Fenerbahçe Üniversitesi

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Citation Count: 0
Age-Specific Seroprevalence of Hepatitis a Virus in Turkey Between 2000 and 2023: Systematic Review and Meta-Analysis
(Mdpi, 2024) Kahraman Kılbaş, Elmas Pınar; Koroglu, Mehmet; Demiray, Tayfur; Terzi, Huseyin Agah; Kilbas, Elmas Pinar Kahraman; Tıbbi Hizmetler ve Teknikler Bölümü
Background: Hepatitis A virus (HAV) is a leading cause of acute viral hepatitis and is primarily transmitted by the fecal-oral route. The clinical presentation and progression of the disease varies according to the age of the patient. Turkey is classified as a moderately endemic country, and HAV infection continues to be an important public health problem worldwide. Methods: In this study, a systematic meta-analysis was conducted to evaluate age-specific HAV seroprevalence rates in Turkey between 2000 and 2023. A comprehensive literature review identified 57 articles that met the inclusion criteria. The studies were assessed for quality, and seroprevalence rates were evaluated across four different age groups. Statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software (CMAVersion 3.0) and SPSS (SPSS Statistics 25.0). Results: HAV seroprevalence rates were found to be 73.18% in the 0 < 5 age group and 90.90% in the >35 age group. The overall seroprevalence estimated using a random effects model was 64.5% (95% CI: 58.3-70). High heterogeneity was observed among the studies, and the prevalence estimates changed when low-quality studies were excluded. Conclusions: This meta-analysis suggests that the increasing trend in HAV IgG seroprevalence in Turkey, especially among young populations, is likely due to the vaccination program initiated in 2012. Furthermore, the heterogeneity observed among regions highlights the importance of regional public health strategies. Future studies should focus on providing more detailed data to evaluate the long-term effects of vaccination and to explain regional differences in HAV seroprevalence.
Citation Count: 0
Aktivist Reklamlara Yönelik Y ve Z Kuşağının Tutumunun Satın Alma Niyetine Etkisi
(2024) Ugur, Hülya; Tosun, Nurhan Zeynep
Tüketicilerin beklenti ve istekleri doğrultusunda markaların toplumsal konuları gündeme getirerek yeniden canlanması ve eşitlik, adalet gibi temel ve varoluşsal konuları içeren reklam mesajları, yeni bir reklam paradigmasının ortaya çıkmasına zemin hazırlamıştır. Aktivist reklamcılık olarak ifade edilen bu yaklaşım markaların reklam kampanyalarında hedef kitlelerine toplumsal ve sosyal konulara yönelik mesajlar iletmelerini içermektedir. Özellikle toplumsal ve sosyal konularda daha duyarlı olan ve markalardan farklılıklar bekleyen Y ve Z kuşakları için markaların aktivist bir duruş sergilemeleri büyük önem taşımaya başlamıştır. Bu doğrultuda bu çalışma, yeni bir reklamcılık akımına ışık tutan aktivist reklamlara yönelik tutumların satın alma niyeti üzerindeki etkisini değerlendirmeyi amaçlamaktadır. Bu kapsamda çalışmada reklama yönelik tutum oluşumu üzerinde önemli bir etkiye sahip olan (a) reklam değeri, (b) güvenilirlik (c) bilgilendiricilik, (d) aldatıcılık, (e) eğlendiricilik ve (f) rahatsız edicilik tutum değişkenlerinin aktivist reklama yönelik tutum ve satın alma niyeti üzerindeki etkisi de irdelenmiştir. Bu bağlamda çalışmada nicel araştırma yöntemlerinden biri olan anket tekniği kullanılarak 417'si Y kuşağı ve 417'si Z kuşağı olmak üzere 834 birey anket çalışmasıyla değerlendirilmiştir. Y ve Z kuşağı katılımcıları bağlamında aktivist reklamlara yönelik tutumların satın alma niyeti üzerindeki etkisi değerlendirildiğinde, regresyon analizinin bağımlı değişken (satın alma niyeti) ile bağımsız değişken (reklama yönelik tutum) arasındaki etkileşimi anlamlı bir şekilde ortaya konmuştur. Ayrıca reklama yönelik tutum oluşumunda önemli rol oynayan tutum değişkenleri boyutlarının aktivist reklama yönelik tutum ve satın alma niyeti üzerindeki etkisi değerlendirildiğinde, bağımlı değişkenler (tutum, satın alma niyeti) ile bağımsız değişkenler (reklam değeri, bilgilendiricilik, aldatıcılık, eğlendirici ve rahatsız edici, güvenilirlik) arasındaki etkileşimi açıklayan regresyon analizinin de anlamlı sonuçlar verdiği görülmektedir.
