Kahraman Kılbaş, Elmas Pınar

Kahraman Kılbaş, Elmas Pınar

Profile URL

https://hdl.handle.net/20.500.14627/685

Name Variants

Kilbas, Elmas Pinar Kahraman
Kahraman Kilbas, Elmas Pinar
Kahraman Kilbas, E.P.
Kılbaş, Elmas Pınar Kahraman
Kahraman Kilbas, Elmas Pinar
Kılbaş, E.P.K.

Job Title

Öğretim Görevlisi

Email Address

elmas.kahraman@fbu.edu.tr

Main Affiliation

Tıbbi Hizmetler ve Teknikler Bölümü
Tıbbi Hizmetler ve Teknikler Bölümü
Tıbbi Hizmetler ve Teknikler Bölümü

Sustainable Development Goals

3

GOOD HEALTH AND WELL-BEING

12

Research Products

6

CLEAN WATER AND SANITATION

1

Research Products

15

LIFE ON LAND

1

Research Products

Scholarly Output

20

Articles

20

Citation Count

11

Supervised Theses

0 Scholarly Output Search Results

Now showing 1 - 10 of 20

Citation - WoS: 1
Citation - Scopus: 1
A Systematic Review and Meta-Analysis of Molecular Characteristics on Colistin Resistance of acinetobacter Baumannii
(Mdpi, 2024) Ciftci, Ihsan Hakki; Kilbas, Elmas Pinar Kahraman; Kilbas, Imdat
Background: This study aimed to determine the molecular epidemiology of colistin-resistant A. baumannii in the last ten years and the frequency of gene regions related to pathogenesis, to compare the methods used to detect genes, and to confirm colistin resistance. Methods: This meta-analysis study was conducted under Preferred Reporting Items for Systematic Reviews and Meta-Analysis Guidelines. In the meta-analysis, research articles published in English and Turkish in electronic databases between January 2012 and November 2023 were examined. International Business Machines (IBM) Statistical Package for the Social Sciences (SPSS) Statistics for Macbook (Version 25.0. Armonk, NY, USA) was used for statistical analysis. The Comprehensive Meta-Analysis (CMA) (Version 3.0. Biostat, NJ, USA) program was used for heterogeneity assessment in the articles included in the meta-analysis. Results: After evaluating the studies according to the elimination criteria, 18 original articles were included. Among colistin-resistant strains, blaOXA-51 positivity was 243 (19.61%), blaOXA-23 was 113 (9.12%), blaOXA-58 was 7 (0.56%), blaOXA-143 was 15 (1.21%), and blaOXA-72 was seen in two (0.16%) strains. The positivity rates of pmrA, pmrB, and pmrC were found to be 22 (1.77%), 26 (2.09%), and 6 (0.48%). The mcr-1 rate was found to be 91 (7.34%), the mcr-2 rate was 78 (6.29%), and the mcr-3 rate was 82 (6.61%). Conclusions: The colistin resistance rate in our study was found to be high. However, only some research articles report and/or investigate more than one resistance gene together. Additionally, it may be challenging to explain colistin resistance solely by expressing resistance genes without discussing accompanying components such as efflux pumps, virulence factors, etc.
Sakarya İlinde İçme ve Kullanma Sularından İzole Edilen Escherichia Coli Suşlarının Antibiyotik Direnç Durumlarının Belirlenmesi
(2024) Naşide,; Kılbaş, Elmas Pınar Kahraman; Çıftcı, Ihsan Hakkı
Su sistemlerinde patojen kontaminasyonu giderek artmakta ve bu durum, özellikle çocuklar arasında gastrointestinal enfeksiyonların artmasına yol açmaktadır. Bu çalışmanın amacı, Sakarya il sınırlarında içme ve kullanma sularındaki Escherichia coli kontaminasyon riskini belirlemek ve izole edilen suşların antibiyotik direnç durumlarını incelemektir. Sakarya ilçelerinden 2023-2024 yılları arasında toplanan 450 su numunesinden E. coli izolasyonu, membran filtreleme yöntemi ve kromojenik koliform agar (CCA) kullanılarak yapıldı. Bakterilerin antibiyotik dirençleri disk difüzyon yöntemi ile değerlendirildi. Çalışmada 450 su numunesinin %15,6'sında E. coli tespit edildi. Geyve ilçesinden alınan su numunelerinin %72'sinde E. coli bulunmuş olup, bu oran diğer ilçelere