TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9

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Citation - WoS: 6
Citation - Scopus: 6
beta Vulgaris L. Var. Cicla Improves Memory Deficits in Intracerebroventricular Streptozotocin Injected Rats: Role on Neuroinflammation
(Marmara Univ, 2021) Ertas, Busra; Topal, Fadime; Gulhan, Rezzan; Yanardag, Refiye; Sacan, Ozlem; Sener, Goksel
Alzheimer's disease is a challenging disease for patients due to progressive loss of cognition and behavioral disorders. Disruption of cholinergic transmission and neuroinflammation are the most important mechanisms underlying cognitive damage. Beta vulgaris L. var. cicla (BV) has been reported to have various pharmacological effects associated with its rich antioxidant content. In addition, anti-cholinesterase and antiinflammatory activities of BV have been demonstrated in vitro. The aim of this study is to elucidate the therapeutic effect of BV against cognitive impairment, reduction in cholinergic transmission and neuroinflammation caused by intracerebroventricular (ICV) administration of streptozotocin (STZ). STZ was administered bilaterally at a dose of 3 mg/kg via ICV to rats, and BV treatment at a dose of 2 g/kg for 21 days was administered orally to STZ-induced animals. After behavioral tests, AChE activity, TNF-alpha and IL-1 beta levels were measured in hippocampus and cortex tissues excised from decapitated animals. Novel object recognition and passive avoidance test showed that the treatment of BV reverted the ICV-STZ induced memory dysfunctions in rats. Furthermore, increased AChE levels in the hippocampal and cortical tissues of STZ-induced rats were significantly reduced with 21 days of BV treatment. In conclusion, these results confirm that STZ administration caused cholinergic hypofunction, neuronal inflammation and cognitive dysfunction in rats, and BV therapy significantly inhibited these changes with its potential neuroprotective activity.
Citation - Scopus: 2
Platanus Orientalis (Plane Tree) Extract Protects Against Hyperoxaluria Induced Kidney Damage
(Marmara University, 2022) Ayaz Adakul, B.; Şen, A.; Şener, T.E.; Erdoğan, Ö.; Çevik, Ö.; Eker, P.; Şener, G.
The aim of this study is to determine whether Platanus orientalis (PO) which has anti-inflammatory, antioxidant and diuretic properties and used in the treatment of kidney stones as traditional folk medicine, will reduce or prevent the stone formation in the urinary system. To simulate the urolithiasis model 0.75% ethylene glycol (EG) and 1% ammonium chloride (AC) were applied to Sprague-Dawley rats. The rats were divided into four groups (n=8). The control group was given standard drinking water for 5 weeks. EG group received 0.75% EG in their drinking water containing 0.75% EG and 1% AC. PO extract (100 mg/kg) was given orally for 5 weeks to the preventive group and for last 2 weeks to the therapeutic group, respectively. At the end of experiment, 24-hour urine and kidney samples were obtained. In urine samples, calcium and citrate levels were decreased and oxalate level was increased in the EG group. In kidney samples myeloperoxidase, caspase-3, N-acetyl-β-glycosaminidase (NAG) activities, malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), tumor necrosis factor-α and interleukin-1β levels were increased while superoxide dismutase activity and glutathione levels were decreased in the EG group. These biochemical parameters returned to control levels in both PO treatment groups. Histological findings also correlate with these results. Our findings are suggested that PO treatments is effective in both preventive and therapeutic groups. © 2022 Marmara University Press.
Ensemble-Based Alzheimer's Disease Classification Using Features Extracted From Hog Descriptor and Pre-Trained Models
(Sakarya University, 2024) Muzoğlu, Nedim; Akbacak, Enver
Alzheimer's Disease is the most common type of dementia and is a progressive, neurodegenerative disease. The disease worsens over time, and the patient becomes bedridden, unable to move or understand what is happening around him. The main concern of medicine is to slow down the progression of the disease for which no treatment has yet been developed. Artificial intelligence studies have achieved significant success in detecting many diseases. In this study, an artificial intelligence-based approach that uses MR images of the early stage of Alzheimer's Disease to detect the disease at an early stage is presented. Initially, a new dataset was created through the application of the fuzzy technique, thereby expanding the feature space. Then, an ensemble learning-based hybrid deep learning model was developed to reduce the misclassification rate for all classes. The features derived from the inception module, residual modules, and histogram of oriented gradients descriptor are subjected to classification through bagging and boosting algorithms. The proposed model has surpassed many state-of-the-art studies by achieving a high success rate of 99.60% in detecting Alzheimer's disease in its early stages.
