Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/7

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Acute Serious Hepatitis of Unknown Cause in Children
(Galenos Publishing House, 2022) Kılbaş, E.P.K.; Altındiş, M.; Tıbbi Hizmetler ve Teknikler Bölümü
On April 5, 2022, an increase in cases of acute hepatitis of unknown etiology was reported in previously healthy children under the age of 10 in the United Kingdom. Since there is no link between these patients, called acute non-HepA-E hepatitis, and viral hepatitis agents (hepatitis A, B, C, D, and E), the possible etiology, and pathogenesis of this emergency is being investigated. One of the alarming features of this epidemic is the high requirement for liver transplantation in a fraction of the cases. In cases other than hepatitis A, B, C, D, and E, a case definition is made by looking at a series of clinical pictures, including serum transaminase levels and age. As of August 26, 2022, 513 cases of acute hepatitis have been reported in Europe and 1,010 globally. Adenovirus was detected in 75% of cases tested in the UK, but data for other countries are still lacking. The role of other etiologic agents is still under investigation. The exact disease pathogenesis has not yet clear. Evidence of human-to-human transmission of the disease remains unclear. Epidemiological studies are critical in clarifying the uncertainties regarding the existence of links between the cases reported to date. Continuing the national and international surveillance activities of the countries in an organized manner is the most basic issue required for the elimination of the epidemic. Copyright © 2022 Tehran University of Medical Sciences.
Citation - WoS: 3
Citation - Scopus: 4
Analysis for Two-Dimensional Inverse Quasilinear Parabolic Problem by Fourier Method
(Taylor & Francis Ltd, 2021) Kanca, Fatma; Baglan, Irem; Bilgisayar Mühendisliği Bölümü
In this work, two-dimensional inverse quasi-linear parabolic problem with periodic boundary and integral overdetermination conditions is investigated. The formal solution is obtained by the Fourier approximation. Under some natural regularity and consistency conditions on the input data,the existence, uniqueness and continuously dependence upon the data of the solution are proved by iteration method. The inverse problem is first examined by linearization and then used implicit finite difference scheme for the numerical solution. Also predictor corrector method is considered in the numerical approach. Some results on the numerical solution with two examples are presented with figures and tables. The sensitivity of the scheme with respect to noisy overdetermination data is illustrated.
An Analysis of Psychological Resilience Levels Among Judo Coaches According to Selected Demographic Factors
(Idokan Poland Association, 2025) Beşiktaş, M.Y.; Terekli, M.S.; Beden Eğitimi ve Spor Bölümü; Antrenörlük Eğitimi Bölümü
Background. Psychological resilience is a crucial personal trait that enables individuals, especially those in high-stress professions like coaching, to adapt and thrive in the face of adversity. Understanding how resilience manifests among coaches can contribute to more effective support and development strategies in sports psychology. Problem and aim. This study aims to determine whether the psychological resilience levels of judo coaches differ according to demographic variables such as age, educational background, coaching certification level, years of coaching experience, profession, and perceived economic status. Material and methods. The sample included 284 active judo coaches (58 women and 226 men) from Istanbul, Kutahya, and Eskisehir. Data were collected using the “Psychological Resilience Scale for Adults” [Friborg et al. 2003; Basim, Cetin 2011] and a “Personal Information Form.” Statistical analyses were conducted using SPSS 24.0, including independent samples t-tests, one-way ANOVA, and Eta squared analysis to assess the influence of demographic actors on resilience levels. Results. The findings indicated significant differences in psychological resilience levels based on gender, marital status, age, educational attainment, coaching experience, income level, and coaching certification level. Conclusions. The results suggest that psychological resilience among judo coaches is meaningfully influenced by various demographic characteristics. These findings underscore the importance of tailoring psychological support and development programs to the specific profiles of coaches. © Yoshin Academy
Avatar: a Film at the Center of the Feminine Other
(Univ Pittsburgh, Univ Library System, 2025) Dereboyu, Pelin Guregen; Guzel, Ebru; Olaru, Gabriela Oana; Ayberk, Erhan
This study analyzes James Cameron's 2009 film Avatar from the perspective of the feminine other through deconstruction. In the movie, nature and the Na'vi people are depicted as feminine, while modern man and the science, technology, and military power he represents are portrayed as masculine. Although it critiques the colonialist structure of modernity, the film's narrative structure and character portrayals indicate that it reproduces the superiority of Western-centered ideology and the masculine mind. The study analyzes how the film's narrative and character representations implicitly support masculine centrism. The analysis reveals how nature and marginalized cultures are romanticized and presented in the film and how the notion that the feminine can only survive by adopting masculine traits is processed in the subtext. Grounded in a conceptual and theoretical framework, this research focuses on the sustainability of the patriarchal capitalist system and gender politics while critically examining how cinema reconstructs ideological structures through the narratives in the film.
