WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6
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Article Montelukast Attenuates Abdominal Aortic Aneurysm in Rats: Anti-Inflammatory and Antioxidant Effects(Elsevier, 2026) Tekin, Gozde; Cevik, Ozge; Cetinel, Sule; Sener, Goksel; Kizilay, MehmetObjective: Oxidative stress and inflammation are widely recognized as central mechanisms in the pathogenesis of abdominal aortic aneurysm. This study sought to examine the potential protective properties of montelukast in a rat model of aortic aneurysm. Methods: Male Sprague-Dawley rats were randomly allocated into three experimental groups. Abdominal aortic aneurysm was induced using the calcium chloride (CaCl2) model, in which gauze soaked in 0.5 M CaCl2 was placed directly onto the adventitial surface of the infrarenal abdominal aorta for 15 minutes. After induction, the treatment group received daily intraperitoneal injections of montelukast (10 mg/kg) for 4 consecutive weeks. At the study end point, animals were euthanized, and infrarenal aortic tissues were harvested for biochemical and histological evaluations. Measured parameters included matrix metalloproteinase (MMP)-2 and MMP-9 expression, myeloperoxidase (MPO) activity, and 8-hydroxy-2 '-deoxyguanosine levels. Antioxidant capacity was assessed through superoxide dismutase (SOD) activity assays. Histopathological examinations were performed, and statistical analysis was conducted using GraphPad Prism v.5. Results: Exposure to CaCl2 triggered pronounced oxidative injury and inflammation, as evidenced by elevated 8-hydroxy-2 '-deoxyguanosine levels, increased MPO activity, reduced SOD activity, and upregulated MMP-2 and MMP-9 expression. Montelukast administration markedly attenuated these changes, normalizing oxidative and inflammatory markers while improving histopathological architecture. Conclusions: Montelukast effectively counteracted CaCl2-induced aortic damage. The protective effects of montelukast appear to be mediated through suppression of MMP activity, restoration of SOD levels, and reduction of MPO-driven oxidative injury. By mitigating both inflammatory and oxidative mechanisms, montelukast contributes to the preservation of aortic wall structure. Clinical Relevance: Abdominal aortic aneurysm remains a major vascular disorder without an effective pharmacological therapy to slow its progression. In this experimental study, montelukast, a leukotriene receptor antagonist widely used in asthma, attenuated abdominal aortic aneurysm formation in rats and was associated with increased superoxide dismutase activity, reduced myeloperoxidase levels, and suppressed matrix metalloproteinase activation. These combined antioxidant, anti-inflammatory, and matrix-stabilizing effects preserved aortic wall integrity. Given montelukast's established safety and clinical availability, these findings support its potential for future clinical investigation as a pharmacological approach to limit aneurysm progression. (JVS-Vascular Science 2026;7:100405.)Article Safety and Efficacy of Colchicine in COVID-19 Treatment: Systematic Review and Meta-Analysis(Elsevier, 2025) Nada, Ahmed Hosney; Ibrahim, Ismail A.; Asar, Nada Khalid; Qenawy, Abdulrahman; Mohammed, Mariam M.; Wagdy, Mohamed; Farouk, Heidi SherifBackground: Colchicine is an anti-inflammatory drug used for the treatment of gout and other autoinflammatory conditions. Several trials reported promising results of the efficacy of colchicine in Covid-19 due to its antiinflammatory properties. However, applying these results to clinical settings remains the subject of ongoing research. Methods: We performed a systematic review and meta-analysis on the efficacy and safety of colchicine in the treatment of Covid-19. PubMed, Cochrane Library, Web of Science, and Scopus were searched for relevant studies. The primary outcomes were 28-day mortality, invasive mechanical ventilation, non-invasive mechanical ventilation, and ICU admissions. The risk ratio was used to compare effectiveness between the two groups. Subgroup analysis was done for C-reactive protein and duration of hospitalization. Results: 17 randomized controlled trials with a total of 25478 patients were included. The overall Risk ratio didn't favor any of the two groups in terms of 28-day mortality (RR =1.03, 95 % CI [0.93:1.15], P = 0.58), noninvasive mechanical ventilation (RR = 0.81, 95 % CI [0.44:1.48], P = 0.49), ICU admission (RR = 0.89, 95 % CI [0.56:1.41], P = 0.62). The overall mean difference (MD) did not show statistical significance between both groups in terms of Creactive protein (CRP) (mg/dl) (MD = -1.21, 95 % CI [-2.42:0.01], P = 0.05), lactate dehydrogenase (LDH) (U/ L) (MD = 50.95, 95 % CI [-92.07: 193.98], Ferritin (ng/ml) (MD = 128.08, 95 % CI [51.97:204.18], P = 0.001), ICU length of stay (MD = -0.09, 95 % CI [-0.34:0.15], P = 0.45) and duration of hospitalization (MD = -0.41, 95 % CI [-1.56:0.73], P = 0.48). Conclusion: In Covid-19 treatment, colchicine didn't result in significant benefits in terms of clinical outcomes. More large-scale randomized clinical trials with standardized dosages and long-term follow-up are needed for further investigation into the colchicine effect.Article Turkish Validity and Reliability Study of the Kidney Transplant Understanding Tool (K-TUT) in Kidney Transplant Recipients(Elsevier, 2025) Akinci, Naile; Genc, Kadriye Nilay; Toprak, CaglaAim: The study was conducted methodologically to evaluate the validity and reliability of the KTUT scale in kidney transplant recipients. Material