WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Citation - Scopus: 1A Quest for Formant-Based Compact Nonuniform Trapezoidal Filter Banks for Speech Processing With Vgg16(Springer Birkhauser, 2024) Parlak, Cevahir; Altun, YusufIn this text, we discuss the filter banks used for speech analysis and propose a novel filter bank for speech processing applications. Filter banks are building blocks of speech processing applications. Multiple filter strategies have been proposed, including Mel, PLP, Seneff, Lyon, and Gammatone filters. MFCC is a transformed version of Mel filters and is still a state-of-the-art method for speech recognition applications. However, 40 years after their debut, time is running out to launch new structures as novel speech features. The proposed acoustic filter banks (AFB) are innovative alternatives to dethrone Mel filters, PLP filters, and MFCC features. Foundations of AFB filters are based on the formant regions of vowels and consonants. In this study, we pioneer an acoustic filter bank comprising 11 frequency regions and conduct experiments using the VGG16 model on the TIMIT and Speech Command V2 datasets. The outcomes of the study concretely indicate that MFCC, Mel, and PLP filters can effectively be replaced with novel AFB filter bank features.Article Citation - WoS: 41Citation - Scopus: 39Synthesis and Anticancer Activity of Novel Hydrazone Linkage-Based Aryl Sulfonate Derivatives as Apoptosis Inducers(Springer Birkhauser, 2022) Senkardes, Sevil; Han, M. Ihsan; Gurboga, Merve; Ozakpinar, Ozlem Bingol; Kucukguzel, S. Guniz; Güniz Küçükgüzel, Ş.; İhsan Han, M.In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate moieties were synthesized and characterized by FTIR, H-1-NMR, C-13-NMR spectroscopy and LC-MS spectrometry, besides elemental analysis. The compounds were evaluated for their antiproliferative effects against six cancer cell lines, namely A549 (non-small cell lung cancer), MCF-7 (breast cancer), HT-29 (colorectal adenocarcinoma cancer), PC-3 (androgen-independent prostate adenocarcinoma), Hep3B (hepatocellular carcinoma cancer), and HeLa (epitheloid cervix carcinoma cancer). Among all the target compounds, compounds 4g and 4h exhibited more promising effects on MCF-7 cell lines (IC50 = 17.8 mu M and 21.2 mu M, respectively) with high selectivity. Further mechanistic studies proposed that compounds 4g and 4h induced apoptosis is mediated through the intrinsic apoptotic pathway with changes in mitochondrial membrane potential by finally activating caspase-9 and caspase-3. The results have been encouraging enough to merit further investigation. [GRAPHICS] .