WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Citation - WoS: 2Analysis of Selected Steroid Hormones in Sea of Marmara Sediment Samples by Lc-esi/Ms-ms(Istanbul Univ, Fac Pharmacy, 2023) Aysel, Esra; Yurdun, TurkanBackground and Aims: Sediment is the general name given to the muddy structure located at the bottom of aquatic environments such as the sea. In our study, the amounts of steroid hormones were investigated in the sediment samples taken from the Marmara Sea. According to other studies, it has been determined that the excess of the hormone load in the sediments may be an indicator of human/animal sourced pollution, as well as the negative effects of the hormones mixed in the seas with the ecological cycle on the health of humans and animals.Methods: In our study, 31 selected human/animal, plant, natural and synthetic hormone-steroids were studied using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI/MS-MS). Methanol and QuEChERS were used as extraction methods. Sediment samples were taken from a total of 27 points selected for sampling at the Marmara Sea.Results: According to the results we found, the androgens: androsterone (24.50-1718.18 ng g-1), testosterone (86.30-1600.32 ng g-1); the estrogens: mestranol (33.73-228.32 ng g-1), equilin (53.44-1232.53 ng g-1); the progestagens; pregnenolone (37.50374.76 ng g-1), progesterone (39.96-405.60 ng g-1); levonorgestrel (325.25 and 937.93 ng g-1); the fecal sterols: cholestanone (57.57-1726.32 ng g-1), coprostanol + epicoprostanol (51.43-1370.33 ng g-1); and the plant sterol; campesterol (35.30-1859.90 ng g-1) were the compounds detected.Conclusion: Estrogens and progestogens are active components of birth control pills, and cholestanone and coprostanol + epicoprostanol are steroids that are indicative of human/animal pollution. Coprostanol + epicoprostanol and cholestanone, which are indicators of fecal pollution, were detected in all sediment samples. In our study, steroid hormones were detected for the first time in Sea of Marmara sediments and possible environmental risks were evaluated.Review Molecular Characterization of Resistance and Virulence Genes in Enterococcus Faecium Strains Isolated Between 2000-2021; Systematic Review(Bilimsel Tip Yayinevi, 2022) Kahraman Kilbas, Elmas Pinar; Kilbas, Imdat; Ciftci, Ihsan Hakki; Kılbaş, Elmas Pınar KahramanIntroduction: The spread of Vancomycin-Resistant Enterococci (VRE) is a major threat in healthcare institutions, especially for patients in the risk group. The aim of this study is to reveal the antibiotic resistance genes, virulence genes and other accompanying factors detected in vancomycin resistant Enterococcus faecium strains isolated from various clinical specimens in different parts of Turkiye. Material and Methods: For this purpose, a systematic search was carried out using different electronic databases between January 2000 and September 2021. A total of 17 studies were evaluated within the scope of systematic review. Results: The vanA gene was detected the most between the years 2000-2007, and no statistically significant difference was found according to the years. The prevalence of the vanB gene was highest between 2008 and 2013, and no statistical difference was found according to the years (p> 0.05). The vanA gene was mostly detected in Eastern Anatolia, Black Sea, Mediterranean and Aegean, vanB Central Anatolia and Southeastern Anatolia regions. No reports related to the vanC gene were found. Since all strains were E. faecium in our study, it is an expected finding that the vanC gene region was never reported. The esp and hyl gene between 2014-2021. Conclusion: The prevalence of resistance and virulence genes among bacteria is a matter of great concern, limiting treatment options. In particular, effective measures should be taken to prevent healthcare-associated VRE infections, and each institution should report its own resistance data.Article Citation - WoS: 3Obesity Risk Factors in Turkish Preschool Children: a Cross-Sectional Study(Cukurova Univ, Fac Medicine, 2022) Ozkaya, Sebnem Ozgen; Ozkaya, Volkan; Garipagaoglu, MuazzezPurpose: The present study aims to identify the potential risk factors - pre and post-pregnancy, children's, parental, and environmental factors - concerning obesity in Turkish preschool children.Materials and Methods: The cross-sectional study was conducted with 538 children aged 3-5 and their mothers in 25 private and public kindergartens using a face-to-face survey. Demographic, anthropometric, nutrition, sleep, and physical activity information during pregnancy, infancy, and preschool periods were evaluated. Two-day food records and anthropometric measurements of the children were collected.Results: The prevalence of overweight and obesity in preschool children was found to be 27.0%. Among the 28 potential risk factors examined, pre-pregnancy obesity (odds ratios (OR):1.108, confidence interval (CI): 1.042-1.179), post-pregnancy obesity (OR:4.350, CI: 2.053-9.217), caffeine intake >200 mg/day during pregnancy (OR:1.588, CI:1.031-2.446), father with obesity (OR: 1.089, CI: 1.027-1.155), enrolling a private rather than a public kindergarten (OR: 2.093, CI:1.298-3.376), fast eating (OR:3.355, CI: 1.175-9.583 min), short lunch duration (OR:0.966, CI:0.934-0.998), daily sleep of <10 hours (OR:2.522, 1.439-4.421), and finally screen time of >2 hours/day (OR:1.560, CI:1.012-2.405) were found to be significantly correlated with obesity in preschool children.Conclusion: Parental obesity, caffeine intake during pregnancy, eating speed, daily sleep, and screen time were determined as obesity risk factors in Turkish preschool children. Identifying maternal and child risk factors in early childhood, regulating lifestyle and obesogenic environment can be protective against obesity.