WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Citation - WoS: 5Citation - Scopus: 5Effects of <i>myrtus Communis</I> L. Extract and Apocynin on Lens Oxidative Damage and Boron Levels in Rats With a High Fat-Diet(Galenos Publ House, 2021) Yasar, Ruya Kuru; Kuru, Dilruba; Sen, Ali; Sener, Goksel; Ercan, Feriha; Yarat, Aysen; Kuru, RuyaObjectives: Nutritional obesity causes oxidant damage in the body and cataract formation in the lenses by increasing the formation of free radicals. Myrtus communis leaf extracts (Myr) have antioxidant properties, and apocynin (Apo) is an effective NADPH-oxidase inhibitor. The data on tissue boron levels are quite lacking. The aim of this novel study was to investigate the effects of Myr and Apo treatment on boron levels and oxidative lens damage in rats fed a high-fat diet (HFD). Materials and Methods: Wistar albino male rats were randomly divided into four groups: the control group, HFD group, HFD + Myr group, and HFD + Apo group. Body weight and blood lipids were determined before and after the experiment. After decapitating the rats, the lenses were removed and homogenized. Catalase (CAT) and superoxide dismutase (SOD) activities and boron, malondialdehyde (MDA), and reduced glutathione (GSH) levels in the lens homogenates were determined. Results: The HFD increased serum triglyceride (p<0.05), total cholesterol level (p<0.001), body weight (p<0.001), and lens MDA levels (p<0.01) and decreased lens GSH (p<0.05) and boron level (p<0.01), SOD (p<0.001), and CAT activity (p<0.001). However, Myr and Apo treatment reduced the rats' body weight (p<0.001), serum triglyceride (p<0.05), and total cholesterol level (p<0.001) and increased lens boron (p<0.01; p<0.001), GSH levels (p<0.05; p<0.01), and CAT activity (p<0.001). Conclusion: Both Myr and Apo may be able to reduce oxidative stress in the lenses of obese rats caused by HFD by increasing boron levels.Article Citation - WoS: 3Obesity Risk Factors in Turkish Preschool Children: a Cross-Sectional Study(Cukurova Univ, Fac Medicine, 2022) Ozkaya, Sebnem Ozgen; Ozkaya, Volkan; Garipagaoglu, MuazzezPurpose: The present study aims to identify the potential risk factors - pre and post-pregnancy, children's, parental, and environmental factors - concerning obesity in Turkish preschool children.Materials and Methods: The cross-sectional study was conducted with 538 children aged 3-5 and their mothers in 25 private and public kindergartens using a face-to-face survey. Demographic, anthropometric, nutrition, sleep, and physical activity information during pregnancy, infancy, and preschool periods were evaluated. Two-day food records and anthropometric measurements of the children were collected.Results: The prevalence of overweight and obesity in preschool children was found to be 27.0%. Among the 28 potential risk factors examined, pre-pregnancy obesity (odds ratios (OR):1.108, confidence interval (CI): 1.042-1.179), post-pregnancy obesity (OR:4.350, CI: 2.053-9.217), caffeine intake >200 mg/day during pregnancy (OR:1.588, CI:1.031-2.446), father with obesity (OR: 1.089, CI: 1.027-1.155), enrolling a private rather than a public kindergarten (OR: 2.093, CI:1.298-3.376), fast eating (OR:3.355, CI: 1.175-9.583 min), short lunch duration (OR:0.966, CI:0.934-0.998), daily sleep of <10 hours (OR:2.522, 1.439-4.421), and finally screen time of >2 hours/day (OR:1.560, CI:1.012-2.405) were found to be significantly correlated with obesity in preschool children.Conclusion: Parental obesity, caffeine intake during pregnancy, eating speed, daily sleep, and screen time were determined as obesity risk factors in Turkish preschool children. Identifying maternal and child risk factors in early childhood, regulating lifestyle and obesogenic environment can be protective against obesity.