Burn Rehabilitation: Evaluation of Physiotherapists' Knowledge and Awareness Levels
(Elsevier Sci Ltd, 2025) Seyyah, Mine; Akkurt, Mustafa Ferit; Yilmaz, Nergis
Objective: The aim of this study was to evaluate the level of knowledge and awareness of physiotherapists working in Turkey about burn rehabilitation. Method: This was a cross-sectional study conducted between March and June 2025 and data were collected using Google Form. A total of 324 people were included in the study. The level of knowledge and awareness of the participants about burn rehabilitation was evaluated with 28 questions created by taking expert opinion. Results: While 25.6 % of participants had experience in burn rehabilitation, only 1.2 % frequently encountered burn patients. Although 60.5 % had taken courses on burn rehabilitation, only 15.1 % considered their knowledge sufficient. Correct response rates to key knowledge questions were 78.7 % for exercise applicability, 79.6 % for timing, 54.6 % for the most common burn type in Turkey, 35.8 % for edema management, and 13 % for pressure garment duration, revealing gaps in clinical knowledge. Additionally, 92.9 % believed early physiotherapy improves recovery, and 98.4 % reported positive effects on quality of life. Discussion: Our results indicate that although most physiotherapists had taken courses on burn rehabilitation, their knowledge remains insufficient, whereas their awareness is high, underscoring the need for targeted training and certification programs.
Cell-Based Therapy for Cancer in Regenerative Medicine
(CRC Press, 2025) Sel, Figen Abatay; Oǧuz, Fatma Savran
Regenerative medicine focuses on developing and applying new cell-based therapies to heal tissues and organs and restore function lost due to aging, disease, tissue damage, or cancer. Cancer is a complex disease. It can occur with dysfunction in multiple systems, including DNA repair and apoptotic and immune functions. One form of regenerative medicine is cancer immunotherapy. In cancer immunotherapy, the immune system is activated, replaced, engineered, or regenerated to fight cancer. Stem cells are the most widely used for cancer immunotherapy. Stem cells have a natural capacity for self-healing via asymmetric division. Mesenchymal stem cells (MSCs) are a specific group of stem cells that have the potential to be used most often in regenerative medicine. In addition to MSCs, induced pluripotent stem cells (iPSCs) and hematopoietic stem cells (HSCs) are used in regenerative medicine for cancer treatment. This chapter will discuss using different types of stem cells in other cancers and the pros and cons of using stem cell-based therapies. © 2025 Elsevier B.V., All rights reserved.
Challenging Discrimination in Different Areas: Turkey
(Peter Lang AG, 2021) Akincilar Köseoğlu, N.; Apak, D.; Siyaset Bilimi ve Uluslararası İlişkiler Bölümü
This book aims to evaluate the issue of discrimination in Turkey from different points of view. Valued academics have addressed issues of discrimination in different fields such as press, sports media, social media, politics, political discourse, immigration, economics, architecture, gender, identity, and violence. Turkey is also encountered in both implicit and explicit examples of discrimination in a way as it is in many other countries. Discrimination can be adopted through discourses and can be reproduced in a wide range from politics to sports, from media to economy and can also be carried over generations. Although legal arrangements have been made against discrimination, discrimination is still active in different parts of society and in different areas. © Peter Lang GmbH Internationaler Verlag der Wissenschaften Berlin 2021.
