WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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Subject: search.filters.subject.Prostate CancerWoS Q: search.filters.wosQuartile.Q2

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  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Evaluation of the Effect of Sociodemographic Characteristics of Patients With Prostate Cancer on Their Sexual Experiences and Self-Efficacy Sexual Experiences and Self-Efficacy of Individuals With Prostate Cancer
    (Springer, 2023) Eroglu, Nermin; Ozkan, Ilknur
    The study was planned as a descriptive study to evaluate the effects of sociodemographic characteristics of prostate cancer patients on their sexual experiences and self-efficacy. The sample of the study consisted of 69 patients with prostate cancer who were followed up for treatment in the outpatient clinic of an oncology hospital between December 2020 and March 2021 and met the inclusion criteria of the stud. Research data were collected by using the Patient Information Form, Arizona Sexual Experiences Scale (ASEX)-Male, and Sexual Self-Efficacy Scale (SSES). The mean age of prostate cancer patients was 67.1 & PLUSMN; 11.74 years, 95.7% (n = 66) were married, 37.7% (n = 66) were university graduates, and 75.4% (n = 52) were unemployed. Patients' mean scores were 19.29 & PLUSMN; 7.66 on the total Sexual Self-Efficacy Scale and 22.08 & PLUSMN; 4.92 on the total Arizona Sexual Experiences Scale. In the study, it was determined that the sexual experiences and sexual self-efficacy of prostate cancer patients differed according to their education level, employment status, and duration of treatment. In the study, it was determined that patients with prostate cancer experienced sexual dysfunction and had low self-efficacy. In line with these results, our recommendations are for health professionals to evaluate the sexual functions of patients with prostate cancer and their sexual self-efficacy, which is an important determinant of sexual life, during the diagnosis, treatment, and care process. In addition, the sociodemographic characteristics of the patients should be considered when planning interventions that increase sexual self-efficacy in the management of sexual problems.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    A Novel Petox-Based Nanogel Targeting Prostate Cancer Cells for Drug Delivery
    (Wiley-v C H verlag Gmbh, 2024) Gulyuz, Sevgi; Sessevmez, Melike; Ukuser, Gokcen; Khalily, Melek Parlak; Tiryaki, Selen; Sipahioglu, Tarik; Yilmaz, Ozgur
    This study focuses on creating a specialized nanogel for targeted drug delivery in cancer treatment, specifically targeting prostate cancer. This nanogel (referred to as SGK 636/Peptide 563/PEtOx nanogel) is created using hydrophilic poly(2-ethyl-2-oxazoline) (PEtOx) through a combination of living/cationic ring-opening polymerization (CROP) and alkyne-azide cycloaddition (CuAAC) "click" chemical reactions. A fluorescent probe (BODIPY) is also conjugated with the nanogel to monitor drug delivery. The characterizations through 1H-NMR, and FT-IR, SEM, TEM, and DLS confirm the successful production of uniform, and spherical nanogels with controllable sizes (100 to 296 nm) and stability in physiological conditions. The biocompatibility of nanogels is evaluated using MTT cytotoxicity assays, revealing dose-dependent cytotoxicity. Drug-loaded nanogels exhibited significantly higher cytotoxicity against cancer cells in vitro compared to drug-free nanogels. Targeting efficiency is examined using both peptide-conjugated and peptide-free nanogels, with the intracellular uptake of peptide 563-conjugated nanogels by tumor cells being 60-fold higher than that of nanogels without the peptide. The findings suggest that the prepared nanogel holds great potential for various drug delivery applications due to its ease of synthesis, tunable functionality, non-toxicity, and enhanced intracellular uptake in the tumor region. This study emphisizes an innovative PEtOx-based nanogel tailored for targeted drug delivery in prostate cancer. Developed using click chemistry, a valuable technique for chemical synthesis, it exhibits consistent nanogel formation with customizable sizes. In vitro, drug-loaded nanogel exhibits potent cytotoxicity against cancer cells. Notably, peptide-conjugated nanogels significantly boost tumor cell uptake, showcasing promising promising potential for effective cancer drug delivey.image