Citation Count: 15
Appraising Systematic Reviews: a Comprehensive Guide To Ensuring Validity and Reliability
(Frontiers Media Sa, 2023) Shaheen, Nour; Shaheen, Ahmed; Ramadan, Alaa; Hefnawy, Mahmoud Tarek; Ramadan, Abdelraouf; Ibrahim, Ismail A.; Flouty, Oliver
Systematic reviews play a crucial role in evidence-based practices as they consolidate research findings to inform decision-making. However, it is essential to assess the quality of systematic reviews to prevent biased or inaccurate conclusions. This paper underscores the importance of adhering to recognized guidelines, such as the PRISMA statement and Cochrane Handbook. These recommendations advocate for systematic approaches and emphasize the documentation of critical components, including the search strategy and study selection. A thorough evaluation of methodologies, research quality, and overall evidence strength is essential during the appraisal process. Identifying potential sources of bias and review limitations, such as selective reporting or trial heterogeneity, is facilitated by tools like the Cochrane Risk of Bias and the AMSTAR 2 checklist. The assessment of included studies emphasizes formulating clear research questions and employing appropriate search strategies to construct robust reviews. Relevance and bias reduction are ensured through meticulous selection of inclusion and exclusion criteria. Accurate data synthesis, including appropriate data extraction and analysis, is necessary for drawing reliable conclusions. Meta-analysis, a statistical method for aggregating trial findings, improves the precision of treatment impact estimates. Systematic reviews should consider crucial factors such as addressing biases, disclosing conflicts of interest, and acknowledging review and methodological limitations. This paper aims to enhance the reliability of systematic reviews, ultimately improving decision-making in healthcare, public policy, and other domains. It provides academics, practitioners, and policymakers with a comprehensive understanding of the evaluation process, empowering them to make well-informed decisions based on robust data.
Citation Count: 0
Decreased Stuttering While Walking: Speech and Fmri Findings
(Galenos Publ House, 2023) Oge-Dasdogen, Ozlem; Ulasoglu-Yildiz, Cigdem; Kurt, Elif; Demiralp, Tamer
[No Abstract Available]
Citation Count: 0
Determining the Type 2 Diabetes Risks and Healthy Lifestyle Behaviors of First Year University Students (vol 6, Pg 420, 2022)
(Dokuz Eylul Univ inst Health Sciences, 2023) Eroğlu, Nermin; Temiz, Gamze; Hemşirelik Bölümü
[No Abstract Available]
Citation Count: 0
Developmental Care in İran: an Approach To Optimal Utilization of Nursing Care Aimed at Reducing Long-Term Complications in Preterm Neonates
(Elsevier Ltd, 2024) Akbari, N.
We have carefully reviewed the article titled ‘Developmental Care in Iran: An Approach to Optimal Utilization of Nursing Care Aimed at Reducing Long-term Complications in Preterm Neonates' with great interest. The author provides valuable insights into the correlation between developmental care and the mitigation of long-term complications, and we commend their efforts in shedding light on this crucial aspect. This letter aims to articulate our concerns regarding certain issues identified in the publication. While common and observed in various publications, these concerns have the potential to introduce bias into the study, as indicated by various research findings. Our perspective, supported by a range of research publications, suggests that addressing these issues is essential to uphold the integrity and reliability of the study. © 2024 Neonatal Nurses Association
Citation Count: 0
Effect of Everolimus on Prognosis of Neurofibromatosis Type 1 Lesions: a Systematic Review and Meta Analysis
(Elsevier, 2024) Ibrahim, Ismail A.; Abdelkader, Rem Ehab; Nada, Ahmed Hosney; Younes, Siham; Hanen, George; Shahwan, Ghena; Nashwan, Abdulqadir J.
