Şahin, Sevim

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Profile URL
https://hdl.handle.net/20.500.14627/509
Name Variants
Şahin, S.
Sahin, S.
Sahin, Sevim
Job Title
Doktor Öğretim
Email Address
sevim.sahin@fbu.edu.tr
Main Affiliation
Elektrik-elektronik Mühendisliği Bölümü
Status
Website
ORCID ID
0000-0002-0886-3762
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
ACU-4827-2022
Files
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Sustainable Development Goals

15

LIFE ON LAND
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3

GOOD HEALTH AND WELL-BEING
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AFFORDABLE AND CLEAN ENERGY
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RESPONSIBLE CONSUMPTION AND PRODUCTION
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INDUSTRY, INNOVATION AND INFRASTRUCTURE
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QUALITY EDUCATION
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Scholarly Output

4

Articles

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Citation Count

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2021 - 20252
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Now showing 1 - 2 of 2
  • Thumbnail Image
    Article
    The Therapeutic Role of Ginseng in Promoting Hippocampal Neurogenesis and Ameliorating Cognitive Function Following Whole Brain Radiotherapy in Rats
    (Springer/Plenum Publishers, 2025) Sahin, Sevim; Bayindir, Nihan; Ertas, Busra; Ceylan, Cemile; Elibol, Birsen; Ozkan, Alper; Sener, Goksel
    Whole-brain radiotherapy (WBRT) is a prevalent technique for managing multiple intracranial metastases, however, the cognitive damage in long-term survivors due to WBTR is a critical concern that impacts patients' quality of life. Panax ginseng, a bioactive compound recognized for its neuroprotective benefits, also enhances cognitive functions, including memory and learning. This study aims to examine the potential protective effects of Panax ginseng supplementation on cognitive dysfunction and the levels of neurogenesis-related proteins in the hippocampus of rats that underwent WBRT, which was delivered as 3 fractions of 6 Gy (total dose 18 Gy) using a linear accelerator. Thirty-six male Sprague-Dawley rats were divided into three groups: radiation, ginseng treatment, and control. After 60 days of Panax ginseng administration (100 mg/kg), behavior tests (Morris water maze and novel object recognition) were performed, followed by western blot analysis of the hippocampus. Results indicated that Panax ginseng supplementation ameliorated radiation-induced cognitive impairments. Additionally, western blot analyses revealed that Panax ginseng promoted neuronal recovery and neuroplasticity processes in the hippocampus, simultaneously exhibiting a neuroprotective mechanism by reducing apoptosis and neurotoxicity markers. Panax ginseng ameliorates cognitive dysfunction after WBRT by enhancing neurogenesis and diminishing cell death in the hippocampus.
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    Article
    Efficiency of Modulated and Dose Rate Altered Flattening Filter Free Beams in High Dose Per Fraction Radiotherapy Applications on the Survival of Prostate Cancer Cell Lines
    (Ijrr-iranian Journal Radiation Res, 2021) Ceylan, C.; Ozturk, A.; Gungor, G.; Karabey, A. U.; Sahin, S.; Duruksu, G.; Gundogdu, O.
    Background: The radiobiological effect of high dose rate FFF beams on the DU-145 cells was investigated with SBRT plans which have >10 Gy. Methods and Materials: To compare the radiobiological effect on DU-145 cell line four experiments designed: (1) the constant dose rate of 6 MV and 6 MV FFF with increased dose per pulse (2) the effect of dose per pulse while increasing instantaneous dose rate for 6 MV and 6 MV FFF, (3) the effect of increased average dose rate for 6 MV FFF and (4) the effect of protracted treatment time and modulation of 6 MV FFF beams. The survival fraction was counted with WST. Results: FF and FFF for 6 MV with same dose rate and treatment time has no effect on cell survival. Significant differences was observed on survival which were irradiated with 6 MV 600 MU/min and 6 MV FFF 1400 MU/min (p=0.024). There was no difference between 6 MV FFF 600 MU/min and 6 MV FFF 1400 MU/min for 10 Gy. The significant survival difference obtained for 20 Gy. The survival percentages for both 10 Gy and 20 Gy with Cyberknife were obtained higher than FFF. Conclusion: Our in-vitro study presented here show that higher dose rate and reduced treatment time might become a crucial factor for SBRT especially which has >10 Gy fraction dose.