Fenerbahçe Üniversitesi

Permanent URI for this communityhttps://acikerisim.fbu.edu.tr/handle/123456789/1

Browse

Now showing 1 - 20 of 673

1,2,4-Triazole Conjugates as HEGFR Inhibitors: Synthesis, Anticancer Evaluation, and in Silico Studies
(Wiley-V C H Verlag GmbH, 2026) Bulbul, Bahadir; Kulabas, Necla; Gurboga, Merve; Ozakpinar, Ozlem Bingol; Cakmak, Ummuhan; Tuncay, Fulya Oz; Kucukguzel, Ilkay
A series of novel 1,2,4-triazole-acetamide derivatives was synthesized and evaluated for anticancer and hEGFR inhibitory activity. The compounds were obtained via multistep synthesis and characterized by spectroscopic methods. Cytotoxicity was tested against PC-3, MCF-7, A549, and K562 cell lines. Compounds 18, 19, and especially 24 showed notable antiproliferative effects, with compound 24 exhibiting higher selectivity and potency than gefitinib. It also induced apoptosis and inhibited migration in A549 and PC-3 cells, while selectively promoting invasion in PC-3, suggesting EMT-related behavior. In vitro kinase assays revealed compound 20 as the most potent hEGFR inhibitor (IC50 = 43.8 +/- 1.3 nM). Molecular docking and 200 ns molecular dynamics simulations confirmed its stable interaction with EGFR, particularly involving Cys797. These findings highlight compounds 20 and 24 as promising candidates for further development as EGFR-targeted anticancer agents.
2000’lı Yıllarda Türkiye Ekonomisi: İmalat Sanayinde Verimlilik Değişimleri
(2021) Özşahin, Gülşah; Das, Zuhal Ozbay
Bu çalışmanın amacı, 2000’li yıllarda Türkiye'nin imalat ve hizmet sektörlerinin verimlilik performanslarını tartışmaktır. 2000'li yıllarda Türkiye imalatının yapısal değişiminin yönü konusunda fikir edinmek için bir ayrıştırma analizi uygulanmıştır. Sonuçlar, 2003–2007 döneminde tüm imalat kategorilerinde, emek verimliliğinin düştüğünü, buna karşın 2010–2015 döneminde tüm imalat kategorilerinde emek verimliliğinin arttığını göstermektedir. 2016-2018 döneminde tüm gruplarda emek verimliliği daha da artmıştır, ancak, orta-düşük-teknoloji kategorisinde artış hızı daha yavaş, yüksek-teknoloji endüstrileri durağan bir görünüm sergilemiştir. Hizmet sektöründe emek verimliliği, dönemler itibarıyla imalatta görülenden biraz farklı bir yapı sergilemektedir. Özellikle yüksek teknolojili hizmet grubunda neredeyse tüm dönemlerde nispeten düşük verimli sektörlere doğru bir statik kayma gözlenmiştir. Daha az bilgi yoğun hizmetlerde, emek verimliliği ilk dönemde azalmış, ancak 2010-2015 döneminde belirgin biçimde artmıştır. Sonuçlar, özellikle 2010 sonrası dönemde sanayi politikalarının rolünü tartışmanın anlamlı olduğunu göstermektedir. Bununla birlikte, 2016 sonrasında siyasi ve ekonomik ortamdaki değişiklikler imalat sektöründeki verimlilik değişimlerinin anlaşılmasında ipuçları vermektedir.
Citation - WoS: 1
Citation - Scopus: 1
A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhiza Glabra L. Varieties Root Extracts
(Marmara University, 2025) Sen, Ali; Servı, Hüseyın; Barak, Timur Hakan; Tekin, Fethullah; Şener, Azize; Marzi, Mahdi; Gülmez, Gizem
Plants are the significant global interest as alternative treatment sources with their biologically activecompounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobialproperties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemicalcompositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC)contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showedthe highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. TheMIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714;2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies haveshown that TPC was 100.60±5.06, 127.90±0.30, 69.01±0.30 mg GAE /g extract; TFC was 80.07±0.15, 25.35±0.0, 16.58±0.31mg KE/g and TTC was 217.30±6.05,172.40±2.17, 126.30±4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 inparticular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategiesand potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also apreliminary study for future studies.