Purpose: This study addresses the effectiveness of oral everolimus in treating various malignancies associated with Neurofibromatosis Type 1 (NF1). The purpose is to determine whether everolimus reduces lesion size in NF1 patients, considering the controversial findings from previous clinical trials. The scientific hypotheses and questions involve evaluating the impact of everolimus on NF1-associated lesions and understanding the variability in treatment outcomes. Methods: A systematic review and meta-analysis were conducted following PRISMA and Cochrane Collaboration guidelines. The study included four-phase II, single-arm, nonrandomized trials investigating the effect of oral everolimus on NF1-associated lesion size. The search covered multiple databases, and data extraction involved evaluating studies for inclusion criteria and assessing quality using the Cochrane Collaboration's Risk of Bias in Nonrandomized Studies tool. Statistical analysis utilized Open Meta(Analyst). Findings: The search yielded 388 studies, with 10 selected for full-text review and four included in the final analysis. The quality of the studies ranged from low to moderate. The meta-analysis indicated no observed heterogeneity (I2 = 0%), and the overall estimate suggested no significant reduction in NF1-associated lesion size with everolimus ( P = 0.069). Implications: The findings reveal a varied and inconsistent picture of everolimus efficacy in NF1 treatment. The study highlights the need for personalized approaches, considering individual genetic and clinical differences. The limitations, including small sample sizes and nonrandomized trials, call for larger, more standardized research efforts. The study emphasizes ongoing trials and the importance of future research in understanding predictors of everolimus response and optimizing treatment strategies for NF1 patients. Conclusion: While everolimus shows promise in reducing lesion size in a subset of NF1 patients, the study cannot draw conclusive results due to limitations in the included studies. Ongoing, adequately powered trials are crucial for advancing the evidence base and informing the potential role of everolimus in NF1 treatment. Others: There was no funding for this review and no conflicts of interest.
Citation Count: 0
Effectiveness of Non-Invasive Vagal Nerve Stimulation in Parkinson's Disease: a Comprehensive Systematic Review And Meta-analysis
(Elsevier Sci Ltd, 2025) Abouelmagd, Moaz Elsayed; Yousef, Obai; Ibrahim, Ismail A.; Elshahat, Ahmed
Background: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by movement impairments. Vagus nerve stimulation (VNS) is a non-invasive brain stimulation technique that has shown promise in treating various neurological conditions, including PD. This systematic review aimed to evaluate the existing evidence on the efficacy of nVNS in managing PD symptoms. Methods: A comprehensive literature search was conducted to identify relevant studies published up to July 2024. The included studies investigated the effect of nVNS on various PD motor symptoms. The quality of studies was assessed using the Cochrane Risk of Bias 2 (ROB-2) and NIH tool for RCTs, single-arm studies, and case series studies respectively. Statistical analysis was conducted using Review Manager version 5.4.1 with outcomes expressed as Mean differences (MD) with 95% confidence intervals (CI). Results: The systematic review included eight randomized controlled trials (RCTs), one single-arm study, and one case series, encompassing a total of 217 patients with PD. The review revealed that nVNS in increasing Freezing of Gait (FOG) in PD (p = 0.04). However, no significant differences were found in UPDRS-III (p = 0.19 and p = 0.89 for on and off-medication conditions, respectively), UPDRS-II (p = 0.9), UPDRS-I (p = 0.46), Time Up and Go (p = 0.61), stand time (p = 0.87), walking speed (p = 0.22), or step length measured in meters (p = 0.8). Interestingly, a significant improvement was observed in step length measured in centimetres (p = 0.0005). No study reported serious adverse effects associated with nVNS treatment. Conclusion: Our finding suggests a potential benefit of nVNS in reducing FOG in PD, but did not demonstrate a significant improvement in other motor symptoms. Larger, longer follow-up studies are needed to confirm the effect nVNS on PD management. PROSPERO number: CRD42024574822.
Citation Count: 0
Effectiveness of Postoperative Cephalosporins in Reducing Urinary Tract Infections and Other Parameters Following Transurethral Resection of the Prostate: a Systematic Review and Meta-Analysis
(Mosby-elsevier, 2025) Hafez, Wael; Al-Obeidat, Feras; Rashid, Asrar; Venkatachalapathi, Arun Kumar; Massaod, Amr; Albaha, Ziad; Cherrez-Ojeda, Ivan
[No Abstract Available]
Citation Count: 11
How Do Mobile Wallets Improve Sustainability in Payment Services? a Comprehensive Literature Review
(Mdpi, 2022) Hopali, Egemen; Vayvay, Ozalp; Kalender, Zeynep Tugce; Turhan, Deniz; Aysuna, Ceyda
Easy access to the Internet, smartphones, and mobile-based banking change customer shopping intentions. As a crucial component of financial technology (Fintech), mobile wallets enable customers to shop via smartphones. Mobile wallets present a cashless transactional method, cost-efficient services, and traceable options that improve sustainability in payment services. Over the last decade, mobile wallet services have evolved and attracted considerable attention from customers and companies. Due to the need for a comprehensive mobile wallet literature survey, this article aims at filling this research gap by covering articles published between 2012 and 2022 over the Scopus, Web of Science, and Science Direct databases. A clear filtering policy was conducted to observe the related article topics. Thus, 128 articles that met the inclusion and exclusion criteria were analyzed. Moreover, the articles were initially classified into three main groups, which was performed via scanning and categorizing all studies in the last ten years from different databases. In addition, the literature was systematically reviewed, providing a better understanding of mobile wallets and contributing to the literature by researching how this service can be improved for payment services with a focus on sustainability. The conducted literature review revealed that mobile wallets could be promoted in terms of environmental traceability, customer lifetime value, and security.
