WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Citation - WoS: 2Analysis of Selected Steroid Hormones in Sea of Marmara Sediment Samples by Lc-esi/Ms-ms(Istanbul Univ, Fac Pharmacy, 2023) Aysel, Esra; Yurdun, TurkanBackground and Aims: Sediment is the general name given to the muddy structure located at the bottom of aquatic environments such as the sea. In our study, the amounts of steroid hormones were investigated in the sediment samples taken from the Marmara Sea. According to other studies, it has been determined that the excess of the hormone load in the sediments may be an indicator of human/animal sourced pollution, as well as the negative effects of the hormones mixed in the seas with the ecological cycle on the health of humans and animals.Methods: In our study, 31 selected human/animal, plant, natural and synthetic hormone-steroids were studied using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI/MS-MS). Methanol and QuEChERS were used as extraction methods. Sediment samples were taken from a total of 27 points selected for sampling at the Marmara Sea.Results: According to the results we found, the androgens: androsterone (24.50-1718.18 ng g-1), testosterone (86.30-1600.32 ng g-1); the estrogens: mestranol (33.73-228.32 ng g-1), equilin (53.44-1232.53 ng g-1); the progestagens; pregnenolone (37.50374.76 ng g-1), progesterone (39.96-405.60 ng g-1); levonorgestrel (325.25 and 937.93 ng g-1); the fecal sterols: cholestanone (57.57-1726.32 ng g-1), coprostanol + epicoprostanol (51.43-1370.33 ng g-1); and the plant sterol; campesterol (35.30-1859.90 ng g-1) were the compounds detected.Conclusion: Estrogens and progestogens are active components of birth control pills, and cholestanone and coprostanol + epicoprostanol are steroids that are indicative of human/animal pollution. Coprostanol + epicoprostanol and cholestanone, which are indicators of fecal pollution, were detected in all sediment samples. In our study, steroid hormones were detected for the first time in Sea of Marmara sediments and possible environmental risks were evaluated.Article Citation - Scopus: 1Ethanolic Extract of Cotinus Coggygria Leaves Attenuates Crystalluria and Kidney Damage in Ethylene Glycol-Induced Urolithiasis in Rats(Kare Publishing, 2023) Gumru, S.; Ozgur, G.; Ertas, B.; Sen, A.; Eker, P.; Sener, T.E.; Sener, G.OBJECTIVE: Nephrolithiasis is a common cause of kidney insufficiency. Nephrolithiasis is proven to be the result of various biochemical and inflammatory processes that result in crystal formation and subsequent aggregation. Cotinus coggygria L. (CCog) is a plant extract which has been used as a Turkish remedy for kidney stones. With this study, we planned to evaluate the effects of CCog extract in ethylene glycol (EG)-induced nephrolithiasis model in rats. METHODS: The study group comprised 32 Wistar albino rats which were divided into Control (C), EG, CCog Prophylaxis (CC+EG+CC), and CCog Treatment (EG+CC) groups. Stone formation was induced by adding EG (0.75%) into rat’s drinking water. Normal drinking water was given to Control group for 8 weeks. Throughout the study period of 8 weeks, EG group was given only EG (0.75%) and CC+EG+CC group was given both EG and CCog. In EG+CC group, EG (0.75%) was given for 8 weeks whereas CCog was given for the past 4 weeks. After the 8th week, 24-h urine samples were collected. Rats were then sacrificed and kidney tissue samples were harvested. RESULTS: Metabolites (calcium, citrate) and creatinine in 24 h urine samples were decreased in CC+EG+CC and EG+CC groups. While hyperoxaluria was observed in the EG group, oxalate levels were similar to control levels in the P-CCog and C-CCog groups. The N-acetyl-β-glucosaminidase and myeloperoxidase activities were both increased in EG group and these parameters were significantly decreased on CCog treatment. CONCLUSION: We can conclude that C. coggygria extract can have beneficial effect on lowering concentration of stone-forming metabolites in urine and consequently protect renal tissues from damage due to nephrolithiasis. C. coggygria extract can be considered as a potential prophylactic and therapeutic option in high-risk stone formers. Furthermore, our data confirm ethnobotanical use of CC against nephrolithiasis. © 2023 by Istanbul Provincial Directorate of Health.Article Citation - WoS: 4Citation - Scopus: 3Multidrug Resistance in Pathogens of Community-Acquired Urinary Tract Infections in Turkey: a Multicentre Prospective Observational Study(Tubitak Scientific & Technological Research Council Turkey, 2023) Sencan, Irfan; Karabay, Oguz; Altay, Fatma Aybala; Suzuk Yildiz, Serap; Simsek, Husniye; Gozukara, Melih Gaffar; Surme, Serkan; Engin, Derya Öztürk; Cag, Yasemin; Kul, Gülnur; Habip, Zafer; Kaya, Safak; Tasbakan, MeltemBackground/aim: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options.Materials and methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed. Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advanced age, and having two or more risk factors showed a statistically significant relation with MDR existence (p < 0.001, p: 0.014, p < 0.001, respectively) that increasing number of risk factors or degree of advancing in age directly affects the number of antibiotic groups detected to have resistance by pathogens. In total, MDR isolates corresponded to 36.1% of our CAUTI samples; MDR existence was 35.7% in E. coli isolates and 57.2% in Klebsiella spp. isolates. Our results did not show an association between resistance or MDR occurrence rates and NUTS regions.Conclusion: The necessity of urine culture in outpatient clinics should be taken into consideration, at least after evaluating risk factors for antibacterial resistance individually. Community-acquired UTIs should be followed up time-and region-dependently. Antibiotic stewardship programmes should be more widely and effectively administrated.Article Relationship Between Coronaphobia, Cognitive Functions, Sleep Quality, and Diet Quality in Older Adults During Covid-19(Galenos Publ House, 2024) Balci, Leyla Atas; Polat, Selda; Coskunsu, Dilber Karagoezoglu; Altuncevahir, Ilayda; Koc, Bilge Meral; Ozkul, EcenurObjective: The relationship between the quality of diet and sleep, cognitive function, and fear related to coronavirus disease-2019 (COVID-19) among older adults in Turkey during the pandemic remains unclear. This study aimed to investigate the correlation between diet quality, cognitive function, sleep quality, and levels of coronaphobia in individuals aged 65 and above, to understand the impact of COVID-19. Materials and Methods: Sleep quality, diet quality, coronaphobia, and cognitive status of 72 older individuals were evaluated using the Pittsburgh sleep quality index, healthy eating index 2010, Montreal cognitive assessment scale, and coronavirus-19 phobia scale, respectively. Results: The participants had poor diet quality (54.2%), poor sleep quality (62.5%), obesity (41.7%), higher levels of coronaphobia, and cognitive impairment. There was a moderate negative relationship between sleep quality and coronaphobia and between cognitive status and coronaphobia (p <= 0.00); and a weak positive relationship between diet quality and cognitive status (p<0.05). However, no relationship was found between sleep quality and diet quality, and between coronaphobia and diet quality (p>0.05). Conclusion: Our study highlights the significant challenges faced by older adults during the COVID-19 pandemic, including poor nutrition quality, sleep disturbances, coronaphobia, and cognitive impairment. Our findings suggest a potential interplay between nutrition quality, sleep patterns, and cognitive function among older adults, with those experiencing coronaphobia exhibiting additional cognitive and sleep-related concerns. We advocate the implementation of targeted interventions aimed at mitigating cognitive impairment, addressing nutritional deficiencies, and improving sleep quality among older adults, irrespective of COVID-19 infection status, to enhance overall well-being during these challenging times.Article Evaluation of Growth in Children Aged One- Two Years: a Cross- Sectional Study(Istanbul Univ, 2022) Guldemir, Hilal Hizli; Simsek, Tugce; Garipagaoglu, MuazzezObjective: The study was conducted to evaluate growth in children aged 1-2 years. Methods: In this study conducted with 302 children and their mothers, data on children and their families were obtained using a questionnaire. Z-scores were determined by measuring the weight and height of the children, and these were compared with percentile curves developed for Turkish children. Energy and macronutrient consumption were determined by taking a daily food consumption record for each child. Results: The average age, birth weight and height of children were 18.6 +/- 3.2 months, 3.2 +/- 0.5 kg and 50.0 +/- 2.3 cm, respectively. Their current weight and height were determined as 11.4 +/- 1.6 kg and 80.6 +/- 6.5 cm. It was observed that 85.6% of the children had normal body weight, 69.5% normal BMI and 56.2% normal height z score. It has been determined that body weight and height z-scores are higher in girls compared to boys (22.1%, 32.6% and 24.7% respectively in + 2SD). Body weights