Radioprotective Effect of Resveratrol for Early and Late Ionizing Radiation-Induced Damages on Colon and Rectum in Rats
(Marmara Univ, 2023) Beceren, Ayfer; Aydemir, Sezgin; Atasoy, Beste Melek; Esin, A. K.; Ercan, Feriha; Sener, T. Emre; Sener, Goksel
Radiotherapy, which is routinely used to treat a wide range of oncological disorders, primarily affects the malignant tissue in the targeted area, but also have negative effects in the surrounding tissues. Pelvic radiotherapy causes early and late effects on the colon and rectum. Resveratrol (RVT) has been revealed to have a number of pharmacological effects in a variety of experimental models and clinical circumstances, therefore it has piqued the interest of scientists in recent years. In this study, we aimed to investigate the potential protective effects of resveratrol (RVT), a strong antioxidant, anti-inflammatory and anti-mutagenic agent, against toxicity of colonic and rectal tissues seen in the early and late stages after pelvic radiation. The treatment durations of the current study were designed as one week and ten weeks interval by following radiation exposure. Sprague Dawley rats were divided into 5 groups (8 animals/group) as the control, radiation-early effects (Rd-E), radiation-late effects (Rd-L), and RVT-treated Rd-E (Rd-E+RVT) and RVT-treated Rd-L (Rd-L+RVT) groups. Ionizing radiation was performed to the pelvic area that covers colon and rectum in single fraction of 20 Gy in a linear accelerator using with 6 MV photon energy. RVT was orally administered (10 mg/kg/day) immediately following the radiation exposure and continued daily for 1 and 10 weeks for early and late groups, respectively. Pelvic radiation caused a significant decrease in glutathione level, while malondialdehyde levels, myeloperoxidase activity and 8-hydroxydeoxyguanosine were increased in both Rd-E and Rd -L groups in the colon and rectum tissues. Additionally, light microscopic evaluations (H & E staining) revealed degeneration of epithelium and inflammatory cell infiltration in the colonic and rectal tissues in radiation groups. RVT treatment reversed all conducted biochemical parameters and ameliorated histomorphological changes following early and late effects of pelvic radiation in tissues. In conclusion, resveratrol may be a candidate as a radioprotector for normal tissues during and after radiotherapy.
Reading Basic Design Principles Through Modern Architectural Structures
(Nilay Ozsavas Ulucay, 2023) Yıldırım Coruk, İ.
Basic design principles are taught within the scope of basic design education in the first-year studios. Basic design education and its content have different dimensions from the education system the student previously received due to its structure and difficulty comprehending because it contains new literature for the student and often has abstract educational content. On the other hand, the students have difficulty perceiving the information acquired in this course and question how they can benefit from it in the following years and professional life. Therefore, the aim of the study is to analyze the basic design principles through modern architectural structures. In the study created by qualitative research method, the data were obtained by analyzing the principles mentioned in the determined examples. These examples were selected among the Bauhaus and later modern buildings by considering the role of the Bauhaus school, where the basic design principles emerged in the spread of modern architecture, and the scope of the study was created. As a result of the study, concrete uses and equivalents of basic design principles were revealed with the determined examples. Thus, data on how students will benefit from basic design principles have been revealed. © 2023, Nilay OZSAVAS ULUCAY. All rights reserved.
Citation - Scopus: 1
Management of Diversities in the Context of Healthcare Professionals’ Attitudes Towards Diversities
(Association of Executive Nurses, 2021) Çakır, H.; Harmancı Seren, A.K.