Citation Count: 3
The Impact of Interaction Between Verteporfin and Yes-Associated Protein 1/Transcriptional Coactivator With Pdz-Binding Motif-Tea Domain Pathway on the Progression of Isocitrate Dehydrogenase Wild-Type Glioblastoma
(Sage Publications Ltd, 2023) Osama, Mahmoud; Essibayi, Muhammed Amir; Osama, Mona; Ibrahim, Ismail A.; Mostafa, Mostafa Nasr; Eksi, Murat Sakir
Verteporfin and 5-ALA are used for visualizing malignant tissue components in different body tumors and as photodynamic therapy in treating isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM). Additionally, verteporfin interferes with Yes-associated protein 1 (YAP)/Transcriptional coactivator with PDZ-binding motif - TEA domain (TAZ-TEAD) pathway, thus inhibiting the downstream effect of these oncogenes and reducing the malignant properties of GBM. Animal studies have shown verteporfin to be successful in increasing survival rates, which have led to the conduction of phase 1 and 2 clinical trials to further investigate its efficacy in treating GBM. In this article, we aimed to review the novel mechanism of verteporfin's action, the impact of its interaction with YAP/TAZ-TEAD, its effect on glioblastoma stem cells, and its role in inducing ferroptosis.
Citation Count: 0
Introduction: General Information About Discrimination in Turkey
(Peter Lang AG, 2021) Köseoğlu, Nihan; Apak, D.; Siyaset Bilimi ve Uluslararası İlişkiler Bölümü
[No abstract available]
Citation Count: 4
Kidney Transplantation: a Possible Solution To Obstructive Sleep Apnea in Patients With End-Stage Kidney Disease
(Springer Heidelberg, 2023) Kanbay, Mehmet; Ureche, Carina; Copur, Sidar; Covic, Alexandra M. M.; Tanriover, Cem; Esen, Bugra H. H.; Covic, Adrian
IntroductionObstructive sleep apnea (OSA) is frequently reported among patients with chronic kidney disease resulting in considerable morbidity and mortality. OSA may cause repetitive stimulation of the sympathetic nervous system and elevations in pulmonary artery pressure leading to an elevated risk of cardiac and vascular complications in patients with chronic kidney disease. Furthermore, OSA is associated with progressive worsening of kidney injury and loss of renal function. MethodsIn this systematic review and meta-analysis, we evaluated the effect of renal transplantation on the progression of OSA in patients with end-stage kidney disease. ResultsThe meta-analysis included eight studies with a total of 401 patients. Findings showed that kidney transplantation does not lead to a statistically significant effect on the apnea-hypopnea index (MD 2.6 events/hr, 95% CI -3.2 to 8.3, p = 0.21), total sleep time (MD 14.7 min/night, 95% CI -8.4 to 37.8, p = 0.76), sleep efficiency (MD 2.5%, 95% CI -1.4 to 6.3, p = 0.57), slow wave sleep (MD 0.4% of total sleep time, 95% CI -7.5 to 8.4, p = 0.05), and rapid eye movement sleep (MD 0.6% of total sleep time, 95% CI -2.2 to 3.3, p = 0.98). There was no statistically significant effect of kidney transplantation on OSA in patients with chronic renal disease.