Citation - WoS: 4
Accentuated Eccentric Load Training: Traditional Set Versus Cluster Set
(Iermakov S S, 2022) Ersoz, Mehmet; Pinar, Salih; Kaya, Selman
Background and Study Aim Material and MethodsThis study aims to comparatively analyse the effects of cluster set (CS) and traditional set (TS) applications on strength and power outputs in accentuated eccentric load (AEL) training. Thirty-two amateur male football players with at least 2 years of strength training history participated in the study (Xage: 18,78 +/- 0,83 years, Xheight:166,73 +/- 8,61 cm., Xbody weight: 69,59 +/- 6,03 kg.). Participants were randomly divided into two groups: CS (n=16) and TS (n=16). In both groups, the same "AEL Training" was applied and different set models were used. Augmented eccentric load (AEL) training was performed with 3 sets of 8 repetitions, 50% concentric and 80% eccentric of 1 Repetition Maximum (1-RM) and with a fast lifting tempo. The sets were completed with 20 seconds of rest after every two repetitions in the AEL-CS group and without any rest between repetitions in the AEL-TS group, and the training sessions were performed twice a week for 4 weeks. Countermovement jump (CMJ), 50cm drop jump-reactive strenght index (DJ-RSI) test, 1-RM strenght test, 10-20-30m sprint test and Illinois Agility Test (IAT) were performed on the athletes before and after the training.ResultsWhen analysing the data obtained in this study, Skewness and Kurtosis values and Kolmogorov-Smirnov values were examined to determine homogeneity. In order to compare the pre-test and post-test averages between groups, ANOVA was used for Repeated Measures, and Sample T Test was used to compare the pre-test and post-test averages within groups. The statistical significance level was determined as p<0.05. When the groups were compared, the difference in the improvement rate averages was tested. At the end of the four-week study, drop jump-reactive strength index (DJ-RSI), countermovement jump (CMJ), Illinois Agility Test (IAT) 10-20-30m sprint values and 1-RM values were improved percentage-wise in both AEL-CS and AEL-TS groups. Between the groups, a significant difference was observed between DJ-RSI, CMJ, and 10-20-m Sprint Test results (p<0.05). When we compare the results within groups, it can be concluded that the AEL-CS group showed more improvement in terms of strength, change of direction (COD) skills and Sprint compared to the AEL-TS group.ConclusionsIn conclusion, it can be advised to use cluster set in accentuated eccentric load training in order to improve strength, Sprint and COD skills.
Citation - WoS: 8
Citation - Scopus: 9
Acute Changes in Electrophysiological Brain Dynamics in Elite Karate Players
(Springer international Publishing Ag, 2020) Duru, Adil Deniz; Balcioglu, Taylan Hayri; Ozcan Cakir, Canan Elif; Goksel Duru, Dilek
Regular physical exercise has enhanced effects on the human anatomy and functionality. Recently, an effect of a single set of exercise is shown to have positive effects on mood and on cognitive functioning. The aim of this study is to investigate the effect of a single bout of moderate exercise on the brain electrophysiological dynamics in resting-state condition and under the mental workload situation from elite-level athletes. For this purpose, electroencephalogram (EEG) is measured before and after the exercise sessions from 17 elite karate players who are members of the national karate team of Turkey. Blood lactate measurements are implemented to monitor the volunteers before EEG measurements. EEG data are analyzed using three metrics: conventional band power of each electrode, coherence metrics between electrodes for each band and source coherence values corresponding to each frequency band. Each metric is statistically analyzed between pre- and post-values, and results revealed that in all frequency bands, right parietal electrode had increased connection values which are thought to be related to ongoing sympathetic nervous system response observed during the recovery period. Another finding is the enhanced connectivity of frontal sources under the resting state as well as during the increased mental workload periods.
