two-Dimensional Inverse Quasilinear Parabolic Problem by Fourier Method
(Taylor & Francis Ltd, 2021) Kanca, Fatma; Baglan, Irem
In this work, two-dimensional inverse quasi-linear parabolic problem with periodic boundary and integral overdetermination conditions is investigated. The formal solution is obtained by the Fourier approximation. Under some natural regularity and consistency conditions on the input data,the existence, uniqueness and continuously dependence upon the data of the solution are proved by iteration method. The inverse problem is first examined by linearization and then used implicit finite difference scheme for the numerical solution. Also predictor corrector method is considered in the numerical approach. Some results on the numerical solution with two examples are presented with figures and tables. The sensitivity of the scheme with respect to noisy overdetermination data is illustrated.
Cell-Based Therapy for Cancer in Regenerative Medicine
(CRC Press, 2025) Sel, Figen Abatay; Oǧuz, Fatma Savran
Regenerative medicine focuses on developing and applying new cell-based therapies to heal tissues and organs and restore function lost due to aging, disease, tissue damage, or cancer. Cancer is a complex disease. It can occur with dysfunction in multiple systems, including DNA repair and apoptotic and immune functions. One form of regenerative medicine is cancer immunotherapy. In cancer immunotherapy, the immune system is activated, replaced, engineered, or regenerated to fight cancer. Stem cells are the most widely used for cancer immunotherapy. Stem cells have a natural capacity for self-healing via asymmetric division. Mesenchymal stem cells (MSCs) are a specific group of stem cells that have the potential to be used most often in regenerative medicine. In addition to MSCs, induced pluripotent stem cells (iPSCs) and hematopoietic stem cells (HSCs) are used in regenerative medicine for cancer treatment. This chapter will discuss using different types of stem cells in other cancers and the pros and cons of using stem cell-based therapies. © 2025 Elsevier B.V., All rights reserved.
Challenging Discrimination in Different Areas: Turkey
(Peter Lang AG, 2021) Akincilar Köseoğlu, N.; Apak, D.
This book aims to evaluate the issue of discrimination in Turkey from different points of view. Valued academics have addressed issues of discrimination in different fields such as press, sports media, social media, politics, political discourse, immigration, economics, architecture, gender, identity, and violence. Turkey is also encountered in both implicit and explicit examples of discrimination in a way as it is in many other countries. Discrimination can be adopted through discourses and can be reproduced in a wide range from politics to sports, from media to economy and can also be carried over generations. Although legal arrangements have been made against discrimination, discrimination is still active in different parts of society and in different areas. © Peter Lang GmbH Internationaler Verlag der Wissenschaften Berlin 2021.
Citation - WoS: 1
Citation - Scopus: 1
Design and Development of a New Tactile Stimulator
(Ieee, 2019) Kazma, Coskun; Levent, Vecdi Emre; Aydin, Nizamettin
We have designed and implement a tactile stimulator to obtain information from the central nervous system. Our system consists of two main components. The first one is tactile stimulator, which was designed to stimulate index and middle finger tips, stimulating mechanoreceptors according to the test protocol. Second one is a personal computer running a desktop software for the implementation of test protocols. The flow is as follows; the subjects are asked the question of the test protocol through the personal computer. The parameters are then transmitted to the embedded board on the machine. The embedded board drives step motors to apply the relevant test parameters. The desktop software expects the individual to answer the question using the right or the left mouse button of the computer mouse. After answering the relevant question, the test proceeds to the next step. According to the test protocol, the stimulation process of the mechanoreceptors located at the index and middle finger tips must start and terminate at the same time. From this perspective, the embedded board with 3 18F46K22 PIC microcontrollers produces 2 square wave signals with different frequencies and amplitudes at the same time. The embedded system card developed with the PIC microcontroller is also developed with FPGA. The system has also been tested on 24 blue and white collar employees and a significant result has been obtained.
The Destruction of a Generation by War: Syrian Families, Children’s Education, and the Risks for Turkey
(Dr. Esmeralda F. Sanchez, 2025) Terekli, M.S.; Beşiktaş, M.Y.
This study examines the phenomenon of migration, focusing on Syrian families under temporary protection who migrated to Turkey following the mass movement of people from Syria after 2011. The research explores the education of Syrian children and the risks faced by Turkey in this context. It also evaluates the economic, social, and cultural impacts of the Syrian refugee crisis on Turkey, highlighting both its positive and negative aspects, as well as related security concerns. Syrian children require increased access to psychological and psychiatric healthcare services. However, many are forced to work under harsh conditions as cheap labor. The employment rates of these children, categorized by age groups, exhibit similarities to those in Turkey but differ significantly from global trends. Applying these observations to Turkey, this study discusses the stages of educational services provided to Syrian children and suggests practical recommendations to improve their quality. The findings reveal that although Syrian children increasingly benefit from educational services each year, their participation rates remain below Turkey's national average. The study also highlights deficiencies in education, healthcare, employment, and socioeconomic conditions for children under temporary protection. Predictably, migration flows intensify during periods of intense conflict. Data from international organizations such as the United Nations High Commissioner for Refugees (UNHCR) and the International Organization for Migration (IOM) have been utilized in this research. © 2025 Elsevier B.V., All rights reserved.
