WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Google Trend Index as an Investor Sentiment Proxy in Cryptomarket: Nonlinear Relationships With Cryptomarket and Predicting Bitcoin Returns With Machine Learning Approach(Springer, 2025) Koy, Ayben; Demir, Semra; Colak, Andac BaturThis study investigates the utility of Google trend indices as proxies of investor sentiment, examining their relationships with cryptocurrency market prices and their potential for return prediction. Employing several nonlinear econometric models including the momentum threshold autoregressive AR (MTAR), Kapetanios, Shin, and Snell, and exponential smooth transition autoregressive vector error correction model, the research the relationships between Google trend indices and BTC prices. Additionally, the study evaluates the performance of three developed artificial neural network models in predicting bitcoin returns based on investor sentiment derived from Google trend indices. The findings highlight that the MTAR model effectively captures significant relationships between the variables studied. However, predicting bitcoin returns remains challenging due to their typically small values, which represent the changes between observation points.Article Recognition of Clove (Eugenia Caryophyllata) Oil Adulteration by Monitoring Phenolic and Antioxidative Fingerprint Markers Utilizing Online HPLC Post Column and Spectrophotometric Assays With Chemometric Analysis(Springer, 2025) Ersoy, Seyda Karaman; Kaya, Elif Nilay; Celik, Saliha Esin; Senol, Onur; Apak, Resat; Karaman Ersoy, ŞeydaThis research aims to develop a reliable and versatile methodology for authenticating clove (Eugenia caryophyllata) oil (CLO). Key variables included total antioxidant capacity (TAC), total phenolic content (TPC), quantitative analyses and/or individual antioxidant capacity of fingerprint markers including eugenol (EUG) and tocopherol isomers (alpha-T, gamma-T, and delta-T) using reversed-phase liquid-chromatography (RP-HPLC) with post-column detection. A total of 28 commercial CLO samples (certified as 100% pure and other commercial samples), potential adulterants like vegetable oils (sunflower oil (SFO) and corn oil (CO)), and 14 synthetically adulterated CLO samples blended with varying proportions (ranging from 5 to 50%) of SFO and CO were analyzed. The EUG content and antioxidant capabilities of each marker were ascertained by online RP-HPLC analysis with post column detection utilizing CUPRAC (cupric reducing antioxidant capacity). EUG content in commercial CLO ranged from 1.46 to 98.06 mg g(-1), while TAC ranged between 18.54 and 748.46 mu mol g(-1) Trolox equivalents (TE), as determined by the online HPLC-CUPRAC method. Depending on the type and ratio of adulterating oils, a considerable decrease in the TAC values of virgin CLO was recorded. Classification of the commercial and synthetically adulterated CLOs (total of 42 samples) was performed using partial least square discrimination analysis (PLS-DA) and hierarchical cluster analysis (HCA). Adulteration levels above > 5% were successfully detected with 95% confidence. Thus, the proposed chemometric strategy combining selected chemical markers and TAC data demonstrated high potential for authenticating CLO. This technique provides a more focused investigation alternative for determining the authenticity and quality of commercial CLO.Article Citation - WoS: 1Citation - Scopus: 1Isolation of Rosmarinic Acid From Rosemary Extract Utilizing a Molecularly Imprinted Polymer(Springer, 2025) Ersoy, Ş.K.Molecularly imprinted polymers are polymeric materials engineered with specific templates capable of recognizing molecules selectively. Rosmarinic acid, an ester formed from caffeic acid and 3,4-dihydroxyphenyllactic acid and commonly occurring in plants, exhibits a broad spectrum of bioactive properties, including antioxidant, antiviral, analgesic, antibacterial, antimutagenic, antiallergic, anti-inflammatory, and neuroprotective effects. It is prominently present in rosemary (Rosmarinus officinalis) extracts, where it acts as the primary phenolic compound responsible for antioxidant activity. Advancements in the refining techniques for recovering and purifying rosmarinic