The Acute Effects of Various Dynamic Stretching Exercises on Jump Performance and Range of Motion
(Universidad de Murcia, 2025) Savaan, Mustafa; Pmar, Yeliz; Pmar, Salih
This study aimed to investigate the acute effects of different dynamic stretching (DS) protocols on vertical jump performance and range of motion (ROM). Thirty healthy male participants, with an average age of 23.48 years, body weight of 76.90 kg, and height of 181.87 cm, who had engaged in recreational exercise for at least two years, participated voluntarily. A "cross-controlled randomized" experimental design was utilized to assess four distinct DS protocols: a-DS at 100 bpm for 30", b-DS at 100 bpm for 75" s, c-DS at 150 bpm for 30", and d-DS at 150 bpm for 75". Acute ROM was measured using the Passive Straight Leg Raise Test (PSLR), while jump performance was assessed via countermovement jump (CMJ). Data were analyzed using repeated measures ANOVA and paired samples T-tests with significance set at p<.05. All four DS techniques significantly increased angles measured by PSLR following application (p <.05). CMJ values also showed significant improvements in both groups subjected to the shorter protocols lasting 30"at either tempo (p <.05). Consideration should be given to application duration and tempo when planning DS exercises, as structured warmup routines can enhance flexibility and optimize athletic performance.
Acute Serious Hepatitis of Unknown Cause in Children
(Galenos Publishing House, 2022) Kılbaş, E.P.K.; Altındiş, M.
On April 5, 2022, an increase in cases of acute hepatitis of unknown etiology was reported in previously healthy children under the age of 10 in the United Kingdom. Since there is no link between these patients, called acute non-HepA-E hepatitis, and viral hepatitis agents (hepatitis A, B, C, D, and E), the possible etiology, and pathogenesis of this emergency is being investigated. One of the alarming features of this epidemic is the high requirement for liver transplantation in a fraction of the cases. In cases other than hepatitis A, B, C, D, and E, a case definition is made by looking at a series of clinical pictures, including serum transaminase levels and age. As of August 26, 2022, 513 cases of acute hepatitis have been reported in Europe and 1,010 globally. Adenovirus was detected in 75% of cases tested in the UK, but data for other countries are still lacking. The role of other etiologic agents is still under investigation. The exact disease pathogenesis has not yet clear. Evidence of human-to-human transmission of the disease remains unclear. Epidemiological studies are critical in clarifying the uncertainties regarding the existence of links between the cases reported to date. Continuing the national and international surveillance activities of the countries in an organized manner is the most basic issue required for the elimination of the epidemic. Copyright © 2022 Tehran University of Medical Sciences.
Adaptation of Caregivers' Task Scale for Multiple Sclerosis To Turkish Society: Validity and Reliability Study
(Dokuz Eylul Univ inst Health Sciences, 2022) Eroglu, Nermin; Tosun, Anil Tekeoglu
Objectives: This study was planned and carried out methodologically to adapt the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS) to Turkish society. Methods: A methodological research. The study was conducted with caregivers of individuals with multiple sclerosis who presented to the neurology clinic of a university hospital between June 2019 and September 2020. The validity and reliability study of the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS) was performed with a total of 142 individuals, which is more than 5 times the number of items on the scale (24 items). Results: The validity of the CTiMSS was evaluated with language validity, construct validity (CFA), and content validity. The reliability coefficient of the internal consistency analysis (Cronbach's Alpha) was found to be extremely high (0.97). Item-total correlation of the scale was examined, and accordingly, no items were removed from the scale. The scale was administered to 30 patients at a two-week interval to analyze test-retest reliability and time-dependent invariance. Conclusion: The CTiMSS, which was adapted to Turkish society to evaluate the tasks of individuals providing care for individuals with multiple sclerosis, is a valid and reliable tool. We recommend that it should be administered to different groups and cultures to increase its evidence value. CTiMSS is an appropriate measurement tool to determine the duties of caregivers of individuals with multiple sclerosis.