People belonging to different cultures, ethnic origins, geographic regions, speak different languages and live together more and more in the world. This change has also found its counterpart in management practices, and diversity management approaches have begun to be included in the literature. In the light of the existing national and international literature, the study aimed to examine health professionals’ attitudes towards diversities and the factors affecting their attitudes. Considering the lack of literature in this field, the data compiled in this study are aimed to be useful in practices related to the management of diversities in the field of nursing. The study aims to provide a professional perspective on diversity and awareness of changing management paradigms for the manager nurses. © 2021 SHYD.
Farklı Kilo Verme Yöntemlerinin ve Yöntemlere Uyumun Kilo Verme ve Kontrolü ile İlişkisi
(2021) Çıtıl, Rıza; Eğri, Mücahit; Gurdal, Osman; Kişioğlu, Ahmet Nesimi; İlhan, İlter; Gültekin, Fatih; Orhan, Hikmet
Amaç: Obezite, çağımızın en önemli sağlık sorunlarından biridir. Birçok insan kilo vermek veya korumak için çeşitli yöntemler kullanır. Bu çalışmada kilo kontrolü için kullanılan yöntemlerin etkinliğini değerlendirmeyi amaçladık.Yöntem: Toplam 861 katılımcı ile yüz yüze ve elektronik olarak görüşüldü.Bulgular: Çalışmamızda kilo verme yöntemlerindeki çeşitli farklılıkların kilo kontrolü üzerinde önemli bir etkisinin olmadığı; ancak diyetin başlangıcındaki vücut kitle indeksi (VKİ) ve süresi, medeni durum, yaş ve meslek gibi değişkenlerin kilo kontrolü üzerinde farklı etkileri olduğu bulunmuştur. Ek olarak, belirli bir süre boyunca hedeflenen kilo kaybının diyet başarısı üzerinde yeterli olduğu bulunmuştur.Sonuç: Çalışmamız kilo vermek için kullanılan farklı diyet türlerinin hedeflenen ağırlığa ulaşmada veya kilo kontrolünü sürdürmede etkisi olmadığını ortaya koymuştur.
Citation - Scopus: 6
Myrtus Communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation
(Istanbul University Press, 2022) Mustafaoglu, F.K.; Ertas, B.; Sen, A.; Akakin, D.; Sener, G.; Ercan, F.
Objective: Obesity is associated with many diseases, including urinary system disorders such as chronic kidney disease and overactive bladder syndrome. Myrtus communis L. (MC) extract has been reported to have antioxidant and anti-inflammatory effects. The aim of this study was to investigate the protective effects of MC extract on high-fat diet (HFD)-induced kidney and bladder damage. Materials and Methods: Wistar albino male rats were divided into three experimental groups: control, HFD and HFD+MC. Experimental groups were fed a standard diet (control group) or HFD (HFD and HFD+MC groups) for 16 weeks. MC extract (100 mg/kg) was administered to the HFD+MC group orally during the last 4 weeks (5 days/week) of the experiment. High-density lipoprotein, total cholesterol, triglyceride and leptin levels were measured in blood serum. Tissue malondialdehyde (MDA), glutathione (GSH), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and myeloperoxidase (MPO) levels were evaluated biochemically. Kidney and bladder morphology, NADPH oxidase-2 (NOX-2) and nuclear factor-kappa B (NF-ҡB)-positive and apoptotic cells were evaluated histologically. Results: Lipid profiles altered and leptin levels increased in blood serum. MDA, 8-OHdG and MPO levels increased and GSH level decreased in kidney and bladder in the HFD group. Moreover, degenerated kidney and bladder morphology, increased NOX-2 and NF-ҡB-positive and apoptotic cells were observed in this group. All of these biochemical and histological parameters were ameliorated in the HFD+MC group. Conclusion: HFD-induced obesity causes kidney and bladder damage by oxidative and inflammatory processes. MC extract may reduce oxidative stress and inflammation and play a protective role in obesity-related kidney and bladder damage. © 2022 by the Author(s).
