WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Effect of Gender Equality Education on Health Students Gender Perceptions and Roles: A Randomized Controlled Trial(Routledge Journals, Taylor & Francis Ltd, 2026) Isbay Aydemir, Beyzanur; Sahin Tokatlioglu, Tugba; Kuru Akturk, Nur Bahar; Dikec, GulAim To evaluate the impact of community gender equality education program on health sciences students' perceptions of gender, gender roles, and their awareness of social norms and gender inequality. Design A single-blind, two-arm, parallel-group randomized controlled trial. Methods Conducted with 70 students at a foundation university in Istanbul (2024-2025). The intervention group received two weeks structured training. Data were collected using the Perception of Gender Scale (PGS) and Gender Roles Attitude Scale (GRAS). Results No significant differences were observed at baseline. Post-intervention, the intervention group showed significant improvements in PGS and GRAS scores, while no change was found in the control group. Conclusion Short-term gender equality education program effectively improved students' gender perceptions and attitudes.Article Machine Learning Model for Predicting Multidrug Resistance in Clinical Klebsiella pneumoniae Isolates(MDPI, 2026) Akkaya, Yuksel; Aydin, Irfan; Tanyildizi-Kokkulunk, Handan; Erturk, Ayse; Kilic, Ibrahim HalilBackground/Objectives: Klebsiella pneumoniae is an opportunistic pathogen increasingly resistant to carbapenems and broad-spectrum antibiotics, complicating timely infection management. In critical cases like septic shock, where initiating effective antibiotics within 3 h improves survival, culture-based resistance testing is often too slow. This study evaluates machine learning (ML) algorithms for faster antimicrobial resistance prediction than conventional methods. Methods: In this retrospective study, antibiogram results of 607 Klebsiella pneumoniae isolates collected between 2017 and 2024 were combined with demographic and clinical information of the patients from whom the isolates were obtained. Four different ML algorithms, namely Decision Tree (DT), Support Vector Classifier (SVC), K-Nearest Neighbors (KNN) and Random Forest (RF), were applied to classify the resistance status for 22 antibiotics. Model performances were evaluated using accuracy, precision, recall, F-score, AUC and feature importance metrics. Results: The RF model showed the highest overall performance in accurately predicting resistance to 22 antibiotics, achieving an average AUC value of 0.96. In particular, it predicted resistance to treatment-critical antibiotics such as Ertapenem (100%), Imipenem (93%) and Meropenem (95%) with high accuracy. Conclusions: ML models, especially RF, offer a powerful tool for rapid antibiotic resistance prediction, supporting accurate empirical treatment decisions and antimicrobial stewardship.Article Past and Present of Nation-Building: Ideological Instrumentalization of Ministry of Youth and Sports of Turkey(Routledge Journals, Taylor & Francis Ltd, 2026) Erturan-Ogut, Esin EsraWhen Erdogan declared in 2012, 'We will raise a pious generation', Turkey already had a national identity rooted in secularism and Turkism since the early Republic. His statement signalled an attempt to reshape identity along the AKP's anti-Kemalist lines. This study examines shifting nation-building agendas in state-run youth and sports institutions, comparing the early Republican era with the AKP period. Early programmes emphasized Turkism, secularism, and paramilitarism, reflecting the ideological imperatives of the time. Under the AKP, however, programmes increasingly promoted Islamism and neo-Ottomanism, opposing earlier values. The study argues that AKP-era youth policies deliberately sought to replace Kemalist principles, with the Ministry of Youth and Sports serving as a channel for ideological nation-building absent in formal education.Article Investigating Text Neck Syndrome and Duration of Mobile Phone Use, Muscle Activity, Hand Grip Strength, Posture, and Disability(Elsevier Sci Ltd, 2026) Yasaci, Zeynal; Zirek, Emrah; Mustafaoglu, Rustem; Ozdincler, Arzu RazakNeck and shoulder musculoskeletal symptoms related to smartphone use are becoming increasingly prevalent, yet the underlying mechanisms including smartphone usage duration, muscle activity, hand grip strength, posture, and disability remain incompletely understood. This study examined the interaction between text-neck syndrome and factors such as smartphone usage duration, muscle activity, hand