WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
Browse
11 results
Search Results
Article Advances and Strategies in Biosensor-Based Diagnostics for Parasitic Infections: A Comprehensive Scoping Review(Springer, 2026) Aminizadeh, Selva; Alizadeh, Gita; Alizadeh, Zahra; Khalilzadeh, Balal; Abidin, Zurina Zainal; Marzi, Mahdi; Rafiei-Sefiddashti, RahelehParasitic diseases are among the most widespread infections worldwide, causing millions of deaths and illnesses each year. So rapid and accurate diagnosis is essential, requiring highly sensitive and specific tests. Biosensors can provide significant advantages over traditional diagnostic methods because of their specificity, sensitivity, speed, simplicity, ease of use, repeatability, and capacity for early-stage disease detection. Recent advances in modern diagnostic tools for detecting parasitic infections use nanomaterials such as gold nanoparticles, carbon nanofibers, and carbon nanotubes. These developments have significantly lowered detection limits to the picogram and femtogram levels. This review will cover recent advancements in biosensor-based diagnostic techniques in parasitology.Article Google Trend Index as an Investor Sentiment Proxy in Cryptomarket: Nonlinear Relationships With Cryptomarket and Predicting Bitcoin Returns With Machine Learning Approach(Springer, 2025) Koy, Ayben; Demir, Semra; Colak, Andac BaturThis study investigates the utility of Google trend indices as proxies of investor sentiment, examining their relationships with cryptocurrency market prices and their potential for return prediction. Employing several nonlinear econometric models including the momentum threshold autoregressive AR (MTAR), Kapetanios, Shin, and Snell, and exponential smooth transition autoregressive vector error correction model, the research the relationships between Google trend indices and BTC prices. Additionally, the study evaluates the performance of three developed artificial neural network models in predicting bitcoin returns based on investor sentiment derived from Google trend indices. The findings highlight that the MTAR model effectively captures significant relationships between the variables studied. However, predicting bitcoin returns remains challenging due to their typically small values, which represent the changes between observation points.Article Recognition of Clove (Eugenia Caryophyllata) Oil Adulteration by Monitoring Phenolic and Antioxidative Fingerprint Markers Utilizing Online HPLC Post Column and Spectrophotometric Assays With Chemometric Analysis(Springer, 2025) Ersoy, Seyda Karaman; Kaya, Elif Nilay; Celik, Saliha Esin; Senol, Onur; Apak, Resat; Karaman Ersoy, ŞeydaThis research aims to develop a reliable and versatile methodology for authenticating clove (Eugenia caryophyllata) oil (CLO). Key variables included total antioxidant capacity (TAC), total phenolic content (TPC), quantitative analyses and/or individual antioxidant capacity of fingerprint markers including eugenol (EUG) and tocopherol isomers (alpha-T, gamma-T, and delta-T) using reversed-phase liquid-chromatography (RP-HPLC) with post-column detection. A total of 28 commercial CLO samples (certified as 100% pure and other commercial samples), potential adulterants like vegetable oils (sunflower oil (SFO) and corn oil (CO)), and 14 synthetically adulterated CLO samples blended with varying proportions (ranging from 5 to 50%) of SFO and CO were analyzed. The EUG content and antioxidant capabilities of each marker were ascertained by online RP-HPLC analysis with post column detection utilizing CUPRAC (cupric reducing antioxidant capacity). EUG content in commercial CLO ranged from 1.46 to 98.06 mg g(-1), while TAC ranged between 18.54 and 748.46 mu mol g(-1) Trolox equivalents (TE), as determined by the online HPLC-CUPRAC method. Depending on the type and ratio of adulterating oils, a considerable decrease in the TAC values of virgin CLO was recorded. Classification of the commercial and synthetically adulterated CLOs (total of 42 samples) was performed using partial least square discrimination analysis (PLS-DA) and hierarchical cluster analysis (HCA). Adulteration levels above > 5% were successfully detected with 95% confidence. Thus, the proposed chemometric strategy combining selected chemical markers and TAC data demonstrated high potential for authenticating CLO. This technique provides a more focused investigation alternative for determining the authenticity and quality of commercial CLO.Article Citation - WoS: 1Citation - Scopus: 1Isolation of Rosmarinic Acid From Rosemary Extract Utilizing a Molecularly Imprinted Polymer(Springer, 2025) Ersoy, Ş.K.Molecularly imprinted polymers are polymeric materials engineered with specific templates capable of recognizing molecules selectively. Rosmarinic acid, an ester formed from caffeic acid and 3,4-dihydroxyphenyllactic acid and commonly occurring in plants, exhibits a broad spectrum of bioactive properties, including antioxidant, antiviral, analgesic, antibacterial, antimutagenic, antiallergic, anti-inflammatory, and