of children with high monthly income were also found to be significantly higher (15.6% in + 2SD, p=0.038). Conclusions: It has been concluded that the standards, gender and the economic status of the family in this age period are effective on childrens' growth.Article Citation - WoS: 4Citation - Scopus: 4Is Plantar Foot Sensation Affected in Patients With Gonarthrosis(Turkish Assoc Orthopaedics Traumatology, 2021) Tascilar, Lacin Naz; Utlu, Defne Kaya; Sayaca, Cetin; Polat, Gokhan; Kuyucu, Ersin; Erdil, Mehmet Emin; Utlu, Prof.dr. Defne KayaObjective: The aim of this study was to compare pain, plantar foot sensation, postural control, fear of movement, and functional level between women patients with early-stage gonarthrosis and those with late-stage gonarthrosis. Methods: A total of 62 women with gonarthrosis were included in the study. Patients were then divided into two groups: early-stage gonarthrosis group (31 women) and late-stage gonarthrosis group (31 women) according to Kellgren Lawrence criteria. Light touch-pressure sensation (Semmes Weinstein Monofilaments), two-point discrimination sensation (esthesiometer), and vibration sensation (128 Hz diapason) were used to evaluate plantar foot sensation. Pain intensity was assessed by the numeric rating scale, postural control by Berg balance scale, fear of movement by the Tampa kinesiophobia scale, functional mobility by the Timed Up and Go test and knee injury and osteoarthritis outcome score. Results: Early-stage patients were found to have higher light-touch pressure sensation on 1st metatarsal head of dominant side, 5th metatarsal head of non-dominant side, heel of non-dominant side than late stage patients. Early-stage patients had a higher sensation of vibration than late stage patients. The patients in the early stage were found to have higher two-point discrimination sensation on middle of dominant side, heel of dominant side, trans-metatarsal of non-dominant side, middle of non-dominant side, heel of non-dominant side than late stage. Postural control of early-stage patients were found to be higher than late-stage patients. Early-stage patients had lower kinesophobia and higher functional levels than late-stage patients. Conclusion: The light touch sensation, vibration sensation, and two-point discrimination deteriorated by the progression of the disease should be important criteria in patients with gonarthrosis.Article Investigation of the Synergic Effect of the Colistin/Sulbactam Combination in Carbapenem-Resistant <i>acinetobacter Baumannii</I> Complex Strains With Time-Kill and Checkerboard Methods(Bilimsel Tip Yayinevi, 2021) Kilbas, Imdat; Hatipoglu, Huseyin; Kilic, Umit; Kahraman Kilbas, Elmas Pinar; Koroglu, Mehmet; Altindis, Mustafa; Kılbaş, Elmas Pınar KahramanIntroduction: Infections caused by carbapenem-resistant Acinetobacter strains have become very common in recent years, and the most frequently used medicinal treatment is colistin. Combination treatments should also be applied to prevent development of resistance to colistin. This study examines the in vitro synergic effect of the colistin/sulbactam combination in carbapenem-resistant Acinetobacter strains with the time-kill and checkerboard methods. Materials and Methods: Twenty carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex strains, which were isolated from various clinical samples, were included in this study. Strains were identified with mass spectrometry, and antibiotic sensitivity results were determined with the VITEK 2 (R) system. The in vitro effect and synergic activity of the colistin, sulbactam, and colistin/sulbactam combination on the carbapenem-resistant strains were determined using the time-kill and checkerboard methods. Seventeen strains were examined with the time-kill method, and twenty strains were examined using the checkerboard method. The fractional inhibitory concentration index of strains was calculated for detection of synergic effect. Results: Using the time-kill method applied on the colistin/sulbactam combination showed that the combination had a synergic effect on all 17 strains, while sulbactam alone did not have a bactericidal effect in the studied concentrations. When applying the checkerboard method, it was determined that the colistin/sulbactam combination had a synergic effect on 17 of the strains (85%) and an additive effect on 3 strains (15%), sulbactam had a low effect alone (15%), and colistin was effective on all strains. Conclusion: Study results indicated that the colistin/sulbactam combination had a high level of synergic effect on all studied strains using both methods.