Citation - Scopus: 2
Comparison of the Hidden Curriculum for Nursing Education of Two Different Universities in the East and West of Turkiye
(Inonu University, 2024) Elmali Şimşek, H.; Aksoy, M.
The present study aimed to determine and compare the hidden curriculum of two institutions that provide undergraduate nursing education in two different regions of Türkiye. The descriptive and cross-sectional research was conducted with 319 nursing students. Data were collected with the Introductory Information Form and Hidden Curriculum Evaluation Scale in Nursing Education (HCES-N). While the mean score of the HCES-N total score of the nursing students attending the university in the West of Türkiye was 163.31 ± 21.69. The HCES-N total mean score of the nursing students attending in the East of Türkiye was calculated as 145.50 ± 25.81. While the HCES-N total score, school atmosphere, and professional achievement scores of the nursing students attending the university in the West of Türkiye were statistically higher than the nursing students attending the university in the east, the student-teacher-school interaction score was statistically lower. It was determined that the perceptions of the students participating in the study towards the hidden curriculum were moderate, while the perceptions of the students studying in the West of Türkiye were better. In line with these results, it is important to improve the physical conditions of schools in improving the hidden curriculum. © 2024, Inonu University. All rights reserved.
Comprehensive Bibliometric Analysis of Characteristics, Patterns, and Causes of Retractions in Pediatric Literature
(Springer, 2025) Abo-Elnour, Dina Essam; Helal, Mohamed Mohsen; Albalasy, Abdulrahman Ahmed; Abdul-Hafez, Hamza A.; Abdelkader, Ahmed; El-Sherbini, Eman Raafat; Amer, Samar A.
This study aimed to systematically identify the key characteristics of retracted articles in pediatric literature and explore the patterns and reasons of pediatric retraction from 1995 to 2024. We searched PubMed and Retraction Watch databases to identify all retracted publications in the field of pediatrics. After the screening process, data were extracted into Excel. Statistical analysis was conducted using Jamovi and Excel. A correlation matrix was used for the important retraction-related factors. After screening, 590 unique retracted pediatric articles were included, with most of them, 572 (96.9%), having retraction notices available; 516 (87.5%) published as open access; 433 (73.4%) from Asia-mostly China; 348 (59%) retracted by the publisher; 301 (51.0%) published by Hindawi; 275 (46.6%) observational studies; and 221 (37.5%) retracted due to misconduct. Articles with four authors showed the highest retraction rate, and the retraction rate generally decreased as the number of authors increased. Most retractions occurred in 2023. The most common pediatric age group included in the retracted papers was children. The median H-index of authors of retracted papers was 8 for first authors and 10 for senior authors. The median time from submission to acceptance of retracted papers was 50 days and that from publication to retraction was 15 months. Additionally, time to retraction was positively correlated with the journal's impact factor (r = 0.106, p = 0.015) and the citation count (r = 0.213, p < 0.001) but showed no significant correlation with time to acceptance (r = - 0.019, p = 0.675). Conclusion: The increasing number of retracted pediatric papers reflects a growing concern with a complex pattern and various determinants. Researchers and publishers should adopt strong regulations and guidelines to improve the integrity of scientific research, especially pediatric research.