grip strength, posture, and disability. Forty participants (Text Neck group: n = 18; 14 females or Control group: n = 22; 15 females) underwent neuromuscular assessment. Surface electromyography measured bilateral muscle activity in the upper trapezius (UT) and abductor pollicis brevis (APB) muscles during smartphone use. Secondary outcomes included the Visual Analogue Scale (VAS) to assess pain intensity, hand grip strength, New York Posture Rating Scale (NYPRS), Neck Disability Index (NDI), and Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. The Text Neck group demonstrated significantly higher smartphone use (p < 0.001), higher texting time (p = 0.006), and lower muscle activation at activity in the dominant APB (p = 0.011), dominant UT (p < 0.001), and non-dominant UT (p = 0.008). These findings provide novel insights into how excessive smartphone use alters muscle function and postural alignment in individuals with text-neck syndrome. Understanding these mechanisms may inform targeted prevention and rehabilitation strategies to mitigate musculoskeletal risk associated with modern technology use.Article Pathologies of the Modern Paradigm and the Refugee Question: A Critical Analysis(Springer Nature, 2026) Yamaner, Onur; Ozalp, AhmetThis article examines the internal contradictions and social pathologies generated by the modern paradigm, focusing especially on the issue of migration. Using epistemological critiques from thinkers like Adorno, Kuhn, Popper, Hayek, and the Frankfurt School, the paper argues that modernity's promise of universal rationality and scientific progress has frequently resulted in structures that are exclusionary, homogenizing, and sometimes even totalitarian. The paper then links these theoretical debates to contemporary migration. It emphasizes how refugee women-especially those facing the combined challenges of gender and displacement-experience complex layers of social invisibility and discursive erasure. By critically applying recognition theory and discourse analysis, the study highlights how modernity's promise of inclusion frequently hides the actual mechanisms of marginalization. In this part, the article demonstrates that these marginalization processes are linked to the scientific premises of the modern paradigm and considers the migration problem as an example of the pathology of the modern paradigm.Article Harnessing Adaptive Urban Service Frameworks and Smart Technologies for Sustainable Urban Development in Rapidly Urbanising Cities(Elsevier, 2026) Agboola, Oluwagbemiga Paul; Uzun, Turkan Irgin; Cakir, Hulya Soydas; Soydaş Çakır, HülyaRapid urbanisation and escalating climate change impacts pose significant challenges for sustainable urban governance in developing nations, particularly where infrastructural inadequacies and resource inefficiencies persist. This study examines how urban systems in rapidly growing cities in Nigeria can utilise smart technologies to enhance resilience, inclusivity, and environmental sustainability. The study's aim is to develop and evaluate an Adaptive Urban Service Framework (AUSF) that integrates digital innovations to foster low-carbon, climate-resilient, and inclusive cities. Objectives of the study include (i) identifying adaptive urban service models that improve resource efficiency, environmental sustainability, and quality of life, and (ii) assessing the extent to which these services strengthen urban resilience and social inclusivity under demographic and infrastructural pressures. A structured survey involving 286 respondents from selected Nigerian cities was conducted, and the data were analysed using SPSS Version 22. The correlation results reveal a positive relationship between adaptive urban service mechanisms and sustainability outcomes (r = 0.987, p < 0.001), indicating that improvements in smart technologies, resource efficiency, environmental sustainability, and quality of life strongly reinforce sustainable urban performance. Similarly, experts' evaluations demonstrate a positive correlation between Adaptive Urban Services (AUS) and the enhancement of resilience and inclusivity within smart urban environments (r = 0.865, p < 0.001). These findings collectively underscore that adaptive, smart-driven frameworks exert substantial synergistic effects on environmental sustainability, social inclusivity, and urban resilience, confirming that the effective integration of smart technologies serves as a strong determinant of sustainability outcomes in rapidly urbanising Nigerian cities. The paper offers