Detached Yet Connected: Life and Tension Between the Dodecanese Islands and the Turkish Mainland in the Interwar Period
(Taylor and Francis, 2024) Papuççular, H.
This chapter shows that the formation of a vague border in the Aegean Sea after the transfer of the Dodecanese to Italy created legal and quotidian problems for the islanders. It reveals that these problems, ranging from property rights to fishing and sponge-diving rights, could not be solved within this period as constant tension reigned in the Aegean. However, the formation of a border did not mean the total disruption of the connection between the islands and the Anatolian mainland. On the contrary, the mobility of the islanders generated a constant challenge to the notion of a border, the constitution of which was apparently not only a political but also a social process. © 2025 selection and editorial matter, Valerie McGuire and Aron Rodrigue.
Digital Society and Togetherness Against Discrimination: Analyzing Reactions in Turkish Tweets on George Floyd Protest
(Peter Lang AG, 2021) Eyrek, A.
This study aims to examine how people react, interact, and come together against discrimination by using social media even if they are in a spatially different location. George Floyd protests spreading around the world are selected as case study for explaining reaction against discrimination on social media. On May 25, 2020, George Floyd died after being arrested by police officers in Minneapolis, United States. After the footage that displays the fatal arresting of George Floyd by police officers had been circulated on social media, street demonstrations were organized. The reaction of people spread through social media networks around the world. Using social movement theories as a theoretical framework and applying a content analysis, this study focuses on the tweets that are written in Turkish under the hashtags related to George Floyd’s death. The data set involves 12 thousand tweets, between May 28 and June 4 (during the first weeks of protests). The results reveal that social media is an essential part of interaction with people and combination of solidarity against discrimination. © Peter Lang GmbH Internationaler Verlag der Wissenschaften Berlin 2021.
Citation - WoS: 5
Citation - Scopus: 5
Effects of myrtus Communis L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats With a High Fat-Diet
(Galenos Publ House, 2021) Yasar, Ruya Kuru; Kuru, Dilruba; Sen, Ali; Sener, Goksel; Ercan, Feriha; Yarat, Aysen
Objectives: Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals. Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor. The data on tissue boron levels are quite lacking. The aim of this novel study was to investigate the effects of Myr and Apo treatment on boron levels and oxidative lens damage in rats fed a high-fat diet (HFD). Materials and Methods: Wistar albino male rats were randomly divided into four groups: the control group, HFD group, HFD + Myr group, and HFD + Apo group. Body weight and blood lipids were determined before and after the experiment. After decapitating the rats, the lenses were removed and homogenized. Catalase (CAT) and superoxide dismutase (SOD) activities and boron, malondialdehyde (MDA), and reduced glutathione (GSH) levels in the lens homogenates were determined. Results: The HFD increased serum triglyceride (p<0.05), total cholesterol level (p<0.001), body weight (p<0.001), and lens MDA levels (p<0.01) and decreased lens GSH (p<0.05) and boron level (p<0.01), SOD (p<0.001), and CAT activity (p<0.001). However, Myr and Apo treatment reduced the rats' body weight (p<0.001), serum triglyceride (p<0.05), and total cholesterol level (p<0.001) and increased lens boron (p<0.01; p<0.001), GSH levels (p<0.05; p<0.01), and CAT activity (p<0.001). Conclusion: Both Myr and Apo may be able to reduce oxidative stress in the lenses of obese rats caused by HFD by increasing boron levels.