A Micrology of Pattern Recognition in Philip K. Dick's a Scanner Darkly
(Istanbul Univ, Fac Letters, 2023) Ustun, Berkay
This article is a conjointly formal and thematic inquiry dedicated to unpacking the internal coherence of Philip K. Dick's A Scanner Darkly (1976). Organized around the unifying problem of pattern recognition, the article clarifies the deep congruence that exists between the seemingly unrelated imaginary technologies of the novel, used on both sides of the central demarcation that divides the identity of its protagonist: law enforcement and the trade in controlled substances. While it benefits from concepts designed to investigate science fiction as a genre, it also brings in discourses developed to make sense of media technologies in the real world. Guarding against the danger of eclipsing the text under information about the media historical context, this article allies media theory with narrative analysis and relies on "micrology" as a strategy of selective close reading following the logic of detection, recognition, and the failures thereof in the novel. This manner of inquiry allows me to specify the nature of pattern recognition as a lost capacity in the narrative arc, tracking the problems of information theory and the decline of cognitive capacities, as well as demonstrating their immanence to a single complex of ideas. In this sense, what belongs to intellectual history in the following discussion, is subject to the requirement that it makes the technological and psychological aspects of the narrative more intelligible and respond to the unique challenges of its combination of estranging world-building and all too familiar countercultural tropes.
Citation - Scopus: 4
Dodder (Cuscuta Sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats
(Istanbul University Press, 2022) Albayrak, O.; Ozbeyli, D.; Sen, A.; Cevik, O.; Erdogan, O.; Ercan, F.; Sener, G.
Objective: The aim is to examine the possible protective effect of Cuscuta sp. extract against liver damage induced by biliary obstruction in rats. Materials and Methods: To induce biliary obstruction, the bile duct ligation (BDL) method was used. Sprague Dawley rats were allocated to 4 groups: Control (C), Cuscuta (CUS), bile duct ligation (BDL), and bile duct ligation + Cuscuta (BDL+CUS). Control and BDL rats were given physiological saline (SF), while CUS and BDL+CUS groups were administered 250 mg/ kg of Cuscuta extract by oral gavage. At the end of 28th day, the rats were decapitated, serum and tissue samples were collected, and aspartate aminotransferase (AST), alanine transaminase (ALT), and direct and total bilirubin (DB and TB) levels were determined in blood samples. In liver tissues, transforming growth factor-β (TGF-β), 8-hydroxyguanosine (8-OHdG), hydroxyproline, and sodium-potassium ATPase (Na+/K+-ATPase) levels were determined. Results: Serum samples of rats with cholestasis had high ALT, AST, DB, and TB levels, while TGF-β, 8-OHdG, and hydroxyproline concentrations were found to be significantly high in tissues. Hepatic Na+/K+-ATPase levels were decreased through biliary obstruction. Biochemical parameters were drastically reversed by Cuscuta care; also, this was supported histologically. Conclusion: Results showed that Cuscuta extract, through its antioxidant and anti-inflammatory properties, provided protection against oxidative injury by biliary obstruction. Also, these results confirm the traditional use of Cuscuta sp. as hepatoprotective. © Ankara Medical Journal.All rights reserved.
Hemşirelerde İşten Ayrılma Niyeti ile Zorunlu Vatandaşlık Davranışı Arasındaki İlişki*
(2024) Selçuk, Deniz; Seren, Arzu Kader Harmancı
Amaç: Bu araştırmada, İstanbul’daki bir eğitim ve araştırma hastanesinde çalışan hemşireler örnekleminde işten ayrılma niyeti ile zorunlu vatandaşlık davranışı arasında ilişki olup olmadığını incelemek amaçlanmıştır. Yöntem: Tanımlayıcı ve ilişki arayıcı bu araştırmanın verileri, İstanbul’da bulunan bir eğitim ve araştırma hastanesinde görev yapmakta olan 191 hemşirenin katılımı ile Aralık 2016 – Şubat 2017 tarihleri arasında toplanmıştır. Veri toplamada, kişisel bilgileri öğrenmeyi amaçlayan bir soru formunu, “İşten Ayrılma Niyeti Ölçeği”ni ve “Zorunlu Vatandaşlık Davranışı Ölçeği”ni içeren bir anket kullanılmıştır. Veriler, bilgisayar ortamında analiz edilmiştir. Tanımlayıcı istatistikler, parametrik ve parametrik olmayan karşılaştırma testleri ve Pearson korelasyon analizi yapılmıştır. Bulgular: Hemşirelerin “İşten Ayrılma Niyeti Ölçeği” ile “Zorunlu Vatandaşlık Davranışı Ölçeği” puan ortalamaları sırasıyla 2,90 (SS=1,11) ve 3,42 (SS=0,90) olarak bulunmuştur. İşten ayrılma niyetiyle zorunlu vatandaşlık davranışı arasındaki ilişkinin katsayısının r=0,315 olduğu saptanmıştır (p<0,001). Sonuç: Hemşirelerin orta düzeyin altında işten ayrılma niyetinde oldukları, orta düzeyin üstünde zorunlu vatandaşlık davranışı sergiledikleri, işten ayrılma niyetiyle zorunlu vatandaşlık davranışı arasında da olumlu yönlü, orta güçte ve çok ileri derecede anlamlı doğrusal bir ilişki olduğu belirlenmiştir.
