WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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Subject: search.filters.subject.Breast CancerWoS Q: search.filters.wosQuartile.Q4

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  • Article
    Citation - WoS: 7
    Effect of Flurbiprofen Derivative (sgk597) on Cell Proliferation and Apoptosis of Breast Cancer Cell Lines
    (Istanbul Univ, Fac Pharmacy, 2022) Atlihan, Irem; Sevinc, Sevgi Kocyigit; Orun, Oya; Yilmaz, Ozgur; Kucukguzel, S. Guniz; Tiber, Pinar Mega
    Background and Aims: The incidence of breast cancer is increasing day by day, especially in women. The search for new drugs against breast cancer is the focus of attention in research. Breast cancer and prostate cancer have remarkable biological similarities. Therefore, the 4-(4-chlorophenyl)-3-(1-(2-fluoro-[1,1'-biphenyl]-4-yl)ethyl)-5-((4-fluorobenzyl)thio)-4H-1,2,4-triazole (SGK597) compound that is suppressing cell proliferation in prostate cancer, was studied in MCF-7 breast can-cer and MCF-10A mammary epithelial cell lines. Methods: The WST-8 method was used to determine cell viability and cytotoxicity of SGK597 in MCF-7 and MCF10-A cell lines. The JC-1 test was applied to determine changes in mitochondrial membrane potential. The protein expression levels of Bax, Bcl-2, and c-PARP associated with apoptosis were determined using Western blot analysis.Results: After 24 and 48 hours of incubation of SGK597, the IC50 values were 28.74 pM and 17.28 pM for MCF-7; 65.9 pM and 50.5 pM for MCF-10A, respectively. Mitochondrial membrane potential showed a tendency toward depolarization in MCF-7 cells as a result of increasing concentration of SGK597, while the same tendency was not seen for MCF-10A. As a result of western blot experiments, no increase in the Bax/Bcl-2 ratio and c-PARP expression level was observed, indicating no apoptosis.Conclusion: It was observed that the compound SGK597 suppressed MCF-7 cell proliferation. These results indicate that SGK597 may be a candidate compound for use as an anticancer agent. Keywords: Apoptosis, breast cancer, flurbiprofen, thioether, triazole
  • Article
    Validity and Reliability of the Symptom-Management Self- Efficacy Scale for Breast Cancer Related To Chemotherapy
    (Galenos Publ House, 2022) Semiz, Demet; Saglam Aksut, Rabia; Sağlam, Rabia
    Objective: Since breast cancer (BC) is one of the most common cancer types among women, it is very important for nurses to assess symptom-management and self-efficacy of patients during chemotherapy treatment. This study was carried out to examine the validity and reliability of the symptom-management self-efficacy scale for BC related to chemotherapy. Methods: The study sample of this methodological research consisted of 248 women receiving chemotherapy treatment due to breast cancer in a public hospital in Istanbul between November 2017 ans March 2018. Translation-back translation method was used to assess the language validity of the scale. Kaiser-Mayer-Olkin and Bartlett's tests were applied to evaluate the sampling adequacy and the suitability of the data for factor analysis. Results: The content validity of the Turkish form was 0.912; Cronbach alpha coefficient of the scale was 0.905. The factor loads of all the items belonging to the scale were above 0.40, and explained variance for the scale was as follows; 16,284 for the problem-solving sub-dimension; 13,517 for the sub-dimension of managing problems in emotional and interpersonal relationships, and total explained variance of the scale was found to be 46,944. For this reason, no items were removed from the scale and the scale was accepted as having 3 sub-dimensions as it was in the original. Conclusion: Findings obtained from this study showed that the Turkish version of the scale was valid and reliable and could be used in research and clinical practice in Turkey.