and Method: The population of the study consisted of kidney transplant patients at a private hospital group in Istanbul, while the sample comprised patients who met the inclusion criteria and volunteered for the study. Based on ten times the number of scale items, 220 individuals were included in the sample to prevent data loss and to ensure high representativeness. In the study, data collection tools such as the "Patient Information Form" and the "KTUT" scale were employed. The test-retest study was repeated two weeks later with 50 participants. The participants in the retest were not included in other tests of the scale. Findings: The overall content validity index of the scale (S-CVI/Ave) was found to be 0.93. According to the experts' opinions, the content validity of the scale is high, and the majority of the items have been deemed appropriate for the measurement purpose. The internal consistency reliability coefficient of the scale (Cronbach's Alpha) was calculated as 0.789. This threshold indicates that the scale possesses an acceptable level of reliability for use at the group level. In addition, the results of the study reveal that the scores of the K-TUT scale show a significant difference in the 27 % lower and 27 % upper groups. Conclusion: As a result of the study, the K-TUT scale has been shown to reliably distinguish knowledge levels and to be an effective measurement tool in the field of kidney transplant. It is thought that using the Turkish version of the K-TUT to evaluate the knowledge levels of kidney transplant recipients will contribute to evaluation of developed programs and the improvement of patients' treatment processes.Article Evaluation of Hopelessness, Decision Regret and Desire for Retransplantation in Patients With Graft Loss After Kidney Transplantation(Elsevier, 2025) Akinci, Naile; Toprak, CaglaAim: In this descriptive study, it was aimed to evaluate hopelessness, decision regret, and desire to be transplanted again in patients who developed graft loss after kidney transplantation. Material and Method: The study sample consisted of all patients who developed graft loss after kidney transplantation between January 2017 and February 2021 in a private hospital in XXX, who met the inclusion criteria and volunteered for the study. "Patient Information Form", 'Beck Hopelessness Scale' and 'Decision Regret Scale' were used as data collection tools in the study. Findings: It was determined that participants experienced a moderate level of hopelessness after graft rejection (13.370 +/- 4.379) while the average scores on the decision regret scale were generally high (66.435 +/- 18.213). Regarding the desire to be transplanted again, it was observed that the majority of the participants (52.2 %) did not want to be transplanted again. According to the results of the correlation analysis, there was a significant correlation between hopelessness and decision regret scores (p* < 0.05) while there was no significant correlation with the desire to be transplanted again (p > 0.05). In addition, hopelessness (p = 0.034) scores of individuals who were not employed were significantly higher than those who were employed, and both hopelessness (p = 0.000) and decision regret (p = 0.048) scores of those without religious belief were significantly higher than those with religious belief. Conclusion: The findings of the study emphasize the critical importance of monitoring and psychological support processes before and after kidney transplantation. Understanding the emotional processes individuals experience after kidney transplant graft loss is important for the development of psychological support and intervention strategies.Article Citation - WoS: 1Citation - Scopus: 1The Effect of Neck Mobilization Vs. Combined Neck and Lumbar Mobilization on Pain and Range of Motion in People With Cervical Disc Herniation: a Randomized Controlled Study(Elsevier, 2025) Ozdincler, Arzu; Aktas, Dogan; Reyhanioglu, Duygu Aktar; Ozturk, Basar; Aktar Reyhanioglu, DuyguBackground: To assess the effectiveness of Kaltenborn-Evjenth Orthopedic Manual Therapy (KEOMT) applied to cervical-only mobilization versus both lumbar and cervical regions on pain intensity and range of motion (ROM) in individuals with cervical disc herniation. Methods: Thirty-three participants were enrolled in the study. The patients were randomly assigned to two groups. Group A received cervical-only KEOMT, while Group B received combined lumbar and cervical KEOMT. Interventions were administered three times a week for four weeks. Pain was measured using the Visual Analog Scale (VAS), ROM was assessed for flexion and lateral flexion, and Neck Pain and Disability Index (NPDI) and Short-Form 36 Health Survey (SF-36) were used for evaluation. Results: In intra-group measurements, a statistically significant difference was observed in all parameters of pain, ROM, disability, and quality of life for the mobilization methods applied in both groups (p < 0.05). Group B demonstrated significantly greater improvements in ROM/flexion, pain, and disability outcomes compared to Group A in inter-group measurements (p < 0.05). Physical and emotional sub-groups of quality of life measures also favored Group B in intergroup analysis (p < 0.05). However, the power values for ROM and quality of life parameters were found to be low. Conclusions: The cervical plus lumbar KEOMT technique is more effective than cervical-only mobilization in improving pain and disability. However, low power values for ROM and quality of life suggest