a methodology that integrates digital innovation with climate-responsive planning, which theoretically advances urban systems theory. In practical terms, it provides policymakers and urban planners with a scalable road map for implementing adaptive service solutions that connect sustainability, equity, and technology. Overall, within similar emerging urban environments, the study highlights the transformative potential of adaptive urban services in furthering climate adaptation, fostering inclusion, and attaining sustainable urban development.Article Burn Rehabilitation: Evaluation of Physiotherapists' Knowledge and Awareness Levels(Elsevier Sci Ltd, 2025) Seyyah, Mine; Akkurt, Mustafa Ferit; Yilmaz, NergisObjective: The aim of this study was to evaluate the level of knowledge and awareness of physiotherapists working in Turkey about burn rehabilitation. Method: This was a cross-sectional study conducted between March and June 2025 and data were collected using Google Form. A total of 324 people were included in the study. The level of knowledge and awareness of the participants about burn rehabilitation was evaluated with 28 questions created by taking expert opinion. Results: While 25.6 % of participants had experience in burn rehabilitation, only 1.2 % frequently encountered burn patients. Although 60.5 % had taken courses on burn rehabilitation, only 15.1 % considered their knowledge sufficient. Correct response rates to key knowledge questions were 78.7 % for exercise applicability, 79.6 % for timing, 54.6 % for the most common burn type in Turkey, 35.8 % for edema management, and 13 % for pressure garment duration, revealing gaps in clinical knowledge. Additionally, 92.9 % believed early physiotherapy improves recovery, and 98.4 % reported positive effects on quality of life. Discussion: Our results indicate that although most physiotherapists had taken courses on burn rehabilitation, their knowledge remains insufficient, whereas their awareness is high, underscoring the need for targeted training and certification programs.Article Investigation of Novel Nimesulide Derivatives Against Breast Cancer(Academic Press Inc Elsevier Science, 2025) Birgul, Kaan; Atlihan, Irem; Dere, Damla; Yelekci, Kemal; Tiber, Pinar Mega; Orun, Oya; Kucukguzel, S. GunizThis study focused on the synthesis of novel nimesulide semicarbazone derivatives and the evaluation of their cytotoxic potential against luminal-A (MCF-7) and triple-negative (MDA-MB-231) breast cancer cell lines. Additionally, their effects on mitochondrial membrane potential (MMP), apoptosis, and mitogen-activated protein kinase (MAPK) pathway modulation were investigated. Breast cancer remains the most prevalent malignancy among women, with luminal-A and triple-negative subtypes posing significant therapeutic challenges due to drug resistance and the lack of effective targeted treatments. The MAPK pathway plays a crucial role in breast cancer progression, making its inhibition a promising therapeutic approach. Non-steroidal anti-inflammatory drugs (NSAIDs), particularly nimesulide, have demonstrated anticancer potential beyond their well-established anti-inflammatory properties. Accordingly, the semicarbazone moiety was incorporated into the molecular scaffold to enhance the antiproliferative efficacy of nimesulide derivatives, as it has been reported to exhibit cytotoxic and apoptosis-inducing effects across various cancer cell lines. A series of nimesulide semicarbazone derivatives (5a-m) were synthesized through multi-step reactions and characterized using elemental analysis, FT-IR, 1H NMR, 13C NMR and Mass spectroscopy (5e). In silico studies were performed to predict their binding affinities to MAPK12. The cytotoxic effects of the synthesized compounds were assessed by determining IC50 values in MCF-7 and MDA-MB-231 cell lines (CCK8 test). Compounds exhibiting strong cytotoxic activity were further examined for their impact on MMP depolarization (JC-1 assay), apoptosis induction (Annexin V-FITC/PI staining), and MAPK pathway modulation (Western blotting of p-ERK and ERK protein). Molecular docking results indicated that the synthesized compounds exhibited favorable interactions with MAPK12, with compound 5e showing one of the highest binding affinity (-9.29 kcal/mol, Ki = 0.154 mu M). Cytotoxicity assays revealed that compound 5e had the lowest IC50 values (11.77 +/- 0.26 mu M in MCF-7; 20.72 +/- 0.25 mu M in MDA-MB-231), demonstrating significantly higher cytotoxicity than nimesulide. JC-1 assays confirmed that compound 5e induced