Citation - WoS: 1
Citation - Scopus: 1
Design and Development of a New Tactile Stimulator
(Ieee, 2019) Kazma, Coskun; Levent, Vecdi Emre; Aydin, Nizamettin; Bilgisayar Mühendisliği Bölümü
We have designed and implement a tactile stimulator to obtain information from the central nervous system. Our system consists of two main components. The first one is tactile stimulator, which was designed to stimulate index and middle finger tips, stimulating mechanoreceptors according to the test protocol. Second one is a personal computer running a desktop software for the implementation of test protocols. The flow is as follows; the subjects are asked the question of the test protocol through the personal computer. The parameters are then transmitted to the embedded board on the machine. The embedded board drives step motors to apply the relevant test parameters. The desktop software expects the individual to answer the question using the right or the left mouse button of the computer mouse. After answering the relevant question, the test proceeds to the next step. According to the test protocol, the stimulation process of the mechanoreceptors located at the index and middle finger tips must start and terminate at the same time. From this perspective, the embedded board with 3 18F46K22 PIC microcontrollers produces 2 square wave signals with different frequencies and amplitudes at the same time. The embedded system card developed with the PIC microcontroller is also developed with FPGA. The system has also been tested on 24 blue and white collar employees and a significant result has been obtained.
The Destruction of a Generation by War: Syrian Families, Children’s Education, and the Risks for Turkey
(Dr. Esmeralda F. Sanchez, 2025) Terekli, M.S.; Beşiktaş, M.Y.
This study examines the phenomenon of migration, focusing on Syrian families under temporary protection who migrated to Turkey following the mass movement of people from Syria after 2011. The research explores the education of Syrian children and the risks faced by Turkey in this context. It also evaluates the economic, social, and cultural impacts of the Syrian refugee crisis on Turkey, highlighting both its positive and negative aspects, as well as related security concerns. Syrian children require increased access to psychological and psychiatric healthcare services. However, many are forced to work under harsh conditions as cheap labor. The employment rates of these children, categorized by age groups, exhibit similarities to those in Turkey but differ significantly from global trends. Applying these observations to Turkey, this study discusses the stages of educational services provided to Syrian children and suggests practical recommendations to improve their quality. The findings reveal that although Syrian children increasingly benefit from educational services each year, their participation rates remain below Turkey's national average. The study also highlights deficiencies in education, healthcare, employment, and socioeconomic conditions for children under temporary protection. Predictably, migration flows intensify during periods of intense conflict. Data from international organizations such as the United Nations High Commissioner for Refugees (UNHCR) and the International Organization for Migration (IOM) have been utilized in this research. © 2025 Elsevier B.V., All rights reserved.
Detached Yet Connected: Life and Tension Between the Dodecanese Islands and the Turkish Mainland in the Interwar Period
(Taylor and Francis, 2024) Papuççular, H.; Siyaset Bilimi ve Uluslararası İlişkiler Bölümü
This chapter shows that the formation of a vague border in the Aegean Sea after the transfer of the Dodecanese to Italy created legal and quotidian problems for the islanders. It reveals that these problems, ranging from property rights to fishing and sponge-diving rights, could not be solved within this period as constant tension reigned in the Aegean. However, the formation of a border did not mean the total disruption of the connection between the islands and the Anatolian mainland. On the contrary, the mobility of the islanders generated a constant challenge to the notion of a border, the constitution of which was apparently not only a political but also a social process. © 2025 selection and editorial matter, Valerie McGuire and Aron Rodrigue.