Citation Count: 3
Managing Viral Emerging Infectious Diseases Via Current and Future Molecular Diagnostics
(Mdpi, 2023) Kahraman Kılbaş, Elmas Pınar; Kilbas, Elmas Pinar Kahraman; Tıbbi Hizmetler ve Teknikler Bölümü
Emerging viral infectious diseases have been a constant threat to global public health in recent times. In managing these diseases, molecular diagnostics has played a critical role. Molecular diagnostics involves the use of various technologies to detect the genetic material of various pathogens, including viruses, in clinical samples. One of the most commonly used molecular diagnostics technologies for detecting viruses is polymerase chain reaction (PCR). PCR amplifies specific regions of the viral genetic material in a sample, making it easier to detect and identify viruses. PCR is particularly useful for detecting viruses that are present in low concentrations in clinical samples, such as blood or saliva. Another technology that is becoming increasingly popular for viral diagnostics is next-generation sequencing (NGS). NGS can sequence the entire genome of a virus present in a clinical sample, providing a wealth of information about the virus, including its genetic makeup, virulence factors, and potential to cause an outbreak. NGS can also help identify mutations and discover new pathogens that could affect the efficacy of antiviral drugs and vaccines. In addition to PCR and NGS, there are other molecular diagnostics technologies that are being developed to manage emerging viral infectious diseases. One of these is CRISPR-Cas, a genome editing technology that can be used to detect and cut specific regions of viral genetic material. CRISPR-Cas can be used to develop highly specific and sensitive viral diagnostic tests, as well as to develop new antiviral therapies. In conclusion, molecular diagnostics tools are critical for managing emerging viral infectious diseases. PCR and NGS are currently the most commonly used technologies for viral diagnostics, but new technologies such as CRISPR-Cas are emerging. These technologies can help identify viral outbreaks early, track the spread of viruses, and develop effective antiviral therapies and vaccines.
Citation Count: 0
Molecular Characterization of Resistance and Virulence Genes in Enterococcus Faecium Strains Isolated Between 2000-2021; Systematic Review
(Bilimsel Tip Yayinevi, 2022) Kahraman Kılbaş, Elmas Pınar; Kilbas, Imdat; Ciftci, Ihsan Hakki; Tıbbi Hizmetler ve Teknikler Bölümü
Introduction: The spread of Vancomycin-Resistant Enterococci (VRE) is a major threat in healthcare institutions, especially for patients in the risk group. The aim of this study is to reveal the antibiotic resistance genes, virulence genes and other accompanying factors detected in vancomycin resistant Enterococcus faecium strains isolated from various clinical specimens in different parts of Turkiye. Material and Methods: For this purpose, a systematic search was carried out using different electronic databases between January 2000 and September 2021. A total of 17 studies were evaluated within the scope of systematic review. Results: The vanA gene was detected the most between the years 2000-2007, and no statistically significant difference was found according to the years. The prevalence of the vanB gene was highest between 2008 and 2013, and no statistical difference was found according to the years (p> 0.05). The vanA gene was mostly detected in Eastern Anatolia, Black Sea, Mediterranean and Aegean, vanB Central Anatolia and Southeastern Anatolia regions. No reports related to the vanC gene were found. Since all strains were E. faecium in our study, it is an expected finding that the vanC gene region was never reported. The esp and hyl gene between 2014-2021. Conclusion: The prevalence of resistance and virulence genes among bacteria is a matter of great concern, limiting treatment options. In particular, effective measures should be taken to prevent healthcare-associated VRE infections, and each institution should report its own resistance data.
Citation Count: 3
Molecular Epidemiology of Carbapenem-Resistant Acinetobacter Baumannii Isolates in Turkiye: Systematic Review
(Kare Publ, 2023) Kahraman Kılbaş, Elmas Pınar; Kilbas, Imdat; Ciftci, Ihsan Hakki; Tıbbi Hizmetler ve Teknikler Bölümü
The World Health Organization has designated carbapenem-resistant Acinetobacter baumannii (CRAB) as a "critical" pathogen on the global priority list of antibiotic-resistant bacteria. This study aims to discuss the molecular epidemiology of CRAB isolates in Turkiye in the last 12 years and the prevalence of gene regions associated with resistance or pathogenesis using a systematic review method. Our study consists of a literature search, determination of eligibility and exclusion criteria, qualitative analysis of studies, data extraction, and statistical analysis. All studies were analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Guidelines. The incidence rates of blaOXA-23, blaOXA-23-like, blaOXA-24/40, blaOXA-24/40-like, blaOXA-51, blaOXA-51-like, blaOXA-58, and blaOXA-58-like genes in CRAB strains were 76.4%, 68.6%, 1.2%, 3.4%, 97.0%, 98.6%, 8.4%, and 17.1%, respectively. It was determined that the prevalence of the blaOXA-23 and blaOXA-58 gene regions showed a statistically significant change over the years. Due to the high prevalence of A. baumannii strains carrying the blaOXA-23 variant, it is necessary to follow its geographical distribution and transposon and plasmid movements. Based on available data, molecular surveillance of CRAB strains should be standardized. In addition, sterilization and disinfection processes applied within the scope of an effective struggle against CRAB strains that can remain live on surfaces for a long time should be reviewed frequently.