acid from rosemary extracts have driven progress in molecularly imprinted solid-phase extraction methods. Remarkably, the molecularly imprinted solid-phase extraction approach utilizing the 1:4:16 caffeic acid-imprinted polymer exhibited outstanding selectivity for rosmarinic acid in authentic rosemary samples, achieving a purity level of 84% ± 2.96%. This research marks a significant advancement in the literature, being the first to demonstrate the effective purification of rosmarinic acid using caffeic acid-imprinted polymers. These findings underscore the efficacy of the MIPs in accurately capturing rosmarinic acid, illuminating their potential applications in pharmaceutical and analytical settings where precise molecule recognition and extraction methodologies are crucial. This innovative approach not only enhances the extraction process but also opens new avenues for the application of MIPs in various fields, including food chemistry and natural product research. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.Article Citation - WoS: 1Citation - Scopus: 1Evaluation of the Effect of Sociodemographic Characteristics of Patients With Prostate Cancer on Their Sexual Experiences and Self-Efficacy Sexual Experiences and Self-Efficacy of Individuals With Prostate Cancer(Springer, 2023) Eroglu, Nermin; Ozkan, IlknurThe study was planned as a descriptive study to evaluate the effects of sociodemographic characteristics of prostate cancer patients on their sexual experiences and self-efficacy. The sample of the study consisted of 69 patients with prostate cancer who were followed up for treatment in the outpatient clinic of an oncology hospital between December 2020 and March 2021 and met the inclusion criteria of the stud. Research data were collected by using the Patient Information Form, Arizona Sexual Experiences Scale (ASEX)-Male, and Sexual Self-Efficacy Scale (SSES). The mean age of prostate cancer patients was 67.1 & PLUSMN; 11.74 years, 95.7% (n = 66) were married, 37.7% (n = 66) were university graduates, and 75.4% (n = 52) were unemployed. Patients' mean scores were 19.29 & PLUSMN; 7.66 on the total Sexual Self-Efficacy Scale and 22.08 & PLUSMN; 4.92 on the total Arizona Sexual Experiences Scale. In the study, it was determined that the sexual experiences and sexual self-efficacy of prostate cancer patients differed according to their education level, employment status, and duration of treatment. In the study, it was determined that patients with prostate cancer experienced sexual dysfunction and had low self-efficacy. In line with these results, our recommendations are for health professionals to evaluate the sexual functions of patients with prostate cancer and their sexual self-efficacy, which is an important determinant of sexual life, during the diagnosis, treatment, and care process. In addition, the sociodemographic characteristics of the patients should be considered when planning interventions that increase sexual self-efficacy in the management of sexual problems.Article Citation - WoS: 11Citation - Scopus: 12Synchronous and Asynchronous Telerehabilitation Methods Produce Similar Benefits in Individuals With Non-Specific Neck Pain(Springer, 2024) Timurtas, Eren; Selcuk, Halit; Canoz, Ekin Ugur; Inceer, Mehmet; Batar, Suat; Demirbuken, Ilksan; Polat, Mine Gulden; Uğur Canöz, EkinIntroduction Evidence exists on clinical benefits of synchronous and asynchronous telerehabilitation for patients with non-specific neck pain (NSNP); however, limited studies are comparing synchronous and asynchronous telerehabilitation (TR) programs in this population. The aim of this study was to estimate the relative effectiveness of an 8-week synchronous or asynchronous TR in improving pain, functional disability, kinesiophobia, and mobility in patients with NSNP.Materials and methods This was a randomized, controlled clinical trial carried out on 60 individuals with NSNP. Participants were randomly assigned to synchronous TR group (n = 30) or asynchronous TR group (n = 30) that received the same exercise program for 8 weeks. Pain measured by Numeric Pain Rating Scale (NPRS), disability measured by Neck Disability Index (NDI), kinesiophobia measured by Tampa Scale of