Relationship Between Coronaphobia, Cognitive Functions, Sleep Quality, and Diet Quality in Older Adults During Covid-19
(Galenos Publ House, 2024) Balci, Leyla Atas; Polat, Selda; Coskunsu, Dilber Karagoezoglu; Altuncevahir, Ilayda; Koc, Bilge Meral; Ozkul, Ecenur
Objective: The relationship between the quality of diet and sleep, cognitive function, and fear related to coronavirus disease-2019 (COVID-19) among older adults in Turkey during the pandemic remains unclear. This study aimed to investigate the correlation between diet quality, cognitive function, sleep quality, and levels of coronaphobia in individuals aged 65 and above, to understand the impact of COVID-19. Materials and Methods: Sleep quality, diet quality, coronaphobia, and cognitive status of 72 older individuals were evaluated using the Pittsburgh sleep quality index, healthy eating index 2010, Montreal cognitive assessment scale, and coronavirus-19 phobia scale, respectively. Results: The participants had poor diet quality (54.2%), poor sleep quality (62.5%), obesity (41.7%), higher levels of coronaphobia, and cognitive impairment. There was a moderate negative relationship between sleep quality and coronaphobia and between cognitive status and coronaphobia (p <= 0.00); and a weak positive relationship between diet quality and cognitive status (p<0.05). However, no relationship was found between sleep quality and diet quality, and between coronaphobia and diet quality (p>0.05). Conclusion: Our study highlights the significant challenges faced by older adults during the COVID-19 pandemic, including poor nutrition quality, sleep disturbances, coronaphobia, and cognitive impairment. Our findings suggest a potential interplay between nutrition quality, sleep patterns, and cognitive function among older adults, with those experiencing coronaphobia exhibiting additional cognitive and sleep-related concerns. We advocate the implementation of targeted interventions aimed at mitigating cognitive impairment, addressing nutritional deficiencies, and improving sleep quality among older adults, irrespective of COVID-19 infection status, to enhance overall well-being during these challenging times.
Panax Ginseng Extract Ameliorates Methotrexate-Induced Multi-Organ Damage Via the Regulation of Oxidative Stress
(Marmara Univ, 2023) Macit, Caglar; Ede-Pazarbasi, Seren; Yilmaz-karaoglu, Suemeyye; Tunali-Akbay, Tugba; Karakaya-Cimen, Fatma Bedia; Ercan, Feriha; Sener, Goksel
Oxidative damage plays an important role in organ toxicities caused by methotrexate (MTX). This study aimed to determine the antioxidant effects of Panax ginseng (PxG) extract against MTX-induced liver, lung, ileum and kidney damage. Twenty-four Sprague Dawley male rats (weight 250-300 g) were used in the study. The animals were randomly separated into three groups: a) Control, b) MTX-treated (MTX) and c) MTX+PxG-treated (MTX+PxG) groups. MTX was administered intraperitoneally at 20 mg/kg, as a single dose to MTX and MTX+PxG groups. PxG was administered orally at 100 mg/kg to the MTX+PxG group for five days. Saline was given to the control and MTX groups for 5 days. At the end of the experiment, liver, lung, ileum, and kidney samples were obtained. Malondialdehyde (MDA) and glutathione (GSH) levels, superoxide dismutase (SOD), glutathione-S-transferase (GST) and tissue factor (TF) activities were determined in all tissues. In addition, histological examinations were done through light microscopy. GraphPad Prism 5v. was used for statistics, and p<0.05 were considered significant. Administration of MTX caused severe injury in tissues. Findings showed that MDA level, SOD, and GST activities were significantly normalized in the MTX+PxG group compared to the control group. A significant reduction in GSH level observed in the MTX group was reversed with PxG administration In addition, TF activity and total protein levels were found to be impaired in the MTX group, but TF activity was significantly improved in liver and lung tissues and total protein level was significantly reversed in lung and ileum in MTX+PxG group. The results of histological examinations showed that MTX-induced damage was ameliorated with the PxG administration. In conclusion, this study shows that Panax ginseng, thanks to its antioxidant properties, reversed MTX-induced tissue damage and therefore may be beneficial against side effects in patients undergoing chemotherapy.
