Fenerbahçe Üniversitesi

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Citation - WoS: 22
Citation - Scopus: 31
Digital Transformation in Project-Based Manufacturing: Developing the Isa-95 Model for Vertical Integration
(Elsevier, 2022) Apiliogullari, Lutfi
The Smart Factory is the intelligent management of all business operations that aims to produce innovative products in the most efficient and faster way through the cyber-physical system (CPS). CPS integrates the cyber (IT) and the physical world (OT) through the hierarchical layers of ISA-95 model and forms the backbone of Industry 4.0. The CPS plays a crucial role in transforming data from interconnected systems, and it is a pre-requisite for the entire system to be able to interact. The ISA-95 model consists of components that can be used to determine how the interaction between domains vertically within the facility. However, the current ISA-95 Model does not include all the components that need to be integrated in vertical integration of all domains. The product domain is one of them. All IT and OT components need to be represented in the ISA-95 layers to achieve an ideal CPS structure. In this study, all components needed to achieve the ideal CPS structure have been identified in an expanded ISA-95 Model for project-based manufacturers. An extended ISA-95 model is proposed so that each manufacturing industry can use it in the digital transformation process by adding a product domain and connectivity layer to the Model. The Model was tested and confirmed, by conducting a case study which was based on implementing the vertical integration on it. This model helps businesses to develop more effective digital transformation strategies by defining where they should focus on or from where they should start the digital transformation processes.
Citation - WoS: 9
Citation - Scopus: 7
Investigation of Land Cover (lc)/Land Use (lu) Change Affecting Forest and Seminatural Ecosystems in Istanbul (turkey) Metropolitan Area Between 1990 and 2018
(Springer, 2023) Bozkurt, Selvinaz Gulcin; Kusak, Lutfiye; Akkemik, Unal
This study was conducted to examine the land cover (LC)/land use (LU) change affecting forest and seminatural ecosystems and the spatio-temporal development of urban expansion between 1990 and 2018 in the city of Istanbul, where urbanization is the most intense in Turkey. For this purpose, using Corine Land Cover (1990, 2000, 2006, 2012, and 2018) dataset, the land cover of the area was determined in 5 different classes (artificial surface, agriculture, forest, water bodies, water), maps were produced, and tabular data were created. The changes in LC/LU between 1990 and 2018 were determined according to the Puyravaud land cover change rate and hot spot analysis methods. According to our findings, we determined that urbanization in Istanbul expanded the most in the east-west direction, and the agricultural and forest areas gradually decreased by 3.02% and 6.66% respectively; urban areas increased at the same rate of 9.69%. It is predicted that this change will continue increasing until 2030 when the forecasting method is applied in the field. It has been determined that the most important reasons for this situation are local government policies, population growth, and economic development initiatives applied in the area. As a result, it has emerged that measures should be taken based on sustainability and naturalness approaches to design urban development plans and to protect natural areas on a large scale, in order to limit possible LC/LU conversion from natural structure to urbanization in the area.
Evaluation of Labor Market Issues in Sport and Exercise Environment in Turkey
(Taylor and Francis, 2021) Ersöz, G.
Does Prolotherapy Have an Effect on the Care of Pressure Injuries? a Pilot Study
(Elsevier Sci Ltd, 2025) Eroglu, Nermin; Kokkiz, Rukiye; Eroglu, Hatice Eda; Kocoglu, Hasan
Background: This study contributes to wound healing with prolotherapy in people with pressure injuries. The study was planned and conducted as a randomized controlled trial to determine the effect of prolotherapy on the care of pressure injuries. Methods: The study was carried out with patients with pressure injuries in the intensive care unit of a city hospital between April and June 2023. A power analysis was performed, and the sample size was calculated as 20 patients, including 10 in the intervention and 10 in the control group. The patients in the experimental group were given wound care with gelofusine as prolotherapy in the morning and evening for three days, and the injury site was covered with a sterile sponge and fixation tape. The patients in the control group were treated with saline in the morning and evening for three days. In both groups, the wound width, depth, and length were measured and evaluated prior to each intervention for three days. Results: In the study, a significant difference was found between the mean ages of the participants in the experimental and control groups (p < 0.05). The decrease in width measurements in the experimental group was found to be statistically significant compared to the previous measurements, while the increase in width measurements in the control group was significant compared to the previous measurements (p < 0.05). Depth measurements decreased statistically significantly in the experimental group, while they increased significantly in the control group compared to previous measurement values (p < 0.05). Conclusion: In conclusion, it was determined that the administration of gelofusine for pressure injuries as prolotherapy in the experimental group may be more effective in wound healing than saline treatment applied in the control group. Further studies are warranted.