neuroprotective effects. It is prominently present in rosemary (Rosmarinus officinalis) extracts, where it acts as the primary phenolic compound responsible for antioxidant activity. Advancements in the refining techniques for recovering and purifying rosmarinic acid from rosemary extracts have driven progress in molecularly imprinted solid-phase extraction methods. Remarkably, the molecularly imprinted solid-phase extraction approach utilizing the 1:4:16 caffeic acid-imprinted polymer exhibited outstanding selectivity for rosmarinic acid in authentic rosemary samples, achieving a purity level of 84% ± 2.96%. This research marks a significant advancement in the literature, being the first to demonstrate the effective purification of rosmarinic acid using caffeic acid-imprinted polymers. These findings underscore the efficacy of the MIPs in accurately capturing rosmarinic acid, illuminating their potential applications in pharmaceutical and analytical settings where precise molecule recognition and extraction methodologies are crucial. This innovative approach not only enhances the extraction process but also opens new avenues for the application of MIPs in various fields, including food chemistry and natural product research. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.Article Citation - WoS: 2Citation - Scopus: 2Best Practice Recommendations for Dysphagia Management in Intensive Care Unit (icu): a Delphi Study From Multidisciplinary Experts in Turkey(Springer, 2024) Umay, Ebru; Eyigor, Sibel; Demirag, Kubilay; Kaymak Karatas, Gulcin; Gundogdu, Ibrahim; Giray, Esra; Adiguzel, EmreThere is no study about all aspects of oropharyngoesophageal (OPE) dysphagia from diagnosis to follow-up in a multidisciplinary manner in the world. In order to close this gap, we aimed to create a recommendation study that can be used in clinical practice, addressing all aspects of dysphagia in the ICU in detail with the opinion of experienced multidisciplinary experts. This recommendation paper was generated by a multidisciplinary team, using the seven-step process and a three-modified Delphi round via e-mail. Firstly, 15 open-ended questions were created, and then detailed recommendations including general principles, management, diagnosis, rehabilitation, and follow-up were created with the answers from these questions, Each recommendation item was voted on by the experts as overall consensus (strong recommendation), approaching consensus (weak recommendation), and divergent consensus (not recommended).In the first Delphi round, a questionnaire consisting of 413 items evaluated with a scale of 0-10 was prepared from the opinions and suggestions given to 15 open-ended questions. In the second Delphi round, 55.4% were accepted and revised suggestions were created. At the end of the third Delphi round, the revised suggestion form was approved again and the final proposals containing 133 items were created. This study includes comprehensive and detailed recommendations, including a broad perspective from diagnosis to treatment and follow-up, as detailed as possible, for management of dysphagia in patients with both oropharyngeal- and esophageal-dysphagia in ICU.Article Citation - WoS: 21Citation - Scopus: 23Effectiveness of Conventional Dysphagia Therapy (cdt), Neuromuscular Electrical Stimulation (nmes), and Transcranial Direct Current Stimulation (tdcs) in Acute Post-Stroke Dysphagia: a Comparative Evaluation(Springer, 2024) Bengisu, Serkan; Demir, Numan; Krespi, YakupThis study aims to compare the effectiveness of conventional dysphagia therapy (CDT), neuromuscular electrical stimulation (NMES), and transcranial direct current stimulation (tDCS) in the treatment of post-stroke dysphagia. A single-blind randomized controlled trial was conducted with 40 acute stroke patients - 18 females and 22 males with a mean age of 65.8 +/- 11.9. The subjects were grouped into 4, with 10 individuals in each. The procedures administered to groups were as follows: the first group, sham tDCS and sham NMES; the second group, tDCS and sham NMES; the third group, NMES and sham tDCS; and the fourth group, all therapy procedures. CDT was applied to all groups either as a standalone procedure or combined with one or two of the instrumental techniques. Gugging Swallowing Screen (GUSS) and Videofluoroscopic Swallowing Study (VFSS) were employed to determine the severity of dysphagia and the effectiveness of treatment modalities. Additionally, the Penetration Aspiration Scale (PAS), Functional Oral Intake Scale (FOIS), and Dysphagia Severity Rating Scale (DSRS) were administered to interpret VFSS data. Pre- and post-treatment comparisons of all groups have revealed a statistically significant difference for all parameters except for the PAS scores at International Dysphagia Diet Standardization Initiative (IDDSI)-Level 4 consistencies. However, the differences between pre- and post-treatment scores of the fourth group across all parameters were significant - GUSS (p = 0.005), FOIS (p = 0.004), DSRS (p = 0.005), PAS IDDSI-4 (p = 0.027), PAS IDDSI-0 (p = 0.004). Inter-group comparisons, on the other hand, pointed out that the difference between pre- and post-treatment GUSS, FOIS, DSRS, and PAS scores at IDDSI Level-0 consistencies was statistically significant for all groups - GUSS (p = 0,009), FOIS (p = 0,004), DSRS (p = 0,002), PAS IDDSI-0 (p = 0,049). Closer examination of treatment groups indicated that the tDCS + CDT group, the NMES + CDT group, and the group that underwent the combination of three modalities made better progress than the one that was treated with only CDT. Though not statistically significant, the NMES + CDT group achieved better improvement than the tDCS + CDT group. This study has yielded that the group in which NMES, tDCS, and CDT were applied in combination has achieved better results than all the other groups. All treatment modalities applied to accelerate the general recovery process in acute stroke patients with dysphagia were found to be effective for the treatment of post-stroke swallowing disorders. The use of instrumental treatments such as NMES and tDCS enhanced the effectiveness of the treatment and provided more significant progress. Furthermore, combining treatment modalities such as NMES and tDCS was more effective when compared to using only conventional therapy. As a result, the most effective treatment outcomes were obtained by the group receiving CDT, NMES, and tDCS in combination. Therefore, the use of combined approaches has been recommended in appropriate patients; yet the provisional results should be tested in randomized trials with more participants.Article Citation - WoS: 3Citation - Scopus: 5<i>cotinus Coggygria</I> Scop. Attenuates Acetic Acid-Induced Colitis in Rats by Regulation of Inflammatory Mediators(Springer, 2023) Sen, Ali; Ertas, Busra; Cevik, Ozge; Yildirim, Aybeniz; Kayali, Damla Gokceoglu; Akakin, Dilek; Sener, GokselIn traditional medicine, many medicinal plants are used in the treatment of various diseases caused by inflammation. The objective of the present study is to elucidate for the first time the effects of Cotinus coggygria (CC) ethanol extract (CCE) on colonic structure and inflammation of acetic acid-induced ulcerative colitis in rats. Colonic damage was assessed using disease activity index score, enzyme-linked immunosorbent assay, and hematoxylin-eosin staining. Also, in vitro antioxidant activity of CCE was investigated by ABTS methods. Total phytochemical content of CCE was measured spectroscopically. Acetic acid caused colonic damage according to disease activity index and macroscopic scoring. CCE significantly reversed these damages. While the levels of proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and TGF-1beta increased in tissue with UC, IL-10 level decreased. CCE increased inflammatory cytokine levels to values close to the sham group. At the same time, while markers indicating disease severity such as VEGF, COX-2, PGE2, and 8-OHdG indicated the disease in the colitis group, these values returned to normal with CCE. Histological research results support biochemical analysis. CCE exhibited significant antioxidant against ABTS radical. Also, CCE was found to have a high content of total polyphenolic compounds. These findings provide evidence that CCE might be benefit as a promising novel therapy in the treatment of UC in humans due to high polyphenol content and justify the use of CC in folkloric medicine for treatment of inflamed diseases.Article Citation - WoS: 1Citation - Scopus: 1Carvacrol Improves Cognitive Dysfunction by Decreasing Amyloid-Β Accumulation and Regulating Neuroinflammation in Ovariectomized Renovascular Hypertensive Rats(Springer, 2024) Bayraktar, Duygu; Ertas, Busra; Aydin, Yasemin; Sener, GokselHypertension contributes to both the development and progression of brain damage and cognitive dysfunction in the postmenopausal period in women. Carvacrol (CAR), which can easily cross the blood-brain barrier, exhibits neuroprotective properties due to its antioxidant, anti-inflammatory, and anti-apoptotic effects. In the present study, we have examined the effect of CAR treatment on learning-memory impairment in a post-menopausal hypertensive rat model that was induced by ovariectomy following two-kidney, one-clip renovascular hypertension surgery. From the third week after the establishment of renovascular hypertension in ovariectomized rats, CAR (40 mg/kg) was administered once daily for consecutive 7 weeks by gastric gavage. Systolic blood pressure was estimated by the tail-cuff method once a week. At the end of the study, cognitive functions were evaluated with behavioral tests and also neurochemical changes were measured in serum, cortex, and hippocampus by ELISA test. Blood pressure was decreased with CAR treatment in hypertensive rats. Serum estrogen levels decreased in ovariectomized rats and did not change with CAR treatment. CAR demonstrated beneficial effects on learning and memory tests as determined by increased