göre istatistiksel olarak anlamlı derecede yüksek bulundu (p<0.05). İzole edilen suşların %25,71'inin bir veya daha fazla antibiyotiğe dirençli olduğu belirledi. E. coli suşları genel olarak karbapenemler ve 3. kuşak sefalosporinlere duyarlıdır, ancak bazı bakteri izolatlarında penisilin ve sefalosporinlere karşı direnç tespit edildi. Tarım ve hayvancılığın yoğun olduğu bölgelerde içme ve kullanma sularında yüksek E. coli kontaminasyonu ve antibiyotik direnci tespit edilmiştir. Bu durum, yanlış ve aşırı antibiyotik kullanımının bir sonucu olarak görülmektedir. İçme sularındaki bu kontaminasyon, halk sağlığı açısından büyük bir risk oluşturmaktadır. İçme ve kullanma sularındaki E. coli varlığı, suyun dezenfeksiyonunda eksiklikler olduğunu ve fekal kontaminasyon riskini işaret etmektedir. Su arıtma tesislerinin ve dezenfeksiyon yöntemlerinin iyileştirilmesi, antibiyotik direncinin önlenmesi ve halkın bilinçlendirilmesi büyük önem taşımaktadır. Bu çalışmanın sonuçları, suyun güvenli ve hijyenik bir şekilde temin edilmesinin gerekliliğini vurgulamaktadır.
Saliva in the Diagnosis of Covid-19
(Galenos Publ House, 2021) Kilbas, Elmas Pinar Kahraman; Altindis, Mustafa
The use of saliva samples for the diagnosis of severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) provides several advantages over the use of nasopharyngeal (NP) swabs, such as comfort, ease of self-collection, less use of personal protective equipment, and protection of healthcare personnel from transmission. This review included current studies using saliva samples for the detection of SARS-CoV-2, comparing its sensitivity, cycle threshold, and specificity with those of NP swab. In the literature, the sensitivity rates of saliva samples in the diagnosis of SARS-CoV-2 ranged from 70% to 98%. Despite different opinions, we concluded that saliva is a reliable sample for the detection of SARS-CoV-2. However, studies with large samples and comparing different diagnostic methods are needed to reach precise and reliable results and include saliva collection in diagnostic guidelines.
Covıd-19 Enfeksiyonlarında Dizi Analizi Yöntemlerine Genel Bakış
(2022) Kılbaş, Elmas Pınar Kahraman; Aslan, Ferhat Gürkan; Altindis, Mustafa
Şiddetli akut solunum sendromu koronavirüs 2 (SARS-CoV-2), koronavirüs hastalığı 2019'un (COVID-19) etkeni olarak tanımlandı ve genomik veriler ilk olarak 10 Ocak 2020'de Çin tarafından paylaşıldı. O tarihten itibaren, dünya genelinde toplanan örneklerden viral genomu dizilemek için çok büyük çaba harcandı. Yakın geçmişte, kökenleri izlemek ve bulaşıcı ajanların evrimini anlamak, salgınların yayılma zincirlerini araştırmak, hem etkili ve hızlı moleküler tanı testlerinin geliştirilmesini kolaylaştırmak hem de tedavi ve aşıların araştırılmasına katkıda bulunmak için, yeni nesil dizileme (NGS) stratejileri, başarıyla kullanılmıştır. Teknoloji ve bilimdeki son gelişmeler, COVID-19'un etkeni olan ağır akut solunum sendromu koronavirüsü-2'nin (SARS-CoV-2) genomlarının, bir vakanın tanımlanmasından sonraki saatler veya günler içinde dizilenmesine olanak sağlamıştır. Bu sayede, ilk kez, bir pandeminin halk sağlığı ve epidemi boyutu gerçek zamanlı olarak izlenebilmektedir. SARS-CoV-2 genom dizilerinin erken paylaşımı, moleküler tanı testlerinin hızla geliştirilmesine olanak sağlayarak, küresel hazırlığa ve karşı önlemlerin tasarımına katkıda bulunmuştur. Hızlı, büyük ölçekli virüs genom dizilimi, viral salgınların dinamiklerini anlama ve kontrol önlemlerinin etkinliğini değerlendirmede oldukça önemlidir. SARS-CoV-2 gen dizilimi, gelişmiş tanılar, karşı önlemlerin geliştirilmesi ve hastalık epidemiyolojisinin araştırılması dahil olmak üzere birçok farklı alanda kullanılabilir. COVID-19'un etiyolojik ajanının genomik dizisini tam olarak tanımlamak