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Ludwig's Angina in a 6-Year Child: Case Report
(Wiley, 2025) Akbari, Negarin; Razavi, Ali; Sabzi, Zahra; Parhiz, Jabbar
Ludwig's angina is a rare but potentially fatal cellulitis that affects the submandibular, sublingual, and submental spaces, typically triggered by dental infections. This case report details a severe presentation of Ludwig's angina in a 6-year-old girl who presented with submandibular swelling, fever, voice alterations, and respiratory distress. Diagnosis was based on clinical evaluation, supported by CT imaging, revealing significant airway narrowing and lymphadenopathy. The patient was promptly intubated to secure the airway, followed by emergency surgical drainage and intravenous antibiotics. Postoperative care included sedation, ongoing monitoring in the PICU, and close follow-up by multiple specialties. After a 10-day hospitalization, the patient showed significant recovery with no complications. The case underscores the importance of early diagnosis and intervention in preventing severe complications such as airway obstruction, sepsis, and mediastinal spread. It highlights the critical role of interdisciplinary collaboration, including pediatric infectious disease specialists, surgeons, and anesthesiologists, in managing this life-threatening condition effectively.
Post-Covid Neutropenia in an Infant With Thalassemia Minor: Case Report
(Wiley, 2025) Elsherif, Yasmine; Elsherif, Omar; Karimi, Mehran; Ibrahim, Ismail A.; Abukhadijah, Hana J.
This case of an 11-month-old female who developed severe neutropenia following COVID-19 infection underscores the need for heightened vigilance and monitoring of hematological parameters in infants post-COVID-19. The exact mechanism of COVID-19-induced neutropenia is not fully understood, but it may involve cytokine-induced suppression of hematopoiesis and bone marrow repression due to the inflammatory response. Given the potential for serious clinical implications, including increased susceptibility to infections, it is crucial to effectively identify and manage neutropenia in this vulnerable population. Further research is necessary to elucidate the underlying mechanisms and optimize treatment strategies for COVID-19-related hematological complications in infants.
Tinea Capitis (favus) in a 8-Year Child: Case Report
(Wiley, 2024) Akbari, Negarin; Parhiz, Jabbar; Sabzi, Zahra
Key Clinical MessageIn examining any scalp itch or skin lesions, especially in children with long hair, fungal lesions under the hair may not be diagnosed in a timely manner. Additionally, fungal infection of the scalp, known as tinea capitis, is considered a chronic condition and if left untreated, it can lead to alopecia (hair loss) and permanent scarring.AbstractTinea capitis (TC) is a common cutaneous fungal infection in childhood. In this report, we describe the case of an 8-year-old child presenting with erythematous scalp lesions accompanied by hair loss. Upon examination, palpation revealed a swollen and tender left parotid gland. Notably, the frontal region of the scalp exhibited erythematous lesions and scaly red plaques resembling yellowish paste-like dough. Subsequent clinical evaluation and culture analysis confirmed the diagnosis of TC. The patient received treatment with Terbinafine 125 mg for a duration of 8 weeks. Follow-up examinations conducted after 3 months showed no signs of recurrence. Accurate diagnosis and timely treatment, along with adherence to medication regimens, are crucial in cases of TC, and differential diagnoses should be considered. Treatment should commence promptly upon diagnosis to prevent complications such as scalp baldness and transmission to others. This case report underscores the significance of establishing a precise diagnosis and effective treatment for this dermatophytosis to mitigate the risk of recurrences or therapeutic shortcomings, particularly in infants.
Citation - WoS: 1
The Unlikely Combination: Anderson-Fabry Disease and Congenital Dyserythropoietic Anemia Type Ii in a Pediatric Patient
(Wiley, 2024) Elsherif, Yasmine; Ibrahim, Ismail A.; Elsherif, Omar; Abukhadijah, Hana J.
Anderson- Fabry disease (AFD) is a rare condition, characterized by a lysosomal storage disorder affecting lipid storage. It manifests in two forms: classic (early- onset) and nonclassic (late- onset). Conversely, congenital dyserythropoietic anemia (CDA) is a rare blood disorder caused by ineffective erythropoiesis, which results in the production of abnormal erythroblasts during the maturation of red blood cells, with CDA type II being the most frequent type. Both disorders have well- understood pathophysiologies, yet they are genetically distinct. AFD is inherited in an X- linked manner, whereas CDA type II follows an autosomal recessive pattern of inheritance. Although both AFD and CDA type II have been reported separately in the literature. The co- existence for both AFD and CDA type II has not been reported. We describe a 10- year- old boy, with both which is believed to be the first documented case.

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