WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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Subject: search.filters.subject.ObesityWoS Q: search.filters.wosQuartile.Q4

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Now showing 1 - 5 of 5
  • Article
    Citation - WoS: 1
    Citation - Scopus: 2
    Apocynin Exhibits an Ameliorative Effect on Endothelial Dysfunction/ Atherosclerosis-Related Factors in High-Fat Diet-Induced Obesity in Rats
    (Marmara Univ, Fac Medicine, 2024) Ayci, Nurdan Bulbul; Ertas, Busra; Kaya, Rumeysa Keles; Sevinc, Sevgi Kocyigit; Amuran, Gokce Gullu; Ercan, Feriha; Cetinel, Sule; Keles Kaya, Rumeysa; Bulbul Ayci, Nurdan; Kocyigit Sevinc, Sevgi
    Objective: The aim of this study was to reveal the effect of apocynin (APO) on the factors involved in obesity-related endothelial dysfunction (ED) and atherosclerosis (AS). Materials and Methods: Male Wistar albino rats were divided into control (CNT), high-fat diet (HFD) and HFD+APO groups. HFD and HFD+APO groups were fed HFD for sixteen weeks. APO (25 mg/kg) was administered to the HFD+APO group for the last four weeks. The effects of APO on: AS-related metabolic parameters (triglyceride, total cholesterol, high-density lipoprotein-cholesterol, insulin and leptin), oxidative stress (OS), [ malondialdehyde, glutathione, nicotinamide adenine dinucleotide phosphate (NADPH)oxidase-2, oxidised-low-density lipoprotein (ox-LDL) and 8-hydroxy-2-deoxyguanosine], low-density lipoprotein and ox-LDL uptake potential (activin receptor-like kinase-1 and lectin-like oxidized low-density lipoprotein receptor-1, respectively), tissue inflammation inducible-nitric oxide synthase, nitric oxide), programmed cell death (terminal deoxynucleotidyl-transferase-dUTP-nick-end (alpha-smooth muscle actin), histology and ultrastructure of thoracic aorta were evaluated. Results: In obesity, APO had an ameliorative effect on metabolic parameters, OS, inflammation, ED, programmed cell death and oxLDL uptake potential, but not on foam cell formation and LDL uptake potential. Conclusion: Apocynin may improve ED and AS in obesity by suppressing OS-linked factors involved in the early stage of AS.
  • Article
    Citation - WoS: 1
    Morphological Andbiochemical Evaluation of Effects Of<i> Myrtus</I><i> Communis</I> L. Extract on Heart and Aorta in High Fat-Diet Obese Rats
    (Marmara Univ, Fac Medicine, 2023) Yay, Nagehan Ozyilmaz; Ayci, Nurdan Bulbul; Kaya, Rumeysa Keles; Sen, Ali; Sener, Goksel; Ercan, Feriha
    Objective: The purpose of this study was to examine the protective effects of Myrtus communis L. (MC) extract on high fat-diet (HFD) induced heart and aorta damage by evaluating oxidative stress and the endothelial nitric oxide system (eNOS).Materials and Methods: Wistar albino male rats were divided into 3 groups (n=7) as control, HFD, and HFD+MC. Rats in HFD and HFD+MC groups were HFD fed for 16 weeks and in the last 4 weeks saline or MC (100 mg/kg) was administered orally (5 days/week). Triglyceride, cholesterol, and high-density lipoprotein (HDL) were estimated in blood serum. Tissue oxidative stress and inflammatory parameters were evaluated biochemically. Tissue morphologies, eNOS, inducible NOS (iNOS), and NADPH oxidase-2 (NOX-2)-immunopositive and apoptotic cells were evaluated histologically.Results: Altered serum lipid profiles, degenerated heart, and aorta morphology, increased malondialdehyde, 8-hydroxy-2-deoxyguanosine, tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and myeloperoxidase levels, and iNOS, NOX-2 immunopositive and apoptotic cells, decreased NO levels, eNOS-immunopositive cells in both tissues were observed in HFD group. All these parameters improved in the HFD+MC group. Conclusion: This study revealed that HFD-induced obesity increased iNOS activation and oxidative stress in the cardiac and aortic tissues of the rats. MC improved oxidant/antioxidant balance and prevented heart and aorta damage via eNOS involvement.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 4
    Prevalence of Obesity in Prepubertal and Pubertal With Turkish Population Type 1 Diabetes
    (Springer Japan Kk, 2021) Ozkaya, Volkan; Eren, Erdal; Ozgen Ozkaya, Sebnem; Denkboy Ongen, Yasemin