için etkili ve hızlı dizileme yöntemlerinin geliştirilmesi, tanısal moleküler testlerin tasarımı ve pandemi yayılımını azaltmada etkili önlemlerin alınması ve stratejilerin belirlenmesinde temel olmuştur. Mevcut dizilerin sayısından anlaşıldığı gibi, SARS-CoV-2 genomlarına, farklı yaklaşımlar ve dizileme yöntemleri uygulanabilir. Bununla birlikte, her teknoloji ve dizileme yaklaşımının kendi avantajları ve sınırlamaları vardır. Bu derlemede, SARS-CoV-2 genomlarının dizilenmesi için şu andaki mevcut platformlar ve metodolojik yaklaşımlardan bahsedilecektir.
Citation - WoS: 2
The War Against the Resistance of acinetobacter Baumannii: a Meta-Analysis of Findings in Turkiye
(Erciyes Univ Sch Medicine, 2022) Ciftci, Ihsan Hakki; Kilbas, Imdat; Kilbas, Elmas Pinar Kahraman
Objective: Bacterial resistance to antibiotics continues to be a significant challenge to the global health system. This study was designed to examine changes in the antibiotic resistance of Acinetobacter baumannii (A. baumannii) strains isolated from various clinical samples taken between 2005 and 2020 and to support the development of new antibiotics policies for empirical treatment of multidrug-resistant isolates in Turkiye. Materials and Methods: This meta-analysis included a data search phase, determination of eligibility criteria, qualitative analysis of the studies selected, data extraction, and statistical analyses. All of the data were analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: According to Clinical and Laboratory Standards Institute and/or European Committee on Antimicrobial Susceptibility Testing standards and a random effects model, the breakpoint estimate of A. baumannii strain resistance in Turkiye for ampicillin-sulbactam, ceftazidime, imipenem, meropenem, gentamicin, amikacin, ciprofloxacin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, netilmicin, colistin, and tigecycline was 90.7%, 92.1%, 86.8%, 87.3%, 72.6%, 63.7%, 88%, 91.2%, 76.7%, 27.1%, 7.9%, and 18.5%, respectively. Conclusion: The reported rates of A. baumannii resistance from different regions demonstrated heterogeneity. Unfortunately, the use of standard antibiotics is unlikely to provide effective therapy throughout Turkiye. New therapy options and protocols are needed.
Citation - WoS: 1
Citation - Scopus: 1
Age-Specific Seroprevalence of Hepatitis a Virus in Turkey Between 2000 and 2023: Systematic Review and Meta-Analysis
(Mdpi, 2024) Ciftci, Ihsan Hakki; Koroglu, Mehmet; Demiray, Tayfur; Terzi, Huseyin Agah; Kilbas, Elmas Pinar Kahraman
Background: Hepatitis A virus (HAV) is a leading cause of acute viral hepatitis and is primarily transmitted by the fecal-oral route. The clinical presentation and progression of the disease varies according to the age of the patient. Turkey is classified as a moderately endemic country, and HAV infection continues to be an important public health problem worldwide. Methods: In this study, a systematic meta-analysis was conducted to evaluate age-specific HAV seroprevalence rates in Turkey between 2000 and 2023. A comprehensive literature review identified 57 articles that met the inclusion criteria. The studies were assessed for quality, and seroprevalence rates were evaluated across four different age groups. Statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software (CMAVersion 3.0) and SPSS (SPSS Statistics 25.0). Results: HAV seroprevalence rates were found to be 73.18% in the 0 < 5 age group and 90.90% in the >35 age group. The overall seroprevalence estimated using a random effects model was 64.5% (95% CI: 58.3-70). High heterogeneity was observed among the studies, and the prevalence estimates changed when low-quality studies were excluded. Conclusions: This meta-analysis suggests that the increasing trend in HAV IgG seroprevalence in Turkey, especially among young populations, is likely due to the vaccination program initiated in 2012. Furthermore, the heterogeneity observed among regions highlights the importance of regional public health strategies. Future studies should focus on providing more detailed data to evaluate the long-term effects of vaccination and to explain regional differences in HAV seroprevalence.