Determination of Post-Earthquake Trauma Level and Investigation of the Relationship with Physical Activity Status
(Turkish Physiotherapy Association, 2025) Tosun, Anil; Yılmaz, Nergis; Luque, Demet Tekın De Las Penas; Fizyoterapi Ve Rehabilitasyon Bölümü
Amaç: Çalışmanın amacı; 06 Şubat 2023’te meydana gelen Pazarcık-Elbistan merkezli depremler sebebiyle kişilerde oluşan travma düzeyinin, kişinin fiziksel aktivite durumu ile ilişkisini incelemektir. Aynı zamanda, kişilerde deprem sonrası ağrı varlığının sorgulanması ve bu durumun travma düzeyi ile ilişkisini ortaya koymaktır. Yöntem: Veriler çevrimiçi olarak Google formları aracılığıyla toplandı, 18-65 yaş arası 388 gönüllü katılımcı (299 kadın, 89 erkek) çalışmaya dahil edildi. Katılımcıların genel özelliklerini belirlemek için “Sosyodemografik Bilgi Formu”, travma düzeyini değerlendirmek için “Deprem Sonrası Travma Düzeyini Belirleme Ölçeği” (DSTDBÖ) ve fiziksel aktivite durumlarını belirlemek için “Uluslararası Fiziksel Aktivite Anketi Kısa Formu” (IPAQ-KF) kullanıldı. Bulgular: Deprem bölgesinde bulunma durumuna göre DSTDBÖ genel puan ortalamaları arasında anlamlı fark saptandı (p<0,001). Deprem bölgesinde bulunan 126 kişinin DSTDBÖ genel puan ortalaması 57,66±19,87 iken, bölgede bulunmayan 262 kişinin ortalaması 49,00±18,49 olarak bulundu. Spearman korelasyon analiziyle deprem bölgesinde olan ve olmayan bireylerin IPAQ-KF toplam puanları, DSTDBÖ alt faktör ve toplam puanları arasındaki ilişki incelenmiş olup sadece “Bilişsel Yapılandırma” alt faktörü ile IPAQ-KF toplam puanları arasında anlamlı bir ilişkiyi yansıtmayan negatif zayıf ilişki bulundu (deprem bölgesinde olanlar için Spearman korelasyon katsayı değeri =-0,18, p=0,042). Ve deprem sonrası ağrı yaşayan bireylerin DSTDBÖ puanları, ağrı yaşamayanlardan daha yüksek olarak saptandı (p=0,000). Sonuç: Bu çalışma ile deprem sonrası travma düzeyinin, fiziksel aktivite ile negatif ilişki gösterdiği belirlendi. İnaktif bireyler daha yüksek travma düzeylerine sahipken, minimal aktif bireylerde travma düzeyleri daha düşük bulundu. Bu bulgular, deprem sonrası fiziksel aktivitenin artırılmasının travma düzeylerini azaltmada etkili bir strateji olabileceğini göstermektedir. Bu alanda daha fazla araştırma, eğitim ve proje çalışmalarının yapılması gerekmektedir.
Development and Psychometric Properties of the Home Programme Quality Evaluation Tool for Therapists, Clients and Caregivers: A Validity and Reliability Study
(MA Healthcare Ltd, 2025) Akyurek, Gokcen; Bektas, Selen Aydoner; Sipahi, Busra
Background/Aims Home programmes - where rehabilitation activities are carried out in the client's home - are frequently used in the rehabilitation process but there are no standardised measurements to assess preparation, delivery and quality. The aim of this study was to determine the validity and reliability of two different forms - one for therapists and one for client and caregivers - that were developed as part of the Home Programme Quality Evaluation tool. Methods Initially, two 38-item forms were created based on a comprehensive literature review and expert panel evaluation. These forms were piloted with 30 participants from each target group to assess grammatical clarity, comprehensibility and cultural appropriateness. Based on the pilot feedback, minor linguistic adjustments were made, and the refined 38-item forms were then administered to 179 physiotherapists, occupational therapists and speech and language therapists, and 185 clients/caregivers (100 clients, 85 caregivers) for psychometric analyses. Psychometric analyses were conducted to evaluate validity and reliability, including exploratory and confirmatory factor analyses (chi-square/degree of freedom ratio, Goodness-of-Fit Index, Tucker-Lewis Index, Comparative Fit Index, Incremental Fit Index, root mean square error of approximation, standardised root mean square residual and internal consistency (Cronbach's alpha) and test-retest reliability (intraclass correlation coefficient and Pearson correlation). Results Exploratory and confirmatory factor analyses supported a one-factor structure for both forms, resulting in the final 11-item therapist form and 8-item client/caregiver form. The Home Programme Quality Evaluation tool demonstrated a good model fit for both forms (therapist