The Effects Of Panax Ginseng on Serum Oxidative Stress Following Bisphenol a Exposure
(Istanbul Univ, 2024) Fazalyar, Najiullah; Pazarbasi, Seren Ede; Dorucu, Dogancan; Sener, Goksel; Tunali-Akbay, Tugba
Objective: Bisphenol A (BPA) is a toxic compound that causes oxidative stress by disrupting antioxidant enzymes and promoting tissue lipid peroxidation. This study aimed to examine the impacts of BPA on serum oxidative stress in rats and to detect the antioxidant feature of Panax ginseng (PxG) in reducing BPA-induced oxidative stress. Materials and Methods: Wistar Albino rats (250-300 g) were divided into control, control + PxG, BPA, and BPA + PxG groups. 50 mg/kg BPA and 100 mg/g PxG were given for six weeks. Serum total antioxidant and oxidant status, lipid peroxidation, and glutathione levels were determined. Results: BPA administration increased total oxidant status and lipid peroxidation, while PxG administration to the BPA group decreased these parameters. PxG also increased total antioxidant status and glutathione levels compared to the BPA group. Conclusion: BPA was seen to cause an increase in oxidative parameters and PxG administration to restore the oxidative stress that was generated after BPA exposure, suggesting that this may help to prevent the adverse effects caused by BPA exposure.
Child And Adolescent Mindfulness Measure Turkish Validity And Reliability Study;
(Galenos Publishing House, 2024) Bilaç, Ö.; Dikeç, G.; Akyol, C.K.; Kale, M.K.; Sapmaz, Ş.Y.; Kandemir, H.; Aydemir, Ö.
Objectives: The number of studies on mindfulness in children and adolescents has rised in recent years, and it is crucial to evaluate the mindfulness-based interventions applied with standardized measurement tools. This aim of this study was to make the Turkish language validity and reliability of the Child and Adolescent Mindfulness Measure (CAMM), which can be used in children and adolescents about mindfulness, which has been very well-liked in recent years, and which has validity and reliability in many languages, and to bring it into our language for the ages of 9-18. Materials and Methods: The total sample of the current study consisted of 156 children and adolescents, 48 of whom were children and adolescents with any mental disorderdiagnosis according to Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5). One hundred eight of them did not have any mental disorders diagnosis according to DSM-5, who had only periodic problems or were brought for counseling. Results: In the reliability analysis of the scale, the Cronbach’s alpha coefficient was found to be 0.76 for the whole scale. In test-retest reliability two weeks apart, the two measurements have a strong correlation between the measurements (r=0.634 p<0.0001). Conclusion: In conclusion, our findings show that the Turkish version of the CAMM is a valid and reliable measurement tool for the 9-18 age group. © 2024, Galenos Publishing House. All rights reserved.