recognition index, the number of platforms crossed, and time spent in the target quadrant. Due to CAR treatment, there was a marked reduction in the hippocampal and cortex amyloid-beta, osteopontin, interleukin-6 and tumor necrosis factor-alpha levels, and acetylcholinesterase activity, while an increment in neprilysin and interleukin-10 levels was found. In conclusion, since CAR suppressed amyloid-beta deposition and neuroinflammation in ovariectomized-hypertensive rats, it is thought that it may be protective against memory disorders in postmenopausal hypertensive women.Article Citation - WoS: 8Citation - Scopus: 8Functional Groups Matter: Metabolomics Analysis of <i>escherichia Coli</I> Exposed To Trans-Cinnamic Acid and Its Derivatives Unveils Common and Unique Targets(Springer, 2024) Onat-Tasdelen, Kadriye Aslihan; Ozturkel-Kabakas, Hatice; Yuksektepe, Ecem; Catav, Sukru Serter; Guzel, Gulnur; Col, Bekir; Elgin, Emine SonayPhenolic acids are derivatives of benzoic and cinnamic acids, which possess important biological activities at certain concentrations. Trans-cinnamic acid (t-CA) and its derivatives, such as p-coumaric acid (p-CA) and ferulic acid (FA) have been shown to have antibacterial activity against various Gram-positive and -negative bacteria. However, there is limited information available concerning the antibacterial mode of action of these phenolic acids. In this study, we aimed to ascertain metabolic alterations associated with exposure to t-CA, p-CA, and FA in Escherichia coli BW25113 using a nuclear magnetic resonance (NMR)-based metabolomics approach. The results showed that t-CA, p-CA, and FA treatments led to significant changes (p < 0.05) in the concentration of 42, 55, and 74% of the identified metabolites in E. coli, respectively. Partial least-squares discriminant analysis (PLS-DA) revealed a clear separation between control and phenolic acid groups with regard to metabolic response. Moreover, it was found that FA and p-CA treatment groups were clustered closely together but separated from the t-CA treatment group. Arginine, putrescine, cadaverine, galactose, and sucrose had the greatest impact on group differentiation. Quantitative pathway analysis demonstrated that arginine and proline, pyrimidine, glutathione, and galactose metabolisms, as well as aminoacyl-tRNA and arginine biosyntheses, were markedly affected by all phenolic acids. Finally, the H2O2 content of E. coli cells was significantly increased in response to t-CA and p-CA whereas all phenolic acids caused a dramatic increase in the number of apurinic/apyrimidinic sites. Overall, this study suggests that the metabolic response of E. coli cells to t-CA is relatively different from that to p-CA and FA. However, all phenolic acids had a certain impact on oxidative/antioxidant status, genomic stability, arginine-related pathways, and nucleic acid metabolism.Article Citation - WoS: 21Citation - Scopus: 22Assessment of the Quality and Reliability of Information on Nutrition After Bariatric Surgery on Youtube(Springer, 2020) Batar, Nazli; Kermen, Seda; Sevdin, Sezen; Yildiz, Nida; Guclu, DuyguBackground YouTube (TM) is a platform that many people, including patients, use to access health information. Recent studies have revealed that videos on YouTube (TM) are misleading or that medical videos may not contain appropriate information. This study aimed to assess the quality and reliability of videos on nutrition after bariatric surgery. Materials and Methods The keywords "after bariatric surgery diet" and "weight loss surgery postop diet" were used, and the first 100 videos for each keyword on YouTube (TM) were analyzed by considering the source, duration, content, and the number of likes of the video. The popularity of the video was calculated using the video power index (VPI) and view rate. The educational quality of the videos was evaluated using the DISCERN score, the Journal of the American Medical Association (JAMA) score, the Global Quality Score (GQS), the usefulness score, and a novel postoperation nutrition score (PONS). Results One hundred fourteen patients were included in the study. The mean duration and number of views were 12.51 min and 87,558.46, respectively. The DISCERN score, JAMA score, GQS, and usefulness score of the physicians or dietician-based videos were significantly higher than those of the patient-based videos (p < 0.001). Positive correlations were found between the VPI and view ratio, as well as between the duration and number of likes. Additionally, the DISCERN score was significant correlated with the duration and number of likes. Significantly positive correlations were found between the usefulness score and duration, usefulness score and number of likes, and PONS and duration (p < 0.01). Conclusions Informational videos on nutrition after bariatric surgery on YouTube (TM) are of low quality. Although the videos uploaded by physicians and dieticians have higher quality, only a few are available. Additionally, patients prefer to watch low-quality videos.