WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
Browse
3 results
Search Results
Review Citation - WoS: 7Citation - Scopus: 6The Impact of Interaction Between Verteporfin and Yes-Associated Protein 1/Transcriptional Coactivator With Pdz-Binding Motif-Tea Domain Pathway on the Progression of Isocitrate Dehydrogenase Wild-Type Glioblastoma(Sage Publications Ltd, 2023) Osama, Mahmoud; Essibayi, Muhammed Amir; Osama, Mona; Ibrahim, Ismail A.; Mostafa, Mostafa Nasr; Eksi, Murat Sakir; Şakir Ekşi, Murat; Nasr Mostafa, MostafaVerteporfin and 5-ALA are used for visualizing malignant tissue components in different body tumors and as photodynamic therapy in treating isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM). Additionally, verteporfin interferes with Yes-associated protein 1 (YAP)/Transcriptional coactivator with PDZ-binding motif - TEA domain (TAZ-TEAD) pathway, thus inhibiting the downstream effect of these oncogenes and reducing the malignant properties of GBM. Animal studies have shown verteporfin to be successful in increasing survival rates, which have led to the conduction of phase 1 and 2 clinical trials to further investigate its efficacy in treating GBM. In this article, we aimed to review the novel mechanism of verteporfin's action, the impact of its interaction with YAP/TAZ-TEAD, its effect on glioblastoma stem cells, and its role in inducing ferroptosis.Article Citation - WoS: 19Citation - Scopus: 18Tele-Assessment of Core Performance and Functional Capacity: Reliability, Validity, and Feasibility in Healthy Individuals(Sage Publications Ltd, 2024) Gungor, Feray; Ovacik, Ugur; Harputlu, Ozge Ertan; Yekdaneh, Ayse Asena; Kurt, Irem; Uzunoglu, Gamze Erturk; Akbaba, Yildiz Analay; Ertürk Uzunoğlu, Gamze; Ertan Harputlu, ÖzgeIntroduction Many assessment methods are used in physiotherapy to analyze the fitness level and injury risk in athletes, and to determine the general health status and the effectiveness of the treatment applied in patients. Considering the need for telehealth use, it is essential to determine the usability of tests performed as tele-assessment. This study aimed to examine the intra-rater reliability, validity, and feasibility of the tele-assessment version of core strength and endurance and functional capacity assessments in healthy individuals. Methods "Curl-up," "Modified Push-up," "Plank," and "Lateral Bridge" tests were used for core strength and endurance performance assessment, and "Timed Up and Go," "30 second Sit to Stand," and "Functional Reach Test" tests were used for functional capacity assessment in healthy individuals. Participants were evaluated first by tele-assessment, then one hour later on the same day, all assessments were repeated face-to-face procedures by the researchers thus the validity of the tele-assessment method was determined. All tests were applied as tele-assessment one week later to determine the intra-rater reliability of the tele-assessment method. The system usability scale was applied to evaluate the usability of our tele-assessment method. Results Eighty healthy people were enrolled. Intraclass correlation coefficients ranged between 0.91 and 0.97 for core performance tests and between 0.95 and 0.97 for functional tests. All tele-assessment versions of the core performance and functional tests were highly correlated with the face-to-face versions. Discussion Core strength-endurance and functional tests performed via tele-assessment were reliable, valid, and feasible for practically measuring the performance of healthy young adults. This study supports the tele-assessment versions of these tests.Article Citation - WoS: 2Citation - Scopus: 2Investigation of University Websites From Technology Acceptance Model and Information Architecture Perspective: a Case Study(Sage Publications Ltd, 2024) Sonmez, Ferdi; Aydin, Uygar; Perdahci, Ziya N.Factors, such as whether a website is designed to be user-oriented beyond its mere visual design, its effectiveness and efficiency, its usability, and the organisation of the information it offers, have come to the fore once again after the Covid-19 pandemic. It has been evident that the link structure in a website, better known as the website's information architecture, helps the practitioners with identifying factors that affect the usability of a website. In this sense, practitioners must ensure that the information architecture supports the usage intentions of a websites' visitors to better serve and motivate them. However, in many cases, different types of users navigate websites that contain immense amounts of information, so understanding their needs is also important for practitioners. In parallel, this article addresses the problem that different visitors of a large-scale website will need to navigate through dense information to find the information they are looking for, and the information architecture of the website must support different user tasks for the website to be widely adopted. Thus, unlike previous studies, this article combines the principles of information architecture and the technology acceptance model to investigate the effect of information architecture on visitor's usage intentions. The work also guides practitioners in developing architectural strategies to better enable visitors to fulfil their objectives in the least amount of time.