In Vitro Efficacy of Sumac (Rhus coriaria) Extracts Against Leishmania Tropicana and Leishmania Mexicana: A Preliminary Study from Turkiye
(Istanbul Univ, 2025) Mete, Ergun; Ozel, Yener; Bardakci, Hilal; Durmuskahya, Cenk; Koseler, Aylin; Kurt, Ozgur
Objective: Cutaneous leishmaniasis (CL) is a common clinical manifestation of leishmaniasis. Here, the in vitro anti-leishmanial efficacy of sumac extracts was tested for the first time on both Leishmania (L.) tropica and L. mexicana isolates using Rhus (R.) coriaria plant, which was collected in western Anatolia. Materials and Methods: The dried and powdered fruits of R. coriaria were macerated in acetone, ethyl alcohol, and ethyl alcohol-water mixture at room temperature for two days. The pooled extracts were evaporated under reduced pressure and lyophilized form for the study. Isolates of L. tropica and L. mexicana in Acibadem University R&D Laboratory were initially thawed and cultivated in NNN medium. Assessments were made using the haemocytometer and MTT methods at 24 and 48 h, compared with meglumine antimoniate as the control group. Results: For L. tropica, the effective concentration ranges of the extracts and the infusion were found to be 578.13-289.06 pg/mL and 289.06-144.53 pg/mL, respectively. For L. mexicana, the ranges were found to be 289.06-144.53 pg/mL and 144.53-72.27 pg/mL, respectively. It was shown that all extracts of R. coriaria were effective against both L. tropica and L. mexicana in higher doses, compared to meglumine antimoniate. Conclusion: An interesting finding was that higher sumac doses were required to eliminate L. tropica of the Old World, compared to L. mexicana of the New World. In addition, the aqueous alcohol extract showed efficacy that lasted for 48 h in half doses compared to others in L. tropica. Further assessments for both the identification of the active compounds within R. coriaria and their efficacy in vivo are planned.
The Correlation Between Vitamin D Levels and Thyroid Functions in Early Pregnancy
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Dinmez, Sinem; Özlem, Dülger; Oğul, Zeynep
Vitamin D deficiency (serum vitamin D <10 ng/ml) and thyroid dysfunctions are prevalent issues globally, particularly during pregnancy. Evidence suggests a potential link between thyroid function and vitamin D levels. This study aims to investigate the correlation between serum vitamin D levels and thyroid functions in wome n during the first trimester of pregnancy. The study was conducted retrospectively at a University Education and Research Hospital’s pregnancy clinic, covering data from August 2023 to March 2024. The sample group consisted of first -trimester pregnant women who attended routine pregnancy check-ups and had complete vitamin D levels and thyroid function tests (n=185). The sociodemographic data form and blood serum level assessment forms were used as data collection tools. The data were analyzed using descriptive statistics and correlation analysis. The average age of the pregnant women participating in our study was 27.6±4.9 years, and the Body Mass Index (BMI) was 25.4±4.8 (overweight). The mean number of pregnancies was 1.13±0.3, and the gestational week was 8.19±1.8. Of the participants, 35 had subclinical hypothyroidism, 37 had thyroiditis, and 113 had normal thyroid functions. The study identified 36 women with normal/adequate vitamin D levels (≥20 ng/ml), 113 with vitamin D insufficiency (10–20 ng/ml), and 36 with vitamin D deficiency (<10 ng/ml). The correlation analysis revealed no significant relationship between the thyroid function tests and vitamin D levels of the pregnant women. It was determined that vitamin D levels do not affect thyroid gland function in the first trimester.
Citation - Scopus: 3
Comparison of the Hidden Curriculum for Nursing Education of Two Different Universities in the East and West of Turkiye
(Inonu University, 2024) Elmali Şimşek, H.; Aksoy, M.
The present study aimed to determine and compare the hidden curriculum of two institutions that provide undergraduate nursing education in two different regions of Türkiye. The descriptive and cross-sectional research was conducted with 319 nursing students. Data were collected with the Introductory Information Form and Hidden Curriculum Evaluation Scale in Nursing Education (HCES-N). While the mean score of the HCES-N total score of the nursing students attending the university in the West of Türkiye was 163.31 ± 21.69. The HCES-N total mean score of the nursing students attending in the East of Türkiye was calculated as 145.50 ± 25.81. While the HCES-N total score, school atmosphere, and professional achievement scores of the nursing students attending the university in the West of Türkiye were statistically higher than the nursing students attending the university in the east, the student-teacher-school interaction score was statistically lower. It was determined that the perceptions of the students participating in the study towards the hidden curriculum were moderate, while the perceptions of the students studying in the West of Türkiye were better. In line with these results, it is important to improve the physical conditions of schools in improving the hidden curriculum. © 2024, Inonu University. All rights reserved.