these results may lack clinical significance, warranting further research.Article Citation - WoS: 2Citation - Scopus: 2Investigation of Physical Parameters Influencing Body Awareness in Adults With Obesity: an Observational, Controlled Study(Elsevier, 2024) Eryildiz, Ezgi; Delibas, Elifnur; Kesgin, Ilayda Melek; Ozturk, Ipek Beyza; Huseyinsinoglu, Burcu Ersoz; Ersoz Huseyinsinoglu, BurcuAim: The primary aim was to compare the body awareness (BA) level in adults with obesity and non-obese adults. The secondary aim was to investigate the physical parameters associated with BA and compare them between adults with obesity and non-obese adults. Method: Thirty-two adults with obesity and age and sex-matched 32 non-obese adults were included in the study. The outcome measures were the Body Awareness Questionnaire, International Physical Activity QuestionnaireShort Form and Functional Reach Test to detect BA, physical activity (PA), and dynamic balance level, respectively. Reaction time was assessed by the Nelson Foot Reaction Test and knee and trunk position error by inclinometer. Results: There was no significant difference between the obese and non-obese group in terms of BA score (p = 0.18) and PA level (p = 0.50). Lower dynamic balance was observed in the obese group (p = 0.003). Only the trunk position error was higher in the obese group in the measurement of joint position error (p = 0.010). There were no significant differences in the right and left feet reaction times between the groups (p = 0.68 and p = 0.23). There were no relationships between BA score and PA level (p = 0.93), dynamic balance (p = 0.82), joint position error (p = 0.14), and right (p = 0.33) and left (p = 0.25) reaction times. Conclusion: There was no significant difference in body awareness between the non-obese and the obese group and there was no association between body awareness and the physical parameters. However, adults with obesity had impaired balance and proprioception compared to non-obese ones.Article Citation - Scopus: 1Investigating the Impact of Various Insole Applications on Balance and Postural Stability in the Elderly(Elsevier, 2025) Ozturk, Basar; Ozdincler, Arzu Razak; Kocyigit, Ahmet; Kaya, Begum Kara; Kisa, Eylul PinarObjectives: Aging leads to physical and cognitive declines, notably affecting balance and motor skills, making falls a prevalent health concern among the elderly. Falls, a significant health issue among the elderly, often stem from these impairments. This study aims to investigate the impact of different insole materials, specifically cork and silicone, on balance and postural stability in the elderly. Methods: A randomized controlled trial was conducted at the Istanbul Barinyurt Elderly Care Center with 24 participants, divided into two groups to test cork and silicone insoles. Balance parameters, plantar pressure, the Timed Up and Go (TUG) test, and the Five Times Sit-to-Stand Test were used as measures. Data analysis was performed using the Mann-Whitney U and Wilcoxon tests. Results: Post-intervention, the cork insole group showed significant improvements in balance, maximum plantar pressure, and functional mobility tests compared to the silicone insole group. While both insoles enhanced certain balance parameters and walking performance, cork insoles proved more effective in key outcomes. Additionally, maximum plantar pressure for the cork insoles group decreased significantly, indicating better pressure distribution and potentially enhanced balance. Conclusion: Cork insoles are superior to silicone insoles in improving balance and postural stability among the elderly. This study supports using cork insoles as part of fall prevention strategies, emphasizing the importance of material properties in orthopedic insole design. Future research should explore long-term effects and integrate insoles with other postural stability methods for comprehensive elderly care.Article Citation - WoS: 1Immediate Effects of Soft Tissue Mobilization and Percussive Massage on Balance in Young Adults With Pes Planus: a Single Blind, Randomized Controlled Pilot Study(Elsevier, 2024) kethudaoglu, Mustafa Oguz; Ozdemir, Aysem Ecem; Saglam, Oznur Kaya; Caglar, Engin; Caglar, Meltem Meran; Demir, Gokhan; Duymaz, Tomris; Meran Çağlar, Meltem; Kaya Sağlam, ÖznurBackground: Presence of pes planus is known to effect balance. In this study, it was aimed to examine the immediate effects of IASTM and PMT on static and dynamic balance in young adults with pes planus. Method: The navicular drop test was used to diagnose pes planus. 51 individuals were included in the study and divided into three groups [IASTM (n:15), percussive massage (n:18) and control (n:18) groups] by simple randomization. Flamingo and Y Balance test was assessed before and immediately after intervention. Repeated Measures ANOVA test was used for the intergroup comparison, and the One -Way ANOVA test was used for the intragroup comparison, also post -hoc test with Tukey correction was performed. Results: There was no significant difference in static balance between the three groups (p > 0.05). There was a significant difference in dynamic balance between groups (p < 0.05). Only IASTM group had significant differences at before and after intervention of all directions except for posterolateral direction of Y Balance Test (p < 0.05). Conclusion: IASTM applied to the plantar fascia of individuals with pes planus have immediate effects on dynamic balance when compared to no intervention and percussive massage even within a small sample size.