Adölesanlarda Fiziksel Aktivite Düzeyleri Üzerine Bir İzlem Kohort Çalışması
(2025) Tımurtas, Eren; Akkurt, Burcu; Durusoy, Ebru; Timurtas, Meral; Çolak, Betül Beyza; Akkurt, Mustafa Ferit
Amaç: Düzenli fiziksel aktivite (FA), sağlığın korunması ve kronik hastalıkların önlenmesi açısından hayati öneme sahiptir. Ancak, küresel bulgular adölesan dönemde FA’da tutarlı bir azalma olduğunu göstermekte, Türk adölesanların da son on yıllarda giderek artan hareketsizlik düzeyleri yaşadığı bildirilmektedir. Adölesan dönem, FA alışkanlıklarının oluştuğu ve uzun dönem sağlık sonuçlarını etkilediği kritik bir gelişim evresini temsil etmektedir; ancak Türkiye’de bu konuda uzunlamasına kanıtlar sınırlıdır. Bu çalışma, prospektif kohort tasarımı kullanılarak adölesanlar arasında 18 aylık süreçte FA’daki değişimleri incelemeyi amaçlamıştır. Yöntem: Bu çalışma, prospektif kohort çalışması olarak planlanmıştır. Kasım–Aralık 2022 döneminde temel anketi tamamlayan 296 adölesan (5.–8. sınıf, 11–13 yaş), bunlardan rastgele seçilen bir okuldan 192 öğrenci Mayıs–Haziran 2024’te tekrar takip edilmiştir. Her iki zamanda da antropometrik ölçümler ve Fiziksel Aktivite Anketi–Çocuklar için Versiyonunun (PAQ-C) Türkçe geçerlilik çalışması yapılmış formu kullanılarak FA düzeyleri değerlendirilmiştir. Bulgular: Toplam 157 katılımcı (erkek, n=74; kız, n=83) her iki zamanda da değerlendirmeyi tamamlamıştır. Erkeklerde dokuz PAQ-C maddesinin altısında, kızlarda ise iki maddede anlamlı düşüş gözlenmiştir (p<0,05). Okul zamanı FA (maddeler 2–4) belirgin olarak azalmış, boş zaman ve ders dışı FA (maddeler 1 ve 5–9) ise büyük ölçüde değişmemiştir (p>0,05). Cinsiyet farklılıkları, erkeklerde kızlara kıyasla daha büyük azalmalar olduğunu göstermiştir. Sonuç: On sekiz aylık dönemde adölesanlarda FA düzeylerinde düşüş gözlenmiş, en belirgin azalmalar okul zamanı FA’da ve erkeklerde görülmüştür. Bu bulgular, Türkiye’de ergen FA’sının uzunlamasına izlenmesinin gerekliliğini ortaya koymaktadır. Türkiye’de ergenlerde FA’nın takip edilmesine yönelik çalışmalar halen sınırlıdır.