Emergency Department Nurses’ Knowledge and Practices Related to Extravasation Injuries of Non-Cytotoxic Medications
(Turkish Association of Trauma and Emergency Surgery, 2025) Kuğu, Emre; Akyüz, Nuray
BACKGROUND: Extravasation of non-cytotoxic medications can lead to serious complications such as pain, tissue necrosis, limb loss, and even death. This descriptive cross-sectional study aims to assess the knowledge levels of emergency department (ED) nurses regarding extravasation incidents involving non-cytotoxic medications and to highlight the importance of effective management and prevention. METHODS: The study was conducted in the EDs of three hospitals in Istanbul, Türkiye, between November 19, 2020 and December 31, 2020. A total of 100 ED nurses participated in the study. Inclusion criteria required nurses to be working full-time in the EDs during the study period and to provide written and verbal consent. The study utilized a survey to assess sociodemographic characteristics, knowledge of non-cytotoxic medications (e.g., epinephrine), symptoms of extravasation, prevention strategies, and intervention practices. RESULTS: The mean age of the nurses was 29.43 years, with 57% female and 73% holding a bachelor’s degree. Among participants, 52% had 0-3 years of ED experience. Ninety-one percent reported not receiving education on extravasation after graduation, and 82% indicated no extravasation protocol was in place at their workplace. Knowledge about non-cytotoxic medications causing extravasation significantly increased with ED experience (p=0.035). Nurses in units with an extravasation protocol had significantly higher knowledge levels (p=0.007). Female nurses demonstrated better knowledge of extravasation symptoms than male nurses (p=0.012). Nurses with a bachelor’s or higher degree had significantly better knowledge than others (p=0.015). The knowledge rate for the extravasation care protocol was 64%, with the most recognized protocol item being “immediately stop the infusion” (97%) and the least recognized being “aspirate the medication not to exceed 3-5 mL” (33%). Strong correlations were found between non-pharmacological factors and knowledge of non-cytotoxic medications (r=0.601; p<0.001), as well as between knowledge of extravasation care protocols and non-pharmacological factors (p<0.001). CONCLUSION: The study highlights the need for targeted education and the establishment of institutional protocols for managing and preventing extravasation in EDs. Nurses' knowledge significantly impacts their adherence to prevention and care protocols. To ensure patient safety, it is important to provide ongoing education and implement evidence-based intervention protocols for the management of extravasation in ED settings. © 2025 Elsevier B.V., All rights reserved.
Evaluation of Labor Market Issues in Sport and Exercise Environment in Turkey
(Taylor and Francis, 2021) Ersöz, G.
Citation - Scopus: 3
Fpga Based Dco-Ofdm Phy Transceiver for Vlc Systems
(Institute of Electrical and Electronics Engineers Inc., 2019) Levent, V.E.; Uysal, M.; Saglam, G.; Ugurdag, H.F.; Fajar Rizqi Annafianto, N.; Aydin, F.; Kebapci, B.
Satisfying the demand for high bandwidth and low latency in Visible Light Communication (VLC) systems is a difficult challenge. VLC channels exhibit frequency-selectiveness at peak-speeds. This phenomenon generates a serious inter-symbol interference effect. A physical layer (PHY) design that can carry out physical layer communication tasks to overcome all these strains is required. In this study, an FPGA based PHY design that implements DCO-OFDM algorithm is described for VLC systems. A demo was performed with the developed PHY design using an LED transmitter and a photodetector receiver. © 2019 Chamber of Turkish Electrical Engineers.
From Global Evidence to Local Action Plan: A Novel Building Decarbonization Maturity Scale and Roadmap for nZEB Office Buildings in Developing Contexts − Case of Türkiye
(Elsevier Ltd, 2025) Karanfil, B.Y.; Kayaçetin, N.C.; Tereci, A.; Bıyıklı, N.; Kılınç Gilisıralıoğlu, M.; Karaer, D.
To effectively combat climate change, various policies and strategies are being developed to reduce emissions by 2050. The construction sector assumes a pivotal role in achieving decarbonization targets. It is imperative to acknowledge the potential of practices in developing countries, which can provide the critical part of carbon reduction on a global scale. In this context, Nearly Zero Energy Buildings (nZEB) are attracting global attention as a key component of sustainable construction and urban regeneration. Despite high level of energy efficiency and potential to utilize renewable energy, nZEBs have not found widespread application in developing countries. This study benefits from a systematic review of the whole-life decarbonization process of nZEB office buildings. The study evaluated policy frameworks, implementation, and potential emission reduction strategies through energy efficiency measures, material selection, and the integration of renewable energy. In response, the study proposes a structured, context-sensitive decarbonization maturity scale and roadmap to guide policy and practice in developing countries and utilized Türkiye as a case study example. The findings reveal that Türkiye’s current nZEB definition positions it at Level 2 (Emerging) on the decarbonization maturity scale. The country’s high carbon intensity signals the urgency of prioritizing demand reduction and efficiency. Despite enhancements, nZEB offices in Türkiye exhibit high carbon emissions, with operational emissions ranging from 7.5 to 35 kgCO2-eq/m2/year and embodied carbon from 182 to 201 kgCO2-eq/m2. As a result, the maturity scale identifies leverage points offering a mechanism to benchmark progress and accelerate climate action in line with international examples approaching Level 5. © 2025 Elsevier B.V., All rights reserved.
Global Cyberspace Security and Critical Information Infrastructure Protection
(Springer International Publishing, 2023) Eldem, T.
Government Responses To the Covid-19 Pandemic: Comparative Health Policies in the Us and Canada
(Taylor and Francis, 2023) Erhan, C.; Sıvış, E.