Citation - WoS: 1
Citation - Scopus: 1
Prevalence of Colistin-Resistant Klebsiella Pneumoniae Isolates in Turkey Over a 20-Year Period: a Systematic Review and Meta-Analysis
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Kahraman Kilbas, E.P.; Kilbas, I.; Ciftci, I.H.
Klebsiella pneumoniae is one of the leading causes of healthcare-associated infections and poses challenges in its treatment owing to its high antibiotic resistance. The development of resistance to colistin, which is used as a last resort, has become a major public health problem worldwide. This study was planned according to the PRISMA guidelines and included studies reporting the prevalence of colistin-resistant K. pneumoniae in Turkey between 2004 and 2024 through a systematic literature review. A total of 28 original research articles were included in the meta-analysis. Data were analyzed using the SPSS and CMA software. The pooled colistin resistance of a total of 8916 K. pneumoniae strains from 28 studies included in this meta-analysis was found to be 1.63% (95% CI: 1.51–3.12). Colistin resistance increased significantly over time. A higher resistance rate was detected in the strains tested using the EUCAST guidelines and broth microdilution method. The year of the study and validation methods contributed to the heterogeneity observed in the studies. This meta-analysis reveals that colistin-resistant K. pneumoniae strains have increased over time in Turkey. Current data show that colistin resistance is not only a laboratory finding but has become a crisis, requiring urgent action in terms of hospital infection management and patient safety. Regional and global measures should be taken to ensure the appropriate use of antibiotics to control the development of resistance. © 2025 by the authors.
Citation - WoS: 6
Citation - Scopus: 7
Molecular Epidemiology of Carbapenem-Resistant Acinetobacter Baumannii Isolates in Turkiye: Systematic Review
(Kare Publ, 2023) Kilbas, Elmas Pinar Kahraman; Kilbas, Imdat; Ciftci, Ihsan Hakki
The World Health Organization has designated carbapenem-resistant Acinetobacter baumannii (CRAB) as a "critical" pathogen on the global priority list of antibiotic-resistant bacteria. This study aims to discuss the molecular epidemiology of CRAB isolates in Turkiye in the last 12 years and the prevalence of gene regions associated with resistance or pathogenesis using a systematic review method. Our study consists of a literature search, determination of eligibility and exclusion criteria, qualitative analysis of studies, data extraction, and statistical analysis. All studies were analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Guidelines. The incidence rates of blaOXA-23, blaOXA-23-like, blaOXA-24/40, blaOXA-24/40-like, blaOXA-51, blaOXA-51-like, blaOXA-58, and blaOXA-58-like genes in CRAB strains were 76.4%, 68.6%, 1.2%, 3.4%, 97.0%, 98.6%, 8.4%, and 17.1%, respectively. It was determined that the prevalence of the blaOXA-23 and blaOXA-58 gene regions showed a statistically significant change over the years. Due to the high prevalence of A. baumannii strains carrying the blaOXA-23 variant, it is necessary to follow its geographical distribution and transposon and plasmid movements. Based on available data, molecular surveillance of CRAB strains should be standardized. In addition, sterilization and disinfection processes applied within the scope of an effective struggle against CRAB strains that can remain live on surfaces for a long time should be reviewed frequently.