Citation - WoS: 7
Citation - Scopus: 7
Adsorption Mechanisms, Kinetics and Photoactivities of Green Synthesized Hydroxyapatite Supported Zno and La-Zno Catalysts
(Pergamon-elsevier Science Ltd, 2024) Tuncel, Duygu; Okte, A. Neren
In this study, hydroxyapatite (HAP) is synthesized by a co-precipitation method from the waste eggshell, utilized as a support for ZnO (ZnO-HAP) and La-ZnO (La-ZnO-HAP) and employed to degrade methyl orange (MO) and methylene blue (MB) dyes under UV irradiation. Water vapor adsorption as relative humidity (84 % RH) on the HAP structure and the as-prepared catalysts are also examined. The characteristic ZnO and HAP reflections are detected in X-ray diffraction (XRD) analysis of ZnO-HAP, La-ZnO-HAP and humidified samples. ZnO and La-ZnO existence is also verified by scanning electron microscopy-energy dispersive X-ray (SEM-EDX) analysis, UV-Vis diffuse reflectance (UV-Vis DRS) spectra and X-ray photoelectron spectra (XPS). ZnO and La-ZnO loading on the HAP induce the formation of mesoporous structures with high surface areas. Dark adsorption capacities and photoactivities of the as-prepared samples are explored regarding electrostatic interactions, Lewis acid-base interactions and hydrogen bonding for both MO and MB. In particular, La-ZnO-HAP 500 degrees C and La-ZnO-HAP 500 degrees C (RH) exhibit improved adsorption abilities and photoactivities. The pseudo-second order model describes the kinetic behavior of all samples under dark conditions. Unhumidified samples follow Langmuir isotherm while Freundlich isotherm better fits humidified ones. Under irradiation, the Langmuir-Hinshelwood kinetic model describes the photoactivities of all samples. The four recycling tests confirm the stabilities of HAP 100 degrees C, HAP 500 degrees C, ZnO-HAP 500 degrees C and La-ZnO-HAP 500 degrees C. This study suggests that the ZnO or La-ZnO loaded HAP catalysts prepared in the presence and absence of humid conditions are considered promising materials for environmental remediation.
Advancements in Human Pose Estimation: A Review of Key Studies and Findings Till 2025
(2025) Turna, Özgür Can; Özbalkan, Uğur
This paper presents an in-depth literature review that comprehensively covers the major developments, methods, architectures and datasets used in the field of human pose prediction up to 2025. The review covers a broad spectrum, starting with traditional methods, deep learning-based techniques, convolutional neural networks, graph-based approaches and more recently prominent transformer-based models. In addition to two-dimensional (2D) and three-dimensional (3D) human pose estimation methods, the paper analyses in detail the diversity of data sets, applications of Microsoft Kinect technology, real-time pose estimation systems and related architectural designs. Overall, the review of more than 120 papers shows that existing systems have made significant progress in terms of accuracy, computational efficiency and practical applications, but that there are still some challenges to overcome in complex scenarios such as multiple person detection, occlusion problems and outdoor environments. This in-depth analysis highlights current trends in the field, future research directions and potential applications.
Advances and Strategies in Biosensor-Based Diagnostics for Parasitic Infections: A Comprehensive Scoping Review
(Springer, 2026) Aminizadeh, Selva; Alizadeh, Gita; Alizadeh, Zahra; Khalilzadeh, Balal; Abidin, Zurina Zainal; Marzi, Mahdi; Rafiei-Sefiddashti, Raheleh
Parasitic diseases are among the most widespread infections worldwide, causing millions of deaths and illnesses each year. So rapid and accurate diagnosis is essential, requiring highly sensitive and specific tests. Biosensors can provide significant advantages over traditional diagnostic methods because of their specificity, sensitivity, speed, simplicity, ease of use, repeatability, and capacity for early-stage disease detection. Recent advances in modern diagnostic tools for detecting parasitic infections use nanomaterials such as gold nanoparticles, carbon nanofibers, and carbon nanotubes. These developments have significantly lowered detection limits to the picogram and femtogram levels. This review will cover recent advancements in biosensor-based diagnostic techniques in parasitology.
