WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/6

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  • Article
    Citation - WoS: 4
    Citation - Scopus: 4
    Whey Protein Concentrate Ameliorates the Methotrexate-Induced Liver and Kidney Damage
    (Cambridge Univ Press, 2023) Tufan, Elif; Sivas, Guezin Goksun; Gurel-Gokmen, Begum; Yilmaz-Karaoglu, Suemeyye; Dursun, Ercan; Caliskan-Ak, Esin; Tunali-Akbay, Tugba; Yllmaz-Karaoǧlu, SÜmeyye; Çallşkan-Ak, Esin
    Methotrexate (MTX) is a cytotoxic immunosuppressant that is widely used in the treatment of tumours, rheumatoid arthritis and psoriasis. This study aims to evaluate the effects of whey proteins on MTX-induced liver and kidney damage by focusing on oxidant-antioxidant systems and eating habits. The study was conducted in four groups of thirty Sprague-Dawley rats (control, control + whey protein concentrate (WPC), MTX, MTX + WPC). A single dose of 20 mg/kg MTX was administered intraperitoneally to the MTX groups. Control and MTX groups were given 2 g/kg WPC by oral gavage every day for 10 d. At the end of day 10, blood samples were drawn and liver and kidney tissues were removed. MTX administration increased the lipid peroxidation level and decreased glutathione level, superoxide dismutase and glutathione-S-transferase activities in the liver and kidney. Administration of WPC significantly reduced the damage caused by MTX in the liver and kidney. While a decrease in serum urea level and an increase in serum creatinine level were detected in the MTX group, WPC administration reversed these results up to control group levels. Administration of WPC to the MTX group significantly reversed the histopathological damage scores of the liver and kidney. WPC administration ameliorated the MTX-induced oxidative damage in the liver and kidney tissues due to its antioxidant properties. Liver and kidney damage can be prevented by using whey proteins as a nutraceutical in MTX therapy. In conclusion, whey proteins demonstrated a protective effect against MTX-induced liver and kidney damage.
  • Article
    Citation - WoS: 7
    Citation - Scopus: 7
    Drawing Transmission Graphs for Covid-19 in the Perspective of Network Science
    (Cambridge Univ Press, 2020) Gursakal, N.; Batmaz, B.; Aktuna, G.
    When we consider a probability distribution about how many COVID-19-infected people will transmit the disease, two points become important. First, there could be super-spreaders in these distributions/networks and second, the Pareto principle could be valid in these distributions/networks regarding estimation that 20% of cases were responsible for 80% of local transmission. When we accept that these two points are valid, the distribution of transmission becomes a discrete Pareto distribution, which is a kind of power law. Having such a transmission distribution, then we can simulate COVID-19 networks and find super-spreaders using the centricity measurements in these networks. In this research, in the first we transformed a transmission distribution of statistics and epidemiology into a transmission network of network science and second we try to determine who the super-spreaders are by using this network and eigenvalue centrality measure. We underline that determination of transmission probability distribution is a very important point in the analysis of the epidemic and determining the precautions to be taken.