In this chapter, we seek to analyse how the United States (US) and Canada handled the COVID-19 pandemic, the resulting consequences on domestic politics, and the overall effect on global geopolitics. The record voter turnout for the 2020 US elections is viewed as an outcome of increased polarisation, politicisation and disinformation, and the general lack of transparency and accountability regarding the COVID-19 crisis under the Trump Administration. On the other hand, although Trump’s isolationist and right-wing policies, in general, pushed Canada into a lonely position in tackling the virus, Canada was able to perform better at handling the virus effectively. Due to robust lockdowns and fiscal stimulus packages and investments in healthcare and COVID-related research, Canada recovered well. Moreover, a comparison of the results of the 2020 US and 2021 Canadian elections indicates that while most Americans distrusted Trump’s pandemic agenda, most Canadians chose to re-elect Prime Minister Justin Trudeau given his successful handling of the virus. © 2024 selection and editorial matter, Erman Akilli, Burak Güneş and Ahmet Gökbel.
Citation - Scopus: 1
Green jobs in green transformation story
(IGI Global, 2024) Alkan, B.
Governments around the world are enacting green recovery and transition programs in collaboration with international agencies. Their coordinated efforts attempt to balance economic growth with environmental preservation, emphasizing that for a sustainable and green future the green transformation is an urgent requirement. The employment component of the green transformation has significant social and economic repercussions. Depending on how prepared countries are for the transition process, skill adaptation and the creation of new job opportunities can provide socioeconomic benefits. "Green jobs" are discussed in the chapter as an important part of the transition strategy to a green economy. The chapter outlines what a "green job" is and is not, presents the connection between employment and skills, and emphasizes the relevance of green jobs in the transition process. © 2024, IGI Global. All rights reserved.
Hybrid Swara-Vikor Based on Neutrosophic Fuzzy Numbers: an Application
(IGI Global, 2024) Büyükselçuk, E.C.
In recent years, the burgeoning activity in medical tourism has prompted countries to allocate investments to the healthcare sector, signalling a significant resurgence in national economies. Turkey, like many other nations, has witnessed favourable advancements in this domain. Buoyed by these positive trends and government support, Turkey has expanded its market presence in medical tourism. Concurrently, both public and private hospitals and clinics are endeavouring to capitalize on this growing market share by initiating fresh investments in the sector. This study focuses on assessing the performance of a private healthcare institution operating within Turkey. Leveraging performance criteria established through expert opinions and a thorough literature review, the evaluation of various hospital branches within the healthcare sector was conducted utilizing integrated SWARA-VIKOR methods, employing neutrosophic fuzzy numbers. © 2025 by IGI Global Scientific Publishing. All rights reserved.
Introduction: General Information About Discrimination in Turkey
(Peter Lang AG, 2021) Akincilar Köseoğlu, N.; Apak, D.
[No abstract available]
Machine Learning Model for Predicting Multidrug Resistance in Clinical Escherichia Coli Isolates: A Retrospective General Surgery Study
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Tolan, H.K.; Aydın, İ.; Tanyildizi-Kökkülünk, H.; Karakuş, M.; Akkaya, Y.; Kaya, O.; Işman, F.K.
Background/Objectives: Escherichia coli is one of the leading causes of surgical site infections (SSIs) and poses a growing public health concern due to its increasing antimicrobial resistance. High rates of extended-spectrum beta-lactamase (ESBL) production among E. coli strains complicate treatment outcomes and emphasize the need for effective surveillance and control strategies. Methods: A total of 691 E. coli isolates from general surgery clinics (2020–2025) were identified using MALDI-TOF MS. Antibiotic susceptibility data and patient variables were cleaned, encoded, and used to predict resistance using the Random Forest, CatBoost, and Naive Bayes algorithms. SMOTE addressed class imbalance, and model performance was assessed through various validation methods. Results: Among the three machine learning models tested, Random Forest (RF) showed the best performance in predicting antibiotic resistance of E. coli, achieving median accuracy, precision, recall, and F1-scores of 0.90 and AUC values up to 0.99 for key antibiotics. CatBoost performed similarly but was less stable with imbalanced data, while Naive Bayes showed lower accuracy. Feature importance analysis highlighted strong inter-antibiotic resistance links, especially among β-lactams, and some influence of demographic factors. Conclusions: This study highlights the potential of simple, high-performing models using structured clinical data to predict antimicrobial resistance, especially in resource-limited clinical settings. By incorporating machine learning into antimicrobial resistance (AMR) surveillance systems, our goal is to support the advancement of rapid diagnostics and targeted antimicrobial stewardship approaches, which are essential in addressing the growing challenge of multidrug resistance. © 2025 by the authors.
Military Coups and Military Disengagement
(Springer International Publishing, 2023) Eldem, T.

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