Advances in Ferritin Biosensors: Rapid and Cost-Effective Iron Level Assessment
(Field Crops Central Research Institute, 2025) Vonalioglu, Sena; Okur, Muhammed Daghan; Üstünsoy, Recep; Ertaş, Tahsin; Dinç, Bircan
Iron is an essential element crucial for oxygen transport in the bloodstream; however, deviations from its normal physiological levels can result in health complications. Iron deficiency is a widespread condition and a leading cause of anemia globally. Conversely, excessive iron accumulation can cause severe liver damage, such as cirrhosis, by exacerbating oxidative stress. Consequently, assessing iron status through biomarkers like ferritin, which is a protein that reflects the body’s iron stores, is critical for diagnosing iron-related disorders accurately. The ferritin test, which measures the concentration of ferritin protein in the blood, is a standard method for iron analysis. However, frequent hospital visits for such testing can be both time-intensive and expensive. This has driven significant interest in developing rapid and cost-effective methods for ferritin detection. To meet this demand, a variety of biosensors have been designed using diverse techniques to enable convenient ferritin analysis. Despite considerable advancements in biosensor technologies, a comprehensive classification and analysis of these devices remain lacking, leaving researchers without a unified understanding of their comparative strengths and limitations. This review addresses this gap by systematically categorizing ferritin biosensors based on their underlying mechanisms. The review explores electrochemical biosensors, such as those based on graphene, microfluidics, and ZnO–Mn3O4 nanocomposites, as well as electrical biosensors using quantum dots or gold nanorods. Additionally, optical biosensors, including photonic crystal sensors, surface plasmon resonance systems and magnesium sulfide nanosheets are discussed in detail. Unconventional and immunoassay-based biosensors, such as nanodiamond-based magnetic sensors and nanowire FETs, are also examined to highlight the breadth of detection strategies available. With the rising prevalence of iron-related disorders and the limitations of traditional diagnostic tools, this review underscores the critical need for portable, rapid, and cost-effective ferritin biosensing technologies, offering insights relevant to both clinical practice and future research. © 2025 Elsevier B.V., All rights reserved.
Allegory of Risk Society in John Cheever’s “The Swimmer”
(2025) Uyurkulak, Serhat
Bu makale, Ulrich Beck’in “risk toplumu” kavramının, özellikle belirsizlik, felaket ve risk gibi temaları ele alan edebi metinleri yorumlamak için yeni bir çerçeve sunduğunu öne sürmektedir. Beck’in teorisi, geleneksel toplumlardan modern ve sanayi sonrası toplumlara geçişi, risk, tehlike ve felaket algıları temelinde ele alır. Bu çalışma, endüstriyel toplumdan geç modern topluma geçişin izlerini kaydeden bir eser olarak John Cheever’ın 1964 tarihli çığır açıcı kısa öyküsü “The Swimmer”ı incelemektedir. Beck’in çalışmaları sosyolojide önemli etkiler bırakmış ancak sınırlı sayıdaki iklim değişikliği, çevresel yıkım ve nükleer felaket anlatısı dışında edebiyat incelemelerinde yeterince kullanılmamıştır. Cheever’ın anlatısı, bu makalede, ana karakteri Neddy Merrill’in gerçeküstü ve okurda yön kaybı deneyimi oluşturan yolculuğu üzerinden 1960’larda Amerika Birleşik Devletleri’nde risk toplumunun yükselişini gösteren bir alegori olarak değerlendirilmektedir. “The Swimmer” Amerikan rüyasının ve müreffeh banliyö yaşamının varoluşsal çöküntüsünün bir eleştirisi olarak analiz edilmekte, ana karakterin banliyö havuzlarında yaptığı sıra dışı yolculuk ise endüstriyel modernitenin nispeten öngörülebilir, düzenli dünyasından sanayi sonrası toplumun karmaşık ve istikrarsız koşullarına geçişin bir simgesi olarak okunmaktadır. Bu makale, bahsi geçen kısa öyküsünde Cheever’ın bir dönemin güvensizliğe, yabancılaşmaya ve riske dair artan toplumsal bilincini başarıyla yansıttığını iddia etmektedir. Bu yönüyle mevcut çalışma, Cheever’ın öyküsü üzerine yapılan sınırlı akademik tartışmalara bir katkıda bulunmakta, edebiyat ile sosyolojik teori arasındaki kesişime dair yeni bir bakış açısı sunmaktadır.