Kinesiophobia (TSK), and cervical range of motion were used as outcome measures. Assessments were performed at baseline, 4th week, 8th week, and 16th week.Results The analysis showed a significant effect of time and significant interaction between group and time in NPRS, NDI, TSK, and cervical mobility scores (p < 0.05), yet the group effect was not significant (p > 0.05). There were no significant differences between the groups at all time points (p > 0.05) except for cervical right lateral flexion at 8th week (p = 0.036).Conclusion Telerehabilitation technologies are expanding at a rapid rate, and it is essential to understand the outcomes produced using these technologies in health conditions. This study showed that synchronous and asynchronous telerehabilitation produces similar results in patients with NSNP, supporting that either method can be used interchangeably.Article Citation - WoS: 3Citation - Scopus: 5<i>cotinus Coggygria</I> Scop. Attenuates Acetic Acid-Induced Colitis in Rats by Regulation of Inflammatory Mediators(Springer, 2023) Sen, Ali; Ertas, Busra; Cevik, Ozge; Yildirim, Aybeniz; Kayali, Damla Gokceoglu; Akakin, Dilek; Sener, GokselIn traditional medicine, many medicinal plants are used in the treatment of various diseases caused by inflammation. The objective of the present study is to elucidate for the first time the effects of Cotinus coggygria (CC) ethanol extract (CCE) on colonic structure and inflammation of acetic acid-induced ulcerative colitis in rats. Colonic damage was assessed using disease activity index score, enzyme-linked immunosorbent assay, and hematoxylin-eosin staining. Also, in vitro antioxidant activity of CCE was investigated by ABTS methods. Total phytochemical content of CCE was measured spectroscopically. Acetic acid caused colonic damage according to disease activity index and macroscopic scoring. CCE significantly reversed these damages. While the levels of proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and TGF-1beta increased in tissue with UC, IL-10 level decreased. CCE increased inflammatory cytokine levels to values close to the sham group. At the same time, while markers indicating disease severity such as VEGF, COX-2, PGE2, and 8-OHdG indicated the disease in the colitis group, these values returned to normal with CCE. Histological research results support biochemical analysis. CCE exhibited significant antioxidant against ABTS radical. Also, CCE was found to have a high content of total polyphenolic compounds. These findings provide evidence that CCE might be benefit as a promising novel therapy in the treatment of UC in humans due to high polyphenol content and justify the use of CC in folkloric medicine for treatment of inflamed diseases.Article Citation - WoS: 1Citation - Scopus: 1Carvacrol Improves Cognitive Dysfunction by Decreasing Amyloid-Β Accumulation and Regulating Neuroinflammation in Ovariectomized Renovascular Hypertensive Rats(Springer, 2024) Bayraktar, Duygu; Ertas, Busra; Aydin, Yasemin; Sener, GokselHypertension contributes to both the development and progression of brain damage and cognitive dysfunction in the postmenopausal period in women. Carvacrol (CAR), which can easily cross the blood-brain barrier, exhibits neuroprotective properties due to its antioxidant, anti-inflammatory, and anti-apoptotic effects. In the present study, we have examined the effect of CAR treatment on learning-memory impairment in a post-menopausal hypertensive rat model that was induced by ovariectomy following two-kidney, one-clip renovascular hypertension surgery. From the third week after the establishment of renovascular hypertension in ovariectomized rats, CAR (40 mg/kg) was administered once daily for consecutive 7 weeks by gastric gavage. Systolic blood pressure was estimated by the tail-cuff method once a week. At the end of the study, cognitive functions were evaluated with behavioral tests and also neurochemical changes were measured in serum, cortex, and hippocampus by ELISA test. Blood pressure was decreased with CAR treatment in hypertensive rats. Serum estrogen levels decreased in ovariectomized rats and did not change with CAR treatment. CAR demonstrated beneficial effects on learning and memory tests