form: chi(2)/df=2.66, goodness-of-fit index=0.909, Tucker-Lewis Index=0.886, standardised root mean square residual=0.060; client/caregiver form: chi(2)/df=3.37, goodness-of-fit index=0.929, Tucker-Lewis Index=0.950, standardised root mean square residual=0.027). Cronbach's alpha was 0.868 for the therapist form and 0.932 for the client/caregiver form. Test-retest reliability revealed strong positive correlations (r=0.994, P<0.001; r=0.998, P<0.001) and excellent stability over time (intraclass correlation coefficient=0.998 and 0.990, respectively). Conclusions The Home Programme Quality Evaluation's therapist and client/caregiver forms were found to have strong validity and reliability. The therapist form can enable therapists to monitor themselves, while the client and caregiver form can help clients or caregivers provide feedback on the home programme. Future studies can explore its application across different clinical populations and rehabilitation settings to further refine and optimise home-based interventions. Implications for practice For allied health professionals, the Home Programme Quality Evaluation tool serves as a practical tool for improving home programme design and implementation. By systematically assessing home programme quality, therapists can identify areas for improvement, ensuring that programmes are clear, feasible and well-integrated into the daily life of clients and their caregivers. Integrating the Home Programme Quality Evaluation tool into routine clinical practice can contribute to more effective rehabilitation outcomes, promoting structured, high-quality home programmes that align with the needs and capabilities of both clients and caregivers.
Digital Society and Togetherness Against Discrimination: Analyzing Reactions in Turkish Tweets on George Floyd Protest
(Peter Lang AG, 2021) Eyrek, A.; Yeni Medya ve İletişim Bölümü
This study aims to examine how people react, interact, and come together against discrimination by using social media even if they are in a spatially different location. George Floyd protests spreading around the world are selected as case study for explaining reaction against discrimination on social media. On May 25, 2020, George Floyd died after being arrested by police officers in Minneapolis, United States. After the footage that displays the fatal arresting of George Floyd by police officers had been circulated on social media, street demonstrations were organized. The reaction of people spread through social media networks around the world. Using social movement theories as a theoretical framework and applying a content analysis, this study focuses on the tweets that are written in Turkish under the hashtags related to George Floyd’s death. The data set involves 12 thousand tweets, between May 28 and June 4 (during the first weeks of protests). The results reveal that social media is an essential part of interaction with people and combination of solidarity against discrimination. © Peter Lang GmbH Internationaler Verlag der Wissenschaften Berlin 2021.
The Effect of Vitamin D and Paricalcitol on Protein Disulfide Isomerase
(Marmara University, 2025) Koksal, Murat; Şekerler, Turgut; Şener, Azize; Temel Eczacılık Bilimleri Bölümü
Protein disulfide isomerase (PDI), a multifunctional protein plays an important role as oxidoreductase, isomerase and chaperone in the cell. Prior studies have identified PDI is highly expressed in many different cancer types and presented as a new potential target for cancer treatment. Here, we investigated vitamin D and its analogue paricalcitol in silico interaction of the human PDI and inhibition of PDI reductase activity in vitro. We observed a non-covalent mechanism where the main skeleton of the vitamin D3 ans paricalcitol sturcture is located at the hydrophobic site in the b' domain of PDI and forms a hydrogen bond with a residue (His138) in tihs domain. They also form multiple weak hydrophobic interactions with various chemical groups of the b' subunit. For the first time, we demonstrate that 1,25-dihydroxyvitamin D3 (1a,25(OH)2 vitamin D3) and paricalcitol inhibit the PDI reductase activity in vitro and their IC50 values are 20.79±1.43 nmol/L and 32.83±3.15 nmol/L respectively. The two compounds can also block the denistrosation activity of PDI.