Citation - WoS: 3
Citation - Scopus: 3
An International Multicenter Mental Health Standardized Patient Simulation on Nursing Students? Beliefs Toward Mental Health Conditions
(Elsevier Science inc, 2023) San, Eda Ozkara; Dikec, Gul; Ata, Elvan E.
Background: Negative beliefs can be a barrier to provide quality nursing care for persons living with mental health conditions. This international SP simulation study explored nursing students' beliefs toward persons with mental health conditions in the United States (US) and Turkey before and after participating in a mental health standardized patient simulation. Methods: A quasi-experimental study design was used in two settings in two countries. Measures included a socio-demographic survey and the Beliefs toward Mental Illness scale. Results were analyzed using paired sample t-test, independent t-test, and chi-square tests. Results: Students in the US had significantly lessened negative attitudes toward persons with mental health conditions when compared to the Turkey group. Conclusion: SP simulation may offer opportunities to improve nursing students' beliefs toward persons with mental health conditions.
Citation - Scopus: 1
Where Are We and What Should We Do in Cleaner Production Transformation
(IGI Global, 2023) Büyükselçuk, E.Ç.
Until recently, production models developed according to market conditions focused on reducing costs and increasing profitability at the expense of the destruction of natural resources and the deterioration of ecological balance and human health. However, today, with the effects of the deterioration in the ecosystem reaching sensible dimensions and being accepted as a global threat, a new production approach is needed. Due to environmental pressures, new markets and scarce resources, development, and economic growth are being tried to be redefined. Traditional production methods and environmental technologies are no longer sufficient to provide resource efficiency and increase environmental performance. Therefore, the need for new systems, processes and technologies has arisen for the restructuring of the industry and the creation of green business models. In this chapter, it is discussed how the cleaner production approach will contribute to this transformation, considering the green transformation efforts in question and considering the current situation of the Turkish industry. © 2023, IGI Global.
Efficiency of Modulated and Dose Rate Altered Flattening Filter Free Beams in High Dose Per Fraction Radiotherapy Applications on the Survival of Prostate Cancer Cell Lines
(Ijrr-iranian Journal Radiation Res, 2021) Ceylan, C.; Ozturk, A.; Gungor, G.; Karabey, A. U.; Sahin, S.; Duruksu, G.; Gundogdu, O.
Background: The radiobiological effect of high dose rate FFF beams on the DU-145 cells was investigated with SBRT plans which have >10 Gy. Methods and Materials: To compare the radiobiological effect on DU-145 cell line four experiments designed: (1) the constant dose rate of 6 MV and 6 MV FFF with increased dose per pulse (2) the effect of dose per pulse while increasing instantaneous dose rate for 6 MV and 6 MV FFF, (3) the effect of increased average dose rate for 6 MV FFF and (4) the effect of protracted treatment time and modulation of 6 MV FFF beams. The survival fraction was counted with WST. Results: FF and FFF for 6 MV with same dose rate and treatment time has no effect on cell survival. Significant differences was observed on survival which were irradiated with 6 MV 600 MU/min and 6 MV FFF 1400 MU/min (p=0.024). There was no difference between 6 MV FFF 600 MU/min and 6 MV FFF 1400 MU/min for 10 Gy. The significant survival difference obtained for 20 Gy. The survival percentages for both 10 Gy and 20 Gy with Cyberknife were obtained higher than FFF. Conclusion: Our in-vitro study presented here show that higher dose rate and reduced treatment time might become a crucial factor for SBRT especially which has >10 Gy fraction dose.
Citation - WoS: 3
Citation - Scopus: 3
Analyzing Critical Success Factors of Sustainable Knowledge Management: an Interval-Valued Neutrosophic Approach
(Mdpi, 2024) Turan, Hakan; Bulak, Muhammet Enis; Buyukselcuk, Elif Caloglu
Knowledge management (KM) is a structured approach that includes the organized procedures of generating, capturing, arranging, storing, retrieving, distributing, and harnessing an organization's knowledge resources to attain its goals and improve its effectiveness. Encountering uncertainty and managing imprecise information are fundamental aspects of KM that cannot be avoided. In this context, sustainable KM aims to solve these issues and address prioritizing the long-term sustainability and efficiency of knowledge-related processes within an organization. The aim of this study is to structure a sustainable KM concept for organizations and identify the most common critical success factors (CSFs) with a novel analytical approach. In this context, the Interval-Valued Neutrosophic methodology, which is one of the multi-criteria decision methods (MCDMs), was adopted to evaluate and weight the determined CSFs. Four main headings-KM, environmental, economical, and social criteria-are evaluated along with their subfactors. Our findings show that KM is found to be the most important, and environmental factors followed KM. When the results are examined in terms of subfactors, cleaner production is found to be the most significant, with a global weight value of 11.13.