Citation Count: 0
A Multi-Parameter Evaluation of the Neuroprotective and Cognitive-Enhancing Effects of Origanum Onites L. (turkish Oregano) Essential Oil on Scopolamine-Induced Amnestic Rats (feb,10.1007/S11011-022-00933-6, 2022)
(Springer/plenum Publishers, 2022) Ede Pazarbaşı, Seren; Şener, Göksel; Ozbeyli, Dilek; Ede, Seren; Albayrak, Omercan; Baser, Kemal Husnu Can; Sener, Goksel; Eczane Hizmetleri Bölümü; Eczacılık Meslek Bilimleri Bölümü
[No Abstract Available]
Nurse Employment In Some Countries In The World And In Turkey
(Association of Executive Nurses, 2023) Soydaş, K.; Harmancı Seren, A.K.
For a well-functioning health system, employing a sufficient number of appropriately qualified nurses is essential. The quantity and quality of nursing care are affected by the physical conditions of the workplace, support services, information systems, administrative practices, training and experience of nurses, care delivery models, and the number of nurses in the unit. Many criteria have been developed considering these different variables. These criteria are used in line with the health policies of each country. The aim of this review is to offer a framework for the employment policies of nurses in the world and Turkey. © 2023 The Authors.
Citation Count: 0
Nutrition Therapy in Pediatric Burns
(Bentham Science Publ Ltd, 2021) Garipağaoğlu Denizhan, Muazzez; Garipagaoglu, Muazzez; Beslenme ve Diyetetik Bölümü
Background: Burns are defined as injuries resulting from exposure to thermal radiation, electrical or chemical exposure of the skin or organic tissues. It has high mortality and morbidity in low and middle-income countries. Objective/Methods: The objective of this study is to evaluate the present knowledge principles of nutritional therapy for pediatric burns from the dietician's perspective, taking into account the epidemiology and physiology of the burn. The purpose of burn treatment is to provide survival and tissue repair and to increase immunity. Therefore, besides fluid electrolyte replacement and surgical interventions, nutritional therapy is quite important. Nutrition principles should aim to reduce inflammation and meet hypermetabolic needs. Results: In the clinical practice of children suffering from burns, daily energy need is calculated by adding the recommended energy expenditure to the burn percentage, but the most accurate method is the use of indirect calorimetry. Protein requirement is around 1.5-3.0 g/kg/day. Carbohydrate intake should be 55-60% of total energy intake, while lipids should be less than 30%. Vitamin supplements in the form of a multivitamin are recommended in addition to vitamin A, vitamin C, and Zinc. In cases where oral intake is insufficient, enteral nutrition should be applied as soon as possible. When enteral feeding is contraindicated, parenteral nutrition is preferred. Conclusion: Evaluating the nutritional status of children and meeting macro and micronutrient needs accelerate wound healing, shorten hospital stay, and reduce mortality.
Citation Count: 0
Oral Pharmabiotic Tablet Formulations
(Marmara Univ, 2024) Kandur, Buse; Ugurlu, Timucin; Rayaman, Erkan; Ahbaz, Sevinc S.
Pharmabiotic is a unique and recent term used to describe formulations containing probiotics. Pharmabiotics are probiotics prepared in a pharmaceutical form used to treat diseases and disorders by making physicochemical changes in human health. Probiotics, prebiotics, and synbiotics are included in this scope, and enzobiotics, which are a rising class of supplements, should be evaluated in this context, as they are a subspecies of synbiotics. Pharmabiotics, unlike nutribiotics, do not necessarily contain live microorganisms. The best examples of these are paraprobiotics and postbiotics. Tablet formulations are suitable dosage forms for pharmabiotics due to their redundant superiority over other solid dosage forms. Tablets are frequently preferred because they can be produced at low cost, are easily transported, and modified, are suitable for large-scale production, and are more stable than other dosage forms. Considering the examples in the literature and the definition of pharmabiotic, several tablet formulations can be mentioned as pharmabiotics. They can be divided into conventional uncoated tablets, chewable tablets, and effervescent tablets. With recent studies, this classification has expanded, and buccal mucoadhesive tablets, ODTs (orally disintegrating tablets) and FDTs (fast disintegrating tablets), layered/multi-layered tablets, and tablets within tablets have also taken their place in the classification. This article focuses on oral tablet formulations that can be classified as pharmabiotics.

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