Citation - WoS: 1
Ameliorative Effects of Myrtus Communis L. Extract Involving the Inhibition of Oxidative Stress on High Fat Diet-Induced Testis Damage in Rats
(Taylor & Francis Ltd, 2024) Coskunlu, Busra; Koroglu, M. Kutay; Hersek, Irem; Ertas, Busra; Sen, Ali; Sener, Goksel; Ercan, Feriha
The possible protective effects of Myrtus communis L. (MC) extract on a high fat diet (HFD)-induced testicular injury in a rat model were investigated using histological and biochemical methods. Wistar albino rats were divided into three groups: a standard diet control group; a HFD group; and an HFD+MC group. The HFD and HFD+MC groups were fed with a HFD for 16 weeks. MC extract (100 mg/kg) was given orally five days a week to the rats in the HFD+MC group during the last four weeks of the experiment. Leptin, triglyceride, high-density lipoproteins, cholesterol, estrogen, testosterone, LH and FSH were analyzed in blood serum. Sperm parameters were evaluated from the epididymis. Testicular morphology, proliferative, apoptotic and NADPH oxidase-2 (NOX2)-positive cells were evaluated histologically. Testicular oxidative stress parameters were analyzed biochemically. In the HFD group, lipid and hormone profiles were changed, abnormal spermatozoa, degenerated seminiferous tubules with apoptotic and NOX2-positive cells were increased in number, and sperm motility and germinal proliferative cells decreased compared to the control group. Moreover, testicular malondialdehyde, 8-hydroxy-2-deoxyguanosine and myeloperoxidase levels increased, whereas glutathione and superoxide dismutase levels decreased in the HFD group compared to the control group. All these histological and biochemical features were ameliorated by MC treatment of HFD-fed rats. In conclusion, HFD caused alterations in sperm parameters and testicular morphology by increasing oxidative damage and apoptosis. MC extract may have potential protective effects by inhibiting oxidative damage.
Citation - WoS: 3
Citation - Scopus: 5
Analysis for Two-Dimensional Inverse Quasilinear Parabolic Problem by Fourier Method
(Taylor & Francis Ltd, 2021) Kanca, Fatma; Baglan, Irem
In this work, two-dimensional inverse quasi-linear parabolic problem with periodic boundary and integral overdetermination conditions is investigated. The formal solution is obtained by the Fourier approximation. Under some natural regularity and consistency conditions on the input data,the existence, uniqueness and continuously dependence upon the data of the solution are proved by iteration method. The inverse problem is first examined by linearization and then used implicit finite difference scheme for the numerical solution. Also predictor corrector method is considered in the numerical approach. Some results on the numerical solution with two examples are presented with figures and tables. The sensitivity of the scheme with respect to noisy overdetermination data is illustrated.
An Analysis of Psychological Resilience Levels Among Judo Coaches According to Selected Demographic Factors
(Idokan Poland Association, 2025) Beşiktaş, M.Y.; Terekli, M.S.
Background. Psychological resilience is a crucial personal trait that enables individuals, especially those in high-stress professions like coaching, to adapt and thrive in the face of adversity. Understanding how resilience manifests among coaches can contribute to more effective support and development strategies in sports psychology. Problem and aim. This study aims to determine whether the psychological resilience levels of judo coaches differ according to demographic variables such as age, educational background, coaching certification level, years of coaching experience, profession, and perceived economic status. Material and methods. The sample included 284 active judo coaches (58 women and 226 men) from Istanbul, Kutahya, and Eskisehir. Data were collected using the “Psychological Resilience Scale for Adults” [Friborg et al. 2003; Basim, Cetin 2011] and a “Personal Information Form.” Statistical analyses were conducted using SPSS 24.0, including independent samples t-tests, one-way ANOVA, and Eta squared analysis to assess the influence of demographic actors on resilience levels. Results. The findings indicated significant differences in psychological resilience levels based on gender, marital status, age, educational attainment, coaching experience, income level, and coaching certification level. Conclusions. The results suggest that psychological resilience among judo coaches is meaningfully influenced by various demographic characteristics. These findings underscore the importance of tailoring psychological support and development programs to the specific profiles of coaches. © Yoshin Academy
Citation - WoS: 2
Citation - Scopus: 1
Analysis of Substance Use and Mental Disorder Diagnoses in Adolescents With a History of Delinquency: a Cross-Sectional Study
(Springer, 2024) Baysan Arabaci, Leyla; Dikec, Gul; Tas Soylu, Gulsenay; Bilac, Oznur; Uzunoglu, Gulcin; Ayakdas Dagli, Dilek
This study aimed to evaluate substance use and comorbid mental disorders in delinquent adolescents presenting to a child and adolescent psychiatry outpatient clinic. This study included 47 adolescents aged 15-18 years and had a history of delinquency. Data were collected using the Addiction Profile Index Adolescent Form (API-A) and an information form. Results indicated that the adolescents' mean age is 16.11 +/- 1.05 years, 78.7% had committed crimes against property and 34.0% against the person, and 34.0% were also victims of crime. Mean API-A total scores indicated that their level of substance use was low. In addition, mean API-A total scores showed significant differences according to the adolescents' migration status, age, economic status, school attendance, mental disorder diagnosis, duration of mental disorder, and type of offense (p < 0.05). The benefit provided by timely and appropriate psychosocial interventions may have a key role in solving this problem for adolescents and improving their future as adults.