The Challenges Experienced by International Nursing Students in Nursing Education: a Qualitative Study
(Ataturk Univ, 2024) Elmali Simsek, Hulya; Karali, Ece; Arslan, Gunay
Objective: The study aimed to determine the challenges experienced by international nursing undergraduate students during their education period. Methods: A phenomenological research design was used. The study was conducted with 20 international nursing students enrolled in a foundation university in T & uuml;rkiye. Colaizzi's phenomenological data analysis method was employed in the study. Results: Based on the study's results, three main themes, 'Learning in a different environment', 'Challenges', 'Solution-Non Solution' and 'System difference, Language problems in clinical practice, Broad nursing curriculum, Facilitators, Language barrier, Feeling homesick, Racism and discrimination, Housing difficulties, Lack of funding, Instant solution, Failing to find a solution sub-themes themes were created. Conclusion: It has been observed that students experience different environments, uncertainties, and various challenges, and that these situations directly affect their education and success. To that end, both the institutions they receive education and the academicians must support the students in various ways.
Citation - Scopus: 1
A Systematic Review And Meta-analysis Of The Prevalence, Risk Factors, Agents And Laboratory Diagnosis Of Vulvovaginal Candidiasis İn Türkiye;
(Refik Saydam National Public Health Agency (RSNPHA), 2024) Kilbaş, İ.; Kilbaş, E.P.K.; Çİftçİ, İ.H.
Objective: Vulvovaginal candidiasis (VVC) is the most common superficial mycosis among women, and it is estimated that 75% of women experience at least one in their lifetime, and about 40-50% have a second exposure. This study aims to determine the prevalence, risk factors, etiological factors and laboratory diagnosis of VVC in Türkiye. Methods: In the study, original scientific articles for the reporting of VVC epidemiological features published in English and Turkish languages in national and international databases (PubMed, Embase, Scopus, Google Scholar, Web of Science and Turkish Medline) between January 1995 and December 2021 were searched. Electronic databases were searched using various combinations of “vaginal yeast infection”, “vaginal candidiasis”, “vulvovaginal candidiasis Turkey”, “candidal vaginitis”, “Candida vaginitis”, “vaginal candidosis”, “Candida species”, “epidemiology” key terms. Results: The mean prevalence of VVC in adult women was found to be 57.91% in all of the 28 included studies, and 68.21% in the 2-18 age group. Considering the causative distribution, the most common Candida albicans (54.76%), Candida glabrata (24.04%), other Candida species (12.29%), Candida krusei (3.68%), Candida kefyr (3.37%), and Candida tropicalis (2.07%) positivity has been reported. In the included studies, the most common predisposing factors of the patients were pregnancy (35.71%) and diabetes (35.71%). When the articles were examined according to the year they were published and the provinces, it was seen that the prevalence of Candida did not differ significantly (p>0.05). In the studies, VITEK®2 (bioMérieux, Marcy l’Etoile, France) automatic identification system (15), Germ tube (7) and CHROMagar (7) diagnostic methods were used to identify strains. As a result of the meta analysis, it was determined that there was a high level of heterogeneity among studies (I2=95.28). Conclusion: As a result of our meta-analysis study, the prevalence of VVC was found to be high in women and children in Turkey. In addition, it was determined that non-albicans species increased in the etiology of VVK. It has been observed that the incidence of C. glabrata species in the etiology of VVC has increased since 1999. Considering that VVK infection increases the susceptibility to other sexually transmitted diseases, as well as the risk of preterm birth and congenital cutaneous candidiasis in pregnant women, it is essential to raise awareness of patients on issues such as treatment follow-up and protection from the disease. © (2024), (Refik Saydam National Public Health Agency (RSNPHA)). All Rights Reserved.

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