    To determine the prevalence of prepubertal and pubertal obesity in children and adolescents with type 1 Diabetes Mellitus (Type 1 DM). One hundred fifty children and adolescents aged 6-18 years with Type 1 DM who attended the Pediatric Endocrinology Polyclinic and were diagnosed with type 1 DM were included in the study. Tanner staging was used to estimate pubertal status. Age- and gender-specific body mass index (BMI) percentile between 85 and 95% was accepted as overweight and > 95% as obese. It was determined that the overweight prevalence rates in children and adolescents with type 1 DM were 13.3% and the obesity rate was 14.3%. It was found that while the overweight prevalence rates (14.1%) were higher in males, the obesity prevalence was higher in females (19.0%). The obesity prevalence rates at the prepubertal and pubertal stages were found to be 17.1% and 13.8%, respectively. The obesity prevalence at the pubertal stage was higher in girls (22.4%) than boys (3.9%) (p < 0.05). The rates both of overweight and obesity in boys decreased from prepubertal to pubertal periods, while those rates increased in girls. Our results indicated that the obesity prevalence in prepubertal and pubertal children and adolescents with type 1 DM was higher compared to healthy peers in the literature. The authors believe that the risk factors for obesity in this population should be determined and obesity-prevention programs for diabetes should be prepared.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    Effects of <i>myrtus Communis</I> L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats With a High Fat-Diet
    (Galenos Publ House, 2021) Yasar, Ruya Kuru; Kuru, Dilruba; Sen, Ali; Sener, Goksel; Ercan, Feriha; Yarat, Aysen; Kuru, Ruya
    Objectives: Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals. Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor. The data on tissue boron levels are quite lacking. The aim of this novel study was to investigate the effects of Myr and Apo treatment on boron levels and oxidative lens damage in rats fed a high-fat diet (HFD). Materials and Methods: Wistar albino male rats were randomly divided into four groups: the control group, HFD group, HFD + Myr group, and HFD + Apo group. Body weight and blood lipids were determined before and after the experiment. After decapitating the rats, the lenses were removed and homogenized. Catalase (CAT) and superoxide dismutase (SOD) activities and boron, malondialdehyde (MDA), and reduced glutathione (GSH) levels in the lens homogenates were determined. Results: The HFD increased serum triglyceride (p<0.05), total cholesterol level (p<0.001), body weight (p<0.001), and lens MDA levels (p<0.01) and decreased lens GSH (p<0.05) and boron level (p<0.01), SOD (p<0.001), and CAT activity (p<0.001). However, Myr and Apo treatment reduced the rats' body weight (p<0.001), serum triglyceride (p<0.05), and total cholesterol level (p<0.001) and increased lens boron (p<0.01; p<0.001), GSH levels (p<0.05; p<0.01), and CAT activity (p<0.001). Conclusion: Both Myr and Apo may be able to reduce oxidative stress in the lenses of obese rats caused by HFD by increasing boron levels.
  • Article
    Citation - WoS: 3
    Obesity Risk Factors in Turkish Preschool Children: a Cross-Sectional Study
    (Cukurova Univ, Fac Medicine, 2022) Ozkaya, Sebnem Ozgen; Ozkaya, Volkan; Garipagaoglu, Muazzez
    Purpose: The present study aims to identify the potential risk factors - pre and post-pregnancy, children's, parental, and environmental factors - concerning obesity in Turkish preschool children.Materials and Methods: The cross-sectional study was conducted with 538 children aged 3-5 and their mothers in 25 private and public kindergartens using a face-to-face survey. Demographic, anthropometric, nutrition, sleep, and physical activity information during pregnancy, infancy, and preschool periods were evaluated. Two-day food records and anthropometric measurements of the children were collected.Results: The prevalence of overweight and obesity in preschool children was found to be 27.0%. Among the 28 potential risk factors examined, pre-pregnancy obesity (odds ratios (OR):1.108, confidence interval (CI): 1.042-1.179), post-pregnancy obesity (OR:4.350, CI: 2.053-9.217), caffeine intake >200 mg/day during pregnancy (OR:1.588, CI:1.031-2.446), father with obesity (OR: 1.089, CI: 1.027-1.155), enrolling a private rather than a public kindergarten (OR: 2.093, CI:1.298-3.376), fast eating (OR:3.355, CI: 1.175-9.583 min), short lunch duration (OR:0.966, CI:0.934-0.998), daily sleep of <10 hours (OR:2.522, 1.439-4.421), and finally screen time of >2 hours/day (OR:1.560, CI:1.012-2.405) were found to be significantly correlated with obesity in preschool children.Conclusion: Parental obesity, caffeine intake during pregnancy, eating speed, daily sleep, and screen time were determined as obesity risk factors in Turkish preschool children. Identifying maternal and child risk factors in early childhood, regulating lifestyle and obesogenic environment can be protective against obesity.