Citation - WoS: 3
Citation - Scopus: 1
Work-Related Musculoskeletal Disorders Among Occupational Therapists in Turkey: a Cross-Sectional Study
(Taylor & Francis inc, 2024) Bektas, Selen Aydoner; Degerli, Medine Nur Ozata; Altuntas, Onur; Bumin, Gonca
Work-related musculoskeletal disorders are a common cause of absentism and work disability. As work-related musculoskeletal disorders represent an increasingly important issue for occupational therapists, this study determined musculoskeletal disorders among occupational therapists in Turkey. A total of 238 occupational therapists participated and completed the Nordic Musculoskeletal Questionnaire. As a result, 73.1% of participants reported experiencing neck pain and 72.3% reported experiencing low back pain at 12 months. Statistically significant differences were found between participants with and without work-related musculoskeletal disorders regarding gender, experience, workplace type, treatment, and daily working hours (p < 0.05). Occupational therapists may experience work-related musculoskeletal disorders due to not practicing proper body mechanics or non-provision of transferring equipment.
Military Coups and Military Disengagement
(Springer International Publishing, 2023) Eldem, T.
Citation - WoS: 4
Citation - Scopus: 5
The Validity and Reliability of the Thanatophobia Scale-Turkish Form: a Psychometric Study Among Nurses
(Sage Publications inc, 2024) Cifcioglu, Zulfiye Yildiz; Seren, Arzu K. Harmanci
Purpose: To examine the validity and reliability of the Thanatophobia Scale-Turkish Form among nurses. Design and methods: This methodological study included 154 nurses. Content and construct validity, item analysis, confirmatory factor analysis, and internal consistency were used to evaluate the data. Findings: The content validity index of the scale was 0.91. Item-total score correlation values varied between 0.453 and 0.718. As a result of the confirmatory factor analyses, one factor was confirmed. Cronbach's alpha internal consistency coefficient was 0.854. Practice Implications: Thanatophobia Scale-Turkish Form is a valid and reliable tool used to evaluate the fear of death among nurses.
Citation - WoS: 1
Citation - Scopus: 1
Relationship Between E-Health Literacy and Healthy Lifestyle Behaviours of Turkish Health Sciences Students
(Emerald Publishing, 2025) Çakır, Furkan; Ozturk, Sergen; Gerçek, Hasan; Eryildiz, Ezgi; Kartal, Gokce; Polat, Mine Gulden
Purpose: E-health literacy (EHL) and healthy lifestyle behaviours (HLBs) are important for individuals receiving health education. Health professionals of the future should be conscious, e-health literate and develop HLBs. The aims of this study were to determine the EHL and HLBs of university students receiving health education and to examine the relationship between them. Design/methodology/approach: A total of 1,454 health sciences students, between the ages of 18–27, were included in the study. Participants' data were collected online via Google Forms. Participants' EHL levels were assessed with the E-Health Literacy Scale. Participants' HLB were assessed with the Healthy Lifestyle Behaviours Scale II. Findings: Positive weak correlation was found between EHL and HLB (p < 0.001, r = 0.329). EHL scores of bachelor’s degree students were higher than associate degree students (p = 0.004). HBL total score bachelor’s and associate degree student scores were similar (p = 0.714). Originality/value: This article addresses an important gap in understanding health sciences students' online reading habits about health and their relationship to HLB. Considering that there is a positive relationship between EHL and HLBs of students in the health departments of universities, increasing the EHL levels of students will help to increase HLBs. © 2025, Emerald Publishing Limited.