MMP depolarization at higher concentrations, suggesting apoptosis activation. Flow cytometry analysis further validated a substantial increase in apoptotic cell populations following treatment with compound 5e. Western blot results showed a dose-dependent decrease in p-ERK levels in both MCF-7 and MDA-MB-231 cells, confirming MAPK pathway inhibition. These findings support that nimesulide-based semicarbazones, particularly compound 5e, exhibit potent antiproliferative and pro-apoptotic activity via MAPK pathway modulation, offering a promising avenue for the development of targeted breast cancer therapies.Article Synergistic Effects of Amniotic Membrane and Human Milk Exosomes on Burn Wound Healing(Elsevier Sci Ltd, 2025) Isik, Ferda; Tufan, Elif; Sivas, Guzin Goksun; Ak, Esin; Muhan, Aleyna; Sener, Goksel; Tunali-Akbay, TugbaBackground: Thermal burns are one of the most common burns. Studies are ongoing to develop synthetic or biological wound dressings to ensure painless and scarless healing of burn wounds. Objectives: This study aimed to combine the human amniotic membrane with breast milk-based exosomes and investigate their effects on burn wound healing. Methods: 24 Wistar Albino rats weighing 200-250 g and of both genders were used. Rats were divided into control, burn, burn+human amniotic membrane (hAM) and burn+hAM+Exosomes (hAM+Exo) groups. Burn injury was induced by exposing the back of rats to 90 degrees C water for 10 s. Rats were treated with hAM and hAM+ Exo for seven days after injury. At the end of the 7th day, the skin samples were taken and analyzed biochemically and histologically. TNF-alpha, IL-1(i, type III collagen, malondialdehyde (MDA), glutathione (GSH), total protein, superoxide dismutase (SOD), and tissue factor (TF) activity were determined in skin samples. Results: In the burn group, skin TNF-alpha levels increased, IL-1(i and type III collagen levels decreased. Wound healing therapy reversed these results. In the hAM+Exo group, the TNF-alpha level was lower, and IL-1 beta and type III collagen levels were higher than in the hAM group. MDA and total protein levels increased, and GSH, tissue factor, and SOD activities decreased in the burn group. In hAM and hAM+Exo groups, MDA levels decreased, and GSH and SOD activity increased compared to the burn group. The GSH levels were significantly higher in the hAM+Exo group compared to the hAM group. Conclusion: In conclusion, combining exosomes and amniotic membrane induced changes consistent with better wound healing than amniotic membrane alone.Article Citation - WoS: 1Citation - Scopus: 2Investigating the Relationship Between Caregiver Burden and Quality of Life in Burn Care(Elsevier Sci Ltd, 2025) Seyyah, Mine; Reyhanioglu, Duygu Aktar; Kardas, Ayse Sena YumbulAim: This study aimed to examine the relationship between caregiver burden and quality of life among primary caregivers of burn survivors receiving inpatient treatment in an acute care setting. Methods: This cross-sectional descriptive and correlational study included 53 primary caregivers of hospitalized burn patients, recruited from the Burn Care Unit of a tertiary hospital in Turkey between August 2022 and January 2023. Participants were aged 18 or older, identified as the primary caregiver, and able to communicate in Turkish. Individuals with psychiatric disorders were excluded. Data were collected through face-to-face structured interviews using the Zarit Burden Interview (ZBI) and the Short Form Health Survey (SF-36), in which higher scores indicate better quality of life. Descriptive statistics, Pearson correlation, and linear regression were used to analyze the data. Results: The caregivers had a mean age of 38.75 +/- 10.76 years; 71.7 % were female, and 50.9 % had completed only primary education. The average caregiving duration was 10.6 days. The mean ZBI score was 22.54 +/- 15.11, indicating moderate burden. Demographic variables did not significantly affect caregiver burden (p > .05). A moderate negative correlation was found between caregiver burden and their emotional (r = -0.367, p = .007), psychological (r = -0.313, p = .023), and physical functioning (r = -0.355, p = .009) subdomains of the SF-36. Conclusion: A inverse relationship was observed between caregiver burden and caregiver quality of life, especially in emotional, psychological, and physical functioning domains. Although demographic factors were not influential, lower quality of life was associated with greater caregiver burden.
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