Effectiveness of Vibration in Reducing Pain and Improving Satisfaction During Subcutaneous Injections: A Randomized Crossover Clinical Trial
(Taylor & Francis Ltd, 2025) Yildirim, Dilek; Kugu, Emre
AimThe pain experienced during and after the injection may cause discomfort and lead individuals to develop a negative perception toward future injections. This study aimed to evaluate the impact of vibration stimulation on pain induced by subcutaneous injections and patient satisfaction.MethodsThis was a prospective, randomized, single-blind, crossover study design. Data were collected from 85 patients. Vibration and non-vibration subcutaneous anticoagulant injections were administered randomly by the same investigator following a standardized procedure. Pain and satisfaction were evaluated by a study-blind investigator using the Visual Analogue Scale immediately after the injection. Data were analyzed using descriptive statistics, the Student's t-test, paired sample test, and a generalized linear mixed model.ResultsA total of 175 injections were analyzed. It was found that the pain level of patients was lower when vibration was applied (4.06 +/- 1.68 vs. 5.32 +/- 2.19, p = 0.004). Additionally, patient satisfaction was higher when vibration was used (7.17 +/- 1.71vs. 5.97 +/- 2.46, p = 0.011).ConclusionThe results of this study demonstrated that vibration was effective in reducing the pain associated with subcutaneous anticoagulant injections and in increasing patient satisfaction. Vibration can be used as a method to alleviate pain from subcutaneous anticoagulant injections and enhance patient satisfaction. Clinically, this suggests that incorporating vibration during subcutaneous injections can be a simple, non-pharmacological strategy to improve patient comfort and adherence to therapy.
Citation - WoS: 5
Citation - Scopus: 5
Effects of myrtus Communis L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats With a High Fat-Diet
(Galenos Publ House, 2021) Yasar, Ruya Kuru; Kuru, Dilruba; Sen, Ali; Sener, Goksel; Ercan, Feriha; Yarat, Aysen; Eczacılık Meslek Bilimleri Bölümü
Objectives: Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals. Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor. The data on tissue boron levels are quite lacking. The aim of this novel study was to investigate the effects of Myr and Apo treatment on boron levels and oxidative lens damage in rats fed a high-fat diet (HFD). Materials and Methods: Wistar albino male rats were randomly divided into four groups: the control group, HFD group, HFD + Myr group, and HFD + Apo group. Body weight and blood lipids were determined before and after the experiment. After decapitating the rats, the lenses were removed and homogenized. Catalase (CAT) and superoxide dismutase (SOD) activities and boron, malondialdehyde (MDA), and reduced glutathione (GSH) levels in the lens homogenates were determined. Results: The HFD increased serum triglyceride (p<0.05), total cholesterol level (p<0.001), body weight (p<0.001), and lens MDA levels (p<0.01) and decreased lens GSH (p<0.05) and boron level (p<0.01), SOD (p<0.001), and CAT activity (p<0.001). However, Myr and Apo treatment reduced the rats' body weight (p<0.001), serum triglyceride (p<0.05), and total cholesterol level (p<0.001) and increased lens boron (p<0.01; p<0.001), GSH levels (p<0.05; p<0.01), and CAT activity (p<0.001). Conclusion: Both Myr and Apo may be able to reduce oxidative stress in the lenses of obese rats caused by HFD by increasing boron levels.