Bangladesh Journal of Pharmacology
(Bangladesh Pharmacological Soc, 2024) Kulabas, Necla; Guven, Cansu Tamniku; Duracik, Merve; Ozakpinar, Ozlem Bingol; Kucukguzel, Ilkay
[No Abstract Available]
Effects of an Adapted Dance Exercise Program on Trunk Control, Balance and Functional Mobility in Children and Adolescents with Cerebral Palsy: Randomized Controlled Study
(Taylor & Francis inc, 2025) Yekdaneh, Asena; Arman, Nilay
Aims: The study aimed to investigate whether an 8-week adapted dance exercise program (ADEP), delivered in addition to conventional physiotherapy, would improve trunk control, balance, functional mobility, and quality of life (QoL) in children and adolescents with cerebral palsy (CP) compared with conventional physiotherapy alone. Methods: Thirty participants with CP (Gross Motor Function Classification System Level I - II) were randomly assigned to the ADEP group (n = 15) or the control group (n = 15). Both groups received conventional physiotherapy, while the ADEP group additionally performed physiotherapist-choreographed dance exercises accompanied by music, twice a week for 8 weeks. Outcomes included the Trunk Control Measurement Scale (TCMS) for trunk control, the Pediatric Balance Scale (PBS) for balance, the Timed Up and Go (TUG) for functional mobility, and the Pediatric Outcomes Data Collection Instrument (PODCI) for QoL. Results: The ADEP group showed significantly greater improvements than the control group in TCMS-Total (Delta = 10.53 vs 3.50, p < .001), TCMS-selective motor control (Delta = 6.00 vs 1.42, p < .001), TCMS-dynamic sitting balance (Delta = 7.53 vs 2.28, p < .001), and PODCI-Global scores (Delta = 4.61 vs -1.71, p < .001). Both groups improved in PBS and TUG, but between-group differences were not significant. Effect sizes indicated large improvements in trunk control in favor of the ADEP group. Conclusions: An 8-week ADEP program, when combined with conventional physiotherapy, produced clinically meaningful gains in trunk control and QoL in children and adolescents with CP. These findings support the use of dance-based rehabilitation as a feasible and engaging adjunct to physiotherapy.
Citation - WoS: 3
Citation - Scopus: 3
Effect of Home Care After Cardiac Surgery
(Managed Care & Healthcare Communications Llc, 2023) Aksut, Rabia Saglam; Kilic, Dilek
OBJECTIVES: Home care that maintains continuity of health care services after cardiac surgery is considered a complementary component of clinical care. We estimated that effective home care given with a multidisciplinary approach would contribute to decreasing symptoms and readmissions to the hospital after cardiac surgery.STUDY DESIGN: This experimental study with a 6-week follow-up period and a 2-group repeated measures design with pretest, posttest, and interval tests was conducted in a public hospital in Turkey in 2016.METHODS: We identified the self-efficacy levels, symptoms, and readmissions to the hospital of 60 patients (30 in the experimental group and 30 in the control group) throughout the data collection process, and we estimated the effect of home care on self-efficacy, symptom management, and hospital readmissions by comparing the data of patients in the experimental and control groups. Each patient in the experimental group received 7 home visits along with 24/7 telephone counseling services throughout the first 6 weeks after discharge, and patients were provided physical care, training, and counseling services during these home visits with the collaboration of their physician.RESULTS: Home care resulted in better self-efficacy and fewer symptoms in the experimental group (P < .05), and it also reduced readmissions to the hospital in the experimental group (23.3%) compared with the control group (46.7%).CONCLUSIONS: This study's findings suggest that home care, with a focus on continuity of care, decreases symptoms and readmissions to the hospital and improves the self-efficacy of patients after cardiac surgery.
Citation - WoS: 4
Citation - Scopus: 6
Hepatoprotective Effects of Parsley (petroselinum Crispum) Extract in Rats With Bile Duct Ligation
(Elsevier, 2023) Ede, Seren; Özbeyli, Dilek; Erdogn, Omer; Cevik, Ozge; Kanpalta, Fatma; Ercan, Feriha; Senerg, Goksel
Background and study aims: This study aimed to investigate the possible protective effects of parsley extract (Petroselinum Crispum; PC) against oxidative liver damage caused by bile obstruction in rats. Material and methods: Bile duct ligation (BDL) method was used to induce liver injury in rats. The rats were divided into the three groups each consisting of 8 rats; Sham-operated control (C), bile duct ligated + saline treated (BDL), and BDL + PC treated groups. PC extract was given at a dose of 2 g/kg orally for 28 days. Aspartate amino transferase (AST), alanin amino transferase (ALT), and bilirubin levels were analyzed in sera. In order to determine free radicals in liver injury, luminol and lucigenin chemiluminescence tests used. Oxidative stress was evaluated through superoxide dismutase, glutathione, malondialdehyde, Na+/K+-ATPase and 8-hydroxy guanosine levels. Furthermore, inflammation marker myeloperoxidase, apoptosis marker caspase-3, and fibrosis markers TGF- beta and hydoxyproline were investigated. The liver tissues were also examined for histological evaluations.Results: While PC treatment decreased AST and ALT levels which increased with BDL, oxidant damage parameters also decreased with this treatment. Conclusion: The present study, which is the first research for PC extract on cholestasis induced liver damage, demonstrated that PC extract could be a potential therapeutic agent against liver fibrosis and need further studies.