Citation - WoS: 1
An Analysis of the Gross Motor Skills of Children Aged 3-6 Years With Autism Spectrum Disorder in Comparison With Their Typically Developing Peers
(Sagamore Publishing Llc, 2023) Ozcan, Gulsum Hatipoglu; Ozer, Dilara; Pinar, Salih
The aim of this study is to examine the motor skill levels of children aged 3-6 years with Autism spectrum dis-order (ASD) in comparison with their typically devel-oping (TD) peers and to reveal their needs for motor support programs. The research group consisted of 88 participants aged 3-6 years, including 43 children (40 boys and 3 girls) diagnosed with ASD attending spe-cial education and rehabilitation institutions, and 45 TD children (23 boys and 22 girls) receiving pre-school education in a private institution (ASD=57.4 months, +/- 9.32 - TD=59.06 months, +/- 8.61). The Peabody Devel-opmental Motor Scale-2 (PDMS-2) and the Turkish Ver-sion of the Gilliam Autism Rating Scale-2 (GARS-2-TV) were used as data-collection tools in the study. The Mann-Whitney U test was used for the two-group com-parisons of the parameters that did not exhibit normal distribution in the analysis of the data. The Spearman correlation analysis was applied to determine the relationship between the variables. The significance was evaluated at the p<0.05 level. As a result of the research, the balance, locomotor and manipula-tive skills and total gross motor scores of the children with ASD were found to be lower than those of the TD children (p<0.05). In addition, it was observed that there was a significant correlation between GARS-2 -TV scores and PDMS-2 scores of the children with ASD (p<0.05).
Citation - WoS: 3
Citation - Scopus: 3
Analyzing Critical Success Factors of Sustainable Knowledge Management: an Interval-Valued Neutrosophic Approach
(Mdpi, 2024) Turan, Hakan; Bulak, Muhammet Enis; Buyukselcuk, Elif Caloglu
Knowledge management (KM) is a structured approach that includes the organized procedures of generating, capturing, arranging, storing, retrieving, distributing, and harnessing an organization's knowledge resources to attain its goals and improve its effectiveness. Encountering uncertainty and managing imprecise information are fundamental aspects of KM that cannot be avoided. In this context, sustainable KM aims to solve these issues and address prioritizing the long-term sustainability and efficiency of knowledge-related processes within an organization. The aim of this study is to structure a sustainable KM concept for organizations and identify the most common critical success factors (CSFs) with a novel analytical approach. In this context, the Interval-Valued Neutrosophic methodology, which is one of the multi-criteria decision methods (MCDMs), was adopted to evaluate and weight the determined CSFs. Four main headings-KM, environmental, economical, and social criteria-are evaluated along with their subfactors. Our findings show that KM is found to be the most important, and environmental factors followed KM. When the results are examined in terms of subfactors, cleaner production is found to be the most significant, with a global weight value of 11.13.

Browse

Browsing Fenerbahçe Üniversitesi by Language "en"