Citation - WoS: 1
Effects of Nighttime Eating Behavior on Cardiometabolic Health and Sleep: A Crossover Study
(Elsevier Sci Ltd, 2025) Kesgin, Yavuz Erkam; Hasbal, Nuri Baris; Copur, Sidar; Incir, Said; Kurtulus, Ozlem; Genc, Candan; Kanbay, Mehmet; Terapi ve Rehabilitasyon Bölümü
Background and aims: The impact of night-eating behavior (NEB) on metabolic health remains underexplored, particularly in healthy populations. We have hypothesized that NEB adversely affects metabolic parameters, liver function, and sleep via circadian disruption and neurohormonal alterations. Methods and results: In this single-center crossover study, sixteen healthy adults (aged 18-35 years) with no comorbidities, no medication use, and a body mass index between 18 and 30 kg/m(2) participated in two one-week dietary regimens: regular eating (no food after 7:30 p.m.) and nighttime eating (>= 25 % of daily caloric intake consumed after 9:30 p.m.). Clinical, biochemical, neurohormonal, and respiratory polygraphy data were obtained following each dietary period. The mean age of participants was 27 +/- 4 years. After adjusting for multiple comparisons, nighttime eating behavior (NEB) was associated with significant increases in albuminuria (p = 0.003), serum phosphate (p < 0.001), fasting triglycerides (p = 0.039), and C-reactive protein (CRP; p = 0.01). NEB also elevated serum leptin (p = 0.007), ghrelin (p < 0.001), cortisol (p = 0.041), fibroblast growth factor 21 (FGF-21; p < 0.001), and cytokeratin-18 (p < 0.001), while significantly decreasing melatonin levels (p < 0.001). Sleep study results demonstrated significant increases in the apnea-hypopnea index (AHI; p < 0.001), supine AHI (p < 0.005), oxygen desaturation (7 % +/- 2 % vs. 11 % +/- 3 %; p < 0.001). Conclusion: NEB significantly affects neurohormonal profiles and sleep-related respiratory metrics in healthy individuals, indicating potential adverse effects on cardiometabolic health during short-term evaluation in healthy subjects.
Emergency Department Nurses’ Knowledge and Practices Related to Extravasation Injuries of Non-Cytotoxic Medications
(Turkish Association of Trauma and Emergency Surgery, 2025) Kuğu, Emre; Akyüz, Nuray; Tıbbi Hizmetler ve Teknikler Bölümü
BACKGROUND: Extravasation of non-cytotoxic medications can lead to serious complications such as pain, tissue necrosis, limb loss, and even death. This descriptive cross-sectional study aims to assess the knowledge levels of emergency department (ED) nurses regarding extravasation incidents involving non-cytotoxic medications and to highlight the importance of effective management and prevention. METHODS: The study was conducted in the EDs of three hospitals in Istanbul, Türkiye, between November 19, 2020 and December 31, 2020. A total of 100 ED nurses participated in the study. Inclusion criteria required nurses to be working full-time in the EDs during the study period and to provide written and verbal consent. The study utilized a survey to assess sociodemographic characteristics, knowledge of non-cytotoxic medications (e.g., epinephrine), symptoms of extravasation, prevention strategies, and intervention practices. RESULTS: The mean age of the nurses was 29.43 years, with 57% female and 73% holding a bachelor’s degree. Among participants, 52% had 0-3 years of ED experience. Ninety-one percent reported not receiving education on extravasation after graduation, and 82% indicated no extravasation protocol was in place at their workplace. Knowledge about non-cytotoxic medications causing extravasation significantly increased with ED experience (p=0.035). Nurses in units with an extravasation protocol had significantly higher knowledge levels (p=0.007). Female nurses demonstrated better knowledge of extravasation symptoms than male nurses (p=0.012). Nurses with a bachelor’s or higher degree had significantly better knowledge than others (p=0.015). The knowledge rate for the extravasation care protocol was 64%, with the most recognized protocol item being “immediately stop the infusion” (97%) and the least recognized being “aspirate the medication not to exceed 3-5 mL” (33%). Strong correlations were found between non-pharmacological factors and knowledge of non-cytotoxic medications (r=0.601; p<0.001), as well as between knowledge of extravasation care protocols and non-pharmacological factors (p<0.001). CONCLUSION: The study highlights the need for targeted education and the establishment of institutional protocols for managing and preventing extravasation in EDs. Nurses' knowledge significantly impacts their adherence to prevention and care protocols. To ensure patient safety, it is important to provide ongoing education and implement evidence-based intervention protocols for the management of extravasation in ED settings. © 2025 Elsevier B.V., All rights reserved.

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