Citation - Scopus: 4
Effects of Computer-Based Balance Exercises on Balance, Pain, Clinical Presentation and Nerve Function in Patients With Diabetic Peripheral Neuropathy: a Randomized Controlled Study
(International Society of Musculoskeletal and Neuronal Interactions, 2024) Reyhanıoglu, D.A.; Yıldırım, G.; Sengun, I.Ş.; Kara, B.
Objective:To evaluate the use of a computer-based biodex balance exercise system (BBS) on balance, neuropathic pain, clinical presentation and nerve function in patients with diabetic peripheral neuropathy (DPN). Methods: A total of 32 participants with DPN were randomly assigned in a 1:1 ratio to an intervention group (IG) or control group (CG). The IG performed exercises using the BBS twice weekly for 8 weeks, while CG were informed regarding diabetes self-management. At baseline and after study completion, participants underwent balance (postural stability and fall risk) and neuropathic pain assessment (DN4 questionnaire) and were screened using the Michigan Neuropathy Screening Instrument and nerve conduction test. Results: Among the baseline participants, 14 in the IG and 13 in the CG completed the study. Balance training improved postural stability (overall, p<0.001), fall risk (p<0.001), neuropathic pain (p=0.01) and symptoms (p<0.001), and clinical presentation (p=0.02), but not nerve function, within the IG. At follow-up, IG displayed significantly improved stability (p<0.001) and fall risk (p=0.02) and decreased neuropathic symptoms (p=0.01) compared to the CG. Conclusion: Computer-based balance exercises improve balance, pain, and clinical presentation of DPN, but not nerve function, in patients with DPN. ClinicalTrials.gov ID: NCT05255497. © 2024, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.
Development of the Pediatric Physical Activity Tracking Platform (Pedi@Ctivity) and Smartwatch-Based Big Data Analysis: A Digital Health Application in Society 5.0
(Elsevier, 2025) Arman, N.; Cakar, T.; Gullu, S.; Ayaz, N. Aktay; Yekdaneh, A.; Albayrak, A.
Design and Synthesis of Thiosemicarbazides and 1,2,4-Triazoles Derived From Ibuprofen as Potential Metap (Type II) Inhibitors
(Elsevier Ireland Ltd, 2025) Yilmaz, Ozgur; Biliz, Yagmur; Ayan, Sumeyra; Cevik, Ozge; Karahasanoglu, Mufide; Cotuker, Reyhan; Kucukguzel, S. Guniz
In the present study, a range of novel thiosemicarbazides 4a-i and 1,2,4-triazoles 5a-i derived from ibuprofen, were synthesized. Structural elucidation of these synthesized compounds was performed utilizing a variety of spectroscopic methods, including FTIR, 1H NMR, 13C NMR and HR-MS. The synthesized compounds were tested for cytotoxicity in five different cancer cell lines (cervical cancer (HeLa), human breast cancer (MCF-7), human gastric adenocarcinoma (MKN-45), human metastatic prostate cancer (PC3) and human glioblastoma (U87)). The compounds were compared with healthy cells (NIH-3T3) and the most effective compounds were determined by means of the selectivity index. Thiosemicarbazides derived form ibuprofen 4i and 4d showed anticancer activity, while 1,2,4-triazoles derived form ibuprofen 5b, 5c, 5d, 5e, 5h, 5g showed anticancer activity in HeLa, MCF-7, MKN-45, PC3 and U87 cells. To test the stability of the protein-drug complexes all 18 compounds 4a-i and 5a-i were docked into the active site of the MetAP2 enzyme In general, computational inhibition constants values were correlated with the experimental values. The dynamic behavior of MetAP2-inhibitor complexes was analyzed using all atoms Molecular Dynamic (MD) simulations for 200 ns duration. MD revealed that the drugs bind in the active center of MetAP2 with stable RMSD and RMSF. In conclusion, in-silico results and in-vitro studies suggests that thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen may be novel anticancer drug candidates for treating cervical, breast, prostate, gastric and glioblastoma. Compounds provided induction of apoptotic proteins in the cell by inhibiting MetAP2 enzyme. Furthermore, the potential antioxidant activities of the compounds were evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Among the compounds tested, 4a, 4b, 4e, 4f, 4h, and 4i exhibited values closely resembling the DPPH activity of the standards.
Effects of Osteopathic Manipulative Treatment Alone or in Combination With Respiratory Training on Chest Wall Expansion, Functional Mobility, and Dyspnea Level in Patients With Pulmonary Arterial Hypertension
(Amer Thoracic Soc, 2024) Naci, B.; Demir, R.; Onder, O. O.; Sinan, U. Y.; Kucukoglu, M. S.
[No Abstract Available]

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