as determined by increased recognition index, the number of platforms crossed, and time spent in the target quadrant. Due to CAR treatment, there was a marked reduction in the hippocampal and cortex amyloid-beta, osteopontin, interleukin-6 and tumor necrosis factor-alpha levels, and acetylcholinesterase activity, while an increment in neprilysin and interleukin-10 levels was found. In conclusion, since CAR suppressed amyloid-beta deposition and neuroinflammation in ovariectomized-hypertensive rats, it is thought that it may be protective against memory disorders in postmenopausal hypertensive women.Article Citation - WoS: 8Citation - Scopus: 8Functional Groups Matter: Metabolomics Analysis of <i>escherichia Coli</I> Exposed To Trans-Cinnamic Acid and Its Derivatives Unveils Common and Unique Targets(Springer, 2024) Onat-Tasdelen, Kadriye Aslihan; Ozturkel-Kabakas, Hatice; Yuksektepe, Ecem; Catav, Sukru Serter; Guzel, Gulnur; Col, Bekir; Elgin, Emine SonayPhenolic acids are derivatives of benzoic and cinnamic acids, which possess important biological activities at certain concentrations. Trans-cinnamic acid (t-CA) and its derivatives, such as p-coumaric acid (p-CA) and ferulic acid (FA) have been shown to have antibacterial activity against various Gram-positive and -negative bacteria. However, there is limited information available concerning the antibacterial mode of action of these phenolic acids. In this study, we aimed to ascertain metabolic alterations associated with exposure to t-CA, p-CA, and FA in Escherichia coli BW25113 using a nuclear magnetic resonance (NMR)-based metabolomics approach. The results showed that t-CA, p-CA, and FA treatments led to significant changes (p < 0.05) in the concentration of 42, 55, and 74% of the identified metabolites in E. coli, respectively. Partial least-squares discriminant analysis (PLS-DA) revealed a clear separation between control and phenolic acid groups with regard to metabolic response. Moreover, it was found that FA and p-CA treatment groups were clustered closely together but separated from the t-CA treatment group. Arginine, putrescine, cadaverine, galactose, and sucrose had the greatest impact on group differentiation. Quantitative pathway analysis demonstrated that arginine and proline, pyrimidine, glutathione, and galactose metabolisms, as well as aminoacyl-tRNA and arginine biosyntheses, were markedly affected by all phenolic acids. Finally, the H2O2 content of E. coli cells was significantly increased in response to t-CA and p-CA whereas all phenolic acids caused a dramatic increase in the number of apurinic/apyrimidinic sites. Overall, this study suggests that the metabolic response of E. coli cells to t-CA is relatively different from that to p-CA and FA. However, all phenolic acids had a certain impact on oxidative/antioxidant status, genomic stability, arginine-related pathways, and nucleic acid metabolism.Article Citation - WoS: 2Citation - Scopus: 1Analysis of Substance Use and Mental Disorder Diagnoses in Adolescents With a History of Delinquency: a Cross-Sectional Study(Springer, 2024) Baysan Arabaci, Leyla; Dikec, Gul; Tas Soylu, Gulsenay; Bilac, Oznur; Uzunoglu, Gulcin; Ayakdas Dagli, DilekThis study aimed to evaluate substance use and comorbid mental disorders in delinquent adolescents presenting to a child and adolescent psychiatry outpatient clinic. This study included 47 adolescents aged 15-18 years and had a history of delinquency. Data were collected using the Addiction Profile Index Adolescent Form (API-A) and an information form. Results indicated that the adolescents' mean age is 16.11 +/- 1.05 years, 78.7% had committed crimes against property and 34.0% against the person, and 34.0% were also victims of crime. Mean API-A total scores indicated that their level of substance use was low. In addition, mean API-A total scores showed significant differences according to the adolescents' migration status, age, economic status, school attendance, mental disorder diagnosis, duration of mental disorder, and type of offense (p < 0.05). The benefit provided by timely and appropriate psychosocial interventions may have a key role in solving this problem for adolescents and improving their future as adults.