Citation - WoS: 1
Update on the First Year of Covid-19
(Galenos Publ House, 2021) Kahraman Kilbas, Elmas Pinar; AltindIS, Mustafa; Yilancioglu, Kaan; TekIn, Ishak Ozel; Buran, Duran; Ozkan, Secil; Ilhan, Mustafa Necmi
The current outbreak of the Coronavirus, severe acute respiratory syndrome Coronavirus-2, which originated in the Wuhan province of the People's Republic of China became a pandemic. Although the clinical findings of the infection vary in adults, the most common symptoms are fever, dry cough, and shortness of breath. The diagnosis of the Coronavirus disease-2019 (COVID-19) is made by clinical symptoms, laboratory tests, and radiological methods. Many drugs such as antivirals, antibiotics, and corticosteroids are used in the treatment of COVID-19. For the successful control of the pandemic, prevention strategies are the key. There is strong consensus that, in addition to wearing masks, hand hygiene, and social distancing, an effective COVID-19 vaccine is probably the most effective approach to sustainably control the pandemic. In this article, current information about the pathogenesis, epidemiology, risk groups, diagnosis, treatment, prevention strategies, and vaccination of the disease in the first year of the COVID-19 pandemic are discussed.
Citation - WoS: 1
Citation - Scopus: 2
Seroprevalence of Torch Viral Agents in Pregnant Women in Turkey: Systematic Review and Meta-Analysis
(Mdpi, 2025) Kilbas, Elmas Pinar Kahraman; Ciftci, Ihsan Hakki; Kilbas, Imdat; Toptan, Hande
Rubella Virus, Cytomegalovirus (CMV), Herpes Simplex Virus-2 (HSV-2), Hepatitis B (HBV) and Hepatitis C virus (HCV) can cause serious fetal disease. The seropositivity rates of these agents vary among countries and geographic regions. This study aimed to analyze the prevalence rates and diagnostic methods used in studies investigating the seroprevalence of viral pathogens in the TORCH group among pregnant women in Turkey between 2005 and 2024. A systematic search was conducted using electronic databases between January 2005 and January 2024. A total of 60 studies meeting the inclusion criteria were included. Data quality control was assessed using the Joanna Briggs Institute guideline prevalence studies checklist. Heterogeneity was measured using the I-squared (I-2) statistic in the Comprehensive Meta Analysis (CMA) program. The average seropositivity rates for Rubella, CMV, HSV-2, HBV and HCV in Turkey were determined as 91.18%, 94.81%, 35.52%, 1.66% and 0.25%, respectively. When the diagnostic methods were examined, it was determined that ELISA and ECLIA methods were used most frequently. The seropositivity of the agents did not show statistically significant differences according to the year periods, geographical regions and age of the patients (p > 0.05). The highest prevalence rates of Rubella and HSV-2 in pregnant women were reported in the Mediterranean region, the highest prevalence rates of CMV and HCV in the Southeastern Anatolia region and the highest seroprevalence of Anti HBs in the Marmara region. The results of this study support the necessity of increasing public awareness in the control of fetal infection caused by TORCH viral agents, prenatal screening, vaccination for Rubella and HBV and compliance with hygiene conditions for agents such as CMV, HSV-2 and HCV. The results of this study highlight the need to increase public awareness on prenatal screening for the control of fetal infection caused by all TORCH viral agents, vaccination for Rubella and HBV and compliance with hygiene conditions for agents such as CMV, HSV-2 and HCV.